Flnb (filamin, beta) - Rat Genome Database

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Gene: Flnb (filamin, beta) Mus musculus
Analyze
Symbol: Flnb
Name: filamin, beta
RGD ID: 1323622
MGI Page MGI
Description: Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including cellular response to type II interferon; epithelial cell development; and skeletal muscle tissue development. Located in several cellular components, including brush border; focal adhesion; and stress fiber. Is expressed in several structures, including alimentary system; brain; facial prominence; limb mesenchyme; and skeleton. Used to study spondylocarpotarsal synostosis syndrome. Human ortholog(s) of this gene implicated in Larsen syndrome; bone development disease (multiple); cleft palate; and spinal disease (multiple). Orthologous to human FLNB (filamin B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ABP-280-like protein; actin binding protein 278; actin-binding-like protein; AL024016; beta-filamin; filamin-B; FLN-B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391414,518,185 - 14,651,852 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1414,518,185 - 14,651,816 (-)EnsemblGRCm39 Ensembl
GRCm38147,817,921 - 7,951,588 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl147,817,957 - 7,951,588 (+)EnsemblGRCm38mm10GRCm38
MGSCv37148,650,471 - 8,784,102 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36146,608,366 - 6,743,464 (+)NCBIMGSCv36mm8
Celera143,438,528 - 3,574,962 (+)NCBICelera
Cytogenetic Map14A1NCBI
cM Map144.59NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bromobenzene  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chloropicrin  (ISO)
choline  (EXP)
ciglitazone  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
dicrotophos  (ISO)
dimethylselenide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
fenamidone  (EXP)
fenthion  (EXP)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (EXP)
FR900359  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (EXP)
hydroxyl  (ISO)
indometacin  (ISO)
inulin  (EXP)
ivermectin  (ISO)
L-methionine  (EXP)
menadione  (EXP)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methidathion  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
piroxicam  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
rofecoxib  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
Soman  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thiram  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiogenesis  (IAGP)
abnormal artery development  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone ossification  (IAGP)
abnormal brain vasculature morphology  (IAGP)
abnormal cell adhesion  (IAGP)
abnormal cell physiology  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal chondrocyte physiology  (IAGP)
abnormal extracellular matrix morphology  (IAGP)
abnormal gait  (IAGP)
abnormal hyaline cartilage morphology  (IAGP)
abnormal limb bone morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal middle cerebral artery morphology  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal occipital bone morphology  (IAGP)
abnormal parietal bone morphology  (IAGP)
abnormal patella morphology  (IAGP)
abnormal perichondrium morphology  (IAGP)
abnormal posture  (IAGP)
abnormal radius morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal sternebra morphology  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal thoracic cage morphology  (IAGP)
abnormal ulna morphology  (IAGP)
abnormal vertebral column morphology  (IAGP)
abnormal viscerocranium morphology  (IAGP)
absent intervertebral disk  (IAGP)
brachyphalangia  (IAGP)
cervical vertebral fusion  (IAGP)
decreased body height  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IEA)
decreased bone mineral density  (IAGP)
decreased bone mineral density of vertebrae  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone ossification  (IAGP)
decreased compact bone thickness  (IAGP)
decreased diameter of radius  (IAGP)
decreased diameter of ulna  (IAGP)
decreased distal limb length  (IAGP)
decreased fibroblast cell migration  (IAGP)
decreased lean body mass  (IEA)
decreased length of long bones  (IAGP)
decreased long bone epiphyseal plate size  (IAGP)
decreased neutrophil cell number  (IEA)
decreased red blood cell distribution width  (IEA)
decreased rib number  (IAGP)
decreased survivor rate  (IAGP)
decreased width of hypertrophic chondrocyte zone  (IAGP)
dehydration  (IAGP)
delayed bone ossification  (IAGP)
delayed endochondral bone ossification  (IAGP)
delayed intramembranous bone ossification  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
fused carpal bones  (IAGP)
increased circulating serum albumin level  (IEA)
increased total body fat amount  (IEA)
increased width of hypertrophic chondrocyte zone  (IAGP)
joint laxity  (IAGP)
kyphoscoliosis  (IAGP)
kyphosis  (IAGP)
lordosis  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IAGP)
rib fusion  (IAGP)
scoliosis  (IAGP)
short radius  (IAGP)
short tibia  (IAGP)
slow postnatal weight gain  (IAGP)
small occipital bone  (IAGP)
small thoracic cage  (IAGP)
tachypnea  (IAGP)
thin ribs  (IAGP)
thoracic vertebral fusion  (IAGP)
vertebral fusion  (IAGP)
wide cranial sutures  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mutations in FLNB cause boomerang dysplasia. Bicknell LS, etal., J Med Genet. 2005 Jul;42(7):e43.
2. A molecular and clinical study of Larsen syndrome caused by mutations in FLNB. Bicknell LS, etal., J Med Genet. 2007 Feb;44(2):89-98. Epub 2006 Jun 26.
3. Integrin inactivators: balancing cellular functions in vitro and in vivo. Bouvard D, etal., Nat Rev Mol Cell Biol. 2013 Jul;14(7):430-42. doi: 10.1038/nrm3599. Epub 2013 May 30.
4. Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synostosis syndrome. Farrington-Rock C, etal., Hum Mol Genet. 2008 Mar 1;17(5):631-41. Epub 2007 Jul 17.
5. Mutations in two regions of FLNB result in atelosteogenesis I and III. Farrington-Rock C, etal., Hum Mutat. 2006 Jul;27(7):705-10.
6. Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule. Ficker M, etal., Dev Biol 2004 Apr 1;268(1):7-23.
7. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, etal., PLoS One. 2010 Jul 9;5(7):e11493. doi: 10.1371/journal.pone.0011493.
8. Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis. Krakow D, etal., Nat Genet. 2004 Apr;36(4):405-10. Epub 2004 Feb 29.
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Three novel missense mutations in the filamin B gene are associated with isolated congenital talipes equinovarus. Yang H, etal., Hum Genet. 2016 Oct;135(10):1181-9. doi: 10.1007/s00439-016-1701-7. Epub 2016 Jul 9.
Additional References at PubMed
PMID:7671812   PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:11807098   PMID:12393796   PMID:12466851   PMID:12477932  
PMID:12520002   PMID:12904583   PMID:14610273   PMID:15489334   PMID:15741177   PMID:15747579   PMID:16141072   PMID:16141073   PMID:16783646   PMID:17015433   PMID:17145501   PMID:17360453  
PMID:17510210   PMID:17606870   PMID:17967808   PMID:18799693   PMID:19015242   PMID:19144319   PMID:21267068   PMID:21325628   PMID:21565611   PMID:21677750   PMID:22083510   PMID:22114352  
PMID:22174152   PMID:22421546   PMID:23979929   PMID:24012369   PMID:24194600   PMID:24436304   PMID:24457600   PMID:24551245   PMID:24614889   PMID:24760772   PMID:26496610   PMID:27019229  
PMID:27626380   PMID:27664421   PMID:27789627   PMID:28175289   PMID:28190767   PMID:28378742   PMID:29107558   PMID:30064337   PMID:30333137   PMID:30335684   PMID:30457570   PMID:30550785  
PMID:31162944   PMID:31189591   PMID:32253237   PMID:33013468   PMID:34321999   PMID:35474298   PMID:36417873   PMID:37003352   PMID:37142655   PMID:38355793   PMID:38989458  


Genomics

Comparative Map Data
Flnb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391414,518,185 - 14,651,852 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1414,518,185 - 14,651,816 (-)EnsemblGRCm39 Ensembl
GRCm38147,817,921 - 7,951,588 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl147,817,957 - 7,951,588 (+)EnsemblGRCm38mm10GRCm38
MGSCv37148,650,471 - 8,784,102 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36146,608,366 - 6,743,464 (+)NCBIMGSCv36mm8
Celera143,438,528 - 3,574,962 (+)NCBICelera
Cytogenetic Map14A1NCBI
cM Map144.59NCBI
FLNB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38358,008,422 - 58,172,251 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl358,008,398 - 58,172,251 (+)EnsemblGRCh38hg38GRCh38
GRCh37357,994,149 - 58,157,978 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36357,969,167 - 58,133,018 (+)NCBINCBI36Build 36hg18NCBI36
Build 34357,969,200 - 58,133,015NCBI
Celera358,008,139 - 58,172,548 (+)NCBICelera
Cytogenetic Map3p14.3NCBI
HuRef358,091,507 - 58,255,398 (+)NCBIHuRef
CHM1_1357,944,271 - 58,108,169 (+)NCBICHM1_1
T2T-CHM13v2.0358,048,835 - 58,212,708 (+)NCBIT2T-CHM13v2.0
Flnb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81519,392,212 - 19,525,278 (-)NCBIGRCr8
mRatBN7.21516,961,999 - 17,095,059 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1516,962,003 - 17,095,006 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1519,136,669 - 19,269,742 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01520,095,144 - 20,228,215 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01518,350,059 - 18,483,132 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01518,750,152 - 18,883,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1518,750,118 - 18,883,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01522,716,606 - 22,849,401 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41518,949,027 - 19,082,504 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11518,950,017 - 19,108,490 (-)NCBI
Celera1516,918,384 - 17,051,016 (-)NCBICelera
Cytogenetic Map15p14NCBI
Flnb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554307,680,394 - 7,832,124 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554307,680,394 - 7,832,124 (+)NCBIChiLan1.0ChiLan1.0
FLNB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2257,978,724 - 58,142,635 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1357,983,508 - 58,147,409 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0357,943,263 - 58,107,115 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1359,359,234 - 59,521,989 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl359,359,234 - 59,521,989 (+)Ensemblpanpan1.1panPan2
FLNB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12032,394,755 - 32,533,440 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2032,396,165 - 32,533,275 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2032,324,259 - 32,462,636 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02032,668,416 - 32,806,815 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2032,668,423 - 32,806,776 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12032,123,648 - 32,261,938 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02032,480,340 - 32,618,596 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02032,652,257 - 32,790,526 (-)NCBIUU_Cfam_GSD_1.0
Flnb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118175,129,741 - 175,274,947 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364738,268,496 - 8,411,975 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364738,268,326 - 8,413,955 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLNB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1339,789,739 - 39,938,746 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11339,789,259 - 39,938,751 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21343,752,537 - 43,820,891 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FLNB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12219,304,822 - 19,468,037 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2219,304,781 - 19,468,036 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041147,393,314 - 147,556,732 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Flnb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624821691,272 - 836,322 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624821691,291 - 835,244 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Flnb
3971 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:360
Count of miRNA genes:271
Interacting mature miRNAs:303
Transcripts:ENSMUST00000052678
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141550Dbm3_mdiabetes modifier 3 (mouse)Not determined514347339143596Mouse
27226748Femd8_mfemur midshaft diameter 8, 10 week (mouse)141376927346737457Mouse
1301991Wta3_mweight adult 3 (mouse)Not determined14388747337887650Mouse
4141864Mrdq4_mmodifier of retinal degeneration QTL 4 (mouse)Not determined992324548765082Mouse
11532711Sluc40_msusceptibility to lung cancer 40 (mouse)14127379943Mouse
1300779Dyscalc4_mdystrophic cardiac calcinosis 4 (mouse)Not determined141221287146213007Mouse
10412071Ssen3_msuseptibility to Sendai virus 3 (mouse)Not determined14126987934Mouse
13824988Phsq1_mpercent hyperactivated sperm QTL 1 (mouse)14305000119469772Mouse
4141265Appd2_mAPP associated premature death 2 (mouse)Not determined14594555230114862Mouse
27226752Femd4_mfemur midshaft diameter 4, 5 week (mouse)141376927347237457Mouse

Markers in Region
UniSTS:237125  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38147,920,621 - 7,920,931UniSTSGRCm38
MGSCv37148,753,135 - 8,753,445UniSTSGRCm37
Celera143,543,953 - 3,544,263UniSTS
Cytogenetic Map14A1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001081427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_134080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006518050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA272439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC129222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC140322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF353669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF353672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK047011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
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  BM949278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
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  BP753071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP753072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP753829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP765788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU055777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
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  BY101832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA537344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
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  DV653075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000052678   ⟹   ENSMUSP00000052020
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1414,518,185 - 14,651,816 (-)Ensembl
GRCm38.p6 Ensembl147,817,957 - 7,951,588 (+)Ensembl
Ensembl Acc Id: ENSMUST00000228206
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1414,582,231 - 14,585,032 (-)Ensembl
GRCm38.p6 Ensembl147,884,741 - 7,887,542 (+)Ensembl
RefSeq Acc Id: NM_001081427   ⟹   NP_001074896
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391414,518,185 - 14,651,816 (-)NCBI
GRCm38147,817,957 - 7,951,588 (+)NCBI
Celera143,438,528 - 3,574,962 (+)NCBI
Sequence:
RefSeq Acc Id: NM_134080   ⟹   NP_598841
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391414,518,185 - 14,651,816 (-)NCBI
GRCm38147,817,957 - 7,951,588 (+)ENTREZGENE
MGSCv37148,650,471 - 8,784,102 (+)RGD
Celera143,438,528 - 3,574,962 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006518050   ⟹   XP_006518113
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391414,518,185 - 14,651,852 (-)NCBI
GRCm38147,817,921 - 7,951,588 (+)NCBI
Sequence:
RefSeq Acc Id: NP_598841   ⟸   NM_134080
- Peptide Label: isoform b
- Sequence:
RefSeq Acc Id: XP_006518113   ⟸   XM_006518050
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001074896   ⟸   NM_001081427
- Peptide Label: isoform a
- UniProtKB: Q8VHX7 (UniProtKB/Swiss-Prot),   Q8VHX4 (UniProtKB/Swiss-Prot),   E9QNV9 (UniProtKB/Swiss-Prot),   Q99KY3 (UniProtKB/Swiss-Prot),   Q80X90 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000052020   ⟸   ENSMUST00000052678
Protein Domains
Calponin-homology (CH)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80X90-F1-model_v2 AlphaFold Q80X90 1-2602 view protein structure

Promoters
RGD ID:8681468
Promoter ID:EPDNEW_M18764
Type:initiation region
Name:Flnb_1
Description:Mus musculus filamin, beta , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38147,818,012 - 7,818,072EPDNEW
RGD ID:6824939
Promoter ID:MM_KWN:15640
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000052678,   NM_134080,   UC007SEJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36148,650,341 - 8,650,841 (+)MPROMDB
RGD ID:6824941
Promoter ID:MM_KWN:15641
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:UC007SEL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36148,750,901 - 8,752,052 (+)MPROMDB
RGD ID:6847105
Promoter ID:MM_ACW:14908
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:FLNB.FSEP07,   FLNB.HSEP07-UNSPLICED,   FLNB.RSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36148,771,266 - 8,771,766 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2446089 AgrOrtholog
Ensembl Genes ENSMUSG00000025278 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000052678 ENTREZGENE
  ENSMUST00000052678.9 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/Swiss-Prot
  CH-domain UniProtKB/Swiss-Prot
  CH_dom_sf UniProtKB/Swiss-Prot
  Filamin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Filamin/ABP280_repeat-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Filamin/ABP280_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:286940 UniProtKB/Swiss-Prot
MGD MGI:2446089 ENTREZGENE
NCBI Gene 286940 ENTREZGENE
PANTHER FILAMIN-B UniProtKB/TrEMBL
  JITTERBUG, ISOFORM N UniProtKB/Swiss-Prot
  PTHR38537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Filamin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00307 UniProtKB/Swiss-Prot
PhenoGen Flnb PhenoGen
PROSITE ACTININ_1 UniProtKB/Swiss-Prot
  ACTININ_2 UniProtKB/Swiss-Prot
  FILAMIN_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50021 UniProtKB/Swiss-Prot
SMART IG_FLMN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00033 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47576 UniProtKB/Swiss-Prot
  SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9QNV9 ENTREZGENE
  FLNB_MOUSE UniProtKB/Swiss-Prot
  Q3T9V9_MOUSE UniProtKB/TrEMBL
  Q80X90 ENTREZGENE
  Q8VHX4 ENTREZGENE
  Q8VHX7 ENTREZGENE
  Q99KY3 ENTREZGENE
UniProt Secondary E9QNV9 UniProtKB/Swiss-Prot
  Q8VHX4 UniProtKB/Swiss-Prot
  Q8VHX7 UniProtKB/Swiss-Prot
  Q99KY3 UniProtKB/Swiss-Prot