Cyp2c55 (cytochrome P450, family 2, subfamily c, polypeptide 55) - Rat Genome Database

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Gene: Cyp2c55 (cytochrome P450, family 2, subfamily c, polypeptide 55) Mus musculus
Analyze
Symbol: Cyp2c55
Name: cytochrome P450, family 2, subfamily c, polypeptide 55
RGD ID: 1322741
MGI Page MGI
Description: Enables arachidonate epoxygenase activity and linoleic acid epoxygenase activity. Acts upstream of or within arachidonate metabolic process and linoleic acid metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to human CYP2C18 (cytochrome P450 family 2 subfamily C member 18).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2010318C06Rik; CYPIIC55; cytochrome P450 2C55; cytochrome P450, 2c55
RGD Orthologs
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391938,995,384 - 39,031,134 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1938,995,463 - 39,031,137 (+)EnsemblGRCm39 Ensembl
GRCm381939,006,940 - 39,042,690 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1939,007,019 - 39,042,693 (+)EnsemblGRCm38mm10GRCm38
MGSCv371939,081,509 - 39,117,177 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361939,072,063 - 39,107,731 (+)NCBIMGSCv36mm8
Celera1939,809,823 - 39,845,531 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1933.64NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dichlorobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
4-hydroxytolbutamide  (EXP)
acetamide  (ISO)
Acetyl tributyl citrate  (EXP)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (ISO)
Aroclor 1254  (EXP)
Azoxymethane  (EXP)
benzo[a]pyrene  (EXP)
beta-hexachlorocyclohexane  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bisphenol AF  (EXP)
bisphenol F  (EXP)
captan  (EXP)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
cyanocob(III)alamin  (EXP)
cyclosporin A  (EXP)
cyproconazole  (EXP,ISO)
cyproterone acetate  (EXP)
dextran sulfate  (EXP)
dichloroacetic acid  (EXP)
diclofenac  (EXP)
difenoconazole  (EXP)
dimethyl sulfoxide  (EXP)
dioxygen  (EXP)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
etoposide  (EXP)
finasteride  (ISO)
fluconazole  (EXP)
flutamide  (ISO)
folic acid  (EXP)
furan  (ISO)
glycine betaine  (EXP)
Heptachlor epoxide  (EXP)
indole-3-methanol  (ISO)
inulin  (EXP)
L-methionine  (EXP)
lipopolysaccharide  (EXP)
methidathion  (EXP)
monosodium L-glutamate  (EXP)
N-nitrosodiethylamine  (ISO)
orphenadrine  (ISO)
paracetamol  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenformin  (ISO)
phenobarbital  (EXP)
pioglitazone  (EXP)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP,ISO)
propiconazole  (EXP)
rotenone  (ISO)
sodium arsenite  (EXP)
succimer  (EXP)
sulfasalazine  (EXP)
tetrachloromethane  (EXP,ISO)
thiacloprid  (EXP)
thioacetamide  (ISO)
thiophanate-methyl  (EXP)
titanium dioxide  (EXP)
tolbutamide  (EXP)
triadimefon  (EXP)
trichloroethene  (ISO)
triptonide  (EXP)
valproic acid  (EXP)
verteporfin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
ziram  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Use of analgesics and nonsteroidal anti-inflammatory drugs, genetic predisposition, and bladder cancer risk in Spain. Fortuny J, etal., Cancer Epidemiol Biomarkers Prev. 2006 Sep;15(9):1696-702.
2. Association between CYP2C9 slow metabolizer genotypes and severe hypoglycaemia on medication with sulphonylurea hypoglycaemic agents. Holstein A, etal., Br J Clin Pharmacol. 2005 Jul;60(1):103-6.
3. CYP2C9 genotype and pharmacodynamic responses to losartan in patients with primary and secondary kidney diseases. Joy MS, etal., Eur J Clin Pharmacol. 2009 Sep;65(9):947-53. Epub 2009 Aug 11.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Downregulation of hepatic cytochrome P450 in chronic renal failure. Leblond F, etal., J Am Soc Nephrol. 2001 Feb;12(2):326-32.
6. Failure to upregulate the adenosine2A receptor-epoxyeicosatrienoic acid pathway contributes to the development of hypertension in Dahl salt-sensitive rats. Liclican EL, etal., Am J Physiol Renal Physiol. 2008 Dec;295(6):F1696-704. Epub 2008 Oct 1.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Changes of hepatic microsomal oxidative drug metabolizing enzymes in chronic renal failure (CRF) rats by partial nephrectomy. Uchida N, etal., Jpn J Pharmacol. 1995 Aug;68(4):431-9.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14681479   PMID:15102943   PMID:15489334   PMID:16141072   PMID:16141073   PMID:18794335   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:22918969   PMID:28167773   PMID:32913122   PMID:39432326  


Genomics

Comparative Map Data
Cyp2c55
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391938,995,384 - 39,031,134 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1938,995,463 - 39,031,137 (+)EnsemblGRCm39 Ensembl
GRCm381939,006,940 - 39,042,690 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1939,007,019 - 39,042,693 (+)EnsemblGRCm38mm10GRCm38
MGSCv371939,081,509 - 39,117,177 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361939,072,063 - 39,107,731 (+)NCBIMGSCv36mm8
Celera1939,809,823 - 39,845,531 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1933.64NCBI
Cyp2c24
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,286,341 - 246,348,607 (+)NCBIGRCr8
mRatBN7.21236,873,967 - 236,936,238 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1236,873,967 - 236,936,238 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1245,297,865 - 245,365,048 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01252,191,120 - 252,253,394 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01245,029,377 - 245,091,647 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01258,074,797 - 258,139,176 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1258,074,860 - 258,139,176 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01265,526,375 - 265,590,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,374,165 - 243,579,050 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1233,976,115 - 234,021,371 (+)NCBICelera
Cytogenetic Map1q53NCBI

Variants

.
Variants in Cyp2c55
1309 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:115
Interacting mature miRNAs:116
Transcripts:ENSMUST00000025966
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
13504736Ifvrq6_minfluenza virus resistance QTL 6 (mouse)193690291044913949Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1301479Sluc1_msusceptibility to lung cancer 1 (mouse)Not determined193601694446761521Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192513600242388916Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse

Markers in Region
Cyp2c55  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C3UniSTS
cM Map1933.64UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000025966   ⟹   ENSMUSP00000025966
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1938,995,463 - 39,031,137 (+)Ensembl
GRCm38.p6 Ensembl1939,007,019 - 39,042,693 (+)Ensembl
RefSeq Acc Id: NM_028089   ⟹   NP_082365
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391938,995,463 - 39,031,131 (+)NCBI
GRCm381939,007,019 - 39,042,687 (+)NCBI
MGSCv371939,081,509 - 39,117,177 (+)RGD
Celera1939,809,823 - 39,845,531 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006527355   ⟹   XP_006527418
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391938,995,384 - 39,031,134 (+)NCBI
GRCm381939,006,940 - 39,042,690 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_082365 (Get FASTA)   NCBI Sequence Viewer  
  XP_006527418 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH10824 (Get FASTA)   NCBI Sequence Viewer  
  AAO52738 (Get FASTA)   NCBI Sequence Viewer  
  BAB25759 (Get FASTA)   NCBI Sequence Viewer  
  EDL41813 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000025966
  ENSMUSP00000025966.5
GenBank Protein Q9D816 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_082365   ⟸   NM_028089
- Peptide Label: precursor
- UniProtKB: Q9D816 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006527418   ⟸   XM_006527355
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000025966   ⟸   ENSMUST00000025966

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D816-F1-model_v2 AlphaFold Q9D816 1-490 view protein structure

Promoters
RGD ID:13679418
Promoter ID:EPDNEW_M23858
Type:multiple initiation site
Name:Cyp2c55_1
Description:Mus musculus cytochrome P450, family 2, subfamily c, polypeptide55 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381939,007,020 - 39,007,080EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919332 AgrOrtholog
Ensembl Genes ENSMUSG00000025002 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025966 ENTREZGENE
  ENSMUST00000025966.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot
KEGG Report mmu:72082 UniProtKB/Swiss-Prot
MGD MGI:1919332 ENTREZGENE
NCBI Gene 72082 ENTREZGENE
PANTHER CYTOCHROME P450 2C18 UniProtKB/Swiss-Prot
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP2C18 RGD
PhenoGen Cyp2c55 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt CP255_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE