Rgma (repulsive guidance molecule family member A) - Rat Genome Database

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Gene: Rgma (repulsive guidance molecule family member A) Mus musculus
Analyze
Symbol: Rgma
Name: repulsive guidance molecule family member A
RGD ID: 1323725
MGI Page MGI
Description: Enables coreceptor activity and signaling receptor binding activity. Acts upstream of or within several processes, including BMP signaling pathway; nervous system development; and positive regulation of membrane protein ectodomain proteolysis. Located in cell surface. Is expressed in several structures, including future brain; gut; nervous system; sensory organ; and trunk somite. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human RGMA (repulsive guidance molecule BMP co-receptor a).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BC059072; C230063O06; MGC38550; MGC69915; repulsive guidance molecule A; RGM domain family, member A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39773,025,268 - 73,069,647 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl773,025,257 - 73,069,647 (+)EnsemblGRCm39 Ensembl
GRCm38773,375,520 - 73,419,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl773,375,509 - 73,419,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv37780,520,406 - 80,564,785 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36773,249,020 - 73,293,410 (+)NCBIMGSCv36mm8
Celera770,823,178 - 70,867,680 (+)NCBICelera
Cytogenetic Map7D1NCBI
cM Map741.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
amitrole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
cantharidin  (EXP)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
Cuprizon  (ISO)
DDE  (ISO)
dexamethasone  (EXP,ISO)
dieldrin  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (ISO)
indometacin  (ISO)
Licochalcone B  (ISO)
mercury dibromide  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
niclosamide  (ISO)
Nutlin-3  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
propanal  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Induction of repulsive guidance molecule in neurons following sciatic nerve injury. Doya H, etal., J Chem Neuroanat. 2006 Aug;32(1):74-7. Epub 2006 Jul 24.
2. RGMa inhibition promotes axonal growth and recovery after spinal cord injury. Hata K, etal., J Cell Biol. 2006 Apr 10;173(1):47-58. Epub 2006 Apr 3.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. RGMA and IL21R show association with experimental inflammation and multiple sclerosis. Nohra R, etal., Genes Immun. 2010 Jun;11(4):279-93. Epub 2010 Jan 14.
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. RGMA and neogenin protein expression are influenced by lens injury following optic nerve crush in the rat retina. Schnichels S, etal., Graefes Arch Clin Exp Ophthalmol. 2012 Jan;250(1):39-50. doi: 10.1007/s00417-011-1791-9. Epub 2011 Sep 2.
11. Potential roles of the RGMa-FAK-Ras pathway in hippocampal mossy fiber sprouting in the pentylenetetrazole kindling model. Song MY, etal., Mol Med Rep. 2015 Mar;11(3):1738-44. doi: 10.3892/mmr.2014.2993. Epub 2014 Nov 21.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. CRMP-2 is involved in axon growth inhibition induced by RGMa in vitro and in vivo. Wang T, etal., Mol Neurobiol. 2013 Jun;47(3):903-13. doi: 10.1007/s12035-012-8385-3. Epub 2012 Dec 30.
14. Electrical stimulation of olfactory bulb downregulates RGMa expression after ischemia/reperfusion injury in rats. Zhang G, etal., Brain Res Bull. 2011 Oct 10;86(3-4):254-61. doi: 10.1016/j.brainresbull.2011.08.002. Epub 2011 Aug 5.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:14610273   PMID:14678836   PMID:14749425   PMID:14985445   PMID:15053976   PMID:15084667   PMID:15258590   PMID:15489334  
PMID:15975920   PMID:16032658   PMID:16141072   PMID:16141073   PMID:16782087   PMID:17389603   PMID:17472960   PMID:17942375   PMID:18519029   PMID:18799693   PMID:21059867   PMID:21187450  
PMID:21267068   PMID:21423182   PMID:21467223   PMID:21873635   PMID:21957482   PMID:22183806   PMID:22396795   PMID:22568948   PMID:23457482   PMID:24123853   PMID:24312340   PMID:25456136  
PMID:26073538   PMID:26611327   PMID:26633881   PMID:26651291   PMID:26896667   PMID:26930384   PMID:27143755   PMID:27545491   PMID:29478698   PMID:30333477   PMID:30733433   PMID:31541165  
PMID:32243839   PMID:33740419   PMID:33748906   PMID:34754080   PMID:35029290   PMID:36089003   PMID:37497580   PMID:37992159   PMID:38556067  


Genomics

Comparative Map Data
Rgma
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39773,025,268 - 73,069,647 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl773,025,257 - 73,069,647 (+)EnsemblGRCm39 Ensembl
GRCm38773,375,520 - 73,419,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl773,375,509 - 73,419,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv37780,520,406 - 80,564,785 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36773,249,020 - 73,293,410 (+)NCBIMGSCv36mm8
Celera770,823,178 - 70,867,680 (+)NCBICelera
Cytogenetic Map7D1NCBI
cM Map741.85NCBI
RGMA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381593,035,271 - 93,089,211 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1593,035,271 - 93,089,211 (-)EnsemblGRCh38hg38GRCh38
GRCh371593,578,501 - 93,632,440 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361591,387,641 - 91,433,437 (-)NCBINCBI36Build 36hg18NCBI36
Build 341591,387,640 - 91,433,437NCBI
Celera1569,998,187 - 70,044,004 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1569,723,091 - 69,768,218 (-)NCBIHuRef
CHM1_11593,427,333 - 93,473,451 (-)NCBICHM1_1
T2T-CHM13v2.01590,797,572 - 90,851,558 (-)NCBIT2T-CHM13v2.0
Rgma
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81136,538,782 - 136,582,763 (+)NCBIGRCr8
mRatBN7.21127,128,934 - 127,172,918 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1127,128,934 - 127,172,918 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1135,121,700 - 135,165,733 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01142,291,803 - 142,335,840 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01135,115,277 - 135,159,262 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01134,699,053 - 134,742,512 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1134,699,299 - 134,742,514 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01135,725,212 - 135,768,409 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41128,547,399 - 128,591,304 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11128,641,975 - 128,668,760 (+)NCBI
Celera1119,260,496 - 119,304,476 (+)NCBICelera
Cytogenetic Map1q31NCBI
Rgma
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541621,221,023 - 21,261,831 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541621,221,023 - 21,261,831 (-)NCBIChiLan1.0ChiLan1.0
RGMA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21682,590,158 - 82,635,904 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11586,288,195 - 86,333,861 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01571,728,669 - 71,774,447 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11590,922,199 - 90,951,704 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1590,922,199 - 90,956,179 (-)Ensemblpanpan1.1panPan2
RGMA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1347,044,342 - 47,089,923 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl347,061,910 - 47,089,294 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha349,744,736 - 49,788,688 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0347,453,705 - 47,497,710 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl347,453,784 - 47,498,695 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1346,971,723 - 47,015,658 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0347,203,068 - 47,247,025 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0347,534,393 - 47,578,334 (+)NCBIUU_Cfam_GSD_1.0
Rgma
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640136,541,660 - 136,581,389 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364839,766,275 - 9,793,001 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364839,753,112 - 9,792,817 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGMA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl785,921,594 - 85,968,888 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1785,921,524 - 85,968,887 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2791,815,011 - 91,862,487 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RGMA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12911,592,929 - 11,638,955 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2911,592,604 - 11,638,860 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605935,022,501 - 35,068,477 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgma
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476810,751,991 - 10,778,050 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476810,739,674 - 10,778,036 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rgma
2657 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:2483
Count of miRNA genes:645
Interacting mature miRNAs:809
Transcripts:ENSMUST00000094312, ENSMUST00000119206, ENSMUST00000128471, ENSMUST00000139780
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
26884381Bzwq2_mbi-zygomatic width QTL 2, 5 week (mouse)76524974896949207Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767290094101290240Mouse
1301663Skull9_mskull morphology 9 (mouse)Not determined75732612191326352Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
1301383Aem2_manti-erythrocyte autoantibody modifier 2 (mouse)Not determined76413542498135653Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
27095937Ulnl7_mulna length 7, 10 week (mouse)76644974898349207Mouse
11565101Tsve1_mvariable short tail (Tsv) enhancer 1 (mouse)75588950887142720Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767290094101290240Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
10054064Bwq11_mbody weight QTL 11 (mouse)Not determined75112495485125093Mouse
1357752Tabw_mtally ho asscoiated body weight (mouse)Not determined74919327883193390Mouse
10053685Eae43_mexperimental allergic encephalomyelitis susceptibility 43 (mouse)Not determined75112495485125093Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770143137104143379Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768365595102365702Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
1301465Egrm3_mearly growth rate (mouse)Not determined75732612191326352Mouse
1300952Hcs1_mhepatocarcinogenesis susceptibility 1 (mouse)Not determined75732612191326352Mouse
4142319Powg_mpost-ovarectomy weight gain (mouse)Not determined7285710592582163Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767290094101290240Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74114882075148965Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)767849748105449207Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772263372106263372Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
12880417V125Dq5_mvitamin D active form serum level QTL 5 (mouse)74524974879249748Mouse
12880418V125Dq6_mvitamin D active form serum level QTL 6 (mouse)75214974886149748Mouse
11532741Tbrs5_mtuberculosis resistance 5 (mouse)74915922783235415Mouse
1302141Fcsa6_mfemoral cross-sectional area 6 (mouse)Not determined74838446182384607Mouse
13506750Tbthq2_mtrabecular bone thickness QTL 2 (mouse)76565974877549748Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
12801463Rta1_mretinal aging 1 (mouse)76716802789089989Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)76578898699788986Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)76578898699788986Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
25314302Vmm2_mvariable multisystem mineralization 2, heart (mouse)74714974874149748Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse

Markers in Region
Rgma  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7D1UniSTS
cM Map7 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000094312   ⟹   ENSMUSP00000091870
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl773,025,268 - 73,069,647 (+)Ensembl
GRCm38.p6 Ensembl773,375,520 - 73,419,899 (+)Ensembl
Ensembl Acc Id: ENSMUST00000119206   ⟹   ENSMUSP00000112599
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl773,025,257 - 73,069,647 (+)Ensembl
GRCm38.p6 Ensembl773,375,509 - 73,419,899 (+)Ensembl
Ensembl Acc Id: ENSMUST00000128471   ⟹   ENSMUSP00000116552
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl773,040,908 - 73,059,199 (+)Ensembl
GRCm38.p6 Ensembl773,391,160 - 73,409,451 (+)Ensembl
Ensembl Acc Id: ENSMUST00000139780   ⟹   ENSMUSP00000145758
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl773,040,975 - 73,069,647 (+)Ensembl
GRCm38.p6 Ensembl773,391,227 - 73,419,899 (+)Ensembl
Ensembl Acc Id: ENSMUST00000206253
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl773,041,024 - 73,042,995 (+)Ensembl
GRCm38.p6 Ensembl773,391,276 - 73,393,247 (+)Ensembl
RefSeq Acc Id: NM_177740   ⟹   NP_808408
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39773,025,268 - 73,069,647 (+)NCBI
GRCm38773,375,520 - 73,419,899 (+)ENTREZGENE
MGSCv37780,520,406 - 80,564,785 (+)RGD
Celera770,823,178 - 70,867,680 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006540902   ⟹   XP_006540965
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39773,040,642 - 73,069,647 (+)NCBI
GRCm38773,390,894 - 73,419,899 (+)NCBI
Sequence:
RefSeq Acc Id: NP_808408   ⟸   NM_177740
- Peptide Label: precursor
- UniProtKB: Q7TQ34 (UniProtKB/Swiss-Prot),   Q8CIH6 (UniProtKB/Swiss-Prot),   Q6PCX7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006540965   ⟸   XM_006540902
- Peptide Label: isoform X1
- UniProtKB: Q6PCX7 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000145758   ⟸   ENSMUST00000139780
Ensembl Acc Id: ENSMUSP00000112599   ⟸   ENSMUST00000119206
Ensembl Acc Id: ENSMUSP00000091870   ⟸   ENSMUST00000094312
Ensembl Acc Id: ENSMUSP00000116552   ⟸   ENSMUST00000128471
Protein Domains
Repulsive guidance molecule C-terminal   Repulsive guidance molecule N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6PCX7-F1-model_v2 AlphaFold Q6PCX7 1-454 view protein structure

Promoters
RGD ID:8664427
Promoter ID:EPDNEW_M10244
Type:initiation region
Name:Rgma_1
Description:Mus musculus repulsive guidance molecule family member A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10246  EPDNEW_M10247  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38773,375,509 - 73,375,569EPDNEW
RGD ID:8664431
Promoter ID:EPDNEW_M10246
Type:single initiation site
Name:Rgma_3
Description:Mus musculus repulsive guidance molecule family member A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10244  EPDNEW_M10247  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38773,389,456 - 73,389,516EPDNEW
RGD ID:8664433
Promoter ID:EPDNEW_M10247
Type:initiation region
Name:Rgma_2
Description:Mus musculus repulsive guidance molecule family member A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10244  EPDNEW_M10246  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38773,391,277 - 73,391,337EPDNEW
RGD ID:6841916
Promoter ID:MM_KWN:51112
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   ES_Cell,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000077778,   OTTMUST00000077779
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36780,535,789 - 80,536,289 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2679262 AgrOrtholog
Ensembl Genes ENSMUSG00000070509 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000094312 ENTREZGENE
  ENSMUST00000094312.12 UniProtKB/Swiss-Prot
  ENSMUST00000119206.3 UniProtKB/TrEMBL
  ENSMUST00000128471.2 UniProtKB/TrEMBL
  ENSMUST00000139780 ENTREZGENE
  ENSMUST00000139780.3 UniProtKB/Swiss-Prot
Gene3D-CATH Mog1/PsbP, alpha/beta/alpha sandwich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro RGM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:244058 UniProtKB/Swiss-Prot
MGD MGI:2679262 ENTREZGENE
NCBI Gene 244058 ENTREZGENE
PANTHER PTHR31428 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR31428:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RGM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rgma PhenoGen
UniProt D3Z4W0_MOUSE UniProtKB/TrEMBL
  Q6PCX7 ENTREZGENE
  Q7TQ34 ENTREZGENE
  Q8C4C4_MOUSE UniProtKB/TrEMBL
  Q8CIH6 ENTREZGENE
  RGMA_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q7TQ34 UniProtKB/Swiss-Prot
  Q8CIH6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-12-03 Rgma  repulsive guidance molecule family member A    RGM domain family, member A  Symbol and/or name change 5135510 APPROVED