Cd22 (CD22 antigen) - Rat Genome Database

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Gene: Cd22 (CD22 antigen) Mus musculus
Analyze
Symbol: Cd22
Name: CD22 antigen
RGD ID: 1323160
MGI Page MGI
Description: Enables CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in several processes, including negative regulation of calcium-mediated signaling; negative regulation of immunoglobulin production; and regulation of B cell proliferation. Located in external side of plasma membrane and neuronal cell body membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma. Orthologous to human CD22 (CD22 molecule).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A530093D23; B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; Lyb; Lyb-; Lyb-8; Lyb8; sialic acid-binding Ig-like lectin 2; siglec-2; T-cell surface antigen Leu-14
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,564,829 - 30,579,767 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,564,827 - 30,579,767 (-)EnsemblGRCm39 Ensembl
GRCm38730,865,404 - 30,880,342 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,865,402 - 30,880,342 (-)EnsemblGRCm38mm10GRCm38
MGSCv37731,650,423 - 31,665,361 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36730,574,589 - 30,589,027 (-)NCBIMGSCv36mm8
Celera725,448,881 - 25,463,851 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map719.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (ISO)
amphetamine  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bryostatin 1  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
cisplatin  (ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
dexamethasone  (EXP)
dexamethasone phosphate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP)
diquat  (EXP)
endosulfan  (ISO)
ethyl methanesulfonate  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
kojic acid  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
mercury dichloride  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
tamibarotene  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trametinib  (ISO)
tributylstannane  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (EXP)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell activation  (IAGP)
abnormal B cell calcium ion homeostasis  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal B cell negative selection  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal B cell proliferation  (IAGP)
abnormal CD4-positive, alpha-beta T cell physiology  (IEA)
abnormal class switch recombination  (IAGP)
abnormal humoral immune response  (IEA)
abnormal immune system morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal mature B cell morphology  (IAGP)
abnormal peripheral B cell anergy  (IAGP)
abnormal transitional stage B cell morphology  (IAGP)
absent mature B cells  (IAGP)
arrested B cell differentiation  (IEA)
autoimmune response  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased B-1a cell number  (IAGP)
decreased B-2 B cell number  (IEA)
decreased cell migration  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased memory B cell number  (IAGP)
decreased transitional stage B cell number  (IAGP)
decreased transitional stage T1 B cell number  (IAGP)
decreased transitional stage T2 B cell number  (IAGP)
hydrometra  (IEA)
impaired B cell migration  (IAGP)
increased activation-induced B cell apoptosis  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased B cell apoptosis  (IAGP)
increased B cell proliferation  (IAGP)
increased B-1 B cell number  (IAGP)
increased B-1a cell number  (IEA)
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number  (IEA)
increased CD8-positive, alpha-beta memory T cell number  (IEA)
increased circulating cholesterol level  (IEA)
increased IgG level  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2a level  (IAGP)
increased IgM level  (IAGP)
increased monocyte cell number  (IEA)
increased startle reflex  (IEA)
premature death  (IAGP)
small superior vagus ganglion  (IEA)
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Anti-CD22 and anti-CD79B antibody drug conjugates are active in different molecular diffuse large B-cell lymphoma subtypes. Pfeifer M, etal., Leukemia. 2015 Jul;29(7):1578-86. doi: 10.1038/leu.2015.48. Epub 2015 Feb 24.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1401903   PMID:6984010   PMID:7533044   PMID:7561031   PMID:8100843   PMID:8418208   PMID:8757957   PMID:8864124   PMID:8967951   PMID:8977319   PMID:8986715   PMID:9016707  
PMID:9175829   PMID:9480991   PMID:9586639   PMID:9862363   PMID:9890995   PMID:10209047   PMID:10224292   PMID:10349636   PMID:10373493   PMID:10485654   PMID:10501843   PMID:10748054  
PMID:10829070   PMID:10975807   PMID:11042159   PMID:11076861   PMID:11160300   PMID:11215824   PMID:11217851   PMID:11551923   PMID:11606382   PMID:11826756   PMID:11828373   PMID:11896394  
PMID:11994425   PMID:12055217   PMID:12115612   PMID:12207332   PMID:12421939   PMID:12477932   PMID:12594250   PMID:12646615   PMID:12902484   PMID:14635051   PMID:14688326   PMID:14764675  
PMID:15050965   PMID:15079087   PMID:15095367   PMID:15133509   PMID:15277237   PMID:15364920   PMID:15378059   PMID:15383609   PMID:16141072   PMID:16141073   PMID:16227086   PMID:16278813  
PMID:16291654   PMID:16369536   PMID:16393971   PMID:16497829   PMID:16517735   PMID:16782884   PMID:16920943   PMID:16983722   PMID:17312134   PMID:17420266   PMID:17420268   PMID:17420269  
PMID:17631277   PMID:18024433   PMID:18178830   PMID:18199638   PMID:18217946   PMID:18354178   PMID:19150402   PMID:19380785   PMID:19494269   PMID:19919568   PMID:20038598   PMID:20200274  
PMID:20335532   PMID:20513733   PMID:21089380   PMID:21178016   PMID:21267068   PMID:21464221   PMID:21677750   PMID:21799861   PMID:21873635   PMID:21956693   PMID:22190185   PMID:22724066  
PMID:22761313   PMID:22930244   PMID:22942427   PMID:22945870   PMID:22965838   PMID:23275601   PMID:23302871   PMID:23722906   PMID:23836650   PMID:23878314   PMID:24194600   PMID:24297165  
PMID:24344237   PMID:25252961   PMID:25826454   PMID:26507663   PMID:26561584   PMID:26671981   PMID:27352780   PMID:27729526   PMID:28346517   PMID:28378742   PMID:28972089   PMID:29146181  
PMID:29288201   PMID:29374074   PMID:29617956   PMID:29725338   PMID:30143587   PMID:30196744   PMID:30323814   PMID:30944478   PMID:31019513   PMID:31262443   PMID:31883832   PMID:32324805  
PMID:32325033   PMID:32341059   PMID:32592176   PMID:33589816   PMID:34140954   PMID:34330755   PMID:35230871   PMID:35236989   PMID:35294874   PMID:35921817   PMID:37671595   PMID:37696483  
PMID:38182585   PMID:38355793  


Genomics

Comparative Map Data
Cd22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,564,829 - 30,579,767 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,564,827 - 30,579,767 (-)EnsemblGRCm39 Ensembl
GRCm38730,865,404 - 30,880,342 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,865,402 - 30,880,342 (-)EnsemblGRCm38mm10GRCm38
MGSCv37731,650,423 - 31,665,361 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36730,574,589 - 30,589,027 (-)NCBIMGSCv36mm8
Celera725,448,881 - 25,463,851 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map719.26NCBI
CD22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,329,187 - 35,347,361 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,319,261 - 35,347,361 (+)EnsemblGRCh38hg38GRCh38
GRCh371935,820,090 - 35,838,264 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,511,919 - 40,530,104 (+)NCBINCBI36Build 36hg18NCBI36
Build 341940,511,951 - 40,530,102NCBI
Celera1932,533,518 - 32,551,714 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,328,559 - 32,346,758 (+)NCBIHuRef
CHM1_11935,821,684 - 35,839,873 (+)NCBICHM1_1
T2T-CHM13v2.01937,873,914 - 37,892,093 (+)NCBIT2T-CHM13v2.0
Cd22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8195,243,785 - 95,270,430 (-)NCBIGRCr8
mRatBN7.2186,116,376 - 86,132,782 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,117,459 - 86,132,322 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx191,537,671 - 91,552,509 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01100,003,840 - 100,018,678 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0193,295,970 - 93,310,808 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0189,313,475 - 89,329,902 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,314,558 - 89,329,418 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,468,925 - 90,484,920 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,923,707 - 85,938,567 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1186,002,464 - 86,017,095 (-)NCBI
Celera180,486,049 - 80,501,174 (-)NCBICelera
Cytogenetic Map1q21NCBI
Cd22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554684,612,044 - 4,625,882 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554684,609,601 - 4,622,601 (+)NCBIChiLan1.0ChiLan1.0
CD22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,337,545 - 41,362,265 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,320,913 - 43,343,681 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,265,278 - 32,294,122 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,012,271 - 41,030,719 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,012,222 - 41,030,713 (+)Ensemblpanpan1.1panPan2
CD22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11117,261,730 - 117,285,775 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1117,261,740 - 117,284,818 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1116,664,704 - 116,687,971 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,861,459 - 117,884,944 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,861,538 - 117,902,800 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11117,424,429 - 117,447,695 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01117,050,263 - 117,073,530 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01118,105,745 - 118,129,031 (-)NCBIUU_Cfam_GSD_1.0
Cd22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934910,673,663 - 10,685,813 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936570960,746 - 969,049 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936570960,592 - 971,688 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl644,820,689 - 44,834,389 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1644,820,593 - 44,834,392 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,344,666 - 40,351,564 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,251,220 - 30,285,084 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl630,270,229 - 30,282,859 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660738,052,288 - 8,074,899 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247948,211,094 - 8,221,866 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247948,211,232 - 8,224,020 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cd22
276 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:851
Count of miRNA genes:318
Interacting mature miRNAs:371
Transcripts:ENSMUST00000019248, ENSMUST00000108125
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
7394747asp3_maudiogenic seizure prone 3 (mouse)Not determined72730579836842367Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse

Markers in Region
Cd22  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38730,865,883 - 30,865,996UniSTSGRCm38
MGSCv37731,650,902 - 31,651,015UniSTSGRCm37
Celera725,449,360 - 25,449,473UniSTS
Cytogenetic Map7B1UniSTS
cM Map79.0UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001043317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_102722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_102723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006539493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_391039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC165340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF102134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF115400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF115401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ250684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY231006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L02844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L16928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X98097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000019248   ⟹   ENSMUSP00000019248
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,564,827 - 30,578,453 (-)Ensembl
GRCm38.p6 Ensembl730,865,402 - 30,879,028 (-)Ensembl
Ensembl Acc Id: ENSMUST00000108125   ⟹   ENSMUSP00000103760
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,565,252 - 30,579,490 (-)Ensembl
GRCm38.p6 Ensembl730,865,827 - 30,880,065 (-)Ensembl
Ensembl Acc Id: ENSMUST00000186154   ⟹   ENSMUSP00000139685
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,565,252 - 30,579,694 (-)Ensembl
GRCm38.p6 Ensembl730,865,827 - 30,880,269 (-)Ensembl
Ensembl Acc Id: ENSMUST00000186333
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,577,083 - 30,579,703 (-)Ensembl
GRCm38.p6 Ensembl730,877,658 - 30,880,278 (-)Ensembl
Ensembl Acc Id: ENSMUST00000186354
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,575,489 - 30,578,649 (-)Ensembl
GRCm38.p6 Ensembl730,876,064 - 30,879,224 (-)Ensembl
Ensembl Acc Id: ENSMUST00000187436
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,578,618 - 30,579,767 (-)Ensembl
GRCm38.p6 Ensembl730,879,193 - 30,880,342 (-)Ensembl
Ensembl Acc Id: ENSMUST00000187585
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,577,004 - 30,577,527 (-)Ensembl
GRCm38.p6 Ensembl730,877,579 - 30,878,102 (-)Ensembl
Ensembl Acc Id: ENSMUST00000187989   ⟹   ENSMUSP00000141178
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,565,714 - 30,579,704 (-)Ensembl
GRCm38.p6 Ensembl730,866,289 - 30,880,279 (-)Ensembl
Ensembl Acc Id: ENSMUST00000188157   ⟹   ENSMUSP00000140450
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,576,864 - 30,579,686 (-)Ensembl
GRCm38.p6 Ensembl730,877,439 - 30,880,261 (-)Ensembl
Ensembl Acc Id: ENSMUST00000189718   ⟹   ENSMUSP00000140521
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,565,254 - 30,577,874 (-)Ensembl
GRCm38.p6 Ensembl730,865,829 - 30,878,449 (-)Ensembl
Ensembl Acc Id: ENSMUST00000190170
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,577,044 - 30,579,703 (-)Ensembl
GRCm38.p6 Ensembl730,877,619 - 30,880,278 (-)Ensembl
Ensembl Acc Id: ENSMUST00000190455   ⟹   ENSMUSP00000140357
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,569,917 - 30,572,844 (-)Ensembl
GRCm38.p6 Ensembl730,870,492 - 30,873,419 (-)Ensembl
Ensembl Acc Id: ENSMUST00000190617   ⟹   ENSMUSP00000139871
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,565,688 - 30,579,759 (-)Ensembl
GRCm38.p6 Ensembl730,866,263 - 30,880,334 (-)Ensembl
Ensembl Acc Id: ENSMUST00000190646   ⟹   ENSMUSP00000140528
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,565,252 - 30,579,459 (-)Ensembl
GRCm38.p6 Ensembl730,865,827 - 30,880,034 (-)Ensembl
Ensembl Acc Id: ENSMUST00000190753   ⟹   ENSMUSP00000140014
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,577,159 - 30,579,693 (-)Ensembl
GRCm38.p6 Ensembl730,877,734 - 30,880,268 (-)Ensembl
Ensembl Acc Id: ENSMUST00000214289   ⟹   ENSMUSP00000150025
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl730,566,009 - 30,577,511 (-)Ensembl
GRCm38.p6 Ensembl730,866,584 - 30,878,086 (-)Ensembl
RefSeq Acc Id: NM_001043317   ⟹   NP_001036782
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39730,564,829 - 30,579,767 (-)NCBI
GRCm38730,865,404 - 30,880,342 (-)ENTREZGENE
MGSCv37731,650,423 - 31,665,361 (-)RGD
Celera725,448,881 - 25,463,851 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_009845   ⟹   NP_033975
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39730,564,829 - 30,578,453 (-)NCBI
GRCm38730,865,404 - 30,879,028 (-)NCBI
MGSCv37731,650,423 - 31,665,361 (-)RGD
Celera725,448,881 - 25,463,851 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_102722
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39730,564,829 - 30,579,767 (-)NCBI
GRCm38730,865,404 - 30,880,342 (-)NCBI
Celera725,448,881 - 25,463,851 (-)NCBI
Sequence:
RefSeq Acc Id: NR_102723
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39730,564,829 - 30,579,767 (-)NCBI
GRCm38730,865,404 - 30,880,342 (-)NCBI
Celera725,448,881 - 25,463,851 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006539489   ⟹   XP_006539552
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39730,565,248 - 30,579,718 (-)NCBI
GRCm38730,865,823 - 30,880,293 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006539490   ⟹   XP_006539553
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39730,565,248 - 30,579,762 (-)NCBI
GRCm38730,865,823 - 30,880,337 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006539491   ⟹   XP_006539554
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39730,565,248 - 30,579,740 (-)NCBI
GRCm38730,865,823 - 30,880,315 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006539493   ⟹   XP_006539556
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39730,565,248 - 30,579,762 (-)NCBI
GRCm38730,865,823 - 30,880,337 (-)NCBI
Sequence:
RefSeq Acc Id: XR_391039
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39730,565,248 - 30,579,718 (-)NCBI
GRCm38730,865,823 - 30,880,293 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001036782 (Get FASTA)   NCBI Sequence Viewer  
  NP_033975 (Get FASTA)   NCBI Sequence Viewer  
  XP_006539552 (Get FASTA)   NCBI Sequence Viewer  
  XP_006539553 (Get FASTA)   NCBI Sequence Viewer  
  XP_006539554 (Get FASTA)   NCBI Sequence Viewer  
  XP_006539556 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA02562 (Get FASTA)   NCBI Sequence Viewer  
  AAD30391 (Get FASTA)   NCBI Sequence Viewer  
  AAD30392 (Get FASTA)   NCBI Sequence Viewer  
  AAF02417 (Get FASTA)   NCBI Sequence Viewer  
  AAI50808 (Get FASTA)   NCBI Sequence Viewer  
  BAE25561 (Get FASTA)   NCBI Sequence Viewer  
  BAE33829 (Get FASTA)   NCBI Sequence Viewer  
  BAE42545 (Get FASTA)   NCBI Sequence Viewer  
  BAE42763 (Get FASTA)   NCBI Sequence Viewer  
  BAE42935 (Get FASTA)   NCBI Sequence Viewer  
  CAB85609 (Get FASTA)   NCBI Sequence Viewer  
  CAB85610 (Get FASTA)   NCBI Sequence Viewer  
  CAB85611 (Get FASTA)   NCBI Sequence Viewer  
  CAB85612 (Get FASTA)   NCBI Sequence Viewer  
  CAB85613 (Get FASTA)   NCBI Sequence Viewer  
  CAB85614 (Get FASTA)   NCBI Sequence Viewer  
  CAB85615 (Get FASTA)   NCBI Sequence Viewer  
  CAB85616 (Get FASTA)   NCBI Sequence Viewer  
  CAB85617 (Get FASTA)   NCBI Sequence Viewer  
  EDL23979 (Get FASTA)   NCBI Sequence Viewer  
  EDL23980 (Get FASTA)   NCBI Sequence Viewer  
  EDL23981 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000019248
  ENSMUSP00000019248.7
  ENSMUSP00000103760.3
  ENSMUSP00000139685
  ENSMUSP00000139685.2
  ENSMUSP00000139871
  ENSMUSP00000139871.2
  ENSMUSP00000140014.2
  ENSMUSP00000140357.2
  ENSMUSP00000140450.2
  ENSMUSP00000140521.2
  ENSMUSP00000140528.2
  ENSMUSP00000141178.2
  ENSMUSP00000150025.2
GenBank Protein P35329 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_033975   ⟸   NM_009845
- Peptide Label: precursor
- UniProtKB: Q9R094 (UniProtKB/Swiss-Prot),   Q9R056 (UniProtKB/Swiss-Prot),   Q9JJY1 (UniProtKB/Swiss-Prot),   Q9JJY0 (UniProtKB/Swiss-Prot),   Q9JJX9 (UniProtKB/Swiss-Prot),   Q9JHL2 (UniProtKB/Swiss-Prot),   Q9WU51 (UniProtKB/Swiss-Prot),   P35329 (UniProtKB/Swiss-Prot),   Q3UP36 (UniProtKB/TrEMBL),   Q3TAX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001036782   ⟸   NM_001043317
- Peptide Label: precursor
- UniProtKB: Q9R094 (UniProtKB/Swiss-Prot),   Q9R056 (UniProtKB/Swiss-Prot),   Q9JJY1 (UniProtKB/Swiss-Prot),   Q9JJY0 (UniProtKB/Swiss-Prot),   Q9JJX9 (UniProtKB/Swiss-Prot),   Q9JHL2 (UniProtKB/Swiss-Prot),   Q9WU51 (UniProtKB/Swiss-Prot),   P35329 (UniProtKB/Swiss-Prot),   Q3UP36 (UniProtKB/TrEMBL),   Q3TAX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006539556   ⟸   XM_006539493
- Peptide Label: isoform X2
- UniProtKB: Q9R094 (UniProtKB/Swiss-Prot),   Q9R056 (UniProtKB/Swiss-Prot),   Q9JJY1 (UniProtKB/Swiss-Prot),   Q9JJY0 (UniProtKB/Swiss-Prot),   Q9JJX9 (UniProtKB/Swiss-Prot),   Q9JHL2 (UniProtKB/Swiss-Prot),   Q9WU51 (UniProtKB/Swiss-Prot),   P35329 (UniProtKB/Swiss-Prot),   Q3UP36 (UniProtKB/TrEMBL),   Q3TAX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006539553   ⟸   XM_006539490
- Peptide Label: isoform X1
- UniProtKB: Q3TAX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006539554   ⟸   XM_006539491
- Peptide Label: isoform X1
- UniProtKB: Q3TAX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006539552   ⟸   XM_006539489
- Peptide Label: isoform X1
- UniProtKB: Q3TAX0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000139685   ⟸   ENSMUST00000186154
Ensembl Acc Id: ENSMUSP00000103760   ⟸   ENSMUST00000108125
Ensembl Acc Id: ENSMUSP00000139871   ⟸   ENSMUST00000190617
Ensembl Acc Id: ENSMUSP00000140528   ⟸   ENSMUST00000190646
Ensembl Acc Id: ENSMUSP00000140014   ⟸   ENSMUST00000190753
Ensembl Acc Id: ENSMUSP00000140357   ⟸   ENSMUST00000190455
Ensembl Acc Id: ENSMUSP00000140450   ⟸   ENSMUST00000188157
Ensembl Acc Id: ENSMUSP00000141178   ⟸   ENSMUST00000187989
Ensembl Acc Id: ENSMUSP00000019248   ⟸   ENSMUST00000019248
Ensembl Acc Id: ENSMUSP00000150025   ⟸   ENSMUST00000214289
Ensembl Acc Id: ENSMUSP00000140521   ⟸   ENSMUST00000189718
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35329-F1-model_v2 AlphaFold P35329 1-868 view protein structure

Promoters
RGD ID:8663531
Promoter ID:EPDNEW_M9797
Type:multiple initiation site
Name:Cd22_1
Description:Mus musculus CD22 antigen , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38730,880,279 - 30,880,339EPDNEW
RGD ID:6840802
Promoter ID:MM_KWN:49869
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:NM_009845,   UC009GGR.1,   UC009GGW.1,   UC009GGX.1,   UC009GGY.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36731,664,221 - 31,664,721 (-)MPROMDB
RGD ID:6840806
Promoter ID:MM_KWN:49870
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:ENSMUST00000108123,   NM_001043317,   UC009GGT.1,   UC009GGU.1,   UC009GGV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36731,664,871 - 31,665,371 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88322 AgrOrtholog
Ensembl Genes ENSMUSG00000030577 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000019248 ENTREZGENE
  ENSMUST00000019248.13 UniProtKB/Swiss-Prot
  ENSMUST00000108125.9 UniProtKB/Swiss-Prot
  ENSMUST00000186154 ENTREZGENE
  ENSMUST00000186154.7 UniProtKB/Swiss-Prot
  ENSMUST00000187989.7 UniProtKB/TrEMBL
  ENSMUST00000188157.7 UniProtKB/TrEMBL
  ENSMUST00000189718.7 UniProtKB/Swiss-Prot
  ENSMUST00000190455.2 UniProtKB/TrEMBL
  ENSMUST00000190617 ENTREZGENE
  ENSMUST00000190617.7 UniProtKB/Swiss-Prot
  ENSMUST00000190646 ENTREZGENE
  ENSMUST00000190646.7 UniProtKB/TrEMBL
  ENSMUST00000190753.2 UniProtKB/TrEMBL
  ENSMUST00000214289.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CD80_C2-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12483 UniProtKB/Swiss-Prot
MGD MGI:88322 ENTREZGENE
NCBI Gene 12483 ENTREZGENE
PANTHER B-CELL RECEPTOR CD22 UniProtKB/Swiss-Prot
  B-CELL RECEPTOR CD22 UniProtKB/Swiss-Prot
  B-CELL RECEPTOR CD22 UniProtKB/TrEMBL
  B-CELL RECEPTOR CD22 UniProtKB/TrEMBL
Pfam C2-set_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd22 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WQ27_MOUSE UniProtKB/TrEMBL
  A0A087WQV3_MOUSE UniProtKB/TrEMBL
  A0A087WR31_MOUSE UniProtKB/TrEMBL
  A0A087WR96_MOUSE UniProtKB/TrEMBL
  A0A087WST4_MOUSE UniProtKB/TrEMBL
  A0A1L1SSS3_MOUSE UniProtKB/TrEMBL
  CD22_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3T9T5_MOUSE UniProtKB/TrEMBL
  Q3TAA6_MOUSE UniProtKB/TrEMBL
  Q3TAX0 ENTREZGENE, UniProtKB/TrEMBL
  Q3U0M3_MOUSE UniProtKB/TrEMBL
  Q3UP36 ENTREZGENE
  Q9JHK8_MOUSE UniProtKB/TrEMBL
  Q9JHL2 ENTREZGENE
  Q9JJX9 ENTREZGENE
  Q9JJY0 ENTREZGENE
  Q9JJY1 ENTREZGENE
  Q9R056 ENTREZGENE
  Q9R094 ENTREZGENE
  Q9WU51 ENTREZGENE
UniProt Secondary Q3UP36 UniProtKB/Swiss-Prot
  Q9JHL2 UniProtKB/Swiss-Prot
  Q9JJX9 UniProtKB/Swiss-Prot
  Q9JJY0 UniProtKB/Swiss-Prot
  Q9JJY1 UniProtKB/Swiss-Prot
  Q9R056 UniProtKB/Swiss-Prot
  Q9R094 UniProtKB/Swiss-Prot
  Q9WU51 UniProtKB/Swiss-Prot