Mrgprh (MAS-related GPR, member H) - Rat Genome Database

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Gene: Mrgprh (MAS-related GPR, member H) Mus musculus
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Symbol: Mrgprh
Name: MAS-related GPR, member H
RGD ID: 1321599
MGI Page MGI
Description: Predicted to enable angiotensin receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G protein-coupled receptor 90; G-protein coupled receptor 90; G-protein coupled receptor GPR90; Gpr; Gpr90; Mas-related G protein-coupled receptor b; mas-related G-protein coupled receptor member H; Mgrb; Mrg; MrgH
RGD Orthologs
Human
Rat
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,094,921 - 13,096,729 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1713,094,921 - 13,096,864 (+)EnsemblGRCm39 Ensembl
GRCm381712,876,034 - 12,877,842 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,876,034 - 12,877,977 (+)EnsemblGRCm38mm10GRCm38
MGSCv371713,068,900 - 13,070,708 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,718,966 - 12,720,774 (+)NCBIMGSCv36mm8
Celera1712,907,930 - 12,909,738 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
megacolon  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)
membrane  (IEA)
nucleoplasm  (ISO)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. Wittenberger T, etal., J Mol Biol 2001 Mar 30;307(3):799-813.
5. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Zylka MJ, etal., Proc Natl Acad Sci U S A 2003 Aug 19;100(17):10043-8. Epub 2003 Aug 8.
Additional References at PubMed
PMID:11551509   PMID:12397184   PMID:12477932   PMID:21873635   PMID:24583173  


Genomics

Comparative Map Data
Mrgprh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,094,921 - 13,096,729 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1713,094,921 - 13,096,864 (+)EnsemblGRCm39 Ensembl
GRCm381712,876,034 - 12,877,842 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,876,034 - 12,877,977 (+)EnsemblGRCm38mm10GRCm38
MGSCv371713,068,900 - 13,070,708 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,718,966 - 12,720,774 (+)NCBIMGSCv36mm8
Celera1712,907,930 - 12,909,738 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.7NCBI
MAS1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38629,486,697 - 29,487,956 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl629,486,697 - 29,487,956 (-)EnsemblGRCh38hg38GRCh38
GRCh37629,454,474 - 29,455,733 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36629,562,522 - 29,563,658 (-)NCBINCBI36Build 36hg18NCBI36
Build 34629,562,521 - 29,563,658NCBI
Celera631,060,587 - 31,061,723 (-)NCBICelera
Cytogenetic Map6p22.1NCBI
HuRef629,261,701 - 29,262,837 (-)NCBIHuRef
CHM1_1629,456,662 - 29,457,798 (-)NCBICHM1_1
T2T-CHM13v2.0629,361,354 - 29,362,613 (-)NCBIT2T-CHM13v2.0
Mas1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,416,178 - 50,427,730 (-)NCBIGRCr8
mRatBN7.2147,871,592 - 47,879,942 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx148,564,118 - 48,565,083 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,549,908 - 54,550,873 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,639,637 - 48,640,602 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,068,389 - 48,206,902 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,069,194 - 48,070,536 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,546,345 - 51,683,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,146,949 - 42,147,914 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,149,893 - 42,150,859 (-)NCBI
Celera143,672,936 - 43,673,901 (-)NCBICelera
Cytogenetic Map1q11NCBI
MAS1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2544,110,393 - 44,172,799 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1640,073,708 - 40,136,145 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0629,295,079 - 29,357,477 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1629,955,683 - 29,957,161 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl629,955,952 - 29,957,161 (-)Ensemblpanpan1.1panPan2

Variants

.
Variants in Mrgprh
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:155
Count of miRNA genes:153
Interacting mature miRNAs:155
Transcripts:ENSMUST00000075296
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558807Ceat1_mchronic experimental autoimmune thyroiditis 1 (mouse)Not determined171263668226401133Mouse
12910982Pifs2_mpeptide-induced fatal syndrome 2 (mouse)17126189355Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17129198453Mouse
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17129198453Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
4142507Obrq13_mobesity resistance QTL 13 (mouse)Not determined1219832925076769Mouse
1300613Pcyts4_mplasmacytoma susceptibility 4 (mouse)Not determined17127081639Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17787584329487423Mouse
1357452Vtbt18_mvertebral trabecular bone trait 18 (mouse)Not determined17120975022Mouse
1357902Obq19_mobesity QTL 19 (mouse)Not determined17125662076Mouse
1301327Lmr7_mleishmaniasis resistance 7 (mouse)Not determined17485475227715939Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
1357680Idd23_minsulin dependent diabetes susceptibility 23 (mouse)Not determined17397489026401133Mouse
1302196Myaa1_mmodifier of Yaa 1 (mouse)Not determined17120975022Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
1357743Lith3_mlithogenic gene 3 (mouse)Not determined17126194456Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17129198453Mouse
1301615Cfld3_mcystic fibrosis lung disease 3 (mouse)Not determined17127081639Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17131030170Mouse

Markers in Region
UniSTS:493322  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381712,876,404 - 12,877,842UniSTSGRCm38
MGSCv371713,069,270 - 13,070,708UniSTSGRCm37
Celera1712,908,300 - 12,909,738UniSTS
Cytogenetic Map17A1UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000075296   ⟹   ENSMUSP00000074768
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1713,094,921 - 13,096,864 (+)Ensembl
GRCm38.p6 Ensembl1712,876,034 - 12,877,977 (+)Ensembl
RefSeq Acc Id: NM_030726   ⟹   NP_109651
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391713,094,921 - 13,096,729 (+)NCBI
GRCm381712,876,034 - 12,877,842 (+)ENTREZGENE
MGSCv371713,068,900 - 13,070,708 (+)RGD
Celera1712,907,930 - 12,909,738 (+)RGD
cM Map17 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_109651 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI16697 (Get FASTA)   NCBI Sequence Viewer  
  AAI17526 (Get FASTA)   NCBI Sequence Viewer  
  AAK01865 (Get FASTA)   NCBI Sequence Viewer  
  CDG86214 (Get FASTA)   NCBI Sequence Viewer  
  EDL02042 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000074768
  ENSMUSP00000074768.3
GenBank Protein Q99MT8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_109651   ⟸   NM_030726
- UniProtKB: Q149S2 (UniProtKB/Swiss-Prot),   Q99MT8 (UniProtKB/Swiss-Prot),   W8W3M0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000074768   ⟸   ENSMUST00000075296
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99MT8-F1-model_v2 AlphaFold Q99MT8 1-321 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1934134 AgrOrtholog
Ensembl Genes ENSMUSG00000059408 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000075296 ENTREZGENE
  ENSMUST00000075296.4 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:80978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1934134 ENTREZGENE
NCBI Gene 80978 ENTREZGENE
PANTHER PTHR11334 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11334:SF60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mrgprh PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt MRGRH_MOUSE UniProtKB/Swiss-Prot
  Q149S2 ENTREZGENE
  Q99MT8 ENTREZGENE
  W8W3M0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q149S2 UniProtKB/Swiss-Prot