Hsp90b1 (heat shock protein 90, beta (Grp94), member 1) - Rat Genome Database

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Gene: Hsp90b1 (heat shock protein 90, beta (Grp94), member 1) Mus musculus
Analyze
Symbol: Hsp90b1
Name: heat shock protein 90, beta (Grp94), member 1
RGD ID: 1321410
MGI Page MGI
Description: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and low-density lipoprotein particle receptor binding activity. Predicted to be involved in ERAD pathway; insulin processing; and protein folding. Predicted to act upstream of or within actin rod assembly and cellular response to ATP. Located in endoplasmic reticulum and sperm plasma membrane. Part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including central nervous system; heart; metanephros; pancreas; and respiratory system. Used to study male infertility due to globozoospermia. Orthologous to several human genes including HSP90B1 (heat shock protein 90 beta family member 1).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 94 kDa glucose-regulated protein; end; endoplasmic reticulum resident protein 99; endoplasmin; ERp; ERp99; gp9; gp96; GRP; GRP94; heat shock protein 90 kDa beta member 1; polymorphic tumor rejection antigen 1; TA-3; Tar; Targ2; Tr; Tra; Tra-1; Tra1; transforming growth factor alpha regulated gene 2; tumor rejection antigen (gp96) 1; tumor rejection antigen gp96
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm18954  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391086,526,705 - 86,541,308 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1086,526,073 - 86,541,373 (-)EnsemblGRCm39 Ensembl
GRCm381086,690,841 - 86,705,444 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1086,690,209 - 86,705,509 (-)EnsemblGRCm38mm10GRCm38
MGSCv371086,153,586 - 86,168,189 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361086,120,640 - 86,135,243 (-)NCBIMGSCv36mm8
Celera1088,669,594 - 88,684,200 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1043.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
1,4-dithiothreitol  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dimethoxyphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-deoxy-D-glucose  (ISO)
2-methoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-aminophenol  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-(N,N-hexamethylene)amiloride  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (EXP,ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzatropine  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
brefeldin A  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
chlordecone  (EXP)
chloroacetic acid  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
Di-n-octyl phthalate  (EXP)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
Dienochlor  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (EXP)
diuron  (ISO)
dopamine  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenofibrate  (EXP)
fenpyroximate  (ISO)
fenvalerate  (ISO)
folic acid  (EXP)
folpet  (EXP)
fulvestrant  (EXP,ISO)
furfural  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
glafenine  (ISO)
glucose  (EXP,ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
Ibutilide  (ISO)
imidacloprid  (ISO)
inulin  (EXP)
iron dichloride  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
L-1,4-dithiothreitol  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (EXP)
lithium atom  (ISO)
lithium hydride  (ISO)
manganese(II) chloride  (ISO)
meglumine amidotrizoate  (ISO)
melatonin  (EXP)
menadione  (EXP)
mercury dichloride  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methomyl  (ISO)
methotrexate  (EXP)
methoxyacetic acid  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
morphine  (ISO)
N,N-dimethylformamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosomorpholine  (ISO)
orotic acid  (ISO)
oxidopamine  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
poly(propylene imine) macromolecule  (ISO)
potassium dichromate  (ISO)
procymidone  (ISO)
progesterone  (EXP)
Propiverine  (ISO)
prostaglandin A1  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
SNX-2112  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
streptozocin  (EXP)
succimer  (EXP)
sulforaphane  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (EXP,ISO)
titanium dioxide  (EXP)
trans-caffeic acid  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
tungsten  (EXP)
tunicamycin  (EXP,ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, etal., Hum Mol Genet 1998 Nov;7(12):1967-78.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. LncRNA H19 inhibits ER stress induced apoptosis and improves diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis. Wang S, etal., Aging (Albany NY). 2022 Aug 30;14(16):6809-6828. doi: 10.18632/aging.204256. Epub 2022 Aug 30.
12. Suppression subtractive hybridization identified differentially expressed genes in lung adenocarcinoma: ERGIC3 as a novel lung cancer-related gene. Wu M, etal., BMC Cancer. 2013 Feb 1;13:44. doi: 10.1186/1471-2407-13-44.
Additional References at PubMed
PMID:1692794   PMID:1981053   PMID:2438686   PMID:2546060   PMID:2768254   PMID:2796999   PMID:3036833   PMID:3410508   PMID:3612811   PMID:7558020   PMID:7654366   PMID:7835907  
PMID:7970703   PMID:8179819   PMID:8460400   PMID:8570653   PMID:8747928   PMID:8835541   PMID:8889548   PMID:9363855   PMID:10196250   PMID:10349636   PMID:10441734   PMID:10444069  
PMID:10839811   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11130978   PMID:11265634   PMID:11568360   PMID:11739487   PMID:11884472   PMID:11943765   PMID:12135983   PMID:12189140  
PMID:12244140   PMID:12446445   PMID:12461080   PMID:12475965   PMID:12477932   PMID:12617806   PMID:12805368   PMID:12904583   PMID:14610273   PMID:14668429   PMID:15034032   PMID:15082773  
PMID:15107540   PMID:15128793   PMID:15252132   PMID:15306695   PMID:15782199   PMID:15827139   PMID:15864309   PMID:16141072   PMID:16141073   PMID:16601230   PMID:16604525   PMID:16754684  
PMID:16847323   PMID:17010336   PMID:17090218   PMID:17275357   PMID:17294405   PMID:17411420   PMID:17464327   PMID:17525271   PMID:17634284   PMID:17671676   PMID:17913437   PMID:17934213  
PMID:18001291   PMID:18195024   PMID:18307411   PMID:18340425   PMID:18411291   PMID:18509083   PMID:18776938   PMID:18799693   PMID:18940591   PMID:19000718   PMID:19000834   PMID:19125190  
PMID:19136429   PMID:19158397   PMID:19265198   PMID:19553200   PMID:19839010   PMID:19914304   PMID:19965672   PMID:20159978   PMID:20178780   PMID:20224597   PMID:20352117   PMID:20410492  
PMID:20510162   PMID:20520781   PMID:20865800   PMID:21048103   PMID:21093319   PMID:21208614   PMID:21267068   PMID:21327095   PMID:21358806   PMID:21538020   PMID:21565611   PMID:21576699  
PMID:21647226   PMID:21677750   PMID:21739154   PMID:21795745   PMID:21873635   PMID:22109526   PMID:22223641   PMID:22292497   PMID:22421546   PMID:22532561   PMID:22554506   PMID:22649033  
PMID:22724016   PMID:22745161   PMID:22794259   PMID:22854046   PMID:22876182   PMID:22925884   PMID:23055941   PMID:23553495   PMID:23572575   PMID:23572582   PMID:23671277   PMID:23740953  
PMID:23859598   PMID:23874845   PMID:24024552   PMID:24027047   PMID:24322981   PMID:24457600   PMID:24694561   PMID:24808359   PMID:24888588   PMID:24953136   PMID:25220589   PMID:25332179  
PMID:25607841   PMID:25693689   PMID:26365983   PMID:26396174   PMID:26494538   PMID:26628375   PMID:26816051   PMID:26910913   PMID:26945068   PMID:27034005   PMID:27183126   PMID:27417661  
PMID:27561680   PMID:27626668   PMID:27796797   PMID:28056051   PMID:28378742   PMID:28474670   PMID:28526855   PMID:28634551   PMID:29180572   PMID:29272356   PMID:29391475   PMID:29447283  
PMID:30188326   PMID:30196744   PMID:30209191   PMID:30333137   PMID:30543055   PMID:30550785   PMID:30595499   PMID:30670477   PMID:30713523   PMID:30787103   PMID:31018807   PMID:31025379  
PMID:31040226   PMID:31162944   PMID:31358658   PMID:31395819   PMID:32208002   PMID:32325033   PMID:32968282   PMID:33211673   PMID:33230847   PMID:33811917   PMID:34061598   PMID:34072833  
PMID:34283809   PMID:34321999   PMID:34943901   PMID:35078937   PMID:35129674   PMID:36114006   PMID:36198833   PMID:36293380   PMID:36379376   PMID:36417873   PMID:36516930   PMID:37142655  
PMID:37353485   PMID:37442135   PMID:37487085   PMID:37949474   PMID:38321029   PMID:38811543  


Genomics

Comparative Map Data
Hsp90b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391086,526,705 - 86,541,308 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1086,526,073 - 86,541,373 (-)EnsemblGRCm39 Ensembl
GRCm381086,690,841 - 86,705,444 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1086,690,209 - 86,705,509 (-)EnsemblGRCm38mm10GRCm38
MGSCv371086,153,586 - 86,168,189 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361086,120,640 - 86,135,243 (-)NCBIMGSCv36mm8
Celera1088,669,594 - 88,684,200 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1043.05NCBI
HSP90B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812103,930,410 - 103,947,926 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12103,930,107 - 103,953,931 (+)EnsemblGRCh38hg38GRCh38
GRCh3712104,324,188 - 104,341,704 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612102,848,319 - 102,865,833 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412102,826,655 - 102,844,170NCBI
Celera12103,987,945 - 104,005,473 (+)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12101,383,834 - 101,401,444 (+)NCBIHuRef
CHM1_112104,290,083 - 104,307,660 (+)NCBICHM1_1
T2T-CHM13v2.012103,892,110 - 103,909,638 (+)NCBIT2T-CHM13v2.0
Hsp90b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8722,997,962 - 23,012,293 (-)NCBIGRCr8
mRatBN7.2721,110,431 - 21,124,762 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl721,110,457 - 21,124,788 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx723,085,224 - 23,099,540 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0725,247,933 - 25,262,249 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0725,025,008 - 25,039,326 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0727,226,570 - 27,240,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl727,226,569 - 27,240,533 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0727,345,730 - 27,359,757 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4723,332,986 - 23,347,525 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1723,353,261 - 23,367,796 (-)NCBI
Celera718,290,242 - 18,304,551 (-)NCBICelera
Cytogenetic Map7q13NCBI
Hsp90b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540538,629,691 - 38,645,202 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540538,629,691 - 38,645,202 (+)NCBIChiLan1.0ChiLan1.0
HSP90B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210111,992,374 - 112,010,769 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112111,988,771 - 112,007,166 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012101,506,845 - 101,524,407 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112104,901,997 - 104,919,592 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12104,901,997 - 104,919,329 (+)Ensemblpanpan1.1panPan2
HSP90B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11542,456,793 - 42,474,122 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1542,456,764 - 42,579,311 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1542,826,278 - 42,843,622 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01543,114,295 - 43,131,887 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1543,114,231 - 43,235,108 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11542,380,743 - 42,398,025 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01542,479,226 - 42,496,568 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01542,750,406 - 42,767,726 (+)NCBIUU_Cfam_GSD_1.0
Hsp90b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494517,503,494 - 17,517,769 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649210,513,908 - 10,528,285 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649210,513,908 - 10,528,281 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSP90B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl580,511,506 - 80,530,991 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1580,511,513 - 80,531,016 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2584,016,174 - 84,083,931 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSP90B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11199,119,268 - 99,139,988 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1199,119,224 - 99,139,722 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037145,859,568 - 145,877,331 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsp90b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247504,737,894 - 4,752,221 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247504,738,563 - 4,752,227 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hsp90b1
401 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:429
Count of miRNA genes:328
Interacting mature miRNAs:359
Transcripts:ENSMUST00000020238, ENSMUST00000129178, ENSMUST00000129413, ENSMUST00000134515, ENSMUST00000146897
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
12910789Pwgrq19_mpost-weaning growth rate QTL 19 (mouse)108282870092169056Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1357594Estoq3_membryo survival total QTL 3 (mouse)Not determined1084079650122041528Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
4141479W10q8_mweight 10 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
14700795Mencq7_mmeniscus calcification QTL 7 (mouse)108531386486647864Mouse
14747004Mancz8_mmandible centroid size 8 (mouse)1082078412116078412Mouse
4142496W6q8_mweight 6 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
1357622Espq3_membryo survival preimplantation QTL 3 (mouse)Not determined1084079650122041528Mouse
4142365Egq9_mearly growth QTL 9 (mouse)Not determined84079650122041528Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078381268112381268Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
1301165Lith7_mlithogenic gene 7 (mouse)Not determined1082309418116309657Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse
4141054mwfh_mmodifier of white forlock hypopigmentation (mouse)Not determined83017003117017136Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
1357779Tesq3_mtestis weight QTL 3 (mouse)Not determined1084079650122041528Mouse
11059553Lmr32d_mleishmaniasis resistance 32d (mouse)1082309418116309657Mouse
11059554Lmr32e_mleishmaniasis resistance 32e (mouse)1082309418116309657Mouse
11059555Lmr32f_mleishmaniasis resistance 32f (mouse)1082309418116309657Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
1357638Cia29_mcollagen induced arthritis 29 (mouse)Not determined1085454982118497353Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
10043881Adip24_madiposity 24 (mouse)Not determined1082392803116392952Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
4141387Lgaq5_mlate growth adjusted QTL 5 (mouse)Not determined84079650122041528Mouse
11059550Lmr32a_mleishmaniasis resistance 32a (mouse)1082309418116309657Mouse
11059551Lmr32b_mleishmaniasis resistance 32b (mouse)1082309418116309657Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
4141382Ssrq4_mstress response QTL 4 (mouse)Not determined8249093890856102Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse

Markers in Region
RH129351  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381086,690,951 - 86,691,131UniSTSGRCm38
MGSCv371086,153,696 - 86,153,876UniSTSGRCm37
Celera1088,669,704 - 88,669,884UniSTS
Cytogenetic Map10C1UniSTS
cM Map1049.0UniSTS
J03297  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381086,690,867 - 86,691,019UniSTSGRCm38
GRCm381165,832,604 - 165,832,770UniSTSGRCm38
MGSCv371167,762,735 - 167,762,901UniSTSGRCm37
MGSCv371086,153,612 - 86,153,764UniSTSGRCm37
Celera1088,669,620 - 88,669,772UniSTS
Celera1168,277,540 - 168,277,706UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map1G-HUniSTS
cM Map1049.0UniSTS
Whitehead_YAC2 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC152453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK005469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M29652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000020238   ⟹   ENSMUSP00000020238
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1086,526,704 - 86,541,373 (-)Ensembl
GRCm38.p6 Ensembl1086,690,840 - 86,705,509 (-)Ensembl
Ensembl Acc Id: ENSMUST00000129178
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1086,526,073 - 86,537,832 (-)Ensembl
GRCm38.p6 Ensembl1086,690,209 - 86,701,968 (-)Ensembl
Ensembl Acc Id: ENSMUST00000129413   ⟹   ENSMUSP00000122710
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1086,528,265 - 86,534,302 (-)Ensembl
GRCm38.p6 Ensembl1086,692,401 - 86,698,438 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134515
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1086,529,885 - 86,531,585 (-)Ensembl
GRCm38.p6 Ensembl1086,694,021 - 86,695,721 (-)Ensembl
Ensembl Acc Id: ENSMUST00000146897
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1086,537,810 - 86,538,957 (-)Ensembl
GRCm38.p6 Ensembl1086,701,946 - 86,703,093 (-)Ensembl
RefSeq Acc Id: NM_011631   ⟹   NP_035761
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391086,526,705 - 86,541,308 (-)NCBI
GRCm381086,690,841 - 86,705,444 (-)ENTREZGENE
MGSCv371086,153,586 - 86,168,189 (-)RGD
Celera1088,669,594 - 88,684,200 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035761   ⟸   NM_011631
- Peptide Label: precursor
- UniProtKB: P11427 (UniProtKB/Swiss-Prot),   P08113 (UniProtKB/Swiss-Prot),   Q3UAD6 (UniProtKB/TrEMBL),   Q91V38 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000020238   ⟸   ENSMUST00000020238
Ensembl Acc Id: ENSMUSP00000122710   ⟸   ENSMUST00000129413
Protein Domains
Histidine kinase/HSP90-like ATPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08113-F1-model_v2 AlphaFold P08113 1-802 view protein structure

Promoters
RGD ID:6848569
Promoter ID:MM_TRO:1076
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   Brain,   Liver
Transcripts:MTR000888.10.1646.5,   MTR000888.10.1646.6
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361086,154,331 - 86,154,831 (-)MPROMDB
RGD ID:6819453
Promoter ID:MM_KWN:5235
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:OTTMUST00000048700
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361086,158,041 - 86,159,112 (-)MPROMDB
RGD ID:6819455
Promoter ID:MM_KWN:5236
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   MEF_B6
Transcripts:OTTMUST00000048699
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361086,160,961 - 86,162,102 (-)MPROMDB
RGD ID:6819454
Promoter ID:MM_KWN:5237
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   MEF_B6
Transcripts:OTTMUST00000048698
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361086,164,256 - 86,165,452 (-)MPROMDB
RGD ID:6819457
Promoter ID:MM_KWN:5238
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   ES_Cell,   Liver,   MEF_B6
Transcripts:OTTMUST00000048701
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361086,165,836 - 86,166,782 (-)MPROMDB
RGD ID:6819456
Promoter ID:MM_KWN:5239
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000061458,   NM_001003910,   NM_001003939,   OTTMUST00000048697
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361086,167,121 - 86,169,197 (-)MPROMDB
RGD ID:8672948
Promoter ID:EPDNEW_M14504
Type:initiation region
Name:Hsp90b1_1
Description:Mus musculus heat shock protein 90, beta , member 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381086,705,463 - 86,705,523EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98817 AgrOrtholog
Ensembl Genes ENSMUSG00000020048 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020238 ENTREZGENE
  ENSMUST00000020238.14 UniProtKB/Swiss-Prot
  ENSMUST00000129413.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.230.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.11260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HATPase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_protein_90_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP90_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp90_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp90_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22027 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98817 ENTREZGENE
NCBI Gene 22027 ENTREZGENE
PANTHER ENDOPLASMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11528 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11528:SF100 UniProtKB/TrEMBL
Pfam HATPase_c_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hsp90b1 PhenoGen
PIRSF Hsp90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HEATSHOCK90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ER_TARGET UniProtKB/Swiss-Prot
  HSP90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HATPase_c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF110942 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ENPL_MOUSE UniProtKB/Swiss-Prot
  F7C312_MOUSE UniProtKB/TrEMBL
  P08113 ENTREZGENE
  P11427 ENTREZGENE
  Q3TUD6_MOUSE UniProtKB/TrEMBL
  Q3UAD6 ENTREZGENE, UniProtKB/TrEMBL
  Q3UBU0_MOUSE UniProtKB/TrEMBL
  Q8C2R2_MOUSE UniProtKB/TrEMBL
  Q8CCY5_MOUSE UniProtKB/TrEMBL
  Q91V38 ENTREZGENE, UniProtKB/TrEMBL
  Q9CW12_MOUSE UniProtKB/TrEMBL
UniProt Secondary P11427 UniProtKB/Swiss-Prot