Prss53 (serine protease 53) - Rat Genome Database

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Gene: Prss53 (serine protease 53) Mus musculus
Analyze
Symbol: Prss53
Name: serine protease 53
RGD ID: 1322648
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular region. Orthologous to human PRSS53 (serine protease 53).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FLJ00289; mFLJ00289; Pol3s; polyserase-3; polyserine protease 3; protease, serine 53; protease, serine, 53
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,484,616 - 127,490,594 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,485,013 - 127,490,142 (-)EnsemblGRCm39 Ensembl
GRCm387127,885,444 - 127,892,965 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,885,841 - 127,890,970 (-)EnsemblGRCm38mm10GRCm38
MGSCv377135,028,958 - 135,034,484 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,676,592 - 127,682,118 (-)NCBIMGSCv36mm8
Celera7127,720,640 - 127,726,169 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:21677750   PMID:21873635   PMID:34636707   PMID:35067752   PMID:38355793  


Genomics

Comparative Map Data
Prss53
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,484,616 - 127,490,594 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,485,013 - 127,490,142 (-)EnsemblGRCm39 Ensembl
GRCm387127,885,444 - 127,892,965 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,885,841 - 127,890,970 (-)EnsemblGRCm38mm10GRCm38
MGSCv377135,028,958 - 135,034,484 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,676,592 - 127,682,118 (-)NCBIMGSCv36mm8
Celera7127,720,640 - 127,726,169 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.81NCBI
PRSS53
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,083,437 - 31,088,943 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,083,437 - 31,089,628 (-)EnsemblGRCh38hg38GRCh38
GRCh371631,094,758 - 31,100,264 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,002,246 - 31,007,631 (-)NCBINCBI36Build 36hg18NCBI36
Celera1629,197,373 - 29,202,758 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,656,444 - 28,661,829 (-)NCBIHuRef
CHM1_11632,412,046 - 32,417,431 (-)NCBICHM1_1
T2T-CHM13v2.01631,470,865 - 31,476,371 (-)NCBIT2T-CHM13v2.0
Prss53
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,923,398 - 191,931,292 (-)NCBIGRCr8
mRatBN7.21182,494,944 - 182,501,607 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,494,955 - 182,500,115 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,846,034 - 190,850,698 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,032,128 - 198,036,792 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,702,532 - 190,707,202 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,331,108 - 199,337,129 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,331,787 - 199,336,451 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,353,540 - 206,359,553 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,169,747 - 187,174,411 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1180,146,294 - 180,150,958 (-)NCBICelera
Cytogenetic Map1q37NCBI
Prss53
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554937,921,408 - 7,925,708 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554937,921,335 - 7,927,233 (-)NCBIChiLan1.0ChiLan1.0
PRSS53
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,290,947 - 34,298,383 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,092,350 - 39,099,786 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,876,533 - 23,883,969 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,452,183 - 31,459,549 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,452,183 - 31,459,549 (-)Ensemblpanpan1.1panPan2
PRSS53
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,144,099 - 17,148,767 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,144,154 - 17,148,673 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,718,820 - 18,724,360 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,274,344 - 17,279,885 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,275,035 - 17,279,900 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,074,745 - 17,080,285 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,993,605 - 16,999,145 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,305,990 - 17,311,530 (+)NCBIUU_Cfam_GSD_1.0
Prss53
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,354,227 - 125,360,148 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650113,452,456 - 13,457,629 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650113,452,418 - 13,457,948 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRSS53
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,391,219 - 17,396,885 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,390,801 - 17,396,885 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,721,343 - 17,727,571 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRSS53
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,771,033 - 27,778,544 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,771,384 - 27,776,516 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660681,690,087 - 1,696,864 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prss53
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,134,420 - 14,140,077 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478214,134,968 - 14,140,693 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prss53
57 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:246
Count of miRNA genes:184
Interacting mature miRNAs:200
Transcripts:ENSMUST00000121394
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
11059561Lmr21a_mleishmaniasis resistance 21a (mouse)7117750722127967336Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
4141945Il4ppq_mIL-4 producing potential QTL (mouse)Not determined7124513662128819324Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
38501072Stsl7_mSalmonella typhimurium susceptibility locus 7 (mouse)7115699235128501724Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301903Tlsm1_mthymic lymphoma susceptible 1 (mouse)Not determined7122250663135170901Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
1357613Bsbob2_mBSB obesity 2 (mouse)Not determined7122250663128819324Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117199227134101729Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001081268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003946495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC149222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC147509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC151010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC151017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC172059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ905723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ905724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ905726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ905727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ905728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ905729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM026950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM026951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM026952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM026953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000121394   ⟹   ENSMUSP00000112972
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,485,013 - 127,490,142 (-)Ensembl
GRCm38.p6 Ensembl7127,885,841 - 127,890,970 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205300   ⟹   ENSMUSP00000145763
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,485,265 - 127,490,139 (-)Ensembl
GRCm38.p6 Ensembl7127,886,093 - 127,890,967 (-)Ensembl
RefSeq Acc Id: NM_001081268   ⟹   NP_001074737
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397127,484,616 - 127,490,142 (-)NCBI
GRCm387127,885,444 - 127,890,970 (-)NCBI
MGSCv377135,028,958 - 135,034,484 (-)RGD
Celera7127,720,640 - 127,726,169 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_003946495
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397127,485,024 - 127,490,594 (-)NCBI
GRCm387127,886,562 - 127,892,965 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001074737   ⟸   NM_001081268
- Peptide Label: precursor
- UniProtKB: Q8CFX9 (UniProtKB/Swiss-Prot),   Q571E5 (UniProtKB/Swiss-Prot),   B2RX64 (UniProtKB/TrEMBL),   B7ZWH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000145763   ⟸   ENSMUST00000205300
RefSeq Acc Id: ENSMUSP00000112972   ⟸   ENSMUST00000121394
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q571E5-F1-model_v2 AlphaFold Q571E5 1-552 view protein structure

Promoters
RGD ID:8665727
Promoter ID:EPDNEW_M10894
Type:multiple initiation site
Name:Prss53_1
Description:Mus musculus protease, serine 53 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387127,890,933 - 127,890,993EPDNEW
RGD ID:6840700
Promoter ID:MM_KWN:52827
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:NM_001081268
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367135,034,261 - 135,035,417 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2652890 AgrOrtholog
Ensembl Genes ENSMUSG00000044139 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000121394 ENTREZGENE
  ENSMUST00000121394.3 UniProtKB/Swiss-Prot
  ENSMUST00000205300.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:330657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2652890 ENTREZGENE
NCBI Gene 330657 ENTREZGENE
PANTHER POLYSERASE-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEASE SERINE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prss53 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RX64 ENTREZGENE, UniProtKB/TrEMBL
  B7ZWH8 ENTREZGENE, UniProtKB/TrEMBL
  PRS53_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8CFX9 ENTREZGENE
UniProt Secondary Q8CFX9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-29 Prss53  serine protease 53  Prss53  protease, serine 53  Symbol and/or name change 5135510 APPROVED
2013-11-26 Prss53  protease, serine 53    protease, serine, 53  Symbol and/or name change 5135510 APPROVED
2011-07-27 Prss53  protease, serine, 53  BC039632  cDNA sequence BC039632  Symbol and/or name change 5135510 APPROVED