Foxs1 (forkhead box S1) - Rat Genome Database

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Gene: Foxs1 (forkhead box S1) Mus musculus
Analyze
Symbol: Foxs1
Name: forkhead box S1
RGD ID: 1321723
MGI Page MGI
Description: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in blood vessel development; negative regulation of DNA-binding transcription factor activity; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within neuromuscular process controlling balance and regulation of growth. Located in nucleus. Is expressed in several structures, including ganglia; genitourinary system; gut; hemolymphoid system gland; and yolk sac. Orthologous to human FOXS1 (forkhead box S1).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fkh3; Fkhl1; Fkhl18; forkhead box protein S1; forkhead-like 18 protein; forkhead-related transcription factor 10; FREAC; FREAC-10; FREAC10; transcription factor FKH-3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,773,818 - 152,775,128 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,773,818 - 152,775,128 (-)EnsemblGRCm39 Ensembl
GRCm382152,931,898 - 152,933,208 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,931,898 - 152,933,208 (-)EnsemblGRCm38mm10GRCm38
MGSCv372152,757,634 - 152,758,944 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362152,623,339 - 152,624,649 (-)NCBIMGSCv36mm8
Celera2158,749,741 - 158,751,051 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IDA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:7689224   PMID:9152011   PMID:10208738   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12297093   PMID:12477932   PMID:15618518   PMID:15872002   PMID:15964817   PMID:16141072  
PMID:16141073   PMID:17309606   PMID:18287559   PMID:18288644   PMID:20059953   PMID:21873635   PMID:23471215   PMID:24952961   PMID:25289806   PMID:26120030   PMID:30918291   PMID:38280429  


Genomics

Comparative Map Data
Foxs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,773,818 - 152,775,128 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,773,818 - 152,775,128 (-)EnsemblGRCm39 Ensembl
GRCm382152,931,898 - 152,933,208 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,931,898 - 152,933,208 (-)EnsemblGRCm38mm10GRCm38
MGSCv372152,757,634 - 152,758,944 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362152,623,339 - 152,624,649 (-)NCBIMGSCv36mm8
Celera2158,749,741 - 158,751,051 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
FOXS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382031,844,303 - 31,845,604 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2031,844,303 - 31,845,604 (-)EnsemblGRCh38hg38GRCh38
GRCh372030,432,106 - 30,433,407 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,895,764 - 29,897,081 (-)NCBINCBI36Build 36hg18NCBI36
Build 342029,895,763 - 29,897,081NCBI
Celera2027,188,450 - 27,189,767 (-)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2027,221,024 - 27,222,341 (-)NCBIHuRef
CHM1_12030,336,002 - 30,337,319 (-)NCBICHM1_1
T2T-CHM13v2.02033,568,911 - 33,570,212 (-)NCBIT2T-CHM13v2.0
Foxs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,857,264 - 161,858,548 (-)NCBIGRCr8
mRatBN7.23141,397,012 - 141,398,296 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,397,016 - 141,398,281 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3145,301,956 - 145,303,240 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,885,768 - 153,887,052 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,625,293 - 151,626,577 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03148,406,509 - 148,407,778 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,406,513 - 148,407,778 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,809,501 - 154,810,770 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,272,507 - 143,273,776 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13143,178,128 - 143,179,398 (-)NCBI
Celera3140,146,299 - 140,147,568 (-)NCBICelera
Cytogenetic Map3q41NCBI
Foxs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542229,132,400 - 29,133,395 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542229,132,325 - 29,133,641 (+)NCBIChiLan1.0ChiLan1.0
FOXS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22137,540,989 - 37,542,290 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12037,534,087 - 37,535,388 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02028,137,881 - 28,140,107 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12029,268,112 - 29,269,423 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2029,268,362 - 29,269,354 (-)Ensemblpanpan1.1panPan2
FOXS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,307,275 - 21,308,632 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,307,540 - 21,308,532 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2420,954,673 - 20,955,998 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02421,994,142 - 21,996,972 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,994,405 - 21,995,397 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12421,272,587 - 21,275,417 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02421,377,860 - 21,379,167 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02421,808,519 - 21,811,349 (-)NCBIUU_Cfam_GSD_1.0
Foxs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640170,372,305 - 170,373,825 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648518,803,641 - 18,805,003 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648518,803,675 - 18,804,933 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,523,411 - 35,530,816 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,523,408 - 35,537,618 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,346,692 - 40,351,343 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOXS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,232,873 - 36,234,636 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl236,233,126 - 36,234,124 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605090,680,049 - 90,681,427 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Foxs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624741671,118 - 672,113 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624741667,610 - 672,358 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Foxs1
48 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:190
Count of miRNA genes:167
Interacting mature miRNAs:185
Transcripts:ENSMUST00000099200
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
13825247Agoc2_magouti coat color QTL 2 (mouse)2151841920159841920Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152329820181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
1558842Tailq2_mtail length QTL 2 (mouse)Not determined2151640941162737074Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
10412080Hylaq2_mHyperlocomotor activity related QTL 2 (mouse)Not determined2151640941164119146Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
1357862Epfq1_mepididymal fat pad weight QTL 1 (mouse)Not determined2151640941162737074Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143773445165665019Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152699221169117924Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
1558852Gnf2_mgrowth and fatness 2 (mouse)Not determined2152699221162197085Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
4141033Wg2d_mweight gain in high growth mice 2d (mouse)Not determined143773445160303008Mouse
1357772Scfq1_msubcutaneous fat pad weight QTL 1 (mouse)Not determined2151640941162737074Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
13504830Bacsq1_mbaculum shape QTL 1 (mouse)2145716184161016184Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151709273174389124Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000099200   ⟹   ENSMUSP00000096806
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2152,773,818 - 152,775,128 (-)Ensembl
GRCm38.p6 Ensembl2152,931,898 - 152,933,208 (-)Ensembl
RefSeq Acc Id: NM_010226   ⟹   NP_034356
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392152,773,818 - 152,775,128 (-)NCBI
GRCm382152,931,898 - 152,933,208 (-)ENTREZGENE
MGSCv372152,757,634 - 152,758,944 (-)RGD
Celera2158,749,741 - 158,751,051 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034356   ⟸   NM_010226
- UniProtKB: Q8C5N7 (UniProtKB/Swiss-Prot),   Q61574 (UniProtKB/Swiss-Prot),   Q4VA05 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000096806   ⟸   ENSMUST00000099200
Protein Domains
Fork-head

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61574-F1-model_v2 AlphaFold Q61574 1-329 view protein structure

Promoters
RGD ID:6831398
Promoter ID:MM_KWN:32397
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_010226
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362152,758,601 - 152,759,101 (-)MPROMDB
RGD ID:6879230
Promoter ID:EPDNEW_M3066
Type:multiple initiation site
Name:Foxs1_1
Description:Mus musculus forkhead box S1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382152,933,182 - 152,933,242EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95546 AgrOrtholog
Ensembl Genes ENSMUSG00000074676 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000099200 ENTREZGENE
  ENSMUST00000099200.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
InterPro FH_FOXS1 UniProtKB/Swiss-Prot
  Fork_head_dom UniProtKB/Swiss-Prot
  FOX_domain-containing UniProtKB/Swiss-Prot
  TF_fork_head_CS_1 UniProtKB/Swiss-Prot
  TF_fork_head_CS_2 UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report mmu:14239 UniProtKB/Swiss-Prot
MGD MGI:95546 ENTREZGENE
NCBI Gene 14239 ENTREZGENE
PANTHER FORKHEAD BOX PROTEIN UniProtKB/Swiss-Prot
  FORKHEAD BOX PROTEIN S1 UniProtKB/Swiss-Prot
Pfam Forkhead UniProtKB/Swiss-Prot
PhenoGen Foxs1 PhenoGen
PRINTS FORKHEAD UniProtKB/Swiss-Prot
PROSITE FORK_HEAD_1 UniProtKB/Swiss-Prot
  FORK_HEAD_2 UniProtKB/Swiss-Prot
  FORK_HEAD_3 UniProtKB/Swiss-Prot
SMART SM00339 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniProt FOXS1_MOUSE UniProtKB/Swiss-Prot
  Q4VA05 ENTREZGENE, UniProtKB/TrEMBL
  Q61574 ENTREZGENE
  Q8C5N7 ENTREZGENE
UniProt Secondary Q8C5N7 UniProtKB/Swiss-Prot