Pdcd1 (programmed cell death 1) - Rat Genome Database

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Gene: Pdcd1 (programmed cell death 1) Mus musculus
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Symbol: Pdcd1
Name: programmed cell death 1
RGD ID: 1323232
MGI Page MGI
Description: Involved in negative regulation of immune response. Acts upstream of or within negative regulation of B cell apoptotic process; negative regulation of tolerance induction; and positive regulation of T cell apoptotic process. Located in external side of plasma membrane. Is expressed in retina. Used to study dilated cardiomyopathy and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ly101; mPD-1; PD-; PD-1; Pdc; Pdc1; programmed cell death protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,966,027 - 93,980,278 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,966,027 - 93,980,278 (-)EnsemblGRCm39 Ensembl
GRCm38194,038,305 - 94,052,553 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,038,305 - 94,052,553 (-)EnsemblGRCm38mm10GRCm38
MGSCv37195,934,882 - 95,949,130 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,868,711 - 95,882,959 (-)NCBIMGSCv36mm8
Celera196,903,284 - 96,917,529 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (IMP)
acute myocarditis  (IDA,IMP)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (IMP)
autoimmune hepatitis  (IEP,ISO)
Bethlem Myopathy 1A  (ISO)
Burns  (IEP,IMP)
cervix uteri carcinoma in situ  (ISO)
Chlamydia pneumonia  (IEP)
chromosome 2q37 deletion syndrome  (ISO)
Chronic Hepatitis B  (ISO)
Colonic Neoplasms  (IMP)
Colorectal Neoplasms  (ISO)
cryptococcal meningitis  (IMP,ISO)
cystitis  (IMP)
Cytomegalovirus Infections  (ISO)
D-2-hydroxyglutaric aciduria 1  (ISO)
dilated cardiomyopathy  (IAGP,IMP)
Experimental Autoimmune Encephalomyelitis  (IMP)
Experimental Melanoma  (IMP)
Fungemia  (IEP,IMP)
Graves' disease  (ISO)
Helicobacter Infections  (ISO)
Hepatic Echinococcosis  (IEP)
hepatitis  (ISO)
hepatitis A  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
hereditary spastic paraplegia 30  (ISO)
histoplasmosis  (IMP)
human immunodeficiency virus infectious disease  (ISO)
hydronephrosis  (IGI)
intellectual disability  (ISO)
Lung Neoplasms  (ISO)
lupus nephritis  (IMP,ISO)
lymphocytic choriomeningitis  (IMP)
melanoma  (IMP,ISO)
multiple sclerosis  (ISO)
myocarditis  (IMP)
periodontitis  (ISO)
Pneumovirus Infections  (IMP)
pre-eclampsia  (ISO)
pulmonary tuberculosis  (ISO)
Recurrent Respiratory Papillomatosis  (ISO)
renal cell carcinoma  (ISO)
respiratory syncytial virus infectious disease  (IEP,ISO)
Schistosomiasis Japonica  (IEP,IMP,ISO)
Sepsis  (IMP,ISO)
Spinal Cord Injuries  (ISO)
stomach cancer  (ISO)
Streptococcus pneumonia  (IMP)
systemic lupus erythematosus  (IAGP,ISO)
toxic shock syndrome  (ISO)
Transplant Rejection  (IMP,ISO)
triple-receptor negative breast cancer  (IMP)
tuberculosis  (ISO)
type 2 diabetes mellitus  (IEP)
Viral Bronchiolitis  (IEP)
viral encephalitis  (IEP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cardiac muscle contractility  (IAGP)
abnormal cardiac output  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal heart morphology  (IAGP)
abnormal immune tolerance  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal leukopoiesis  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal response to transplant  (IAGP)
abnormal T cell activation  (IAGP)
abnormal urinary bladder urothelium morphology  (IAGP)
abnormal urine cytokine level  (IAGP)
arthritis  (IAGP)
cardiac fibrosis  (IAGP)
decreased B-1 B cell number  (IAGP)
decreased body weight  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating lipase level  (IAGP)
decreased heart right ventricle wall thickness  (IAGP)
decreased interleukin-17 secretion  (IAGP)
decreased length of allograft survival  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to induced morbidity/mortality  (IAGP)
decreased T cell proliferation  (IAGP)
decreased T-helper 17 cell number  (IAGP)
decreased T-helper 2 cell number  (IAGP)
decreased tumor growth/size  (IAGP)
dilated heart ventricle  (IAGP)
enlarged heart  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
exophthalmos  (IAGP)
extended life span  (IAGP)
glomerulonephritis  (IAGP)
hepatic necrosis  (IAGP)
increased apoptosis  (IAGP)
increased autoantibody level  (IAGP)
increased B cell number  (IAGP)
increased B cell proliferation  (IAGP)
increased B-1 B cell number  (IAGP)
increased effector memory T-helper cell number  (IAGP)
increased IgA level  (IAGP)
increased IgG2b level  (IAGP)
increased IgG3 level  (IAGP)
increased IgM level  (IAGP)
increased inflammatory response  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-17 secretion  (IAGP)
increased interleukin-2 secretion  (IAGP)
increased lymphocyte cell number  (IAGP)
increased regulatory T cell number  (IAGP)
increased retina ganglion cell number  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased susceptibility to autoimmune disorder  (IAGP)
increased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
increased T cell proliferation  (IAGP)
increased T-helper 1 cell number  (IAGP)
increased tumor latency  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
insulitis  (IAGP)
lymph node hyperplasia  (IAGP)
oliguria  (IAGP)
pancreas atrophy  (IAGP)
pancreas inflammation  (IAGP)
pancreas necrosis  (IAGP)
premature death  (IAGP)
pulmonary necrosis  (IAGP)
spleen hyperplasia  (IAGP)
urinary bladder inflammation  (IAGP)
vascular inflammation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Roles of programmed death-1 (PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B3. null
2. Endoplasmic reticulum stress response and inflammatory cytokines in type 2 diabetic nephropathy: role of indoleamine 2,3-dioxygenase and programmed death-1. Baban B, etal., Exp Mol Pathol. 2013 Apr;94(2):343-51. doi: 10.1016/j.yexmp.2012.11.004. Epub 2012 Dec 5.
3. Genetic, immunologic, and immunohistochemical analysis of the programmed death 1/programmed death ligand 1 pathway in human systemic lupus erythematosus. Bertsias GK, etal., Arthritis Rheum. 2009 Jan;60(1):207-18. doi: 10.1002/art.24227.
4. Expression of programmed death 1 and its ligands in the liver of autoimmune hepatitis C57BL/6 mice. Cao J, etal., Chin Med J (Engl). 2009 Aug 20;122(16):1941-6.
5. Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis. Chang KC, etal., Crit Care. 2013 May 11;17(3):R85. doi: 10.1186/cc12711.
6. In vitro and in vivo effect of PD-1/PD-L1 blockade on microglia/macrophage activation and T cell subset balance in cryptococcal meningitis. Che YM, etal., J Cell Biochem. 2018 Apr;119(4):3044-3057. doi: 10.1002/jcb.26432. Epub 2017 Dec 26.
7. Programmed cell death-1 3'-untranslated region polymorphism is associated with spontaneous clearance of hepatitis B virus infection. Chihab H, etal., J Med Virol. 2018 Nov;90(11):1730-1738. doi: 10.1002/jmv.25265. Epub 2018 Aug 13.
8. Phenotypic Characteristics of PD-1 and CTLA-4 Expression in Symptomatic Acute Hepatitis A. Cho H, etal., Gut Liver. 2016 Mar;10(2):288-94. doi: 10.5009/gnl14368.
9. CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion. Correa-Rocha R, etal., PLoS One. 2018 Aug 30;13(8):e0203419. doi: 10.1371/journal.pone.0203419. eCollection 2018.
10. Gene transfer of programmed death ligand-1.Ig prolongs cardiac allograft survival. Dudler J, etal., Transplantation. 2006 Dec 27;82(12):1733-7.
11. Viral acute lower respiratory infections impair CD8+ T cells through PD-1. Erickson JJ, etal., J Clin Invest. 2012 Aug;122(8):2967-82. doi: 10.1172/JCI62860. Epub 2012 Jul 17.
12. Programmed death-1 impairs secondary effector lung CD8⁺ T cells during respiratory virus reinfection. Erickson JJ, etal., J Immunol. 2014 Nov 15;193(10):5108-17. doi: 10.4049/jimmunol.1302208. Epub 2014 Oct 22.
13. Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice. Frebel H, etal., J Exp Med. 2012 Dec 17;209(13):2485-99. doi: 10.1084/jem.20121015. Epub 2012 Dec 10.
14. Therapy With Carboplatin and Anti-PD-1 Antibodies Before Surgery Demonstrates Sustainable Anti-Tumor Effects for Secondary Cancers in Mice With Triple-Negative Breast Cancer. Gao M, etal., Front Immunol. 2020 Mar 5;11:366. doi: 10.3389/fimmu.2020.00366. eCollection 2020.
15. Regulation of Trypanosoma cruzi-induced myocarditis by programmed death cell receptor 1. Gutierrez FR, etal., Infect Immun. 2011 May;79(5):1873-81. doi: 10.1128/IAI.01047-10. Epub 2011 Feb 28.
16. Immune suppression in premalignant respiratory papillomas: enriched functional CD4+Foxp3+ regulatory T cells and PD-1/PD-L1/L2 expression. Hatam LJ, etal., Clin Cancer Res. 2012 Apr 1;18(7):1925-35. doi: 10.1158/1078-0432.CCR-11-2941. Epub 2012 Feb 9.
17. Dexmedetomidine Mitigates Microglia-Mediated Neuroinflammation through Upregulation of Programmed Cell Death Protein 1 in a Rat Spinal Cord Injury Model. He H, etal., J Neurotrauma. 2018 Nov 1;35(21):2591-2603. doi: 10.1089/neu.2017.5625. Epub 2018 Jun 7.
18. Association between a polymorphism in the human programmed death-1 (PD-1) gene and cytomegalovirus infection after kidney transplantation. Hoffmann TW, etal., J Med Genet. 2010 Jan;47(1):54-8. doi: 10.1136/jmg.2009.068841. Epub 2009 Jul 5.
19. A Programmed Cell Death-1 Haplotype is Associated with Clearance of Hepatitis B Virus. Hou Z, etal., Ann Clin Lab Sci. 2017 May;47(3):334-343.
20. PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis. Huang X, etal., Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6303-8. doi: 10.1073/pnas.0809422106. Epub 2009 Mar 30.
21. Prognostic Significance of PD-1, PD-L1 and CD8 Gene Expression Levels in Gastric Cancer. Ito S, etal., Oncology. 2020;98(7):501-511. doi: 10.1159/000506075. Epub 2020 May 7.
22. Correlation of CpG methylation of the Pdcd1 gene with PD-1 expression on CD8+ T cells and medical laboratory indicators in chronic hepatitis B infection. Jiao L, etal., J Gene Med. 2020 Feb;22(2):e3148. doi: 10.1002/jgm.3148. Epub 2020 Jan 9.
23. Association of a PDCD1 polymorphism with renal manifestations in systemic lupus erythematosus. Johansson M, etal., Arthritis Rheum. 2005 Jun;52(6):1665-9.
24. Chronically inflamed livers up-regulate expression of inhibitory B7 family members. Kassel R, etal., Hepatology. 2009 Nov;50(5):1625-37. doi: 10.1002/hep.23173.
25. Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death. Kohlhapp FJ, etal., Cell Rep. 2016 Oct 18;17(4):957-965. doi: 10.1016/j.celrep.2016.09.068.
26. Upregulation of PD-1 on CD4⁺CD25⁺ T cells is associated with immunosuppression in liver of mice infected with Echinococcus multilocularis. La X, etal., Int Immunopharmacol. 2015 Jun;26(2):357-66. doi: 10.1016/j.intimp.2015.04.013. Epub 2015 Apr 20.
27. Anti-programmed death-1 synergizes with granulocyte macrophage colony-stimulating factor--secreting tumor cell immunotherapy providing therapeutic benefit to mice with established tumors. Li B, etal., Clin Cancer Res. 2009 Mar 1;15(5):1623-34. doi: 10.1158/1078-0432.CCR-08-1825. Epub 2009 Feb 10.
28. Genetic polymorphisms of immune checkpoint proteins PD-1 and TIM-3 are associated with survival of patients with hepatitis B virus-related hepatocellular carcinoma. Li Z, etal., Oncotarget. 2016 May 3;7(18):26168-80. doi: 10.18632/oncotarget.8435.
29. Genetic variations in LTA gene and PDCD1 gene and intrauterine infection of hepatitis B virus: a case-control study in China. Liu T, etal., Amino Acids. 2018 Jul;50(7):877-883. doi: 10.1007/s00726-018-2568-9. Epub 2018 May 21.
30. The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum. Lázár-Molnár E, etal., Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2658-63. doi: 10.1073/pnas.0711918105. Epub 2008 Feb 11.
31. Programmed Death-Ligand 1 Expression Is Common in Gastric Cancer Associated With Epstein-Barr Virus or Microsatellite Instability. Ma C, etal., Am J Surg Pathol. 2016 Nov;40(11):1496-1506. doi: 10.1097/PAS.0000000000000698.
32. Blockade of the PD-1/PD-1L pathway reverses the protective effect of anti-CD40L therapy in a rat to mouse concordant islet xenotransplantation model. Mai G, etal., Xenotransplantation. 2007 May;14(3):243-8.
33. Anti-programmed cell death-1 antibody as a new serological marker for type 1 autoimmune hepatitis. Matsumoto K, etal., J Gastroenterol Hepatol. 2014 Jan;29(1):110-5. doi: 10.1111/jgh.12340.
34. PD-1 suppresses protective immunity to Streptococcus pneumoniae through a B cell-intrinsic mechanism. McKay JT, etal., J Immunol. 2015 Mar 1;194(5):2289-99. doi: 10.4049/jimmunol.1401673. Epub 2015 Jan 26.
35. MGDs mouse GO annotations MGD data from the GO Consortium
36. MGD IEA MGD IEA
37. Modulation of expression of Programmed Death-1 by administration of probiotic Dahi in DMH-induced colorectal carcinogenesis in rats. Mohania D, etal., Acta Biomed. 2013 Sep 1;84(2):102-9.
38. A putative regulatory polymorphism in PD-1 is associated with nephropathy in a population-based cohort of systemic lupus erythematosus patients. Nielsen C, etal., Lupus. 2004;13(7):510-6.
39. Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice. Okazaki T, etal., J Exp Med. 2005 Dec 19;202(12):1643-8. Epub 2005 Dec 13.
40. Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. Okazaki T, etal., Nat Med. 2003 Dec;9(12):1477-83. Epub 2003 Nov 2.
41. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
42. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
43. Notch Signaling Pathway Was Involved in Regulating Programmed Cell Death 1 Expression during Sepsis-Induced Immunosuppression. Pan T, etal., Mediators Inflamm. 2015;2015:539841. doi: 10.1155/2015/539841. Epub 2015 Apr 30.
44. Frontline Science: Anti-PD-L1 protects against infection with common bacterial pathogens after burn injury. Patil NK, etal., J Leukoc Biol. 2018 Jan;103(1):23-33. doi: 10.1002/JLB.5HI0917-360R. Epub 2017 Dec 21.
45. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
46. Stimulation of the PD-1/PDL-1 T-cell co-inhibitory pathway is effective in treatment of experimental autoimmune glomerulonephritis. Reynolds J, etal., Nephrol Dial Transplant. 2012 Apr;27(4):1343-50. doi: 10.1093/ndt/gfr529. Epub 2011 Sep 29.
47. Mouse MP Annotation Import Pipeline RGD automated import pipeline
48. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
50. Monocyte programmed death ligand-1 expression after 3-4 days of sepsis is associated with risk stratification and mortality in septic patients: a prospective cohort study. Shao R, etal., Crit Care. 2016 May 9;20(1):124. doi: 10.1186/s13054-016-1301-x.
51. The characteristic profiles of PD-1 and PD-L1 expressions and dynamic changes during treatment in active tuberculosis. Shen L, etal., Tuberculosis (Edinb). 2016 Dec;101:146-150. doi: 10.1016/j.tube.2016.10.001. Epub 2016 Oct 1.
52. Immunovirotherapy with vesicular stomatitis virus and PD-L1 blockade enhances therapeutic outcome in murine acute myeloid leukemia. Shen W, etal., Blood. 2016 Mar 17;127(11):1449-58. doi: 10.1182/blood-2015-06-652503. Epub 2015 Dec 28.
53. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
54. PD-1 Dynamically Regulates Inflammation and Development of Brain-Resident Memory CD8 T Cells During Persistent Viral Encephalitis. Shwetank, etal., Front Immunol. 2019 Apr 17;10:783. doi: 10.3389/fimmu.2019.00783. eCollection 2019.
55. Inhibiting the programmed death 1 pathway rescues Mycobacterium tuberculosis-specific interferon γ-producing T cells from apoptosis in patients with pulmonary tuberculosis. Singh A, etal., J Infect Dis. 2013 Aug 15;208(4):603-15. doi: 10.1093/infdis/jit206. Epub 2013 May 9.
56. Programmed Death Ligand 1 Promotes Early-Life Chlamydia Respiratory Infection-Induced Severe Allergic Airway Disease. Starkey MR, etal., Am J Respir Cell Mol Biol. 2016 Apr;54(4):493-503. doi: 10.1165/rcmb.2015-0204OC.
57. BALB/c-Fcgr2bPdcd1 mouse expressing anti-urothelial antibody is a novel model of autoimmune cystitis. Sugino Y, etal., Sci Rep. 2012;2:317. doi: 10.1038/srep00317. Epub 2012 Mar 19.
58. PD-1 is expressed by tumor-infiltrating immune cells and is associated with poor outcome for patients with renal cell carcinoma. Thompson RH, etal., Clin Cancer Res. 2007 Mar 15;13(6):1757-61.
59. The PD-1/PD-L1 inhibitory pathway is altered in pre-eclampsia and regulates T cell responses in pre-eclamptic rats. Tian M, etal., Sci Rep. 2016 Jun 9;6:27683. doi: 10.1038/srep27683.
60. Association of PDCD1 polymorphisms with childhood-onset systemic lupus erythematosus. Velazquez-Cruz R, etal., Eur J Hum Genet. 2007 Mar;15(3):336-41. Epub 2007 Jan 17.
61. Aberrant production of soluble inducible T cell co‑stimulator and soluble programmed cell death protein 1 in patients with chronic hepatitis B. Wang D, etal., Mol Med Rep. 2017 Dec;16(6):8556-8562. doi: 10.3892/mmr.2017.7630. Epub 2017 Sep 26.
62. TLR4 signaling improves PD-1 blockade therapy during chronic viral infection. Wang Y, etal., PLoS Pathog. 2019 Feb 6;15(2):e1007583. doi: 10.1371/journal.ppat.1007583. eCollection 2019 Feb.
63. Programmed death 1 mRNA in peripheral blood as biomarker of acute renal allograft rejection. Wang YW, etal., Chin Med J (Engl). 2011 Mar;124(5):674-8.
64. Lymphocyte subset expression and serum concentrations of PD-1/PD-L1 in sepsis - pilot study. Wilson JK, etal., Crit Care. 2018 Apr 17;22(1):95. doi: 10.1186/s13054-018-2020-2.
65. Blockade of programmed death-1 in young (New Zealand black x New Zealand white)F1 mice promotes the activity of suppressive CD8+ T cells that protect from lupus-like disease. Wong M, etal., J Immunol. 2010 Dec 1;185(11):6563-71. doi: 10.4049/jimmunol.0903401. Epub 2010 Nov 1.
66. Suppression of furin by interferon-γ and the impact on hepatitis B virus antigen biosynthesis in human hepatocytes. Wu JF, etal., Am J Pathol. 2012 Jul;181(1):19-25. doi: 10.1016/j.ajpath.2012.03.036. Epub 2012 May 24.
67. Expression of CD25(high) regulatory T cells and PD-1 in gastric infiltrating CD4(+) T lymphocytes in patients with Helicobacter pylori infection. Wu YY, etal., Clin Vaccine Immunol. 2011 Jul;18(7):1198-201. doi: 10.1128/CVI.00422-10. Epub 2011 May 11.
68. Immune Checkpoint Receptors Tim-3 and PD-1 Regulate Monocyte and T Lymphocyte Function in Septic Patients. Xia Q, etal., Mediators Inflamm. 2018 Nov 22;2018:1632902. doi: 10.1155/2018/1632902. eCollection 2018.
69. Genetic variations of IL-28B and PD-1 are in association with the susceptibility and outcomes of HCV infection in Southeast China. Xiao W, etal., Infect Genet Evol. 2015 Jun;32:89-96. doi: 10.1016/j.meegid.2015.02.022. Epub 2015 Mar 5.
70. Increased expression of programmed death (PD)-1 and its ligand PD-L1 correlates with impaired cell-mediated immunity in high-risk human papillomavirus-related cervical intraepithelial neoplasia. Yang W, etal., Immunology. 2013 Aug;139(4):513-22. doi: 10.1111/imm.12101.
71. [Temporal expression of PD-1 and PD-L1 during the development of experimental periodontitis in rats and its implications]. Yang X, etal., Shanghai Kou Qiang Yi Xue. 2019 Dec;28(6):591-596.
72. Control of pathogenic effector T-cell activities in situ by PD-L1 expression on respiratory inflammatory dendritic cells during respiratory syncytial virus infection. Yao S, etal., Mucosal Immunol. 2015 Jul;8(4):746-59. doi: 10.1038/mi.2014.106. Epub 2014 Dec 3.
73. Upregulation of circulating PD-L1/PD-1 is associated with poor post-cryoablation prognosis in patients with HBV-related hepatocellular carcinoma. Zeng Z, etal., PLoS One. 2011;6(9):e23621. doi: 10.1371/journal.pone.0023621. Epub 2011 Sep 1.
74. PD-1 deletion restores susceptibility to experimental autoimmune encephalomyelitis in miR-155-deficient mice. Zhang J and Braun MY, Int Immunol. 2014 Jul;26(7):407-15. doi: 10.1093/intimm/dxu043. Epub 2014 Mar 19.
75. Predictive Value of Soluble Programmed Death-1 for Severe Sepsis and Septic Shock During the First Week in an Intensive Care Unit. Zhao Y, etal., Shock. 2019 Mar;51(3):289-297. doi: 10.1097/SHK.0000000000001171.
76. Association between hepatitis B viral burden in chronic infection and a functional single nucleotide polymorphism of the PDCD1 gene. Zheng L, etal., J Clin Immunol. 2010 Nov;30(6):855-60. doi: 10.1007/s10875-010-9450-1. Epub 2010 Aug 11.
77. Blockade of PD-1 Signaling Enhances Th2 Cell Responses and Aggravates Liver Immunopathology in Mice with Schistosomiasis japonica. Zhou S, etal., PLoS Negl Trop Dis. 2016 Oct 28;10(10):e0005094. doi: 10.1371/journal.pntd.0005094. eCollection 2016 Oct.
78. Relationship between programmed cell death-1 polymorphisms and clearance of hepatitis B virus. Ülger Y, etal., Int J Immunogenet. 2015 Jun;42(3):133-9. doi: 10.1111/iji.12187. Epub 2015 Mar 4.
Additional References at PubMed
PMID:1396582   PMID:7851902   PMID:9141617   PMID:9332365   PMID:9796923   PMID:10349636   PMID:10485649   PMID:10704469   PMID:11015443   PMID:11042159   PMID:11076861   PMID:11209085  
PMID:11217851   PMID:11857337   PMID:12161284   PMID:12421930   PMID:12444166   PMID:12477932   PMID:12719480   PMID:12796776   PMID:12847135   PMID:12847136   PMID:12847137   PMID:12874215  
PMID:14515261   PMID:14568931   PMID:14724428   PMID:15030776   PMID:15030777   PMID:15100324   PMID:15237109   PMID:15484188   PMID:15542030   PMID:15568026   PMID:15611321   PMID:15685176  
PMID:15749874   PMID:15780994   PMID:15827960   PMID:15905503   PMID:16087865   PMID:16141072   PMID:16141073   PMID:16237069   PMID:16285013   PMID:16443792   PMID:16493037   PMID:16547224  
PMID:16921384   PMID:17116737   PMID:17142723   PMID:17182110   PMID:17267414   PMID:17289811   PMID:17392506   PMID:17414712   PMID:17606980   PMID:17627890   PMID:17629517   PMID:17667813  
PMID:17785507   PMID:17853943   PMID:17899549   PMID:17911591   PMID:17911595   PMID:18076633   PMID:18212277   PMID:18223165   PMID:18299579   PMID:18354207   PMID:18354211   PMID:18577709  
PMID:18593946   PMID:18599457   PMID:18641123   PMID:18651994   PMID:18684942   PMID:18713967   PMID:18771758   PMID:18813109   PMID:18828017   PMID:18832687   PMID:18832734   PMID:18925909  
PMID:18981087   PMID:18996482   PMID:19035251   PMID:19160960   PMID:19182257   PMID:19197390   PMID:19201863   PMID:19211743   PMID:19230866   PMID:19234176   PMID:19234228   PMID:19261693  
PMID:19299723   PMID:19302141   PMID:19339692   PMID:19368976   PMID:19380790   PMID:19417208   PMID:19420345   PMID:19420358   PMID:19443704   PMID:19454657   PMID:19454660   PMID:19454662  
PMID:19497561   PMID:19553535   PMID:19642196   PMID:19710450   PMID:19723542   PMID:19783989   PMID:19805226   PMID:19811462   PMID:19901343   PMID:19949087   PMID:19955307   PMID:19959639  
PMID:20007574   PMID:20113370   PMID:20118405   PMID:20139271   PMID:20160101   PMID:20215643   PMID:20382886   PMID:20410257   PMID:20453843   PMID:20484136   PMID:20506224   PMID:20570856  
PMID:20624978   PMID:20653631   PMID:20679213   PMID:20686128   PMID:20959049   PMID:21047981   PMID:21118907   PMID:21159661   PMID:21172867   PMID:21263073   PMID:21300912   PMID:21383057  
PMID:21385853   PMID:21393583   PMID:21422469   PMID:21441014   PMID:21464221   PMID:21469086   PMID:21525385   PMID:21576466   PMID:21589883   PMID:21623380   PMID:21697455   PMID:21700764  
PMID:21724589   PMID:21737801   PMID:21739608   PMID:21750671   PMID:21768399   PMID:21873525   PMID:21873635   PMID:21884581   PMID:21906434   PMID:21943489   PMID:21997806   PMID:22003198  
PMID:22144176   PMID:22186141   PMID:22210912   PMID:22319445   PMID:22459706   PMID:22459947   PMID:22491251   PMID:22539724   PMID:22539813   PMID:22544394   PMID:22641383   PMID:22684103  
PMID:22711893   PMID:22798683   PMID:22859605   PMID:22902234   PMID:22906740   PMID:22915761   PMID:22949674   PMID:22993390   PMID:23070399   PMID:23121978   PMID:23178752   PMID:23209326  
PMID:23242415   PMID:23254567   PMID:23303666   PMID:23337809   PMID:23417675   PMID:23530125   PMID:23545706   PMID:23566283   PMID:23583643   PMID:23633484   PMID:23636058   PMID:23686498  
PMID:23756664   PMID:23782245   PMID:23804712   PMID:23851694   PMID:23853599   PMID:23883516   PMID:23888055   PMID:23966393   PMID:23977133   PMID:24021877   PMID:24031027   PMID:24043779  
PMID:24065812   PMID:24076050   PMID:24165808   PMID:24227786   PMID:24240160   PMID:24247196   PMID:24257598   PMID:24316071   PMID:24319287   PMID:24353266   PMID:24379123   PMID:24412610  
PMID:24529703   PMID:24589924   PMID:24672046   PMID:24691202   PMID:24711622   PMID:24728077   PMID:24780756   PMID:24813249   PMID:24853068   PMID:24886298   PMID:24975127   PMID:25027060  
PMID:25047812   PMID:25080485   PMID:25082151   PMID:25113973   PMID:25219397   PMID:25236923   PMID:25299080   PMID:25358006   PMID:25404033   PMID:25404361   PMID:25464856   PMID:25488990  
PMID:25609381   PMID:25623164   PMID:25630305   PMID:25641586   PMID:25695838   PMID:25733520   PMID:25741704   PMID:25794782   PMID:25799228   PMID:25803808   PMID:25810391   PMID:25825451  
PMID:25851535   PMID:25877928   PMID:25902191   PMID:25934860   PMID:25964334   PMID:26034050   PMID:26043977   PMID:26048148   PMID:26105028   PMID:26109574   PMID:26162855   PMID:26208901  
PMID:26247556   PMID:26266810   PMID:26272364   PMID:26277582   PMID:26278059   PMID:26318293   PMID:26359984   PMID:26373277   PMID:26378076   PMID:26392556   PMID:26396175   PMID:26410627  
PMID:26467188   PMID:26608464   PMID:26696540   PMID:26750587   PMID:26769487   PMID:26824266   PMID:26824999   PMID:26910562   PMID:26913605   PMID:26974441   PMID:27060346   PMID:27197251  
PMID:27197661   PMID:27217330   PMID:27244558   PMID:27281199   PMID:27288425   PMID:27294527   PMID:27410049   PMID:27496729   PMID:27533014   PMID:27556047   PMID:27683557   PMID:27705792  
PMID:27717876   PMID:27731324   PMID:27749818   PMID:27760221   PMID:27760760   PMID:27821498   PMID:27825115   PMID:27829150   PMID:27835962   PMID:27856425   PMID:27895178   PMID:28096382  
PMID:28151427   PMID:28153727   PMID:28153736   PMID:28173160   PMID:28265006   PMID:28270509   PMID:28320090   PMID:28331165   PMID:28410988   PMID:28427861   PMID:28490441   PMID:28514441  
PMID:28530662   PMID:28539588   PMID:28586108   PMID:28670716   PMID:28681455   PMID:28686578   PMID:28687491   PMID:28698201   PMID:28710273   PMID:28747424   PMID:28756224   PMID:28768188  
PMID:28768724   PMID:28819064   PMID:28829048   PMID:28847007   PMID:28848055   PMID:28912267   PMID:28931759   PMID:28939757   PMID:28953925   PMID:29018057   PMID:29058703   PMID:29108460  
PMID:29143824   PMID:29282253   PMID:29303012   PMID:29337305   PMID:29337311   PMID:29439955   PMID:29493401   PMID:29531164   PMID:29617671   PMID:29654146   PMID:29695634   PMID:29712685  
PMID:29867974   PMID:29911570   PMID:29967259   PMID:29980219   PMID:30054205   PMID:30076099   PMID:30089911   PMID:30127438   PMID:30206757   PMID:30213644   PMID:30257954   PMID:30262908  
PMID:30274786   PMID:30305604   PMID:30333312   PMID:30382588   PMID:30420753   PMID:30463004   PMID:30485411   PMID:30487606   PMID:30545915   PMID:30564277   PMID:30565754   PMID:30587557  
PMID:30587849   PMID:30607385   PMID:30619369   PMID:30693001   PMID:30709740   PMID:30718426   PMID:30771904   PMID:30804928   PMID:30926234   PMID:30943039   PMID:30971695   PMID:30978356  
PMID:31001256   PMID:31028147   PMID:31031760   PMID:31112568   PMID:31227606   PMID:31241175   PMID:31277964   PMID:31358999   PMID:31429085   PMID:31533057   PMID:31534051   PMID:31553906  
PMID:31606264   PMID:31640402   PMID:31676858   PMID:31681332   PMID:31723059   PMID:31727535   PMID:31742928   PMID:31788554   PMID:31857157   PMID:31901074   PMID:31926212   PMID:31926851  
PMID:32014811   PMID:32048861   PMID:32059873   PMID:32113187   PMID:32122466   PMID:32134744   PMID:32265932   PMID:32306409   PMID:32310956   PMID:32333082   PMID:32347357   PMID:32484460  
PMID:32602900   PMID:32610128   PMID:32719675   PMID:32737343   PMID:32763116   PMID:32778730   PMID:32933159   PMID:32934075   PMID:33045061   PMID:33117347   PMID:33117369   PMID:33129844  
PMID:33151910   PMID:33193372   PMID:33232786   PMID:33233585   PMID:33257470   PMID:33268351   PMID:33280350   PMID:33300057   PMID:33320839   PMID:33419761   PMID:33452107   PMID:33461064  
PMID:33513345   PMID:33598777   PMID:33603737   PMID:33674785   PMID:33705751   PMID:33744709   PMID:33746973   PMID:33759577   PMID:33815358   PMID:33923025   PMID:33974042   PMID:33980853  
PMID:34076502   PMID:34093869   PMID:34157461   PMID:34188068   PMID:34203915   PMID:34231121   PMID:34271894   PMID:34281386   PMID:34321536   PMID:34335618   PMID:34386010   PMID:34417435  
PMID:34453440   PMID:34504192   PMID:34524124   PMID:34531874   PMID:34535576   PMID:34535949   PMID:34551314   PMID:34584206   PMID:34611166   PMID:34628702   PMID:34752634   PMID:34899751  
PMID:34912335   PMID:35014461   PMID:35104810   PMID:35263149   PMID:35356000   PMID:35394861   PMID:35417234   PMID:35589562   PMID:35720419   PMID:35762356   PMID:35812458   PMID:35840162  
PMID:35886878   PMID:35963284   PMID:35963455   PMID:36094816   PMID:36159872   PMID:36265003   PMID:36322628   PMID:36323784   PMID:36385524   PMID:36441248   PMID:36480166   PMID:36577929  
PMID:36581713   PMID:36852791   PMID:36853939   PMID:36876839   PMID:36902442   PMID:36917954   PMID:37030592   PMID:37147330   PMID:37208329   PMID:37280233   PMID:37344588   PMID:37348508  
PMID:37379210   PMID:37520550   PMID:37543948   PMID:37553426   PMID:37553821   PMID:37691307   PMID:37723306   PMID:37737264   PMID:37819238   PMID:37932447   PMID:37972801   PMID:38176655  
PMID:38349740   PMID:38377992   PMID:38386557   PMID:38446596   PMID:38492744   PMID:38503797   PMID:38518774   PMID:38551395   PMID:38615383   PMID:38622764   PMID:38742109   PMID:38815582  
PMID:38861924   PMID:38867043   PMID:38900572   PMID:39016179  


Genomics

Comparative Map Data
Pdcd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,966,027 - 93,980,278 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,966,027 - 93,980,278 (-)EnsemblGRCm39 Ensembl
GRCm38194,038,305 - 94,052,553 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,038,305 - 94,052,553 (-)EnsemblGRCm38mm10GRCm38
MGSCv37195,934,882 - 95,949,130 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,868,711 - 95,882,959 (-)NCBIMGSCv36mm8
Celera196,903,284 - 96,917,529 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.47NCBI
PDCD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,849,884 - 241,858,894 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,849,884 - 241,858,894 (-)EnsemblGRCh38hg38GRCh38
GRCh372242,792,036 - 242,801,046 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362242,440,711 - 242,449,731 (-)NCBINCBI36Build 36hg18NCBI36
Celera2236,456,683 - 236,465,707 (-)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2234,541,510 - 234,550,535 (-)NCBIHuRef
CHM1_12242,797,131 - 242,806,156 (-)NCBICHM1_1
T2T-CHM13v2.02242,351,431 - 242,360,440 (-)NCBIT2T-CHM13v2.0
Pdcd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,866,124 - 101,879,278 (-)NCBIGRCr8
mRatBN7.2994,418,786 - 94,431,945 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl994,418,791 - 94,431,937 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,854,260 - 102,867,404 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,989,476 - 108,002,637 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09106,346,469 - 106,359,638 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09101,305,742 - 101,319,937 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9101,307,764 - 101,319,845 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl9101,025,313 - 101,038,625 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09100,676,274 - 100,690,991 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4993,172,543 - 93,185,687 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera991,952,891 - 91,966,035 (-)NCBICelera
Cytogenetic Map9q36NCBI
Pdcd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495554249,259 - 58,823 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495554249,290 - 57,747 (+)NCBIChiLan1.0ChiLan1.0
PDCD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213144,543,641 - 144,553,063 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B144,558,538 - 144,568,773 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012130,849,353 - 130,858,776 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PDCD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12551,606,559 - 51,618,903 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2551,608,173 - 51,618,723 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2551,830,362 - 51,840,346 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02551,809,256 - 51,820,132 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2551,809,263 - 51,823,016 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12551,659,966 - 51,669,894 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02551,399,146 - 51,409,148 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02551,676,302 - 51,686,322 (-)NCBIUU_Cfam_GSD_1.0
Pdcd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303193,055,706 - 193,066,914 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936745152,612 - 161,587 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936745152,571 - 163,712 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDCD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15140,336,258 - 140,347,478 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115140,337,353 - 140,347,493 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PDCD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110127,877,383 - 127,886,234 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10127,878,554 - 127,886,088 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604071,433,325 - 71,442,153 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdcd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248475,732,767 - 5,742,269 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248475,732,922 - 5,741,908 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pdcd1
92 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:328
Count of miRNA genes:261
Interacting mature miRNAs:277
Transcripts:ENSMUST00000027507
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
15039333Nmrs1_mNAFLD-associated magnetic resonance shift 1 (mouse)189786512123786512Mouse
10045976Tir6_mtrypanosome infection response 6 (mouse)Not determined193536855120529678Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
4141627Bwq7_mbody weight, QTL 7 (mouse)Not determined192940909124497796Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73615692107615830Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177123115110536075Mouse
12879491Hfnq1_mhair follicle number QTL 1 (mouse)193310310123636759Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17747663795827725Mouse
12790991Aath1_maortic arch atherosclerosis 1 (mouse)186483929120483929Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
10412238Alpq5_malcohol preference QTL 5 (mouse)Not determined182832635116832635Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170133533104139557Mouse
1357760Synch3_msynechia 3 (mouse)Not determined192901442126901550Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
4141347Reb1_mrepetitive behavior 1 (mouse)Not determined91468266100413667Mouse
12791004Aath7_maortic arch atherosclerosis 7 (mouse)182832635116832635Mouse
4141725Wbcq4_mwhite blood cell quantitative locus 4 (mouse)Not determined179858683113858791Mouse
12050069Nabq1_mnasal bone morphology QTL 1 (mouse)179858683113858791Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173266214108838414Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)175976637128527737Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180245593126386517Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173615692107615830Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141329Mleu1_mmyeloid leukemia survival 1 (mouse)Not determined89786512123786512Mouse
11667074Led2_mlate embryonic death 2 (mouse)185696027117195081Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse

Markers in Region
X67914  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38194,038,694 - 94,038,838UniSTSGRCm38
MGSCv37195,935,271 - 95,935,415UniSTSGRCm37
Celera196,903,675 - 96,903,819UniSTS
Cytogenetic Map1DUniSTS
Whitehead/MRC_RH11322.98UniSTS


Expression


Sequence


Ensembl Acc Id: ENSMUST00000027507   ⟹   ENSMUSP00000027507
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl193,966,027 - 93,980,278 (-)Ensembl
GRCm38.p6 Ensembl194,038,305 - 94,052,553 (-)Ensembl
RefSeq Acc Id: NM_008798   ⟹   NP_032824
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39193,966,027 - 93,980,278 (-)NCBI
GRCm38194,038,305 - 94,052,553 (-)ENTREZGENE
MGSCv37195,934,882 - 95,949,130 (-)RGD
Celera196,903,284 - 96,917,529 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032824   ⟸   NM_008798
- Peptide Label: precursor
- UniProtKB: Q02242 (UniProtKB/Swiss-Prot),   Q544F3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000027507   ⟸   ENSMUST00000027507
Protein Domains
Ig-like   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02242-F1-model_v2 AlphaFold Q02242 1-288 view protein structure

Promoters
RGD ID:6874588
Promoter ID:EPDNEW_M745
Type:initiation region
Name:Pdcd1_1
Description:Mus musculus programmed cell death 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38194,052,566 - 94,052,626EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104879 AgrOrtholog
Ensembl Genes ENSMUSG00000026285 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000027507 ENTREZGENE
  ENSMUST00000027507.9 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDCD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18566 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104879 ENTREZGENE
NCBI Gene 18566 ENTREZGENE
PANTHER PROGRAMMED CELL DEATH PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdcd1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt PDCD1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q544F3 ENTREZGENE, UniProtKB/TrEMBL