Slc36a4 (solute carrier family 36 (proton/amino acid symporter), member 4) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Slc36a4 (solute carrier family 36 (proton/amino acid symporter), member 4) Mus musculus
Analyze
Symbol: Slc36a4
Name: solute carrier family 36 (proton/amino acid symporter), member 4
RGD ID: 1323034
MGI Page MGI
Description: Predicted to enable L-alanine transmembrane transporter activity; L-proline transmembrane transporter activity; and L-tryptophan transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport and carboxylic acid transport. Located in lysosomal membrane. Orthologous to human SLC36A4 (solute carrier family 36 member 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6330573I15Rik; neutral amino acid uniporter 4; PA; PAT4; proton-coupled amino acid transporter 4; proton/amino acid transporter 4; solute carrier family 36 member 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39915,621,034 - 15,653,684 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl915,621,034 - 15,654,657 (+)EnsemblGRCm39 Ensembl
GRCm38915,709,738 - 15,742,388 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl915,709,738 - 15,743,361 (+)EnsemblGRCm38mm10GRCm38
MGSCv37915,514,213 - 15,543,233 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36915,460,162 - 15,489,182 (+)NCBIMGSCv36mm8
Celera912,988,023 - 13,017,043 (+)NCBICelera
Cytogenetic Map9A2NCBI
cM Map95.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. The human NAD metabolome: Functions, metabolism and compartmentalization. Nikiforov A, etal., Crit Rev Biochem Mol Biol. 2015;50(4):284-97. doi: 10.3109/10409238.2015.1028612. Epub 2015 Apr 2.
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14681479   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23478338  
PMID:24530433   PMID:26811378   PMID:28083894   PMID:38355793  


Genomics

Comparative Map Data
Slc36a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39915,621,034 - 15,653,684 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl915,621,034 - 15,654,657 (+)EnsemblGRCm39 Ensembl
GRCm38915,709,738 - 15,742,388 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl915,709,738 - 15,743,361 (+)EnsemblGRCm38mm10GRCm38
MGSCv37915,514,213 - 15,543,233 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36915,460,162 - 15,489,182 (+)NCBIMGSCv36mm8
Celera912,988,023 - 13,017,043 (+)NCBICelera
Cytogenetic Map9A2NCBI
cM Map95.12NCBI
SLC36A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381193,144,174 - 93,197,991 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1193,144,174 - 93,197,991 (-)EnsemblGRCh38hg38GRCh38
GRCh371192,877,340 - 92,931,157 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361192,520,498 - 92,570,743 (-)NCBINCBI36Build 36hg18NCBI36
Build 341192,520,499 - 92,570,743NCBI
Celera1190,179,804 - 90,230,049 (-)NCBICelera
Cytogenetic Map11q21NCBI
HuRef1188,965,724 - 89,015,692 (-)NCBIHuRef
CHM1_11192,763,842 - 92,814,140 (-)NCBICHM1_1
T2T-CHM13v2.01193,066,962 - 93,120,802 (-)NCBIT2T-CHM13v2.0
Slc36a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8820,801,256 - 20,834,046 (+)NCBIGRCr8
mRatBN7.2812,519,613 - 12,552,671 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl812,519,943 - 12,552,031 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx816,506,726 - 16,536,678 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0814,804,480 - 14,834,432 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0812,782,331 - 12,813,520 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0814,238,975 - 14,271,931 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl814,239,594 - 14,269,162 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0814,329,327 - 14,360,233 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4812,504,817 - 12,534,782 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1812,504,818 - 12,533,407 (+)NCBI
Celera813,985,685 - 14,015,651 (+)NCBICelera
Cytogenetic Map8q12NCBI
Slc36a4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554141,236,141 - 1,285,610 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554141,236,179 - 1,286,680 (+)NCBIChiLan1.0ChiLan1.0
SLC36A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2994,008,249 - 94,062,806 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11195,097,192 - 95,150,608 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01188,164,083 - 88,218,610 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11191,662,625 - 91,880,929 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1191,663,479 - 91,713,388 (-)Ensemblpanpan1.1panPan2
SLC36A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1217,476,291 - 7,523,463 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl217,475,648 - 7,520,331 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha217,474,725 - 7,538,019 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0217,635,696 - 7,698,997 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl217,635,686 - 7,698,993 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1217,421,675 - 7,481,882 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0217,490,947 - 7,554,286 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0217,535,348 - 7,598,628 (+)NCBIUU_Cfam_GSD_1.0
Slc36a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494778,289,864 - 78,363,803 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366741,567,675 - 1,601,635 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366741,567,718 - 1,601,561 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC36A4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl925,639,387 - 25,689,028 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1925,639,370 - 25,689,177 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2928,983,529 - 29,033,251 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC36A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1184,393,698 - 84,487,984 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl184,398,027 - 84,445,971 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604341,344,168 - 41,395,986 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc36a4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473537,791,206 - 37,831,776 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473537,791,690 - 37,831,749 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc36a4
1343 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1606
Count of miRNA genes:706
Interacting mature miRNAs:909
Transcripts:ENSMUST00000061568, ENSMUST00000115588
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902913Mouse
35673312Ari7_mantibody response to influenza 7, day 45, IgG3 (mouse)9780000122211296Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
1300849Sles4_msystemic lupus erythmatosus suppressor 4 (mouse)Not determined9910756237306370Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130341840Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
4142326Tgq19_mtriglyceride QTL 19 (mouse)Not determined121060750Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
13504833Bglu19_mblood glucose level 19 (mouse)9991076843910768Mouse

Markers in Region
Slc36a4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A2UniSTS
cM Map9 UniSTS
Slc36a4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000061568   ⟹   ENSMUSP00000057355
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl915,621,035 - 15,654,657 (+)Ensembl
GRCm38.p6 Ensembl915,709,739 - 15,743,361 (+)Ensembl
Ensembl Acc Id: ENSMUST00000115588   ⟹   ENSMUSP00000111251
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl915,621,034 - 15,649,875 (+)Ensembl
GRCm38.p6 Ensembl915,709,738 - 15,738,579 (+)Ensembl
Ensembl Acc Id: ENSMUST00000214954   ⟹   ENSMUSP00000149875
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl915,638,184 - 15,649,711 (+)Ensembl
GRCm38.p6 Ensembl915,726,888 - 15,738,415 (+)Ensembl
RefSeq Acc Id: NM_001357565   ⟹   NP_001344494
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39915,621,034 - 15,653,684 (+)NCBI
GRCm38915,709,738 - 15,742,388 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001357566   ⟹   NP_001344495
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39915,621,034 - 15,653,684 (+)NCBI
GRCm38915,709,738 - 15,742,388 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001357567   ⟹   NP_001344496
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39915,621,034 - 15,653,684 (+)NCBI
GRCm38915,709,738 - 15,742,388 (+)NCBI
Sequence:
RefSeq Acc Id: NM_172289   ⟹   NP_758493
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39915,621,034 - 15,653,684 (+)NCBI
GRCm38915,709,738 - 15,742,388 (+)NCBI
MGSCv37915,514,213 - 15,543,233 (+)RGD
Celera912,988,023 - 13,017,043 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006510170   ⟹   XP_006510233
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39915,621,302 - 15,653,684 (+)NCBI
GRCm38915,710,001 - 15,742,388 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030244281   ⟹   XP_030100141
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39915,621,299 - 15,653,579 (+)NCBI
GRCm38915,710,005 - 15,742,388 (+)NCBI
Sequence:
RefSeq Acc Id: NP_758493   ⟸   NM_172289
- Peptide Label: isoform 1
- UniProtKB: Q8C077 (UniProtKB/Swiss-Prot),   Q8CH36 (UniProtKB/Swiss-Prot),   A0A0R4J0Q3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006510233   ⟸   XM_006510170
- Peptide Label: isoform X1
- UniProtKB: Q8CH36 (UniProtKB/Swiss-Prot),   Q8C077 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001344494   ⟸   NM_001357565
- Peptide Label: isoform 2
- UniProtKB: D3Z0L1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001344495   ⟸   NM_001357566
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001344496   ⟸   NM_001357567
- Peptide Label: isoform 4
RefSeq Acc Id: XP_030100141   ⟸   XM_030244281
- Peptide Label: isoform X2
Ensembl Acc Id: ENSMUSP00000057355   ⟸   ENSMUST00000061568
Ensembl Acc Id: ENSMUSP00000111251   ⟸   ENSMUST00000115588
Ensembl Acc Id: ENSMUSP00000149875   ⟸   ENSMUST00000214954
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CH36-F1-model_v2 AlphaFold Q8CH36 1-500 view protein structure

Promoters
RGD ID:6845185
Promoter ID:MM_KWN:56437
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000059499,   UC009OGH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36915,513,956 - 15,514,677 (+)MPROMDB
RGD ID:8668854
Promoter ID:EPDNEW_M12458
Type:initiation region
Name:Slc36a4_1
Description:Mus musculus solute carrier family 36 (proton/amino acid symporter),member 4 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38915,709,736 - 15,709,796EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2442595 AgrOrtholog
Ensembl Genes ENSMUSG00000043885 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000061568 ENTREZGENE
  ENSMUST00000115588 ENTREZGENE
InterPro AA_transpt_TM UniProtKB/Swiss-Prot
KEGG Report mmu:234967 UniProtKB/Swiss-Prot
MGD MGI:2442595 ENTREZGENE
NCBI Gene 234967 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/Swiss-Prot
  PROTON-COUPLED AMINO ACID TRANSPORTER 4 UniProtKB/Swiss-Prot
Pfam Aa_trans UniProtKB/Swiss-Prot
PhenoGen Slc36a4 PhenoGen
UniProt A0A0R4J0Q3 ENTREZGENE, UniProtKB/TrEMBL
  A0A1L1SSD8_MOUSE UniProtKB/TrEMBL
  D3Z0L1 ENTREZGENE, UniProtKB/TrEMBL
  Q8C077 ENTREZGENE
  Q8CH36 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8C077 UniProtKB/Swiss-Prot