MS4A3 (membrane spanning 4-domains A3) - Rat Genome Database

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Gene: MS4A3 (membrane spanning 4-domains A3) Homo sapiens
Analyze
Symbol: MS4A3
Name: membrane spanning 4-domains A3
RGD ID: 1321597
HGNC Page HGNC:7317
Description: Predicted to be located in specific granule membrane. Predicted to be active in plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CD20 antigen homolog; CD20 antigen-like protein; CD20L; hematopoietic cell 4 transmembrane protein; hematopoietic-specific transmembrane protein 4; HTM4; IgE receptor beta chain; IgE receptor beta subunit; membrane-spanning 4-domains subfamily A member 3; membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,056,665 - 60,071,115 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,056,587 - 60,071,115 (+)Ensemblhg38GRCh38
GRCh371159,824,138 - 59,838,588 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,580,677 - 59,595,164 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341159,580,706 - 59,595,177NCBI
Celera1157,188,482 - 57,202,973 (+)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1156,171,262 - 56,185,749 (+)NCBIHuRef
CHM1_11159,690,098 - 59,704,585 (+)NCBICHM1_1
T2T-CHM13v2.01160,007,952 - 60,022,403 (+)NCBIT2T-CHM13v2.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7524084   PMID:11401424   PMID:11486273   PMID:11781350   PMID:12477932   PMID:15489334   PMID:15671017   PMID:15830103   PMID:17207965   PMID:19818099   PMID:20237496   PMID:20677014  
PMID:20800603   PMID:21873635   PMID:22367966   PMID:24755620   PMID:25886616   PMID:27579896   PMID:29274779   PMID:32296183   PMID:34780648  


Genomics

Comparative Map Data
MS4A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,056,665 - 60,071,115 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,056,587 - 60,071,115 (+)Ensemblhg38GRCh38
GRCh371159,824,138 - 59,838,588 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,580,677 - 59,595,164 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341159,580,706 - 59,595,177NCBI
Celera1157,188,482 - 57,202,973 (+)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1156,171,262 - 56,185,749 (+)NCBIHuRef
CHM1_11159,690,098 - 59,704,585 (+)NCBICHM1_1
T2T-CHM13v2.01160,007,952 - 60,022,403 (+)NCBIT2T-CHM13v2.0
Ms4a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391911,606,863 - 11,618,215 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1911,606,860 - 11,618,215 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381911,629,499 - 11,640,851 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1911,629,496 - 11,640,851 (-)Ensemblmm10GRCm38
MGSCv371911,703,987 - 11,715,324 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361911,696,542 - 11,707,879 (-)NCBIMGSCv36mm8
Celera1912,301,544 - 12,312,843 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map198.47NCBI
Ms4a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81217,887,105 - 217,904,921 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1217,887,105 - 217,904,907 (-)EnsemblGRCr8
mRatBN7.21208,462,300 - 208,480,129 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1208,462,301 - 208,480,101 (-)EnsemblmRatBN7.2
Rnor_6.01227,979,307 - 227,994,210 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1227,979,481 - 227,992,623 (-)Ensemblrn6Rnor6.0
Rnor_5.01235,041,728 - 235,059,555 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41214,374,827 - 214,391,647 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1205,938,244 - 205,956,390 (-)NCBICelera
RGSC_v3.11214,533,256 - 214,608,521 (-)NCBI
Cytogenetic Map1q43NCBI
MS4A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2961,192,671 - 61,207,155 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11162,236,369 - 62,250,804 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01155,286,806 - 55,301,236 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11158,733,492 - 58,747,968 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1158,733,527 - 58,747,968 (+)EnsemblpanPan2panpan1.1
LOC102155828
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12150,480,386 - 50,495,379 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2149,921,695 - 49,936,218 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02151,653,779 - 51,668,289 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.12150,701,263 - 50,715,784 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02150,798,695 - 50,813,213 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02151,423,486 - 51,438,014 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ms4a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494712,644,677 - 12,656,827 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365812,759,690 - 2,769,093 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365812,759,711 - 2,769,162 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MS4A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl113,675,031 - 13,685,000 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM

Variants

.
Variants in MS4A3
27 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001031809.1(MS4A3):c.169G>A (p.Gly57Arg) single nucleotide variant Malignant melanoma [RCV000062299] Chr11:60064274 [GRCh38]
Chr11:59831747 [GRCh37]
Chr11:59588323 [NCBI36]
Chr11:11q12.1		 not provided
NM_001031666.1(MS4A3):c.-19+1304A>T single nucleotide variant Lung cancer [RCV000110196] Chr11:60065622 [GRCh38]
Chr11:59833095 [GRCh37]
Chr11:11q12.1		 uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
NM_006138.5(MS4A3):c.590A>G (p.Asn197Ser) single nucleotide variant not specified [RCV004318415] Chr11:60069650 [GRCh38]
Chr11:59837123 [GRCh37]
Chr11:11q12.1		 uncertain significance
GRCh37/hg19 11q12.1-12.2(chr11:59679631-60167878)x3 copy number gain See cases [RCV000449175] Chr11:59679631..60167878 [GRCh37]
Chr11:11q12.1-12.2		 uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh38/hg38 11q12.1-12.2(chr11:59851273-60699280)x1 copy number loss See cases [RCV000143668] Chr11:59851273..60699280 [GRCh38]
Chr11:59618746..60466753 [GRCh37]
Chr11:59375322..60223329 [NCBI36]
Chr11:11q12.1-12.2		 likely benign|uncertain significance
NM_006138.5(MS4A3):c.441C>G (p.Ile147Met) single nucleotide variant not specified [RCV004303571] Chr11:60067040 [GRCh38]
Chr11:59834513 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.61G>C (p.Gly21Arg) single nucleotide variant not specified [RCV004319699] Chr11:60061221 [GRCh38]
Chr11:59828694 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.311C>A (p.Thr104Asn) single nucleotide variant not specified [RCV004290489] Chr11:60064278 [GRCh38]
Chr11:59831751 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.182T>A (p.Met61Lys) single nucleotide variant not specified [RCV004293704] Chr11:60062493 [GRCh38]
Chr11:59829966 [GRCh37]
Chr11:11q12.1		 uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_006138.5(MS4A3):c.440T>G (p.Ile147Ser) single nucleotide variant not specified [RCV004331062] Chr11:60067039 [GRCh38]
Chr11:59834512 [GRCh37]
Chr11:11q12.1		 uncertain significance
GRCh37/hg19 11q12.1(chr11:59822741-59875556)x1 copy number loss not provided [RCV000683295] Chr11:59822741..59875556 [GRCh37]
Chr11:11q12.1		 uncertain significance
GRCh37/hg19 11q12.1-12.3(chr11:58935215-62177656)x3 copy number gain not provided [RCV000683362] Chr11:58935215..62177656 [GRCh37]
Chr11:11q12.1-12.3		 likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q12.1(chr11:59701087-59860178)x1 copy number loss not provided [RCV000737537] Chr11:59701087..59860178 [GRCh37]
Chr11:11q12.1		 benign
NC_000011.9:g.(?_59596957)_(68707199_?)dup duplication Familial temporal lobe epilepsy 8 [RCV001372442] Chr11:59596957..68707199 [GRCh37]
Chr11:11q12.1-13.3		 uncertain significance
GRCh37/hg19 11p11.2-q12.2(chr11:51581311-54891247)x3 copy number gain See cases [RCV002286338] Chr11:51581311..54891247 [GRCh37]
Chr11:11p11.2-q12.2		 pathogenic
NM_006138.5(MS4A3):c.30G>T (p.Glu10Asp) single nucleotide variant not specified [RCV004130231] Chr11:60061190 [GRCh38]
Chr11:59828663 [GRCh37]
Chr11:11q12.1		 uncertain significance
GRCh37/hg19 11p11.12-q13.1(chr11:50398499-63924462)x3 copy number gain not specified [RCV003986918] Chr11:50398499..63924462 [GRCh37]
Chr11:11p11.12-q13.1		 likely pathogenic
NC_000011.9:g.(?_58916346)_(64972349_?)dup duplication Leukocyte adhesion deficiency 3 [RCV003113394]|not provided [RCV003113393] Chr11:58916346..64972349 [GRCh37]
Chr11:11q12.1-13.1		 uncertain significance|no classifications from unflagged records
NM_006138.5(MS4A3):c.178G>A (p.Ala60Thr) single nucleotide variant not specified [RCV004313875] Chr11:60062489 [GRCh38]
Chr11:59829962 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.178G>C (p.Ala60Pro) single nucleotide variant not specified [RCV004138792] Chr11:60062489 [GRCh38]
Chr11:59829962 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.521T>C (p.Val174Ala) single nucleotide variant not specified [RCV004196689] Chr11:60069581 [GRCh38]
Chr11:59837054 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.638C>T (p.Ser213Phe) single nucleotide variant not specified [RCV004237254] Chr11:60070226 [GRCh38]
Chr11:59837699 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.148G>C (p.Val50Leu) single nucleotide variant not specified [RCV004229317] Chr11:60061308 [GRCh38]
Chr11:59828781 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.257C>T (p.Thr86Ile) single nucleotide variant not specified [RCV004261451] Chr11:60062568 [GRCh38]
Chr11:59830041 [GRCh37]
Chr11:11q12.1		 likely benign
NM_006138.5(MS4A3):c.295T>C (p.Phe99Leu) single nucleotide variant not specified [RCV004638312] Chr11:60064262 [GRCh38]
Chr11:59831735 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.613G>A (p.Glu205Lys) single nucleotide variant not specified [RCV004638314] Chr11:60069673 [GRCh38]
Chr11:59837146 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.166A>T (p.Ile56Phe) single nucleotide variant not specified [RCV004831096] Chr11:60062477 [GRCh38]
Chr11:59829950 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.29A>G (p.Glu10Gly) single nucleotide variant not specified [RCV005371956] Chr11:60061189 [GRCh38]
Chr11:59828662 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.224C>T (p.Pro75Leu) single nucleotide variant not specified [RCV005371953] Chr11:60062535 [GRCh38]
Chr11:59830008 [GRCh37]
Chr11:11q12.1		 likely benign
GRCh37/hg19 11q12.1-13.3(chr11:56895955-69295402)x3 copy number gain not specified [RCV003986944] Chr11:56895955..69295402 [GRCh37]
Chr11:11q12.1-13.3		 likely pathogenic
NM_006138.5(MS4A3):c.230A>G (p.His77Arg) single nucleotide variant not specified [RCV004503047] Chr11:60062541 [GRCh38]
Chr11:59830014 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.575T>C (p.Ile192Thr) single nucleotide variant not specified [RCV004503071] Chr11:60069635 [GRCh38]
Chr11:59837108 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.559G>A (p.Val187Ile) single nucleotide variant not specified [RCV004503070] Chr11:60069619 [GRCh38]
Chr11:59837092 [GRCh37]
Chr11:11q12.1		 likely benign
NM_006138.5(MS4A3):c.487T>A (p.Cys163Ser) single nucleotide variant not specified [RCV004631691] Chr11:60067086 [GRCh38]
Chr11:59834559 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.223C>G (p.Pro75Ala) single nucleotide variant not specified [RCV004638313] Chr11:60062534 [GRCh38]
Chr11:59830007 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.488G>A (p.Cys163Tyr) single nucleotide variant not specified [RCV004831095] Chr11:60067087 [GRCh38]
Chr11:59834560 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.275C>T (p.Pro92Leu) single nucleotide variant not specified [RCV004831094] Chr11:60062586 [GRCh38]
Chr11:59830059 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.437A>G (p.Asn146Ser) single nucleotide variant not specified [RCV004824896] Chr11:60067036 [GRCh38]
Chr11:59834509 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.360C>G (p.Asn120Lys) single nucleotide variant not specified [RCV005378396] Chr11:60066959 [GRCh38]
Chr11:59834432 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.414T>G (p.Phe138Leu) single nucleotide variant not specified [RCV005371954] Chr11:60067013 [GRCh38]
Chr11:59834486 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.32T>G (p.Leu11Arg) single nucleotide variant not specified [RCV005371955] Chr11:60061192 [GRCh38]
Chr11:59828665 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.197G>A (p.Gly66Asp) single nucleotide variant not specified [RCV005378394] Chr11:60062508 [GRCh38]
Chr11:59829981 [GRCh37]
Chr11:11q12.1		 uncertain significance
NM_006138.5(MS4A3):c.121C>A (p.Pro41Thr) single nucleotide variant not specified [RCV005378395] Chr11:60061281 [GRCh38]
Chr11:59828754 [GRCh37]
Chr11:11q12.1		 uncertain significance
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1188
Count of miRNA genes:440
Interacting mature miRNAs:482
Transcripts:ENST00000278865, ENST00000358152, ENST00000395032, ENST00000525686, ENST00000526199, ENST00000528298, ENST00000528952, ENST00000534744
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597290955GWAS1387029_Hsoluble triggering receptor expressed on myeloid cells 2 measurement QTL GWAS1387029 (human)2e-34soluble triggering receptor expressed on myeloid cells 2 measurement116006776960067770Human
407020865GWAS669841_Hvitamin B12 measurement QTL GWAS669841 (human)3e-15blood vitamin amount (VT:0010626)116006971960069720Human
597227885GWAS1323959_Hheel bone mineral density QTL GWAS1323959 (human)1e-09bone mineral mass (VT:0005007)bone mineral density (CMO:0001226)116005811260058113Human
596989568GWAS1109087_Hsoluble triggering receptor expressed on myeloid cells 2 measurement QTL GWAS1109087 (human)2e-34soluble triggering receptor expressed on myeloid cells 2 measurement116006776960067770Human
597041901GWAS1137975_Hsoluble triggering receptor expressed on myeloid cells 2 measurement QTL GWAS1137975 (human)8e-08soluble triggering receptor expressed on myeloid cells 2 measurement116006424360064244Human

Markers in Region
GDB:437690  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371159,837,686 - 59,838,064UniSTSGRCh37
Build 361159,594,262 - 59,594,640RGDNCBI36
Celera1157,202,071 - 57,202,449RGD
Cytogenetic Map11q12.1UniSTS
HuRef1156,184,847 - 56,185,225UniSTS
MS4A3_941  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371159,837,967 - 59,838,808UniSTSGRCh37
Build 361159,594,543 - 59,595,384RGDNCBI36
Celera1157,202,352 - 57,203,193RGD
HuRef1156,185,128 - 56,185,969UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
823 974 1078 1034 2382 849 1308 2 283 1249 230 1046 3447 3498 5 1845 261 853 991 54

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001031666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001031809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011545363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054332430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054332431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054370530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC226593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL601630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY095480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY258289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE564041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF210971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG495577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L35848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000278865   ⟹   ENSP00000278865
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,056,665 - 60,071,115 (+)Ensembl
Ensembl Acc Id: ENST00000358152   ⟹   ENSP00000350872
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,056,628 - 60,071,114 (+)Ensembl
Ensembl Acc Id: ENST00000395032   ⟹   ENSP00000378473
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,056,587 - 60,070,595 (+)Ensembl
Ensembl Acc Id: ENST00000525686   ⟹   ENSP00000434109
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,056,703 - 60,070,354 (+)Ensembl
Ensembl Acc Id: ENST00000526199
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,060,932 - 60,061,498 (+)Ensembl
Ensembl Acc Id: ENST00000528298
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,056,628 - 60,062,669 (+)Ensembl
Ensembl Acc Id: ENST00000528952
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,069,531 - 60,070,981 (+)Ensembl
Ensembl Acc Id: ENST00000534744   ⟹   ENSP00000434117
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,061,161 - 60,070,233 (+)Ensembl
RefSeq Acc Id: NM_001031666   ⟹   NP_001026836
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,056,665 - 60,071,115 (+)NCBI
GRCh371159,824,101 - 59,838,588 (+)RGD
Build 361159,580,677 - 59,595,164 (+)NCBI Archive
Celera1157,188,482 - 57,202,973 (+)RGD
HuRef1156,171,262 - 56,185,749 (+)RGD
CHM1_11159,690,098 - 59,704,585 (+)NCBI
T2T-CHM13v2.01160,007,952 - 60,022,403 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001031809   ⟹   NP_001026979
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,056,665 - 60,071,115 (+)NCBI
GRCh371159,824,101 - 59,838,588 (+)RGD
Build 361159,580,677 - 59,595,164 (+)NCBI Archive
Celera1157,188,482 - 57,202,973 (+)RGD
HuRef1156,171,262 - 56,185,749 (+)RGD
CHM1_11159,690,098 - 59,704,585 (+)NCBI
T2T-CHM13v2.01160,007,952 - 60,022,403 (+)NCBI
Sequence:
RefSeq Acc Id: NM_006138   ⟹   NP_006129
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,056,665 - 60,071,115 (+)NCBI
GRCh371159,824,101 - 59,838,588 (+)RGD
Build 361159,580,677 - 59,595,164 (+)NCBI Archive
Celera1157,188,482 - 57,202,973 (+)RGD
HuRef1156,171,262 - 56,185,749 (+)RGD
CHM1_11159,690,098 - 59,704,585 (+)NCBI
T2T-CHM13v2.01160,007,952 - 60,022,403 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011545363   ⟹   XP_011543665
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,061,523 - 60,071,115 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054370530   ⟹   XP_054226505
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01160,012,812 - 60,022,403 (+)NCBI
RefSeq Acc Id: NP_006129   ⟸   NM_006138
- Peptide Label: isoform a
- UniProtKB: A8MTP8 (UniProtKB/Swiss-Prot),   Q8NHW2 (UniProtKB/Swiss-Prot),   Q96HJ5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001026836   ⟸   NM_001031666
- Peptide Label: isoform c
- UniProtKB: Q96HJ5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001026979   ⟸   NM_001031809
- Peptide Label: isoform b
- UniProtKB: Q96HJ5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011543665   ⟸   XM_011545363
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSP00000434117   ⟸   ENST00000534744
Ensembl Acc Id: ENSP00000434109   ⟸   ENST00000525686
Ensembl Acc Id: ENSP00000378473   ⟸   ENST00000395032
Ensembl Acc Id: ENSP00000278865   ⟸   ENST00000278865
Ensembl Acc Id: ENSP00000350872   ⟸   ENST00000358152
RefSeq Acc Id: XP_054226505   ⟸   XM_054370530
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96HJ5-F1-model_v2 AlphaFold Q96HJ5 1-214 view protein structure

Promoters
RGD ID:6789133
Promoter ID:HG_KWN:13002
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:NM_001031666,   NM_001031809,   NM_006138
Position:
Human AssemblyChrPosition (strand)Source
Build 361159,580,316 - 59,580,816 (+)MPROMDB
RGD ID:7220457
Promoter ID:EPDNEW_H15974
Type:initiation region
Name:MS4A3_1
Description:membrane spanning 4-domains A3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,056,665 - 60,056,725EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7317 AgrOrtholog
COSMIC MS4A3 COSMIC
Ensembl Genes ENSG00000149516 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000284903 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000278865 ENTREZGENE
  ENST00000278865.8 UniProtKB/Swiss-Prot
  ENST00000358152 ENTREZGENE
  ENST00000358152.6 UniProtKB/Swiss-Prot
  ENST00000395032 ENTREZGENE
  ENST00000395032.6 UniProtKB/Swiss-Prot
  ENST00000644768.2 UniProtKB/Swiss-Prot
  ENST00000711439.1 UniProtKB/Swiss-Prot
  ENST00000711440.1 UniProtKB/Swiss-Prot
GTEx ENSG00000149516 GTEx
  ENSG00000284903 GTEx
HGNC ID HGNC:7317 ENTREZGENE
Human Proteome Map MS4A3 Human Proteome Map
InterPro CD20-like UniProtKB/Swiss-Prot
  MS4A UniProtKB/Swiss-Prot
KEGG Report hsa:932 UniProtKB/Swiss-Prot
NCBI Gene 932 ENTREZGENE
OMIM 606498 OMIM
PANTHER PTHR23320 UniProtKB/Swiss-Prot
  PTHR23320:SF74 UniProtKB/Swiss-Prot
Pfam CD20 UniProtKB/Swiss-Prot
PharmGKB PA31112 PharmGKB
RNAcentral URS00008B266B RNACentral
UniProt A8MTP8 ENTREZGENE
  E9PRW8_HUMAN UniProtKB/TrEMBL
  MS4A3_HUMAN UniProtKB/Swiss-Prot
  Q8NHW2 ENTREZGENE
  Q96HJ5 ENTREZGENE
UniProt Secondary A8MTP8 UniProtKB/Swiss-Prot
  Q8NHW2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 MS4A3  membrane spanning 4-domains A3  MS4A3  membrane-spanning 4-domains subfamily A member 3  Symbol and/or name change 5135510 APPROVED
2016-01-19 MS4A3  membrane-spanning 4-domains subfamily A member 3  MS4A3  membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)  Symbol and/or name change 5135510 APPROVED