Mcrip1 (MAPK regulated corepressor interacting protein 1) - Rat Genome Database

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Gene: Mcrip1 (MAPK regulated corepressor interacting protein 1) Mus musculus
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Symbol: Mcrip1
Name: MAPK regulated corepressor interacting protein 1
RGD ID: 1323636
MGI Page MGI
Description: Predicted to be involved in regulation of epithelial to mesenchymal transition. Predicted to be located in cytoplasmic stress granule and nucleus. Is expressed in alveolus epithelium; lung; and lung epithelium. Orthologous to human MCRIP1 (MAPK regulated corepressor interacting protein 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fam195; Fam195b; family with sequence similarity 195, member B; hypothetical protein LOC192173; mapk-regulated corepressor-interacting protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,433,714 - 120,440,553 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,433,714 - 120,440,553 (-)EnsemblGRCm39 Ensembl
GRCm3811120,542,888 - 120,549,727 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,542,888 - 120,549,727 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711120,404,202 - 120,411,041 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,358,980 - 120,365,794 (-)NCBIMGSCv36mm8
Celera11132,278,296 - 132,285,087 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO,ISS)
cytoplasmic stress granule  (ISO,ISS)
nucleus  (ISO,ISS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11812828   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:18799693   PMID:21267068   PMID:31240265   PMID:32325033  


Genomics

Comparative Map Data
Mcrip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,433,714 - 120,440,553 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,433,714 - 120,440,553 (-)EnsemblGRCm39 Ensembl
GRCm3811120,542,888 - 120,549,727 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,542,888 - 120,549,727 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711120,404,202 - 120,411,041 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,358,980 - 120,365,794 (-)NCBIMGSCv36mm8
Celera11132,278,296 - 132,285,087 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.25NCBI
MCRIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,822,361 - 81,833,291 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,822,361 - 81,833,302 (-)EnsemblGRCh38hg38GRCh38
GRCh371779,780,237 - 79,791,167 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera1776,383,760 - 76,394,631 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,181,966 - 75,184,105 (-)NCBIHuRef
CHM1_11779,866,495 - 79,877,383 (-)NCBICHM1_1
T2T-CHM13v2.01782,689,526 - 82,700,456 (-)NCBIT2T-CHM13v2.0
Mcrip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,318,985 - 106,326,442 (-)NCBIGRCr8
mRatBN7.210105,820,656 - 105,828,146 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,820,656 - 105,828,271 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10110,924,820 - 110,926,871 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,387,847 - 110,389,898 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,741,104 - 105,743,155 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,720,144 - 109,727,595 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,720,144 - 109,722,195 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,313,274 - 109,320,680 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,933,593 - 109,935,644 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,948,097 - 109,950,148 (-)NCBI
Celera10104,364,211 - 104,366,262 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
Mcrip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,329,646 - 1,335,505 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555061,329,646 - 1,335,505 (+)NCBIChiLan1.0ChiLan1.0
MCRIP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,357,981 - 98,368,856 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,258,751 - 103,269,655 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,227,462 - 76,238,363 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11781,930,301 - 81,934,404 (-)NCBIpanpan1.1PanPan1.1panPan2
MCRIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19443,155 - 451,741 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9444,617 - 450,605 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha91,045,318 - 1,053,894 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.091,036,523 - 1,045,104 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.191,061,682 - 1,070,258 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,188,261 - 1,196,835 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,267,187 - 1,275,766 (+)NCBIUU_Cfam_GSD_1.0
Mcrip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,050,205 - 1,055,443 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,356,428 - 5,361,730 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,356,516 - 5,361,734 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCRIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,137,816 - 1,144,555 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,137,797 - 1,144,556 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MCRIP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,696,708 - 73,707,436 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,696,539 - 73,707,045 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607745,150,158 - 45,160,848 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcrip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,687,269 - 10,689,093 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,687,269 - 10,694,188 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mcrip1
198 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:550
Count of miRNA genes:387
Interacting mature miRNAs:436
Transcripts:ENSMUST00000034913, ENSMUST00000135515
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse

Markers in Region
UniSTS:490564  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811120,550,110 - 120,551,113UniSTSGRCm38
MGSCv3711120,411,424 - 120,412,427UniSTSGRCm37
Celera11132,285,470 - 132,286,473UniSTS
Cytogenetic Map11E2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000034913   ⟹   ENSMUSP00000034913
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11120,433,714 - 120,440,553 (-)Ensembl
GRCm38.p6 Ensembl11120,542,888 - 120,549,727 (-)Ensembl
Ensembl Acc Id: ENSMUST00000135515
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11120,433,714 - 120,440,527 (-)Ensembl
GRCm38.p6 Ensembl11120,542,888 - 120,549,701 (-)Ensembl
RefSeq Acc Id: NM_001033231   ⟹   NP_001028403
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911120,433,714 - 120,440,553 (-)NCBI
GRCm3811120,542,888 - 120,549,727 (-)NCBI
MGSCv3711120,404,202 - 120,411,041 (-)RGD
Celera11132,278,296 - 132,285,087 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001373934   ⟹   NP_001360863
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911120,433,714 - 120,440,548 (-)NCBI
GRCm3811120,542,888 - 120,549,722 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001028403 (Get FASTA)   NCBI Sequence Viewer  
  NP_001360863 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH25536 (Get FASTA)   NCBI Sequence Viewer  
  BAE28133 (Get FASTA)   NCBI Sequence Viewer  
  EDL34763 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000034913
  ENSMUSP00000034913.5
GenBank Protein Q3UGS4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001028403   ⟸   NM_001033231
- UniProtKB: Q8QZS4 (UniProtKB/Swiss-Prot),   Q3UGS4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001360863   ⟸   NM_001373934
- UniProtKB: Q3UGS4 (UniProtKB/Swiss-Prot),   Q8QZS4 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000034913   ⟸   ENSMUST00000034913

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3UGS4-F1-model_v2 AlphaFold Q3UGS4 1-97 view protein structure

Promoters
RGD ID:6820859
Promoter ID:MM_KWN:10931
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung,   MEF_B6
Transcripts:ENSMUST00000075027
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611120,405,971 - 120,406,702 (-)MPROMDB
RGD ID:6820866
Promoter ID:MM_KWN:10932
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_001033231,   UC007MTG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611120,410,671 - 120,411,702 (-)MPROMDB
RGD ID:8677690
Promoter ID:EPDNEW_M16875
Type:multiple initiation site
Name:Mcrip1_1
Description:Mus musculus MAPK regulated corepressor interacting protein 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811120,549,704 - 120,549,764EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2384752 AgrOrtholog
Ensembl Genes ENSMUSG00000061111 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034913 ENTREZGENE
  ENSMUST00000034913.5 UniProtKB/Swiss-Prot
InterPro MCRIP UniProtKB/Swiss-Prot
KEGG Report mmu:192173 UniProtKB/Swiss-Prot
MGD MGI:2384752 ENTREZGENE
NCBI Gene 192173 ENTREZGENE
Pfam FAM195 UniProtKB/Swiss-Prot
PhenoGen Mcrip1 PhenoGen
UniProt MCRI1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8QZS4 ENTREZGENE
UniProt Secondary Q8QZS4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-06 Mcrip1  MAPK regulated corepressor interacting protein 1  Fam195b  family with sequence similarity 195, member B  Symbol and/or name change 5135510 APPROVED