CYP2C18 (cytochrome P450 family 2 subfamily C member 18) - Rat Genome Database

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Gene: CYP2C18 (cytochrome P450 family 2 subfamily C member 18) Homo sapiens
Analyze
Symbol: CYP2C18
Name: cytochrome P450 family 2 subfamily C member 18
RGD ID: 1322740
HGNC Page HGNC:2620
Description: Enables retinoic acid 4-hydroxylase activity. Involved in retinoic acid metabolic process. Located in intracellular membrane-bounded organelle and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: (S)-mephenytoin hydroxylase associated cytochrome P450; CPCI; CYP2C; CYP2C17; CYPIIC18; cytochrome P450 2C18; cytochrome P450, family 2, subfamily C, polypeptide 18; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18; cytochrome P450-6B/29C; DKFZp686I24235; flavoprotein-linked monooxygenase; microsomal monooxygenase; P450-6B/29C; P450IIC17; unspecific monooxygenase
RGD Orthologs
Mouse
Rat
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Related Pseudogenes: CYP2C115P   CYP2C59P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381094,683,729 - 94,736,190 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1094,683,729 - 94,736,190 (+)EnsemblGRCh38hg38GRCh38
GRCh371096,443,486 - 96,495,947 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361096,433,368 - 96,485,514 (+)NCBINCBI36Build 36hg18NCBI36
Build 341096,433,367 - 96,485,514NCBI
Celera1090,183,344 - 90,236,039 (+)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1090,070,045 - 90,122,767 (+)NCBIHuRef
CHM1_11096,725,017 - 96,777,714 (+)NCBICHM1_1
T2T-CHM13v2.01095,562,854 - 95,615,317 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (EXP)
1,2-dichloroethene  (ISO)
1,4-naphthoquinone  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-nitrophenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-methylcholanthrene  (ISO)
3-oxo-5beta-cholanic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-hydroxydiclofenac  (EXP)
5-Hydroxythalidomide  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (EXP)
6-propyl-2-thiouracil  (ISO)
acenocoumarol  (EXP)
acetamide  (ISO)
acetonitrile  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-naphthoflavone  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (ISO)
amodiaquine  (EXP)
ampicillin  (ISO)
andrographolide  (ISO)
anthocyanin  (ISO)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
atazanavir sulfate  (EXP)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP)
Benzo[a]pyrene-7,8-oxide  (ISO)
benzophenone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromuconazole  (ISO)
Bufuralol  (ISO)
butanal  (EXP)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
C.I. Natural Red 20  (ISO)
cafestol  (ISO)
carvedilol  (ISO)
cefaloridine  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chlorpromazine  (EXP,ISO)
chlorzoxazone  (ISO)
cholic acid  (ISO)
choline  (ISO)
cimetidine  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
clofibric acid  (ISO)
clotrimazole  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
crocidolite asbestos  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
dehydroepiandrosterone sulfate  (ISO)
deoxycholic acid  (EXP,ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
diethyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dipropyl phthalate  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
dronedarone  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylbenzene  (ISO)
ethylparaben  (ISO)
farnesol  (ISO)
fenofibrate  (ISO)
flavonoids  (ISO)
fluconazole  (ISO)
fluoxetine  (ISO)
fulvestrant  (EXP,ISO)
Furafylline  (ISO)
furan  (ISO)
gadolinium trichloride  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gemfibrozil  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glutathione  (EXP)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
ifosfamide  (EXP)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
kahweol  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
L-methionine  (ISO)
lamotrigine  (ISO)
lansoprazole  (EXP)
lead nitrate  (ISO)
lithocholic acid  (ISO)
Luteolin 7-methyl ether  (ISO)
m-xylene  (ISO)
MeIQx  (ISO)
methapyrilene  (ISO)
methoxsalen  (ISO)
methoxychlor  (EXP,ISO)
methylarsonic acid  (ISO)
metronidazole  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
neomycin  (ISO)
nevirapine  (ISO)
nifedipine  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
oltipraz  (ISO)
oxycodone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
Paraoxon-methyl  (ISO)
parathion-methyl  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenacetin  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (ISO)
profenofos  (ISO)
progesterone  (EXP)
propanal  (EXP)
propiconazole  (ISO)
propylbenzene  (ISO)
propylparaben  (ISO)
pyrene  (ISO)
pyrimidin-2-amine  (ISO)
quinine  (ISO)
resveratrol  (EXP)
riddelliine  (ISO)
rifampicin  (EXP)
rotenone  (ISO)
senecionine  (EXP)
sevoflurane  (ISO)
Shikonin  (ISO)
silicon dioxide  (EXP)
simazine  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
sporidesmin A  (EXP)
streptozocin  (ISO)
styrene  (ISO)
styrene oxide  (ISO)
Sudan I  (ISO)
Sudan III  (ISO)
sulfaphenazole  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tartrazine  (EXP)
taurocholic acid  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
tolbutamide  (EXP)
toluene  (ISO)
torasemide  (ISO)
trans-1,2-dichloroethene  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
triclosan  (EXP)
triflumuron  (EXP)
trimethylarsine oxide  (ISO)
Triptolide  (ISO)
uranium atom  (ISO)
ursodeoxycholic acid  (ISO)
vancomycin  (ISO)
verapamil  (ISO)
warfarin  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comparison of enzyme kinetics of warfarin analyzed by LC-MS/MS QTrap and differential mobility spectrometry. Shaik AN, etal., J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jan 1;1008:164-73. doi: 10.1016/j.jchromb.2015.11.036. Epub 2015 Nov 23.
Additional References at PubMed
PMID:1306110   PMID:1896026   PMID:2009263   PMID:7704034   PMID:8095407   PMID:8110777   PMID:8125298   PMID:8333835   PMID:9028867   PMID:9154796   PMID:9797707   PMID:9890157  
PMID:10487415   PMID:10704292   PMID:10768437   PMID:11093772   PMID:12378636   PMID:12477932   PMID:12694732   PMID:15128046   PMID:15164054   PMID:15302935   PMID:15319333   PMID:15489334  
PMID:16359177   PMID:16385451   PMID:17048007   PMID:17207965   PMID:19038035   PMID:19074885   PMID:19204726   PMID:19290787   PMID:19578179   PMID:19706858   PMID:19751749   PMID:19958090  
PMID:20045989   PMID:20453000   PMID:20529763   PMID:21163940   PMID:21798861   PMID:21873635   PMID:21988832   PMID:23755828   PMID:26186194   PMID:28514442   PMID:33759177   PMID:33961781  


Genomics

Comparative Map Data
CYP2C18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381094,683,729 - 94,736,190 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1094,683,729 - 94,736,190 (+)EnsemblGRCh38hg38GRCh38
GRCh371096,443,486 - 96,495,947 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361096,433,368 - 96,485,514 (+)NCBINCBI36Build 36hg18NCBI36
Build 341096,433,367 - 96,485,514NCBI
Celera1090,183,344 - 90,236,039 (+)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1090,070,045 - 90,122,767 (+)NCBIHuRef
CHM1_11096,725,017 - 96,777,714 (+)NCBICHM1_1
T2T-CHM13v2.01095,562,854 - 95,615,317 (+)NCBIT2T-CHM13v2.0
Cyp2c52-ps
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391938,965,106 - 38,992,071 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1938,965,091 - 38,991,733 (+)EnsemblGRCm39 Ensembl
GRCm381938,976,662 - 39,003,627 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1938,976,647 - 39,003,289 (+)EnsemblGRCm38mm10GRCm38
MGSCv371939,051,152 - 39,078,117 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361939,041,818 - 39,068,332 (+)NCBIMGSCv36mm8
Celera1939,778,406 - 39,806,439 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1933.61NCBI
Cyp2c11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,175,216 - 246,211,445 (+)NCBIGRCr8
mRatBN7.21236,762,719 - 236,799,069 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1236,762,842 - 236,799,066 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1245,186,738 - 245,223,026 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01252,079,990 - 252,116,217 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01244,918,248 - 244,954,476 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01257,676,172 - 258,004,428 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1257,970,345 - 258,004,434 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01265,418,158 - 265,454,574 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,281,320 - 243,320,945 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1233,852,614 - 233,888,873 (+)NCBICelera
RH 3.4 Map11592.1RGD
Cytogenetic Map1q53NCBI
CYP2C18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1288,727,010 - 8,750,427 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl288,727,019 - 8,750,587 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha288,903,247 - 8,926,662 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0288,990,157 - 9,013,592 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl288,990,166 - 9,013,752 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1288,706,115 - 8,729,532 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0288,764,810 - 8,788,314 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0288,908,600 - 8,932,042 (-)NCBIUU_Cfam_GSD_1.0
CYP2C42
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14106,666,419 - 106,713,121 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114106,666,445 - 106,701,809 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214116,299,374 - 116,334,737 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP2C18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1987,881,444 - 87,941,586 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604848,697,490 - 48,740,161 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in CYP2C18
46 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q23.33-24.2(chr10:92626680-97755102)x1 copy number loss See cases [RCV000052564] Chr10:92626680..97755102 [GRCh38]
Chr10:94386437..99514859 [GRCh37]
Chr10:94376417..99504849 [NCBI36]
Chr10:10q23.33-24.2		 pathogenic
GRCh38/hg38 10q23.33-24.32(chr10:93181201-101356779)x1 copy number loss See cases [RCV000052565] Chr10:93181201..101356779 [GRCh38]
Chr10:94940958..103116536 [GRCh37]
Chr10:94930948..103106526 [NCBI36]
Chr10:10q23.33-24.32		 pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3		 pathogenic
NM_000772.2(CYP2C18):c.613C>T (p.Leu205Phe) single nucleotide variant Malignant melanoma [RCV000069090] Chr10:94695048 [GRCh38]
Chr10:96454805 [GRCh37]
Chr10:96444795 [NCBI36]
Chr10:10q23.33		 not provided
NM_000772.2(CYP2C18):c.1169C>T (p.Ser390Phe) single nucleotide variant Malignant melanoma [RCV000069091] Chr10:94733316 [GRCh38]
Chr10:96493073 [GRCh37]
Chr10:96483063 [NCBI36]
Chr10:10q23.33		 not provided
NM_000772.2(CYP2C18):c.1245G>A (p.Lys415=) single nucleotide variant Malignant melanoma [RCV000069092] Chr10:94733392 [GRCh38]
Chr10:96493149 [GRCh37]
Chr10:96483139 [NCBI36]
Chr10:10q23.33		 not provided
NM_000772.2(CYP2C18):c.1003C>T (p.Arg335Trp) single nucleotide variant Malignant melanoma [RCV000062098] Chr10:94724387 [GRCh38]
Chr10:96484144 [GRCh37]
Chr10:96474134 [NCBI36]
Chr10:10q23.33		 not provided
GRCh37/hg19 10q23.32-24.1(chr10:93281410-97596360)x1 copy number loss See cases [RCV003159569] Chr10:93281410..97596360 [GRCh37]
Chr10:10q23.32-24.1		 pathogenic
GRCh38/hg38 10q23.33(chr10:94298267-95267990)x1 copy number loss See cases [RCV000134773] Chr10:94298267..95267990 [GRCh38]
Chr10:96058024..97027747 [GRCh37]
Chr10:96048014..97017737 [NCBI36]
Chr10:10q23.33		 uncertain significance
GRCh38/hg38 10q23.33(chr10:94647983-94760469)x1 copy number loss See cases [RCV000135181] Chr10:94647983..94760469 [GRCh38]
Chr10:96407740..96520226 [GRCh37]
Chr10:96397730..96510216 [NCBI36]
Chr10:10q23.33		 likely benign
GRCh38/hg38 10q23.33(chr10:94694073-94853007)x1 copy number loss See cases [RCV000136823] Chr10:94694073..94853007 [GRCh38]
Chr10:96453830..96612764 [GRCh37]
Chr10:96443820..96602754 [NCBI36]
Chr10:10q23.33		 benign
GRCh38/hg38 10q23.33-24.1(chr10:94401557-95444828)x3 copy number gain See cases [RCV000137970] Chr10:94401557..95444828 [GRCh38]
Chr10:96161314..97204585 [GRCh37]
Chr10:96151304..97194575 [NCBI36]
Chr10:10q23.33-24.1		 uncertain significance
GRCh38/hg38 10q23.33-24.1(chr10:92643919-95471137)x1 copy number loss See cases [RCV000137919] Chr10:92643919..95471137 [GRCh38]
Chr10:94403676..97230894 [GRCh37]
Chr10:94393656..97220884 [NCBI36]
Chr10:10q23.33-24.1		 pathogenic
GRCh38/hg38 10q23.33-24.1(chr10:94376979-95466604)x3 copy number gain See cases [RCV000142079] Chr10:94376979..95466604 [GRCh38]
Chr10:96136736..97226361 [GRCh37]
Chr10:96126726..97216351 [NCBI36]
Chr10:10q23.33-24.1		 uncertain significance
GRCh37/hg19 10q23.33(chr10:96401653-96516326)x1 copy number loss See cases [RCV000446242] Chr10:96401653..96516326 [GRCh37]
Chr10:10q23.33		 likely benign
GRCh37/hg19 10q23.31-24.1(chr10:92667881-98970384)x1 copy number loss See cases [RCV000447362] Chr10:92667881..98970384 [GRCh37]
Chr10:10q23.31-24.1		 pathogenic
GRCh37/hg19 10q23.33(chr10:96383040-96623950)x1 copy number loss See cases [RCV000447385] Chr10:96383040..96623950 [GRCh37]
Chr10:10q23.33		 uncertain significance
GRCh37/hg19 10q23.33(chr10:96401653-96523474)x1 copy number loss See cases [RCV000446750] Chr10:96401653..96523474 [GRCh37]
Chr10:10q23.33		 likely benign
GRCh37/hg19 10q23.1-25.1(chr10:85557432-105804295)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000431909] Chr10:85557432..105804295 [GRCh37]
Chr10:10q23.1-25.1		 pathogenic|drug response
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10q23.33(chr10:96446525-96494686)x1 copy number loss See cases [RCV000448777] Chr10:96446525..96494686 [GRCh37]
Chr10:10q23.33		 likely benign
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10q23.32-26.3(chr10:93283493-135427143)x3 copy number gain See cases [RCV000510972] Chr10:93283493..135427143 [GRCh37]
Chr10:10q23.32-26.3		 pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3		 drug response
NM_000772.3(CYP2C18):c.605A>G (p.Asn202Ser) single nucleotide variant not specified [RCV004284050] Chr10:94695040 [GRCh38]
Chr10:96454797 [GRCh37]
Chr10:10q23.33		 uncertain significance
GRCh37/hg19 10q23.32-24.2(chr10:93908171-101809723)x1 copy number loss See cases [RCV000512315] Chr10:93908171..101809723 [GRCh37]
Chr10:10q23.32-24.2		 pathogenic
GRCh37/hg19 10q23.33(chr10:96339490-96546534)x1 copy number loss not provided [RCV000683203] Chr10:96339490..96546534 [GRCh37]
Chr10:10q23.33		 uncertain significance
GRCh37/hg19 10q23.33-26.3(chr10:94346520-135427143)x3 copy number gain not provided [RCV000683291] Chr10:94346520..135427143 [GRCh37]
Chr10:10q23.33-26.3		 pathogenic
GRCh37/hg19 10q23.33(chr10:96407978-96622313)x1 copy number loss not provided [RCV000737279] Chr10:96407978..96622313 [GRCh37]
Chr10:10q23.33		 benign
GRCh37/hg19 10q23.33(chr10:96468002-96514072)x1 copy number loss not provided [RCV000749779] Chr10:96468002..96514072 [GRCh37]
Chr10:10q23.33		 benign
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
NM_000772.3(CYP2C18):c.495T>C (p.Asp165=) single nucleotide variant not provided [RCV000884581] Chr10:94694930 [GRCh38]
Chr10:96454687 [GRCh37]
Chr10:10q23.33		 benign
NM_000772.3(CYP2C18):c.669C>T (p.Ile223=) single nucleotide variant not provided [RCV000968190] Chr10:94706810 [GRCh38]
Chr10:96466567 [GRCh37]
Chr10:10q23.33		 benign
GRCh37/hg19 10q23.33-24.1(chr10:94393383-97219175) copy number loss not provided [RCV000767566] Chr10:94393383..97219175 [GRCh37]
Chr10:10q23.33-24.1		 likely pathogenic
NM_000772.3(CYP2C18):c.896C>T (p.Thr299Ile) single nucleotide variant not provided [RCV000886211] Chr10:94720472 [GRCh38]
Chr10:96480229 [GRCh37]
Chr10:10q23.33		 benign
NM_000772.3(CYP2C18):c.1325G>T (p.Arg442Leu) single nucleotide variant not provided [RCV000886212] Chr10:94735296 [GRCh38]
Chr10:96495053 [GRCh37]
Chr10:10q23.33		 benign
NM_000772.3(CYP2C18):c.988G>T (p.Val330Leu) single nucleotide variant not provided [RCV000968191] Chr10:94724372 [GRCh38]
Chr10:96484129 [GRCh37]
Chr10:10q23.33		 benign
NM_000772.3(CYP2C18):c.1179T>C (p.Ser393=) single nucleotide variant not provided [RCV000968192] Chr10:94733326 [GRCh38]
Chr10:96493083 [GRCh37]
Chr10:10q23.33		 benign
NM_000772.3(CYP2C18):c.1048G>C (p.Ala350Pro) single nucleotide variant not specified [RCV004608477] Chr10:94724432 [GRCh38]
Chr10:96484189 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.500C>T (p.Thr167Ile) single nucleotide variant not specified [RCV004608478] Chr10:94694935 [GRCh38]
Chr10:96454692 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.1096C>G (p.Leu366Val) single nucleotide variant not specified [RCV004608480] Chr10:94724480 [GRCh38]
Chr10:96484237 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.520C>A (p.Pro174Thr) single nucleotide variant not specified [RCV004608479] Chr10:94694955 [GRCh38]
Chr10:96454712 [GRCh37]
Chr10:10q23.33		 uncertain significance
GRCh37/hg19 10q23.33-24.1(chr10:96140621-97222801)x3 copy number gain not provided [RCV001258459] Chr10:96140621..97222801 [GRCh37]
Chr10:10q23.33-24.1		 uncertain significance
GRCh37/hg19 10q23.33-24.1(chr10:96136737-97224160)x3 copy number gain not provided [RCV001829229] Chr10:96136737..97224160 [GRCh37]
Chr10:10q23.33-24.1		 uncertain significance
GRCh37/hg19 10q23.31-24.1(chr10:92667881-98970384) copy number loss not specified [RCV002052882] Chr10:92667881..98970384 [GRCh37]
Chr10:10q23.31-24.1		 pathogenic
NM_000772.3(CYP2C18):c.414G>C (p.Lys138Asn) single nucleotide variant not specified [RCV004608481] Chr10:94688207 [GRCh38]
Chr10:96447964 [GRCh37]
Chr10:10q23.33		 uncertain significance
GRCh37/hg19 10q23.33-24.1(chr10:96155285-97224160)x3 copy number gain not provided [RCV002474676] Chr10:96155285..97224160 [GRCh37]
Chr10:10q23.33-24.1		 uncertain significance
NM_000772.3(CYP2C18):c.557G>A (p.Arg186Gln) single nucleotide variant not specified [RCV004109096] Chr10:94694992 [GRCh38]
Chr10:96454749 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.424G>A (p.Glu142Lys) single nucleotide variant not specified [RCV004242430] Chr10:94688217 [GRCh38]
Chr10:96447974 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.769A>G (p.Met257Val) single nucleotide variant not specified [RCV004169099] Chr10:94706910 [GRCh38]
Chr10:96466667 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.1218G>A (p.Met406Ile) single nucleotide variant not provided [RCV004695418]|not specified [RCV004103784] Chr10:94733365 [GRCh38]
Chr10:96493122 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.323A>C (p.Lys108Thr) single nucleotide variant not specified [RCV004138077] Chr10:94687924 [GRCh38]
Chr10:96447681 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.572A>G (p.Asp191Gly) single nucleotide variant not specified [RCV004085521] Chr10:94695007 [GRCh38]
Chr10:96454764 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.796T>C (p.Cys266Arg) single nucleotide variant not specified [RCV004139384] Chr10:94706937 [GRCh38]
Chr10:96466694 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.722A>G (p.Lys241Arg) single nucleotide variant not specified [RCV004069779] Chr10:94706863 [GRCh38]
Chr10:96466620 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.1390C>A (p.Pro464Thr) single nucleotide variant not specified [RCV004161378] Chr10:94735361 [GRCh38]
Chr10:96495118 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.465G>T (p.Glu155Asp) single nucleotide variant not specified [RCV004094329] Chr10:94688258 [GRCh38]
Chr10:96448015 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.705A>C (p.Glu235Asp) single nucleotide variant not specified [RCV004276306] Chr10:94706846 [GRCh38]
Chr10:96466603 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.865G>A (p.Ala289Thr) single nucleotide variant not specified [RCV004287497] Chr10:94720441 [GRCh38]
Chr10:96480198 [GRCh37]
Chr10:10q23.33		 uncertain significance
GRCh37/hg19 10p14-q26.3(chr10:11138692-135427143) copy number gain Distal trisomy 10q [RCV003319593] Chr10:11138692..135427143 [GRCh37]
Chr10:10p14-q26.3		 pathogenic
GRCh37/hg19 10p13-q26.3(chr10:12829206-135427143) copy number loss Distal 10q deletion syndrome [RCV003319583] Chr10:12829206..135427143 [GRCh37]
Chr10:10p13-q26.3		 pathogenic
NM_000772.3(CYP2C18):c.1378T>C (p.Ser460Pro) single nucleotide variant not specified [RCV004338517] Chr10:94735349 [GRCh38]
Chr10:96495106 [GRCh37]
Chr10:10q23.33		 likely benign
NM_000772.3(CYP2C18):c.908G>A (p.Ser303Asn) single nucleotide variant not specified [RCV004349380] Chr10:94720484 [GRCh38]
Chr10:96480241 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.224T>C (p.Val75Ala) single nucleotide variant not specified [RCV004357993] Chr10:94687825 [GRCh38]
Chr10:96447582 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.1076T>C (p.Ile359Thr) single nucleotide variant not specified [RCV004359771] Chr10:94724460 [GRCh38]
Chr10:96484217 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.131A>T (p.Gln44Leu) single nucleotide variant not specified [RCV004363477] Chr10:94683950 [GRCh38]
Chr10:96443707 [GRCh37]
Chr10:10q23.33		 uncertain significance
GRCh37/hg19 10q11.21-24.2(chr10:42709645-100834951)x3 copy number gain not provided [RCV003484798] Chr10:42709645..100834951 [GRCh37]
Chr10:10q11.21-24.2		 pathogenic
GRCh37/hg19 10q23.33-24.1(chr10:96298410-97426086)x3 copy number gain not provided [RCV003484810] Chr10:96298410..97426086 [GRCh37]
Chr10:10q23.33-24.1		 uncertain significance
GRCh37/hg19 10q23.32-23.33(chr10:93788061-96452666)x3 copy number gain not provided [RCV003484809] Chr10:93788061..96452666 [GRCh37]
Chr10:10q23.32-23.33		 uncertain significance
NM_000772.3(CYP2C18):c.627C>T (p.Ser209=) single nucleotide variant not provided [RCV003422752] Chr10:94695062 [GRCh38]
Chr10:96454819 [GRCh37]
Chr10:10q23.33		 likely benign
GRCh37/hg19 10q23.33-24.2(chr10:94283369-101820913)x1 copy number loss not specified [RCV003986912] Chr10:94283369..101820913 [GRCh37]
Chr10:10q23.33-24.2		 pathogenic
GRCh37/hg19 10q23.31-24.2(chr10:90796994-100067505)x1 copy number loss not specified [RCV003986861] Chr10:90796994..100067505 [GRCh37]
Chr10:10q23.31-24.2		 pathogenic
GRCh37/hg19 10q23.33-24.1(chr10:96180463-97226361)x3 copy number gain not specified [RCV003986879] Chr10:96180463..97226361 [GRCh37]
Chr10:10q23.33-24.1		 uncertain significance
GRCh37/hg19 10q23.33-26.3(chr10:95078198-135427143)x3 copy number gain not specified [RCV003986893] Chr10:95078198..135427143 [GRCh37]
Chr10:10q23.33-26.3		 pathogenic
NM_000772.3(CYP2C18):c.1060G>A (p.Glu354Lys) single nucleotide variant not specified [RCV004367898] Chr10:94724444 [GRCh38]
Chr10:96484201 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.1072T>C (p.Tyr358His) single nucleotide variant not specified [RCV004367900] Chr10:94724456 [GRCh38]
Chr10:96484213 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.1211C>G (p.Pro404Arg) single nucleotide variant not specified [RCV004367901] Chr10:94733358 [GRCh38]
Chr10:96493115 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.277G>A (p.Glu93Lys) single nucleotide variant not specified [RCV004367904] Chr10:94687878 [GRCh38]
Chr10:96447635 [GRCh37]
Chr10:10q23.33		 likely benign
NM_000772.3(CYP2C18):c.448C>T (p.Arg150Cys) single nucleotide variant not specified [RCV004367905] Chr10:94688241 [GRCh38]
Chr10:96447998 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.592A>C (p.Met198Leu) single nucleotide variant not specified [RCV004367906] Chr10:94695027 [GRCh38]
Chr10:96454784 [GRCh37]
Chr10:10q23.33		 likely benign
NM_000772.3(CYP2C18):c.882G>A (p.Met294Ile) single nucleotide variant not specified [RCV004367908] Chr10:94720458 [GRCh38]
Chr10:96480215 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.718A>G (p.Ile240Val) single nucleotide variant not specified [RCV004367907] Chr10:94706859 [GRCh38]
Chr10:96466616 [GRCh37]
Chr10:10q23.33		 likely benign
NM_000772.3(CYP2C18):c.1220T>A (p.Phe407Tyr) single nucleotide variant not specified [RCV004367902] Chr10:94733367 [GRCh38]
Chr10:96493124 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.1070G>A (p.Arg357Lys) single nucleotide variant not specified [RCV004367899] Chr10:94724454 [GRCh38]
Chr10:96484211 [GRCh37]
Chr10:10q23.33		 uncertain significance
NM_000772.3(CYP2C18):c.1432C>T (p.Arg478Cys) single nucleotide variant not specified [RCV004367903] Chr10:94735403 [GRCh38]
Chr10:96495160 [GRCh37]
Chr10:10q23.33		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:524
Count of miRNA genes:234
Interacting mature miRNAs:244
Transcripts:ENST00000285979, ENST00000339022
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407272485GWAS921461_Hplatelet reactivity measurement, response to clopidogrel QTL GWAS921461 (human)4e-35platelet reactivity measurement, response to clopidogrelplatelet function measurement (CMO:0000923)109472755094727551Human
407065088GWAS714064_Hmetabolonic lactone sulfate measurement QTL GWAS714064 (human)6e-17metabolonic lactone sulfate measurement109473278694732787Human
407148321GWAS797297_HS-warfarin to R-warfarin ratio measurement QTL GWAS797297 (human)5e-13S-warfarin to R-warfarin ratio measurement109470412194704122Human
407048549GWAS697525_Hecosanoids measurement QTL GWAS697525 (human)5e-20eicosanoid amount (VT:0010787)109469745194697452Human
407045957GWAS694933_Hecosanoids measurement QTL GWAS694933 (human)1e-41eicosanoid amount (VT:0010787)109469800594698006Human
407145544GWAS794520_Hserum metabolite measurement QTL GWAS794520 (human)4e-26serum metabolite measurement109470497394704974Human
407026450GWAS675426_Hglycine conjugate of C10H14O2 (1) measurement QTL GWAS675426 (human)2e-35glycine conjugate of C10H14O2 (1) measurement109470052194700522Human
2314551GLUCO52_HGlucose level QTL 52 (human)1.4Glucose level1077605006103605006Human
407323571GWAS972547_Hdiastolic blood pressure QTL GWAS972547 (human)7e-19diastolic blood pressurediastolic blood pressure (CMO:0000005)109470632194706322Human
407097397GWAS746373_Hcommon carotid intimal medial thickness QTL GWAS746373 (human)0.000005common carotid intimal medial thickness109468396694683967Human
407138515GWAS787491_Hplasma clozapine-to-N-desmethylclozapine ratio measurement QTL GWAS787491 (human)5e-22plasma clozapine-to-N-desmethylclozapine ratio measurement109472502094725021Human
407152540GWAS801516_Happendicular lean mass QTL GWAS801516 (human)3e-13appendicular lean mass109473291694732917Human
407154813GWAS803789_HS-6-hydroxywarfarin to S-warfarin ratio measurement QTL GWAS803789 (human)5e-09S-6-hydroxywarfarin to S-warfarin ratio measurement109472924094729241Human
407082521GWAS731497_Hobsolete_red blood cell distribution width QTL GWAS731497 (human)1e-09obsolete_red blood cell distribution widthred blood cell distribution width- standard deviation (CMO:0003232)109468780594687806Human

Markers in Region
D4S1512  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37206,216,686 - 6,216,749UniSTSGRCh37
GRCh37424,777,892 - 24,778,004UniSTSGRCh37
Build 36424,386,990 - 24,387,102RGDNCBI36
Celera425,227,348 - 25,227,459RGD
Celera206,287,860 - 6,287,923UniSTS
HuRef1090,106,085 - 90,106,203UniSTS
HuRef206,173,561 - 6,173,624UniSTS
HuRef424,120,383 - 24,120,494UniSTS
RH2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371096,495,644 - 96,495,781UniSTSGRCh37
Build 361096,485,634 - 96,485,771RGDNCBI36
Celera1090,235,736 - 90,235,873RGD
Cytogenetic Map10q24UniSTS
HuRef1090,122,464 - 90,122,601UniSTS
GeneMap99-GB4 RH Map10448.63UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
772 1875 1469 991 3988 1114 1671 4 613 1052 453 1858 4016 3466 15 2629 595 1266 1056 166

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_008373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001128925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH004309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL157835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL583836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BJ993698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX538127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M61853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M61856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000285979   ⟹   ENSP00000285979
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1094,683,729 - 94,736,190 (+)Ensembl
Ensembl Acc Id: ENST00000339022   ⟹   ENSP00000341293
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1094,683,775 - 94,735,574 (+)Ensembl
RefSeq Acc Id: NM_000772   ⟹   NP_000763
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381094,683,729 - 94,736,190 (+)NCBI
GRCh371096,443,251 - 96,495,947 (+)ENTREZGENE
Build 361096,433,368 - 96,485,514 (+)NCBI Archive
HuRef1090,070,045 - 90,122,767 (+)ENTREZGENE
CHM1_11096,725,017 - 96,777,714 (+)NCBI
T2T-CHM13v2.01095,562,854 - 95,615,317 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001128925   ⟹   NP_001122397
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381094,683,729 - 94,736,190 (+)NCBI
GRCh371096,443,251 - 96,495,947 (+)ENTREZGENE
HuRef1090,070,045 - 90,122,767 (+)ENTREZGENE
CHM1_11096,725,017 - 96,777,714 (+)NCBI
T2T-CHM13v2.01095,562,854 - 95,615,317 (+)NCBI
Sequence:
RefSeq Acc Id: NP_000763   ⟸   NM_000772
- Peptide Label: isoform 1
- UniProtKB: Q4VAT5 (UniProtKB/Swiss-Prot),   Q16751 (UniProtKB/Swiss-Prot),   Q16703 (UniProtKB/Swiss-Prot),   B2R8K2 (UniProtKB/Swiss-Prot),   Q6GRG1 (UniProtKB/Swiss-Prot),   P33260 (UniProtKB/Swiss-Prot),   Q53EX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001122397   ⟸   NM_001128925
- Peptide Label: isoform 2
- UniProtKB: Q53EX9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000285979   ⟸   ENST00000285979
Ensembl Acc Id: ENSP00000341293   ⟸   ENST00000339022

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P33260-F1-model_v2 AlphaFold P33260 1-490 view protein structure

Promoters
RGD ID:7218225
Promoter ID:EPDNEW_H14858
Type:initiation region
Name:CYP2C18_3
Description:cytochrome P450 family 2 subfamily C member 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14859  EPDNEW_H14860  EPDNEW_H14861  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381094,682,904 - 94,682,964EPDNEW
RGD ID:7218227
Promoter ID:EPDNEW_H14859
Type:initiation region
Name:CYP2C18_2
Description:cytochrome P450 family 2 subfamily C member 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14858  EPDNEW_H14860  EPDNEW_H14861  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381094,683,454 - 94,683,514EPDNEW
RGD ID:7218229
Promoter ID:EPDNEW_H14860
Type:multiple initiation site
Name:CYP2C18_1
Description:cytochrome P450 family 2 subfamily C member 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14858  EPDNEW_H14859  EPDNEW_H14861  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381094,683,795 - 94,683,855EPDNEW
RGD ID:7218233
Promoter ID:EPDNEW_H14861
Type:multiple initiation site
Name:CYP2C18_4
Description:cytochrome P450 family 2 subfamily C member 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14858  EPDNEW_H14859  EPDNEW_H14860  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381094,688,224 - 94,688,284EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2620 AgrOrtholog
COSMIC CYP2C18 COSMIC
Ensembl Genes ENSG00000108242 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000285979 ENTREZGENE
  ENST00000285979.11 UniProtKB/Swiss-Prot
  ENST00000339022 ENTREZGENE
  ENST00000339022.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000108242 GTEx
HGNC ID HGNC:2620 ENTREZGENE
Human Proteome Map CYP2C18 Human Proteome Map
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 1562 ENTREZGENE
OMIM 601131 OMIM
PANTHER CYTOCHROME P450 2C18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CYP2C18 RGD, PharmGKB
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2R8K2 ENTREZGENE
  CP2CI_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q16703 ENTREZGENE
  Q16751 ENTREZGENE
  Q2XN56_HUMAN UniProtKB/TrEMBL
  Q4VAT5 ENTREZGENE
  Q53EX9 ENTREZGENE, UniProtKB/TrEMBL
  Q6GRG1 ENTREZGENE
  Q7Z348_HUMAN UniProtKB/TrEMBL
UniProt Secondary B2R8K2 UniProtKB/Swiss-Prot
  Q16703 UniProtKB/Swiss-Prot
  Q16751 UniProtKB/Swiss-Prot
  Q4VAT5 UniProtKB/Swiss-Prot
  Q6GRG1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-15 CYP2C18  cytochrome P450 family 2 subfamily C member 18  CYP2C18  cytochrome P450, family 2, subfamily C, polypeptide 18  Symbol and/or name change 5135510 APPROVED