Adamts13 (ADAM metallopeptidase with thrombospondin type 1 motif 13) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Adamts13 (ADAM metallopeptidase with thrombospondin type 1 motif 13) Mus musculus
Analyze
Symbol: Adamts13
Name: ADAM metallopeptidase with thrombospondin type 1 motif 13
RGD ID: 1323133
MGI Page MGI
Description: Enables endopeptidase activity. Predicted to be involved in several processes, including extracellular matrix organization; peptide catabolic process; and protein catabolic process. Predicted to be located in extracellular space. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in thrombotic thrombocytopenic purpura. Orthologous to human ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif 13).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A disintegrin and metalloproteinase with thrombospondin motifs 13; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13; ADAM-TS 13; ADAM-TS13; ADAMTS-13; ADAMTS13 isoform IAP-b; Gm710; von Willebrand factor-cleaving protease; vWF-cleaving protease; vWF-CP; vWF-CP mRNA for von Willebrand factor-cleaving
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,863,363 - 26,899,638 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,863,428 - 26,899,640 (+)EnsemblGRCm39 Ensembl
GRCm38226,973,361 - 27,009,625 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,973,416 - 27,009,628 (+)EnsemblGRCm38mm10GRCm38
MGSCv37226,828,936 - 26,865,145 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,795,546 - 26,831,456 (+)NCBIMGSCv36mm8
Celera226,682,908 - 26,716,063 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Prevalence of the ADAMTS-13 missense mutation R1060W in late onset adult thrombotic thrombocytopenic purpura. Camilleri RS, etal., J Thromb Haemost. 2008 Feb;6(2):331-8. Epub 2007 Nov 20.
2. Deficient activity of von Willebrand factor-cleaving protease in chronic relapsing thrombotic thrombocytopenic purpura. Furlan M, etal., Blood. 1997 May 1;89(9):3097-103.
3. Mild to moderate reduction of a von Willebrand factor cleaving protease (ADAMTS-13) in pregnant women with HELLP microangiopathic syndrome. Lattuada A, etal., Haematologica. 2003 Sep;88(9):1029-34.
4. Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Levy GG, etal., Nature. 2001 Oct 4;413(6855):488-94.
5. Severe malaria is associated with a deficiency of von Willebrand factor cleaving protease, ADAMTS13. Lowenberg EC, etal., Thromb Haemost. 2010 Jan;103(1):181-7. doi: 10.1160/TH09-04-0223. Epub 2009 Sep 15.
6. Von Willebrand factor cleaving protease (ADAMTS-13) in 123 patients with connective tissue diseases (systemic lupus erythematosus and systemic sclerosis). Mannucci PM, etal., Haematologica. 2003 Aug;88(8):914-8.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice. Motto DG, etal., J Clin Invest. 2005 Oct;115(10):2752-61.
10. Increased ADAMTS-13 proteolytic activity in rat hepatic stellate cells upon activation in vitro and in vivo. Niiya M, etal., J Thromb Haemost. 2006 May;4(5):1063-70.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure. Ono T, etal., Blood. 2006 Jan 15;107(2):528-34. Epub 2005 Sep 27.
13. Impaired activity of plasma von Willebrand factor-cleaving protease may predict the occurrence of hepatic veno-occlusive disease after stem cell transplantation. Park YD, etal., Bone Marrow Transplant. 2002 May;29(9):789-94.
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. ADAMTS-13 is produced by glial cells and upregulated after spinal cord injury. Tauchi R, etal., Neurosci Lett. 2012 May 23;517(1):1-6. doi: 10.1016/j.neulet.2012.03.002. Epub 2012 Mar 7.
18. Potential for Recombinant ADAMTS13 as an Effective Therapy for Acquired Thrombotic Thrombocytopenic Purpura. Tersteeg C, etal., Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):2336-42. doi: 10.1161/ATVBAHA.115.306014. Epub 2015 Sep 3.
19. Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura. Tsai HM and Lian EC, N Engl J Med. 1998 Nov 26;339(22):1585-94.
20. Severe deficiency of the specific von Willebrand factor-cleaving protease (ADAMTS 13) activity in a subgroup of children with atypical hemolytic uremic syndrome. Veyradier A, etal., J Pediatr. 2003 Mar;142(3):310-7.
21. Increased production of ADAMTS13 in hepatic stellate cells contributes to enhanced plasma ADAMTS13 activity in rat models of cholestasis and steatohepatitis. Watanabe N, etal., Thromb Haemost. 2009 Aug;102(2):389-96.
22. Decreased levels of von Willebrand factor-cleaving protease in coronary heart disease and thrombotic thrombocytopenic purpura: study of a simplified method for assaying the enzyme activity based on ristocetin-induced platelet aggregation. Yoo G, etal., Br J Haematol. 2003 Apr;121(1):123-9.
23. Antithrombotic effect of grape seed proanthocyanidins extract in a rat model of deep vein thrombosis. Zhang Y, etal., J Vasc Surg. 2011 Mar;53(3):743-53. doi: 10.1016/j.jvs.2010.09.017. Epub 2010 Nov 20.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:14610273   PMID:15136581   PMID:15806136   PMID:15869605   PMID:16141072   PMID:16141073   PMID:16368888  
PMID:16533881   PMID:17414218   PMID:17414219   PMID:17426255   PMID:17509843   PMID:18006046   PMID:18083848   PMID:18263586   PMID:18695007   PMID:19109562   PMID:19141866   PMID:19541819  
PMID:19687510   PMID:19965676   PMID:20047094   PMID:20200350   PMID:20637190   PMID:20644116   PMID:20695979   PMID:20704649   PMID:21266777   PMID:21494805   PMID:21677750   PMID:21720563  
PMID:21799176   PMID:21873635   PMID:22123843   PMID:22192156   PMID:22212812   PMID:22232208   PMID:22529289   PMID:22652598   PMID:22712744   PMID:22721582   PMID:22915644   PMID:22983446  
PMID:23051932   PMID:23144461   PMID:23515928   PMID:23878316   PMID:24115559   PMID:24261607   PMID:24357063   PMID:24713928   PMID:25442981   PMID:25770910   PMID:25800050   PMID:25813552  
PMID:25835743   PMID:25849793   PMID:25855507   PMID:25977583   PMID:26073538   PMID:26542631   PMID:26929275   PMID:27444201   PMID:27479501   PMID:27507004   PMID:27602496   PMID:27604194  
PMID:27626380   PMID:28011677   PMID:28254814   PMID:28428179   PMID:28495930   PMID:29348121   PMID:29729651   PMID:29941674   PMID:29976618   PMID:30354235   PMID:31340669   PMID:31409673  
PMID:32135568   PMID:32196558   PMID:34666603   PMID:37759076   PMID:38355793   PMID:38597325  


Genomics

Comparative Map Data
Adamts13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,863,363 - 26,899,638 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,863,428 - 26,899,640 (+)EnsemblGRCm39 Ensembl
GRCm38226,973,361 - 27,009,625 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,973,416 - 27,009,628 (+)EnsemblGRCm38mm10GRCm38
MGSCv37226,828,936 - 26,865,145 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,795,546 - 26,831,456 (+)NCBIMGSCv36mm8
Celera226,682,908 - 26,716,063 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.14NCBI
ADAMTS13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,414,337 - 133,459,386 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9133,414,358 - 133,459,402 (+)EnsemblGRCh38hg38GRCh38
GRCh379136,279,457 - 136,324,508 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,276,941 - 135,314,328 (+)NCBINCBI36Build 36hg18NCBI36
Build 349133,316,673 - 133,344,631NCBI
Celera9106,830,032 - 106,875,101 (+)NCBICelera
Cytogenetic Map9q34.2NCBI
HuRef9105,781,289 - 105,826,219 (+)NCBIHuRef
CHM1_19136,429,966 - 136,475,028 (+)NCBICHM1_1
T2T-CHM13v2.09145,628,765 - 145,673,828 (+)NCBIT2T-CHM13v2.0
Adamts13
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,697,354 - 30,736,539 (+)NCBIGRCr8
mRatBN7.2310,299,264 - 10,338,464 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,300,028 - 10,346,687 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.035,519,921 - 5,558,390 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,519,990 - 5,558,166 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0310,881,333 - 10,920,130 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.435,868,906 - 5,908,061 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera35,098,096 - 5,136,496 (+)NCBICelera
Cytogenetic Map3p12NCBI
Adamts13
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,764,186 - 2,786,187 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555132,761,386 - 2,786,447 (+)NCBIChiLan1.0ChiLan1.0
ADAMTS13
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2115,894,039 - 5,935,236 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan195,896,355 - 5,937,896 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09104,541,051 - 104,582,574 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19133,163,788 - 133,193,913 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,156,761 - 133,193,707 (+)Ensemblpanpan1.1panPan2
ADAMTS13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,839,252 - 49,867,295 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl949,839,252 - 49,867,295 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha949,120,490 - 49,148,471 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0950,710,574 - 50,741,239 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,710,605 - 50,741,236 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1949,475,353 - 49,503,303 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,816,885 - 49,845,047 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0949,895,000 - 49,923,185 (+)NCBIUU_Cfam_GSD_1.0
Adamts13
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,894,464 - 199,925,811 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366693,456,494 - 3,478,512 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366693,449,259 - 3,478,471 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTS13
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1273,024,009 - 273,056,039 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11273,022,014 - 273,066,916 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21306,995,806 - 307,029,855 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTS13
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,677,237 - 4,718,825 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl124,677,229 - 4,714,386 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666058270,510 - 311,999 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamts13
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,865,376 - 1,889,203 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247601,865,474 - 1,889,394 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adamts13
1143 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:386
Count of miRNA genes:234
Interacting mature miRNAs:253
Transcripts:ENSMUST00000014996, ENSMUST00000102891, ENSMUST00000147216
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552706Cia24_mcollagen induced arthritis QTL 24 (mouse)Not determined22467911533523172Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
8552705Cia25_mcollagen induced arthritis 25 (mouse)Not determined22467911533523172Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22530805156971811Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
12792980Fbmd1_mfemoral bone mineral density 1, females only (mouse)22503449245034492Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
12904743Carcdq3_mcardiac collagen deposition QTL 3 (mouse)2323494028179150Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
12903993Opfaq1_mopen field activity QTL 1 (mouse)2967669127022642Mouse

Markers in Region
Adamts13  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A3UniSTS
cM Map219.14UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001001322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001290463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001290464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001290465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001782991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB071302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB095445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB112362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL773563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL845266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU034706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000014996   ⟹   ENSMUSP00000014996
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,863,428 - 26,888,592 (+)Ensembl
GRCm38.p6 Ensembl226,973,416 - 26,998,580 (+)Ensembl
Ensembl Acc Id: ENSMUST00000102891   ⟹   ENSMUSP00000099955
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,863,505 - 26,899,640 (+)Ensembl
GRCm38.p6 Ensembl226,973,493 - 27,009,628 (+)Ensembl
Ensembl Acc Id: ENSMUST00000147216
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl226,896,583 - 26,899,457 (+)Ensembl
GRCm38.p6 Ensembl227,006,571 - 27,009,445 (+)Ensembl
RefSeq Acc Id: NM_001001322   ⟹   NP_001001322
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,863,428 - 26,899,637 (+)NCBI
GRCm38226,973,416 - 27,009,625 (+)NCBI
MGSCv37226,828,936 - 26,865,145 (+)RGD
Celera226,682,908 - 26,737,138 (+)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001290463   ⟹   NP_001277392
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,863,428 - 26,899,637 (+)NCBI
GRCm38226,973,416 - 27,009,625 (+)NCBI
Celera226,682,908 - 26,737,138 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001290464   ⟹   NP_001277393
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,863,428 - 26,888,592 (+)NCBI
GRCm38226,973,416 - 26,998,580 (+)NCBI
Celera226,682,908 - 26,737,138 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001290465   ⟹   NP_001277394
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,863,428 - 26,888,592 (+)NCBI
GRCm38226,973,416 - 26,998,580 (+)NCBI
Celera226,682,908 - 26,737,138 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006498100   ⟹   XP_006498163
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,863,363 - 26,899,638 (+)NCBI
GRCm38226,973,361 - 27,009,358 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006498103   ⟹   XP_006498166
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,863,375 - 26,888,603 (+)NCBI
GRCm38226,973,366 - 26,998,591 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006498104   ⟹   XP_006498167
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,863,372 - 26,886,867 (+)NCBI
GRCm38226,973,364 - 26,996,855 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001782991
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39226,863,374 - 26,881,348 (+)NCBI
GRCm38226,973,365 - 26,991,336 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001001322   ⟸   NM_001001322
- Peptide Label: isoform 1 preproprotein
- UniProtKB: A2ALB4 (UniProtKB/Swiss-Prot),   Q76LW1 (UniProtKB/Swiss-Prot),   Q769J6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006498166   ⟸   XM_006498103
- Peptide Label: isoform X2
- UniProtKB: A7LM19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006498163   ⟸   XM_006498100
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006498167   ⟸   XM_006498104
- Peptide Label: isoform X3
- UniProtKB: A7LM19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001277392   ⟸   NM_001290463
- Peptide Label: isoform 2 precursor
- UniProtKB: Q769J6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001277394   ⟸   NM_001290465
- Peptide Label: isoform IAP-b precursor
- UniProtKB: A7LM19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001277393   ⟸   NM_001290464
- Peptide Label: isoform IAP-a precursor
- UniProtKB: A2ALB3 (UniProtKB/TrEMBL),   A7LM19 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000014996   ⟸   ENSMUST00000014996
Ensembl Acc Id: ENSMUSP00000099955   ⟸   ENSMUST00000102891
Protein Domains
CUB   Disintegrin   Peptidase M12B   TSP type-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q769J6-F1-model_v2 AlphaFold Q769J6 1-1426 view protein structure

Promoters
RGD ID:6830705
Promoter ID:MM_KWN:28324
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000027824
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36226,861,786 - 26,862,286 (+)MPROMDB
RGD ID:6876740
Promoter ID:EPDNEW_M1821
Type:multiple initiation site
Name:Adamts13_1
Description:Mus musculus a disintegrin-like and metallopeptidase with thrombospondintype 1 motif, 13 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38226,973,493 - 26,973,553EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685556 AgrOrtholog
Ensembl Genes ENSMUSG00000014852 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000014996 ENTREZGENE
  ENSMUST00000014996.14 UniProtKB/TrEMBL
  ENSMUST00000102891 ENTREZGENE
  ENSMUST00000102891.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.20.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.830 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.1620.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADAM_CR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM_Cys-rich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTS/ADAMTS-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTS_ADAMTS-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTS_spacer1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot
  TSP1_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:279028 UniProtKB/Swiss-Prot
MGD MGI:2685556 ENTREZGENE
NCBI Gene 279028 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADAM_CR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM_CR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_ADAMTS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adamts13 PhenoGen
PRINTS ADAMTSFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART ACR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49854 UniProtKB/Swiss-Prot
  SSF82895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2ALB3 ENTREZGENE, UniProtKB/TrEMBL
  A2ALB4 ENTREZGENE
  A7LM19 ENTREZGENE, UniProtKB/TrEMBL
  ATS13_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q76LW1 ENTREZGENE
UniProt Secondary A2ALB4 UniProtKB/Swiss-Prot
  Q76LW1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Adamts13  ADAM metallopeptidase with thrombospondin type 1 motif 13  Adamts13  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13  Symbol and/or name change 5135510 APPROVED