Sik3 (SIK family kinase 3) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Sik3 (SIK family kinase 3) Mus musculus
Analyze
Symbol: Sik3
Name: SIK family kinase 3
RGD ID: 1323064
MGI Page MGI
Description: Predicted to enable ATP binding activity; magnesium ion binding activity; and protein kinase activity. Acts upstream of or within endochondral bone morphogenesis; limb morphogenesis; and regulation of protein localization. Located in cytoplasm. Is expressed in Meckel's cartilage and vibrissa. Orthologous to human SIK3 (SIK family kinase 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5730525O22Rik; 9030204A07Rik; AI447252; AI846254; AI849445; expressed sequence AI849445; MGC90906; MGC91236; mKIAA0999; Qsk; RIKEN cDNA 9030204A07 gene; salt-inducible kinase 3; serine/threonine-protein kinase QSK; serine/threonine-protein kinase SIK3; SIK-3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39945,924,099 - 46,135,492 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl945,924,118 - 46,135,492 (+)EnsemblGRCm39 Ensembl
GRCm38946,012,820 - 46,224,194 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl946,012,820 - 46,224,194 (+)EnsemblGRCm38mm10GRCm38
MGSCv37945,820,903 - 46,032,277 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36945,763,873 - 45,974,137 (+)NCBIMGSCv36mm8
Celera943,407,782 - 43,513,027 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bile color  (IAGP)
abnormal bile composition  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone structure  (IAGP)
abnormal brain wave pattern  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal cholesterol level  (IAGP)
abnormal circadian sleep/wake cycle  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal coat/hair pigmentation  (IEA)
abnormal cornea morphology  (IEA)
abnormal cranium morphology  (IEA)
abnormal eating behavior  (IAGP)
abnormal energy homeostasis  (IAGP)
abnormal fat cell differentiation  (IAGP)
abnormal femur morphology  (IEA)
abnormal fibula morphology  (IEA)
abnormal gallbladder epithelium morphology  (IAGP)
abnormal gallbladder morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal homeostasis  (IAGP)
abnormal humerus morphology  (IEA)
abnormal joint morphology  (IEA)
abnormal limb long bone morphology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal liver morphology  (IAGP)
abnormal non-rapid eye movement sleep pattern  (IAGP)
abnormal paradoxical sleep pattern  (IAGP)
abnormal parietal bone morphology  (IAGP)
abnormal pelvic girdle bone morphology  (IAGP)
abnormal radius morphology  (IEA)
abnormal retina morphology  (IEA)
abnormal retinol level  (IAGP)
abnormal rib morphology  (IEA)
abnormal sleep duration  (IAGP)
abnormal spine curvature  (IEA)
abnormal tail morphology  (IEA)
abnormal thoracic cage shape  (IEA)
abnormal tibia morphology  (IEA)
abnormal ulna morphology  (IEA)
abnormal vertebrae morphology  (IEA)
abnormal vertebral column morphology  (IAGP)
abnormal zygomatic bone morphology  (IEA)
cholestasis  (IAGP)
decreased alpha-beta T cell number  (IEA)
decreased blood urea nitrogen level  (IEA)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brown adipose tissue amount  (IAGP)
decreased CD4-positive NK T cell number  (IEA)
decreased CD4-positive, alpha-beta T cell number  (IEA)
decreased CD5-positive gamma-delta T cell number  (IEA)
decreased chondrocyte number  (IAGP)
decreased circulating alanine transaminase level  (IAGP)
decreased circulating calcium level  (IEA)
decreased circulating cholesterol level  (IAGP)
decreased circulating fructosamine level  (IEA)
decreased circulating glucose level  (IAGP)
decreased circulating HDL cholesterol level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating potassium level  (IEA)
decreased circulating triglyceride level  (IAGP)
decreased circulating VLDL triglyceride level  (IAGP)
decreased early germinal center B cell number  (IEA)
decreased effector memory T-helper cell number  (IEA)
decreased erythrocyte cell number  (IEA)
decreased fat cell size  (IAGP)
decreased gamma-delta T cell number  (IEA)
decreased germinal center B cell number  (IEA)
decreased gonadal fat pad weight  (IAGP)
decreased hematocrit  (IEA)
decreased kidney weight  (IAGP)
decreased KLRG1-positive NK cell number  (IEA)
decreased KLRG1-positive T-helper cell number  (IEA)
decreased length of long bones  (IAGP)
decreased liver cholesterol level  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased liver weight  (IAGP)
decreased Ly6C-positive mature NK cell number  (IEA)
decreased memory-marker CD4-negative NK T cell number  (IEA)
decreased memory-marker CD4-positive NK T cell number  (IEA)
decreased mesenteric fat pad weight  (IAGP)
decreased NK cell number  (IEA)
decreased NK T cell number  (IEA)
decreased pancreas weight  (IAGP)
decreased regulatory T cell number  (IEA)
decreased renal fat pad weight  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased susceptibility to diet-induced hepatic steatosis  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased T cell number  (IEA)
decreased T-helper cell number  (IEA)
decreased total body fat amount  (IEA)
decreased width of hypertrophic chondrocyte zone  (IAGP)
delayed cranial suture closure  (IAGP)
delayed intramembranous bone ossification  (IAGP)
enlarged gallbladder  (IAGP)
female infertility  (IEA)
improved glucose tolerance  (IAGP)
increased adiponectin level  (IAGP)
increased bile salt level  (IAGP)
increased CD4-negative NK T cell number  (IEA)
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number  (IEA)
increased CD8-positive, alpha-beta T cell number  (IEA)
increased CD8-positive, naive alpha-beta T cell number  (IEA)
increased circulating alanine transaminase level  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating amylase level  (IEA)
increased circulating bilirubin level  (IAGP)
increased circulating sodium level  (IEA)
increased circulating triglyceride level  (IAGP)
increased core body temperature  (IAGP)
increased effector memory T-helper cell number  (IEA)
increased eosinophil cell number  (IEA)
increased follicular B cell number  (IEA)
increased granulocyte number  (IEA)
increased KLRG1+ CD8 alpha-beta T cell number  (IEA)
increased KLRG1-positive CD4-negative NK T cell number  (IEA)
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number  (IEA)
increased KLRG1-positive T-helper cell number  (IEA)
increased lean body mass  (IEA)
increased liver cholesterol level  (IAGP)
increased long bone epiphyseal plate size  (IAGP)
increased Ly6C-positive NK T cell number  (IEA)
increased mean corpuscular hemoglobin  (IEA)
increased mean platelet volume  (IEA)
increased memory-marker gamma-delta T cell number  (IEA)
increased memory-marker NK cell number  (IEA)
increased NK cell number  (IEA)
increased oxygen consumption  (IAGP)
increased plasmacytoid dendritic cell number  (IEA)
increased red blood cell distribution width  (IEA)
increased respiratory quotient  (IAGP)
intrahepatic cholestasis  (IAGP)
kyphosis  (IEA)
large fontanelles  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
rachitic rosary  (IAGP)
rickets  (IAGP)
scoliosis  (IAGP)
short ribs  (IAGP)
short sternum  (IAGP)
thrombocytopenia  (IEA)
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:14621295   PMID:15489334   PMID:16141072  
PMID:16141073   PMID:16959763   PMID:18799693   PMID:20564261   PMID:21267068   PMID:21565611   PMID:21873635   PMID:22318228   PMID:22662228   PMID:23033494   PMID:23393134   PMID:24061540  
PMID:24743732   PMID:25060954   PMID:25088745   PMID:25513882   PMID:25619259   PMID:27009967   PMID:27806374   PMID:27920213   PMID:28671696   PMID:28706196   PMID:29227248   PMID:29941929  
PMID:30254177   PMID:30550785   PMID:30973865   PMID:31280862   PMID:31350328   PMID:31430259   PMID:31636950   PMID:31927188   PMID:32325033   PMID:32343771   PMID:33063669   PMID:33558433  
PMID:33600797   PMID:34160349   PMID:34196217   PMID:34732767   PMID:34856199   PMID:35864266   PMID:35997995   PMID:36477539   PMID:36862513   PMID:36877841   PMID:37321371   PMID:37356786  
PMID:37477881   PMID:37715891   PMID:38355793   PMID:39030684  


Genomics

Comparative Map Data
Sik3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39945,924,099 - 46,135,492 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl945,924,118 - 46,135,492 (+)EnsemblGRCm39 Ensembl
GRCm38946,012,820 - 46,224,194 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl946,012,820 - 46,224,194 (+)EnsemblGRCm38mm10GRCm38
MGSCv37945,820,903 - 46,032,277 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36945,763,873 - 45,974,137 (+)NCBIMGSCv36mm8
Celera943,407,782 - 43,513,027 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.36NCBI
SIK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811116,843,402 - 117,098,428 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11116,843,402 - 117,098,437 (-)EnsemblGRCh38hg38GRCh38
GRCh3711116,714,118 - 116,969,144 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,219,328 - 116,474,203 (-)NCBINCBI36Build 36hg18NCBI36
Celera11113,871,923 - 114,126,759 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11112,646,380 - 112,901,075 (-)NCBIHuRef
CHM1_111116,598,872 - 116,853,881 (-)NCBICHM1_1
T2T-CHM13v2.011116,858,511 - 117,113,691 (-)NCBIT2T-CHM13v2.0
Sik3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8855,208,969 - 55,419,138 (+)NCBIGRCr8
mRatBN7.2846,312,253 - 46,522,444 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl846,311,989 - 46,522,444 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx851,812,531 - 52,023,638 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0850,091,306 - 50,302,413 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0847,955,570 - 48,166,684 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0850,310,263 - 50,520,284 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,310,405 - 50,520,173 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0848,934,932 - 49,146,356 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4848,989,575 - 49,128,359 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera846,004,786 - 46,104,504 (+)NCBICelera
Cytogenetic Map8q22NCBI
Sik3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541218,177,175 - 18,280,748 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541218,177,175 - 18,280,687 (-)NCBIChiLan1.0ChiLan1.0
SIK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29117,546,613 - 117,798,524 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111118,651,837 - 118,903,699 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011111,680,884 - 111,932,424 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111115,613,478 - 115,726,997 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11115,613,478 - 115,730,158 (-)Ensemblpanpan1.1panPan2
SIK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1516,623,756 - 16,733,259 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl516,527,504 - 16,733,243 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha516,546,643 - 16,785,424 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0516,439,296 - 16,679,521 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl516,438,471 - 16,681,460 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1516,577,037 - 16,816,655 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0516,479,515 - 16,719,242 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0516,521,767 - 16,762,124 (+)NCBIUU_Cfam_GSD_1.0
Sik3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494799,195,965 - 99,436,124 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365422,117,349 - 2,357,539 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365422,119,423 - 2,357,533 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,223,232 - 44,513,831 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1944,223,227 - 44,471,689 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,295,477 - 49,350,586 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SIK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11108,209,204 - 108,471,102 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1108,208,921 - 108,470,983 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604317,583,939 - 17,841,442 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sik3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478412,260,564 - 12,547,764 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478412,259,476 - 12,547,650 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sik3
6150 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1864
Count of miRNA genes:696
Interacting mature miRNAs:894
Transcripts:ENSMUST00000120247, ENSMUST00000120463, ENSMUST00000122865, ENSMUST00000126865, ENSMUST00000138338, ENSMUST00000153152
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
13432191Actrse4_mactivity response to saline/ethanol 4 (mouse)94370321448603195Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
10045613Rapop7_mradiation-induced apoptosis 6 (mouse)Not determined93673624349420511Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532693Sluc39_msusceptibility to lung cancer 39 (mouse)94064537448351476Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
1558993Tdmq1_mtype 2 diabetes modifying QTL 1 (mouse)Not determined94041959451808670Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
1301501Lmr2_mleishmaniasis resistance 2 (mouse)Not determined93694340650111140Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse

Markers in Region
RH126838  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38946,080,856 - 46,081,064UniSTSGRCm38
MGSCv37945,888,939 - 45,889,147UniSTSGRCm37
Celera943,365,416 - 43,365,624UniSTS
Cytogenetic Map9A5.2UniSTS
AI447252  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38946,202,530 - 46,202,685UniSTSGRCm38
MGSCv37946,010,613 - 46,010,768UniSTSGRCm37
Celera943,489,657 - 43,489,812UniSTS
Cytogenetic Map9A5.2UniSTS
Whitehead/MRC_RH9500.1UniSTS
RH126001  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38946,115,851 - 46,116,053UniSTSGRCm38
MGSCv37945,923,934 - 45,924,136UniSTSGRCm37
Celera943,400,417 - 43,400,619UniSTS
Cytogenetic Map9A5.2UniSTS
cM Map929.0UniSTS
AI846254  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38946,224,077 - 46,224,163UniSTSGRCm38
MGSCv37946,032,160 - 46,032,246UniSTSGRCm37
Celera943,512,910 - 43,512,996UniSTS
Cytogenetic Map9A5.2UniSTS
Whitehead/MRC_RH9500.76UniSTS
AI849445  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38946,222,867 - 46,223,016UniSTSGRCm38
MGSCv37946,030,950 - 46,031,099UniSTSGRCm37
Celera943,511,700 - 43,511,849UniSTS
Cytogenetic Map9A5.2UniSTS
D9Jpk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38946,218,649 - 46,218,755UniSTSGRCm38
MGSCv37946,026,732 - 46,026,838UniSTSGRCm37
Celera943,507,471 - 43,507,587UniSTS
Cytogenetic Map9A5.2UniSTS
cM Map932.0UniSTS
REN72864  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38946,211,662 - 46,211,892UniSTSGRCm38
MGSCv37946,019,745 - 46,019,975UniSTSGRCm37
Celera943,498,809 - 43,499,039UniSTS
Cytogenetic Map9A5.2UniSTS
AI059153  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38946,220,292 - 46,221,199UniSTSGRCm38
MGSCv37946,028,375 - 46,029,282UniSTSGRCm37
Celera943,509,125 - 43,510,031UniSTS
Cytogenetic Map9A5.2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000120247   ⟹   ENSMUSP00000112859
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl945,924,298 - 46,132,532 (+)Ensembl
GRCm38.p6 Ensembl946,013,000 - 46,221,234 (+)Ensembl
Ensembl Acc Id: ENSMUST00000120463   ⟹   ENSMUSP00000112749
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl945,924,162 - 46,133,573 (+)Ensembl
GRCm38.p6 Ensembl946,012,864 - 46,222,275 (+)Ensembl
Ensembl Acc Id: ENSMUST00000122865   ⟹   ENSMUSP00000115981
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl946,034,535 - 46,114,183 (+)Ensembl
GRCm38.p6 Ensembl946,123,237 - 46,202,885 (+)Ensembl
Ensembl Acc Id: ENSMUST00000126865   ⟹   ENSMUSP00000121032
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl945,924,118 - 46,135,492 (+)Ensembl
GRCm38.p6 Ensembl946,012,820 - 46,224,194 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138338   ⟹   ENSMUSP00000115805
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl946,130,869 - 46,132,532 (+)Ensembl
GRCm38.p6 Ensembl946,219,571 - 46,221,234 (+)Ensembl
Ensembl Acc Id: ENSMUST00000153152
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl946,066,677 - 46,135,486 (+)Ensembl
GRCm38.p6 Ensembl946,155,379 - 46,224,188 (+)Ensembl
Ensembl Acc Id: ENSMUST00000215954
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl946,034,428 - 46,036,760 (+)Ensembl
GRCm38.p6 Ensembl946,123,130 - 46,125,462 (+)Ensembl
RefSeq Acc Id: NM_027498   ⟹   NP_081774
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39945,924,118 - 46,135,492 (+)NCBI
GRCm38946,012,820 - 46,224,194 (+)ENTREZGENE
MGSCv37945,820,903 - 46,032,277 (+)RGD
Celera943,407,782 - 43,513,027 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006510590   ⟹   XP_006510653
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39945,924,099 - 46,135,490 (+)NCBI
GRCm38946,012,825 - 46,224,194 (+)NCBI
Sequence:
RefSeq Acc Id: NP_081774   ⟸   NM_027498
- UniProtKB: Q8K075 (UniProtKB/Swiss-Prot),   Q6ZQ09 (UniProtKB/Swiss-Prot),   Q6P4S6 (UniProtKB/Swiss-Prot),   Q66JZ5 (UniProtKB/Swiss-Prot),   Q641L5 (UniProtKB/Swiss-Prot),   E9PU87 (UniProtKB/Swiss-Prot),   Q9CYD5 (UniProtKB/Swiss-Prot),   F6S7W6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006510653   ⟸   XM_006510590
- Peptide Label: isoform X1
- UniProtKB: F6S7W6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000115805   ⟸   ENSMUST00000138338
Ensembl Acc Id: ENSMUSP00000121032   ⟸   ENSMUST00000126865
Ensembl Acc Id: ENSMUSP00000112749   ⟸   ENSMUST00000120463
Ensembl Acc Id: ENSMUSP00000112859   ⟸   ENSMUST00000120247
Ensembl Acc Id: ENSMUSP00000115981   ⟸   ENSMUST00000122865
Protein Domains
Protein kinase   UBA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P4S6-F1-model_v2 AlphaFold Q6P4S6 1-1369 view protein structure

Promoters
RGD ID:6845068
Promoter ID:MM_KWN:57213
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung
Transcripts:ENSMUST00000120247,   NM_027498,   OTTMUST00000071083
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36945,820,546 - 45,821,112 (+)MPROMDB
RGD ID:6848384
Promoter ID:MM_ACW:50411
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Brain
Transcripts:BC033915.CSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36945,986,409 - 45,986,909 (+)MPROMDB
RGD ID:8669474
Promoter ID:EPDNEW_M12768
Type:multiple initiation site
Name:Sik3_1
Description:Mus musculus SIK family kinase 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38946,012,850 - 46,012,910EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2446296 AgrOrtholog
Ensembl Genes ENSMUSG00000034135 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000120247.8 UniProtKB/TrEMBL
  ENSMUST00000120463 ENTREZGENE
  ENSMUST00000120463.9 UniProtKB/TrEMBL
  ENSMUST00000122865.2 UniProtKB/TrEMBL
  ENSMUST00000126865 ENTREZGENE
  ENSMUST00000126865.8 UniProtKB/Swiss-Prot
  ENSMUST00000138338.2 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:70661 UniProtKB/Swiss-Prot
MGD MGI:2446296 ENTREZGENE
NCBI Gene Sik3 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE SIK3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sik3 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9PU87 ENTREZGENE
  F6S7W6 ENTREZGENE, UniProtKB/TrEMBL
  F6SBP3_MOUSE UniProtKB/TrEMBL
  F6U6U5_MOUSE UniProtKB/TrEMBL
  F6U8X4_MOUSE UniProtKB/TrEMBL
  Q641L5 ENTREZGENE
  Q66JZ5 ENTREZGENE
  Q6P4S6 ENTREZGENE
  Q6ZQ09 ENTREZGENE
  Q8K075 ENTREZGENE
  Q9CYD5 ENTREZGENE
  SIK3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary E9PU87 UniProtKB/Swiss-Prot
  Q641L5 UniProtKB/Swiss-Prot
  Q66JZ5 UniProtKB/Swiss-Prot
  Q6ZQ09 UniProtKB/Swiss-Prot
  Q8K075 UniProtKB/Swiss-Prot
  Q9CYD5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Sik3  SIK family kinase 3  BC033915  cDNA sequence BC033915  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 BC033915  cDNA sequence BC033915  AI849445  expressed sequence AI849445  Symbol and/or name change 5135510 APPROVED
2024-08-21 AI849445  expressed sequence AI849445  Sik3  SIK family kinase 3  Symbol and/or name change 5135510 APPROVED
2024-08-21 Sik3  SIK family kinase 3  BC033915  cDNA sequence BC033915  Symbol and/or name change 5135510 APPROVED
2024-08-21 BC033915  cDNA sequence BC033915  Sik3  SIK family kinase 3  Symbol and/or name change 5135510 APPROVED
2016-04-05 Sik3  SIK family kinase 3  9030204A07Rik  RIKEN cDNA 9030204A07 gene  Data merged from RGD:1607169 737654 PROVISIONAL