Rpp30 (ribonuclease P/MRP 30 subunit) - Rat Genome Database

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Gene: Rpp30 (ribonuclease P/MRP 30 subunit) Mus musculus
Analyze
Symbol: Rpp30
Name: ribonuclease P/MRP 30 subunit
RGD ID: 1321879
MGI Page MGI
Description: Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in tRNA 5'-leader removal. Predicted to be located in nucleolus. Predicted to be part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Is expressed in several structures, including brain ventricular layer; gut gland; olfactory epithelium; submandibular gland primordium; and thymus primordium. Orthologous to human RPP30 (ribonuclease P/MRP subunit p30).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ribonuclease P protein subunit p30; ribonuclease P/MRP 30kDa subunit; ribonuclease P2; Rn; RNase P subunit 2; RNaseP protein p30; Rnasep2; TSG1; TSG15
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391936,061,118 - 36,082,173 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1936,061,116 - 36,082,177 (+)EnsemblGRCm39 Ensembl
GRCm381936,083,689 - 36,104,773 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1936,083,716 - 36,104,777 (+)EnsemblGRCm38mm10GRCm38
MGSCv371936,158,206 - 36,179,263 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361936,148,875 - 36,169,917 (+)NCBIMGSCv36mm8
Celera1936,859,168 - 36,880,210 (+)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1930.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects. Lai LB, etal., FEBS Lett. 2010 Jan 21;584(2):287-96. doi: 10.1016/j.febslet.2009.11.048. Epub .
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1659684   PMID:8889548   PMID:9630247   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12045094   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273  
PMID:14691545   PMID:16141072   PMID:16141073   PMID:18799693   PMID:21267068   PMID:21873635   PMID:31040226   PMID:31138677   PMID:32133736   PMID:32325033   PMID:33378226   PMID:36114006  


Genomics

Comparative Map Data
Rpp30
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391936,061,118 - 36,082,173 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1936,061,116 - 36,082,177 (+)EnsemblGRCm39 Ensembl
GRCm381936,083,689 - 36,104,773 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1936,083,716 - 36,104,777 (+)EnsemblGRCm38mm10GRCm38
MGSCv371936,158,206 - 36,179,263 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361936,148,875 - 36,169,917 (+)NCBIMGSCv36mm8
Celera1936,859,168 - 36,880,210 (+)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1930.41NCBI
RPP30
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381090,871,974 - 90,908,556 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1090,871,952 - 90,908,553 (+)EnsemblGRCh38hg38GRCh38
GRCh371092,631,731 - 92,668,313 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361092,621,689 - 92,658,292 (+)NCBINCBI36Build 36hg18NCBI36
Build 341092,621,254 - 92,651,926NCBI
Celera1086,378,161 - 86,414,769 (+)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1086,260,723 - 86,297,333 (+)NCBIHuRef
CHM1_11092,909,555 - 92,946,159 (+)NCBICHM1_1
T2T-CHM13v2.01091,755,650 - 91,792,233 (+)NCBIT2T-CHM13v2.0
Rpp30
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81243,198,647 - 243,221,559 (+)NCBIGRCr8
mRatBN7.21233,786,048 - 233,808,958 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,786,099 - 233,808,952 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,183,324 - 242,205,801 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01249,099,926 - 249,122,780 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,938,084 - 241,960,936 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01254,697,247 - 254,720,093 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1254,697,247 - 254,720,087 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01262,053,592 - 262,076,260 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41240,286,366 - 240,309,222 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1230,885,463 - 230,908,059 (+)NCBICelera
Cytogenetic Map1q53NCBI
Rpp30
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554252,273,980 - 2,303,314 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554252,276,006 - 2,302,882 (-)NCBIChiLan1.0ChiLan1.0
RPP30
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28102,898,068 - 102,942,388 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110102,903,372 - 102,947,774 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01087,611,699 - 87,646,239 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11091,138,993 - 91,171,848 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1091,138,993 - 91,170,517 (+)Ensemblpanpan1.1panPan2
RPP30
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1285,535,257 - 5,563,820 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl285,535,709 - 5,562,502 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha285,702,828 - 5,731,402 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,755,638 - 5,784,265 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,756,007 - 5,784,125 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1285,512,723 - 5,541,292 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0285,551,517 - 5,580,105 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0285,717,205 - 5,745,776 (+)NCBIUU_Cfam_GSD_1.0
Rpp30
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721341,887,463 - 41,916,620 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366013,517,881 - 3,549,212 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366013,520,066 - 3,549,189 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPP30
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14102,566,046 - 102,597,121 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114102,565,802 - 102,606,046 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214111,677,217 - 111,708,315 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RPP30
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1984,208,181 - 84,237,067 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl984,208,199 - 84,236,957 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604844,917,938 - 44,946,814 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rpp30
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247372,086,748 - 2,114,618 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247372,087,357 - 2,114,878 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rpp30
600 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:84
Interacting mature miRNAs:91
Transcripts:ENSMUST00000025714
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1301479Sluc1_msusceptibility to lung cancer 1 (mouse)Not determined193601694446761521Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192513600242388916Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse

Markers in Region
RH127064  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381936,086,510 - 36,086,757UniSTSGRCm38
MGSCv371936,161,000 - 36,161,247UniSTSGRCm37
Celera1936,861,962 - 36,862,209UniSTS
Cytogenetic Map19C2UniSTS
Whitehead/MRC_RH19335.79UniSTS
U95123  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381936,104,475 - 36,104,612UniSTSGRCm38
MGSCv371936,178,965 - 36,179,102UniSTSGRCm37
Celera1936,879,912 - 36,880,049UniSTS
Cytogenetic Map19C2UniSTS
Whitehead/MRC_RH19335.79UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000025714   ⟹   ENSMUSP00000025714
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1936,061,131 - 36,082,177 (+)Ensembl
GRCm38.p6 Ensembl1936,083,731 - 36,104,777 (+)Ensembl
Ensembl Acc Id: ENSMUST00000235223
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1936,077,561 - 36,081,878 (+)Ensembl
GRCm38.p6 Ensembl1936,100,161 - 36,104,478 (+)Ensembl
Ensembl Acc Id: ENSMUST00000236197
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1936,061,143 - 36,077,729 (+)Ensembl
GRCm38.p6 Ensembl1936,083,743 - 36,100,329 (+)Ensembl
Ensembl Acc Id: ENSMUST00000237251
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1936,061,116 - 36,073,046 (+)Ensembl
GRCm38.p6 Ensembl1936,083,716 - 36,095,646 (+)Ensembl
Ensembl Acc Id: ENSMUST00000237841
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1936,061,190 - 36,064,165 (+)Ensembl
GRCm38.p6 Ensembl1936,083,790 - 36,086,765 (+)Ensembl
RefSeq Acc Id: NM_019428   ⟹   NP_062301
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391936,061,118 - 36,082,173 (+)NCBI
GRCm381936,083,716 - 36,104,773 (+)NCBI
MGSCv371936,158,206 - 36,179,263 (+)RGD
Celera1936,859,168 - 36,880,210 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_182659
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391936,061,118 - 36,082,173 (+)NCBI
RefSeq Acc Id: NP_062301   ⟸   NM_019428
- UniProtKB: O88796 (UniProtKB/Swiss-Prot),   Q6P6M0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000025714   ⟸   ENSMUST00000025714

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88796-F1-model_v2 AlphaFold O88796 1-268 view protein structure

Promoters
RGD ID:13679356
Promoter ID:EPDNEW_M23826
Type:multiple initiation site
Name:Rpp30_1
Description:Mus musculus ribonuclease P/MRP 30 subunit , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381936,083,720 - 36,083,780EPDNEW
RGD ID:6830380
Promoter ID:MM_KWN:26926
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_019428_RPP30
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361936,158,006 - 36,158,506 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1859683 AgrOrtholog
Ensembl Genes ENSMUSG00000024800 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025714 ENTREZGENE
  ENSMUST00000025714.9 UniProtKB/Swiss-Prot
Gene3D-CATH Metal-dependent hydrolases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Pol/histidinol_Pase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNase_P_p30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:54364 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1859683 ENTREZGENE
NCBI Gene Rpp30 ENTREZGENE
PANTHER PTHR13031 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBONUCLEASE P PROTEIN SUBUNIT P30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RNase_P_p30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rpp30 PhenoGen
Superfamily-SCOP SSF89550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt O88796 ENTREZGENE
  Q3TF81_MOUSE UniProtKB/TrEMBL
  Q6P6M0 ENTREZGENE, UniProtKB/TrEMBL
  Q8K238_MOUSE UniProtKB/TrEMBL
  RPP30_MOUSE UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Rpp30  ribonuclease P/MRP 30 subunit  Rnasep2-pending  ribonuclease P2  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 Rnasep2-pending  ribonuclease P2  Rpp30  ribonuclease P/MRP 30 subunit  Symbol and/or name change 5135510 APPROVED
2012-11-27 Rpp30  ribonuclease P/MRP 30 subunit    ribonuclease P/MRP 30 subunit (human)  Symbol and/or name change 5135510 APPROVED