Emx2 (empty spiracles homeobox 2) - Rat Genome Database

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Gene: Emx2 (empty spiracles homeobox 2) Mus musculus
Analyze
Symbol: Emx2
Name: empty spiracles homeobox 2
RGD ID: 1322368
MGI Page MGI
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in stereocilium bundle organization. Acts upstream of or within several processes, including anterior/posterior pattern specification; nervous system development; and ureter morphogenesis. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; future brain; genitourinary system; jaw; and nose. Human ortholog(s) of this gene implicated in colorectal cancer and stomach cancer. Orthologous to human EMX2 (empty spiracles homeobox 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: empty spiracles homolog 2; empty spiracles-like protein 2; homeobox protein EMX2; P; Pdo
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391959,447,122 - 59,453,789 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1959,446,804 - 59,453,789 (+)EnsemblGRCm39 Ensembl
GRCm381959,458,690 - 59,465,357 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1959,458,372 - 59,465,357 (+)EnsemblGRCm38mm10GRCm38
MGSCv371959,533,180 - 59,539,847 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361959,511,622 - 59,518,607 (+)NCBIMGSCv36mm8
Celera1961,658,178 - 61,664,837 (+)NCBICelera
Cytogenetic Map19D3NCBI
cM Map1956.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
15-acetyldeoxynivalenol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
arotinoid acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (ISO)
CHIR 99021  (ISO)
chlordecone  (EXP)
cisplatin  (ISO)
cortisol  (ISO)
Cuprizon  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
fluoranthene  (EXP)
folic acid  (EXP)
furan  (ISO)
gentamycin  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
melphalan  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (ISO)
methylmercury chloride  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP)
nickel atom  (ISO)
ochratoxin A  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
picoxystrobin  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sulfadimethoxine  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
valproic acid  (EXP,ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IEA)
cell projection  (IEA)
nucleoplasm  (TAS)
nucleus  (IBA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adenohypophysis morphology  (IAGP)
abnormal Ammon gyrus morphology  (IAGP)
abnormal anterior commissure morphology  (IAGP)
abnormal astrocyte morphology  (IAGP)
abnormal axon extension  (IAGP)
abnormal brain commissure morphology  (IAGP)
abnormal brain morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal cerebral hemisphere morphology  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal cochlear inner hair cell morphology  (IAGP)
abnormal corpus callosum morphology  (IAGP)
abnormal cortical plate morphology  (IAGP)
abnormal embryonic/fetal subventricular zone morphology  (IAGP)
abnormal forebrain development  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal hippocampal fimbria morphology  (IAGP)
abnormal hippocampal fornix morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal hippocampus region morphology  (IAGP)
abnormal incudomalleolar joint morphology  (IAGP)
abnormal incudostapedial joint morphology  (IAGP)
abnormal incus long process morphology  (IAGP)
abnormal incus morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal lateral ganglionic eminence morphology  (IAGP)
abnormal lateral ventricle morphology  (IAGP)
abnormal lens morphology  (IAGP)
abnormal malleus morphology  (IAGP)
abnormal medial ganglionic eminence morphology  (IAGP)
abnormal metanephric mesenchyme morphology  (IAGP)
abnormal metanephric ureteric bud development  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal midbrain-hindbrain boundary morphology  (IAGP)
abnormal middle ear ossicle morphology  (IAGP)
abnormal nervous system development  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuronal precursor proliferation  (IAGP)
abnormal olfactory bulb mitral cell layer morphology  (IAGP)
abnormal olfactory sensory neuron morphology  (IAGP)
abnormal pallium development  (IAGP)
abnormal posterior commissure morphology  (IAGP)
abnormal pretectal region morphology  (IAGP)
abnormal primary sex determination  (IAGP)
abnormal stapes head morphology  (IAGP)
abnormal stapes morphology  (IAGP)
abnormal tectum morphology  (IAGP)
abnormal telencephalon development  (IAGP)
abnormal telencephalon morphology  (IAGP)
abnormal thalamus morphology  (IAGP)
abnormal ureteric bud tip morphology  (IAGP)
abnormal vestibular hair cell morphology  (IAGP)
absent choroid plexus  (IAGP)
absent cranial vagina  (IAGP)
absent dentate gyrus  (IAGP)
absent diencephalon  (IAGP)
absent efferent ductules of testis  (IAGP)
absent epididymis  (IAGP)
absent hippocampal fimbria  (IAGP)
absent hippocampus  (IAGP)
absent incus  (IAGP)
absent incus lenticular process  (IAGP)
absent internal female genitalia  (IAGP)
absent internal male genitalia  (IAGP)
absent kidney  (IAGP)
absent Mullerian ducts  (IAGP)
absent ovary  (IAGP)
absent oviduct  (IAGP)
absent pinna reflex  (IAGP)
absent seminal vesicle  (IAGP)
absent testes  (IAGP)
absent ureter  (IAGP)
absent uterus  (IAGP)
absent vas deferens  (IAGP)
agonadal  (IAGP)
conductive hearing loss  (IEA)
deafness  (IAGP)
decreased anterior commissure size  (IAGP)
decreased cochlear nerve compound action potential  (IAGP)
decreased corpus callosum size  (IAGP)
decreased hippocampal fornix size  (IAGP)
decreased neuron number  (IAGP)
decreased neuronal precursor cell number  (IAGP)
dilated third ventricle  (IAGP)
enlarged tectum  (IAGP)
gonadal ridge hypoplasia  (IAGP)
impaired branching involved in ureteric bud morphogenesis  (IAGP)
impaired hearing  (IAGP)
increased cochlear inner hair cell number  (IAGP)
increased cochlear nerve compound action potential  (IAGP)
increased cochlear outer hair cell number  (IAGP)
increased metanephric mesenchyme apoptosis  (IAGP)
increased neuron apoptosis  (IAGP)
increased neuron number  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
loss of cortex neurons  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
renal hypoplasia  (IAGP)
retina hyperplasia  (IAGP)
sensorineural hearing loss  (IEA)
small kidney  (IAGP)
small olfactory bulb  (IAGP)
small thalamus  (IAGP)
syndromic hearing loss  (IEA)
Wolffian duct degeneration  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. EMX2 gene expression predicts liver metastasis and survival in colorectal cancer. Aykut B, etal., BMC Cancer. 2017 Aug 22;17(1):555. doi: 10.1186/s12885-017-3556-2.
2. The homeobox gene EMX2 is a prognostic and predictive marker in malignant pleural mesothelioma. Giroux Leprieur E, etal., Lung Cancer. 2014 Sep;85(3):465-71. doi: 10.1016/j.lungcan.2014.06.018. Epub 2014 Jun 30.
3. Adenoviral delivery of the EMX2 gene suppresses growth in human gastric cancer. Li J, etal., PLoS One. 2012;7(9):e45970. doi: 10.1371/journal.pone.0045970. Epub 2012 Sep 21.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma patients. Okamoto J, etal., Clin Lung Cancer. 2011 Jul;12(4):237-44. doi: 10.1016/j.cllc.2011.03.025. Epub 2011 Apr 24.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. EMX2 is epigenetically silenced and suppresses epithelial‑mesenchymal transition in human esophageal adenocarcinoma. Wang L, etal., Oncol Rep. 2019 Nov;42(5):2169-2178. doi: 10.3892/or.2019.7284. Epub 2019 Aug 20.
12. EMX2 Is a Predictive Marker for Adjuvant Chemotherapy in Lung Squamous Cell Carcinomas. Yue D, etal., PLoS One. 2015 Jul 1;10(7):e0132134. doi: 10.1371/journal.pone.0132134. eCollection 2015.
13. Empty Spiracles Homeobox 2 (EMX2) Inhibits the Invasion and Tumorigenesis in Colorectal Cancer Cells. Zhang Y, etal., Oncol Res. 2017 Apr 14;25(4):537-544. doi: 10.3727/096504016X14756640150695. Epub 2016 Oct 5.
Additional References at PubMed
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Genomics

Comparative Map Data
Emx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391959,447,122 - 59,453,789 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1959,446,804 - 59,453,789 (+)EnsemblGRCm39 Ensembl
GRCm381959,458,690 - 59,465,357 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1959,458,372 - 59,465,357 (+)EnsemblGRCm38mm10GRCm38
MGSCv371959,533,180 - 59,539,847 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361959,511,622 - 59,518,607 (+)NCBIMGSCv36mm8
Celera1961,658,178 - 61,664,837 (+)NCBICelera
Cytogenetic Map19D3NCBI
cM Map1956.28NCBI
EMX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810117,542,746 - 117,549,546 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10117,542,445 - 117,549,546 (+)EnsemblGRCh38hg38GRCh38
GRCh3710119,302,257 - 119,309,057 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610119,291,946 - 119,299,043 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410119,291,945 - 119,299,043NCBI
Celera10113,031,949 - 113,039,046 (+)NCBICelera
Cytogenetic Map10q26.11NCBI
HuRef10112,930,193 - 112,937,289 (+)NCBIHuRef
CHM1_110119,586,078 - 119,593,194 (+)NCBICHM1_1
T2T-CHM13v2.010118,437,136 - 118,443,925 (+)NCBIT2T-CHM13v2.0
Emx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81268,612,663 - 268,619,671 (+)NCBIGRCr8
mRatBN7.21258,626,584 - 258,633,594 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1258,626,584 - 258,633,594 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1266,832,393 - 266,839,395 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01273,538,418 - 273,545,420 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01266,179,101 - 266,186,108 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01280,633,938 - 280,640,946 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1280,633,938 - 280,640,946 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01287,993,648 - 288,000,656 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41266,004,257 - 266,011,265 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1254,275,943 - 254,282,950 (+)NCBICelera
Cytogenetic Map1q55NCBI
Emx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543122,192,446 - 22,199,279 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543122,192,446 - 22,199,141 (+)NCBIChiLan1.0ChiLan1.0
EMX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28129,405,618 - 129,419,620 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110129,417,530 - 129,424,956 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010114,124,759 - 114,132,109 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110117,551,451 - 117,557,972 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10117,551,451 - 117,557,972 (+)Ensemblpanpan1.1panPan2
EMX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12828,002,966 - 28,009,955 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2828,003,710 - 28,009,035 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2828,146,341 - 28,153,333 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02828,532,618 - 28,539,604 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2828,532,897 - 28,538,743 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12828,094,345 - 28,101,342 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02828,108,855 - 28,115,187 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02828,303,055 - 28,310,050 (+)NCBIUU_Cfam_GSD_1.0
Emx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721318,241,303 - 18,247,914 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364867,313,190 - 7,319,995 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364867,313,689 - 7,319,971 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EMX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14127,650,688 - 127,655,706 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114127,649,675 - 127,656,972 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214139,052,130 - 139,055,522 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EMX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19110,347,043 - 110,353,647 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9110,347,379 - 110,353,643 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604871,602,815 - 71,610,687 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Emx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473729,103,279 - 29,110,344 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473729,103,378 - 29,110,356 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Emx2
211 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:772
Count of miRNA genes:514
Interacting mature miRNAs:594
Transcripts:ENSMUST00000062216, ENSMUST00000174353, ENSMUST00000174573
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10043896Bw21_mbody weight QTL 21 (mouse)Not determined193959606661420004Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193918406461420004Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
1300585Pgia12_mproteoglycan induced arthritis 12 (mouse)Not determined194258685961420004Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse

Markers in Region
Emx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371959,536,146 - 59,536,265UniSTSGRCm37
Celera1961,661,144 - 61,661,263UniSTS
Cytogenetic Map19D3UniSTS
cM Map1953.5UniSTS
Emx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D3UniSTS
Emx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381959,461,656 - 59,461,775UniSTSGRCm38
MGSCv371959,536,146 - 59,536,265UniSTSGRCm37
Celera1961,661,144 - 61,661,263UniSTS
Cytogenetic Map19D3UniSTS
Emx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D3UniSTS
cM Map1953.5UniSTS
Emx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D3UniSTS
cM Map1953.5UniSTS
Emx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D3UniSTS
cM Map1953.5UniSTS
Emx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D3UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000062216   ⟹   ENSMUSP00000053361
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1959,446,804 - 59,453,789 (+)Ensembl
GRCm38.p6 Ensembl1959,458,372 - 59,465,357 (+)Ensembl
Ensembl Acc Id: ENSMUST00000174353   ⟹   ENSMUSP00000140271
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1959,447,951 - 59,453,785 (+)Ensembl
GRCm38.p6 Ensembl1959,459,519 - 59,465,353 (+)Ensembl
Ensembl Acc Id: ENSMUST00000174573
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1959,451,234 - 59,452,647 (+)Ensembl
GRCm38.p6 Ensembl1959,462,802 - 59,464,215 (+)Ensembl
RefSeq Acc Id: NM_010132   ⟹   NP_034262
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391959,447,122 - 59,453,789 (+)NCBI
GRCm381959,458,690 - 59,465,357 (+)NCBI
MGSCv371959,533,180 - 59,539,847 (+)RGD
Celera1961,658,178 - 61,664,837 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006526657   ⟹   XP_006526720
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391959,447,194 - 59,452,415 (+)NCBI
GRCm381959,458,756 - 59,463,983 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_034262 (Get FASTA)   NCBI Sequence Viewer  
  XP_006526720 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAM94018 (Get FASTA)   NCBI Sequence Viewer  
  CAA48753 (Get FASTA)   NCBI Sequence Viewer  
  EDL01826 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000053361
  ENSMUSP00000053361.3
  ENSMUSP00000140271.2
GenBank Protein Q04744 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_034262   ⟸   NM_010132
- UniProtKB: G3X9A6 (UniProtKB/Swiss-Prot),   Q80UE7 (UniProtKB/Swiss-Prot),   Q04744 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006526720   ⟸   XM_006526657
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000140271   ⟸   ENSMUST00000174353
Ensembl Acc Id: ENSMUSP00000053361   ⟸   ENSMUST00000062216

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q04744-F1-model_v2 AlphaFold Q04744 1-253 view protein structure

Promoters
RGD ID:13679900
Promoter ID:EPDNEW_M24099
Type:initiation region
Name:Emx2_1
Description:Mus musculus empty spiracles homeobox 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381959,458,756 - 59,458,816EPDNEW
RGD ID:6829993
Promoter ID:MM_KWN:27467
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   Kidney,   Lung,   MEF_B6
Transcripts:NM_010132,   NR_002863,   NR_002863_EMX2OS,   NR_002863_EMX2OS.1,   UC008IBK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361959,532,916 - 59,534,177 (+)MPROMDB
RGD ID:6847552
Promoter ID:MM_ACW:27313
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:EMX2.BSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361959,536,176 - 59,536,676 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95388 AgrOrtholog
Ensembl Genes ENSMUSG00000043969 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000062216 ENTREZGENE
  ENSMUST00000062216.4 UniProtKB/Swiss-Prot
  ENSMUST00000174353.2 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot
InterPro EMX-VAX-Noto_Homeobox_TFs UniProtKB/Swiss-Prot
  Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Homeobox_metazoa UniProtKB/Swiss-Prot
  HTH_motif UniProtKB/Swiss-Prot
KEGG Report mmu:13797 UniProtKB/Swiss-Prot
MGD MGI:95388 ENTREZGENE
NCBI Gene 13797 ENTREZGENE
PANTHER HOMEOBOX PROTEIN EMX-RELATED UniProtKB/Swiss-Prot
  HOMEOBOX PROTEIN EMX2 UniProtKB/Swiss-Prot
Pfam Homeodomain UniProtKB/Swiss-Prot
PhenoGen Emx2 PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot
  HTHREPRESSR UniProtKB/Swiss-Prot
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
UniProt A0A087WQN3_MOUSE UniProtKB/TrEMBL
  EMX2_MOUSE UniProtKB/Swiss-Prot
  G3X9A6 ENTREZGENE
  Q04744 ENTREZGENE
  Q80UE7 ENTREZGENE
UniProt Secondary G3X9A6 UniProtKB/Swiss-Prot
  Q80UE7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-31 Emx2  empty spiracles homeobox 2  Emx2  empty spiracles homolog 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED