Lrrc8a (leucine rich repeat containing 8A VRAC subunit A) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Lrrc8a (leucine rich repeat containing 8A VRAC subunit A) Mus musculus
Analyze
Symbol: Lrrc8a
Name: leucine rich repeat containing 8A VRAC subunit A
RGD ID: 1323280
MGI Page MGI
Description: Enables cyclic-GMP-AMP transmembrane transporter activity; identical protein binding activity; and volume-sensitive anion channel activity. Involved in several processes, including cyclic-GMP-AMP transmembrane import across plasma membrane; positive regulation of insulin secretion; and protein hexamerization. Located in plasma membrane. Part of monoatomic ion channel complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and upper leg. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 5. Orthologous to human LRRC8A (leucine rich repeat containing 8 VRAC subunit A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: eb; ebo; leucine rich repeat containing 8A; leucine-rich repeat-containing 8; leucine-rich repeat-containing protein 8A; Lr; Lrrc8; MGC61242; mKIAA1437; SWE; SWELL1; swelling protein 1; volume-regulated anion channel subunit LRRC8A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39230,127,781 - 30,153,802 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl230,127,727 - 30,153,802 (+)EnsemblGRCm39 Ensembl
GRCm38230,237,769 - 30,263,790 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl230,237,715 - 30,263,790 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl230,240,567 - 30,282,148 (+)EnsemblGRCm38mm10GRCm38
MGSCv37230,093,289 - 30,119,310 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36230,059,778 - 30,085,799 (+)NCBIMGSCv36mm8
Celera229,942,159 - 29,968,181 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map221.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (ISO)
bisphenol A  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (EXP)
diallyl trisulfide  (ISO)
Dibutyl phosphate  (ISO)
entinostat  (ISO)
ethanol  (EXP)
fenthion  (EXP)
folic acid  (EXP)
FR900359  (ISO)
furan  (ISO)
glyphosate  (EXP)
ivermectin  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (ISO)
phenobarbital  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (EXP)
rac-lactic acid  (ISO)
rotenone  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
urethane  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (ISO)
cytoplasm  (IBA)
lysosomal membrane  (IEA,ISO)
membrane  (ISO)
monoatomic ion channel complex  (IBA,IDA,ISO,ISS)
plasma membrane  (IBA,IDA,ISO,ISS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal craniofacial morphology  (IEA)
abnormal embryo size  (IEA)
abnormal eye morphology  (IEA)
abnormal fat cell morphology  (IAGP)
abnormal lung morphology  (IEA)
abnormal renal tubule morphology  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T cell selection  (IAGP)
abnormal thymus apoptosis  (IAGP)
abnormal thymus medulla morphology  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal thymus physiology  (IAGP)
absent corpus luteum  (IAGP)
absent thymus corticomedullary boundary  (IAGP)
anophthalmia  (IEA)
decreased B cell number  (IAGP)
decreased body weight  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased DN2 thymocyte number  (IAGP)
decreased DN3 thymocyte number  (IAGP)
decreased DN4 thymocyte number  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased epididymal fat pad weight  (IAGP)
decreased immature B cell number  (IAGP)
decreased inguinal fat pad weight  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
decreased thymocyte number  (IAGP)
decreased total body fat amount  (IAGP)
decreased transitional stage B cell number  (IAGP)
edema  (IEA)
enlarged lung  (IEA)
hydronephrosis  (IAGP)
hyperactivity  (IAGP)
hyperkeratosis  (IAGP)
impaired glucose tolerance  (IAGP)
increased energy expenditure  (IAGP)
increased IgG2a level  (IAGP)
increased pro-B cell number  (IAGP)
increased regulatory T cell number  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased thymocyte apoptosis  (IAGP)
infertility  (IAGP)
insulin resistance  (IAGP)
paraparesis  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
small spleen  (IAGP)
small thymus  (IAGP)
small thymus cortex  (IAGP)
thymus hypoplasia  (IAGP)
waved hair  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, etal., DNA Res 2003 Aug 31;10(4):167-80.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans. Sawada A, etal., J Clin Invest. 2003 Dec;112(11):1707-13.
Additional References at PubMed
PMID:8828840   PMID:10349636   PMID:10512203   PMID:10555545   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:15840001  
PMID:16141072   PMID:16141073   PMID:18799693   PMID:20562862   PMID:21873635   PMID:24194600   PMID:24752297   PMID:27764579   PMID:28192143   PMID:28289711   PMID:28436964   PMID:28553230  
PMID:28873008   PMID:29371604   PMID:29769723   PMID:29773801   PMID:29880644   PMID:30135305   PMID:30775971   PMID:30982627   PMID:31040226   PMID:31387946   PMID:32079488   PMID:32277911  
PMID:32598930   PMID:32802190   PMID:32892951   PMID:32930093   PMID:33216713   PMID:33629656   PMID:33827893   PMID:34469026   PMID:34521847   PMID:34888595   PMID:34968783   PMID:35145074  
PMID:35150591   PMID:35445421   PMID:35777784   PMID:35966575   PMID:36465125   PMID:36522427   PMID:36681074   PMID:36749637   PMID:36989353   PMID:37182109   PMID:37310356   PMID:37925509  
PMID:38006980   PMID:38355793   PMID:38847616  


Genomics

Comparative Map Data
Lrrc8a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39230,127,781 - 30,153,802 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl230,127,727 - 30,153,802 (+)EnsemblGRCm39 Ensembl
GRCm38230,237,769 - 30,263,790 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl230,237,715 - 30,263,790 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl230,240,567 - 30,282,148 (+)EnsemblGRCm38mm10GRCm38
MGSCv37230,093,289 - 30,119,310 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36230,059,778 - 30,085,799 (+)NCBIMGSCv36mm8
Celera229,942,159 - 29,968,181 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map221.41NCBI
LRRC8A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389128,882,133 - 128,918,039 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9128,882,133 - 128,918,039 (+)EnsemblGRCh38hg38GRCh38
GRCh379131,644,412 - 131,680,318 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,684,268 - 130,720,136 (+)NCBINCBI36Build 36hg18NCBI36
Celera9102,296,285 - 102,332,152 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9101,252,498 - 101,288,005 (+)NCBIHuRef
CHM1_19131,795,371 - 131,831,304 (+)NCBICHM1_1
T2T-CHM13v2.09141,086,880 - 141,122,794 (+)NCBIT2T-CHM13v2.0
Lrrc8a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8333,902,299 - 33,934,989 (+)NCBIGRCr8
mRatBN7.2313,509,577 - 13,537,174 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl313,510,513 - 13,536,202 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx316,582,049 - 16,607,745 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0325,167,015 - 25,192,710 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0323,412,851 - 23,438,502 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.038,801,544 - 8,829,506 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,802,852 - 8,828,533 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0314,155,802 - 14,182,455 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.439,280,625 - 9,306,317 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.139,280,924 - 9,306,606 (+)NCBI
Celera38,277,157 - 8,302,778 (+)NCBICelera
Cytogenetic Map3p12NCBI
Lrrc8a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555701,271,131 - 1,295,773 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555701,270,710 - 1,295,658 (+)NCBIChiLan1.0ChiLan1.0
LRRC8A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21110,434,536 - 10,470,431 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1910,436,885 - 10,472,779 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09100,003,969 - 100,039,859 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19128,670,292 - 128,705,466 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9128,670,292 - 128,705,466 (+)Ensemblpanpan1.1panPan2
LRRC8A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1954,732,847 - 54,760,077 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl954,734,505 - 54,756,780 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha953,928,394 - 53,955,628 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0955,653,903 - 55,681,136 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl955,638,508 - 55,681,057 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1954,414,997 - 54,442,249 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0954,727,390 - 54,754,601 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0954,820,897 - 54,848,149 (-)NCBIUU_Cfam_GSD_1.0
Lrrc8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947196,592,173 - 196,619,336 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648716,361,014 - 16,389,380 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648716,360,672 - 16,387,860 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC8A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1269,209,693 - 269,238,521 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11269,209,660 - 269,238,529 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21303,258,058 - 303,270,700 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC8A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,237,706 - 9,272,637 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl129,234,738 - 9,272,565 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666096207,064 - 244,637 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrc8a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247606,122,626 - 6,147,076 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247606,122,626 - 6,148,033 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrrc8a
1104 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1951
Count of miRNA genes:563
Interacting mature miRNAs:690
Transcripts:ENSMUST00000095078, ENSMUST00000113654, ENSMUST00000139454
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552706Cia24_mcollagen induced arthritis QTL 24 (mouse)Not determined22467911533523172Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
12904005Cfq2_mconditioned fear QTL 2 (mouse)22702264256396228Mouse
14746979Manh51_mmandible shape 51 (mouse)22896112962961129Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
8552705Cia25_mcollagen induced arthritis 25 (mouse)Not determined22467911533523172Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22530805156971811Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
14746997Mancz2_mmandible centroid size 2 (mouse)22896112962961129Mouse
12792980Fbmd1_mfemoral bone mineral density 1, females only (mouse)22503449245034492Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse

Markers in Region
RH130300  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38230,263,393 - 30,263,581UniSTSGRCm38
MGSCv37230,118,913 - 30,119,101UniSTSGRCm37
Celera229,967,784 - 29,967,972UniSTS
Cytogenetic Map2BUniSTS
BE197082  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38230,237,205 - 30,237,331UniSTSGRCm38
MGSCv37230,092,725 - 30,092,851UniSTSGRCm37
Celera229,941,594 - 29,941,720UniSTS
Cytogenetic Map2BUniSTS
Whitehead/MRC_RH2478.06UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000095078   ⟹   ENSMUSP00000092690
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl230,127,734 - 30,153,802 (+)Ensembl
GRCm38.p6 Ensembl230,237,722 - 30,263,790 (+)Ensembl
Ensembl Acc Id: ENSMUST00000113654   ⟹   ENSMUSP00000109284
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl230,127,727 - 30,153,797 (+)Ensembl
GRCm38.p6 Ensembl230,237,715 - 30,263,785 (+)Ensembl
Ensembl Acc Id: ENSMUST00000139454   ⟹   ENSMUSP00000139038
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl230,130,579 - 30,172,160 (+)Ensembl
GRCm38.p6 Ensembl230,240,567 - 30,282,148 (+)Ensembl
RefSeq Acc Id: NM_177725   ⟹   NP_808393
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39230,127,781 - 30,153,802 (+)NCBI
GRCm38230,237,769 - 30,263,790 (+)ENTREZGENE
MGSCv37230,093,289 - 30,119,310 (+)RGD
Celera229,942,159 - 29,968,181 (+)RGD
cM Map2 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_808393 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL08450 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000092690
  ENSMUSP00000092690.3
  ENSMUSP00000109284.2
  ENSMUSP00000139038.2
GenBank Protein Q80WG5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_808393   ⟸   NM_177725
- UniProtKB: A2AQZ0 (UniProtKB/Swiss-Prot),   Q80WG5 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000139038   ⟸   ENSMUST00000139454
Ensembl Acc Id: ENSMUSP00000109284   ⟸   ENSMUST00000113654
Ensembl Acc Id: ENSMUSP00000092690   ⟸   ENSMUST00000095078

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80WG5-F1-model_v2 AlphaFold Q80WG5 1-810 view protein structure

Promoters
RGD ID:6831741
Promoter ID:MM_KWN:28513
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000095078,   ENSMUST00000113654,   OTTMUST00000040643
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36230,092,241 - 30,093,322 (+)MPROMDB
RGD ID:6831742
Promoter ID:MM_KWN:28514
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000007620
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36230,111,366 - 30,112,647 (+)MPROMDB
RGD ID:6876886
Promoter ID:EPDNEW_M1894
Type:initiation region
Name:Lrrc8a_1
Description:Mus musculus leucine rich repeat containing 8A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38230,237,688 - 30,237,748EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2652847 AgrOrtholog
Ensembl Genes ENSMUSG00000007476 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSG00000099041 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000095078 ENTREZGENE
  ENSMUST00000095078.3 UniProtKB/Swiss-Prot
  ENSMUST00000113654.8 UniProtKB/Swiss-Prot
  ENSMUST00000139454.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  LRR_domain-containing UniProtKB/Swiss-Prot
  LRRC8_Pannexin-like UniProtKB/Swiss-Prot
KEGG Report mmu:241296 UniProtKB/Swiss-Prot
MGD MGI:2652847 ENTREZGENE
NCBI Gene 241296 ENTREZGENE
PANTHER PTHR48051 UniProtKB/Swiss-Prot
  RAS SUPPRESSOR PROTEIN 1 UniProtKB/Swiss-Prot
Pfam LRR_8 UniProtKB/Swiss-Prot
  Pannexin_like UniProtKB/Swiss-Prot
PhenoGen Lrrc8a PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot
SMART LRR_SD22 UniProtKB/Swiss-Prot
  LRR_TYP UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
UniProt A2AQZ0 ENTREZGENE
  LRC8A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2AQZ0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-05-14 Lrrc8a  leucine rich repeat containing 8A VRAC subunit A  Lrrc8a  leucine rich repeat containing 8A  Symbol and/or name change 5135510 APPROVED