Srf (serum response factor) - Rat Genome Database

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Gene: Srf (serum response factor) Mus musculus
Analyze
Symbol: Srf
Name: serum response factor
RGD ID: 1321394
MGI Page MGI
Description: Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and primary miRNA binding activity. Involved in actin cytoskeleton organization; cardiac muscle cell myoblast differentiation; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including circulatory system development; hemopoiesis; and respiratory system development. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including cardiovascular system; early conceptus; embryo mesenchyme; future forebrain; and genitourinary system. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in cardiomyopathy and lymphangioleiomyomatosis. Orthologous to human SRF (serum response factor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW049942; AW240594
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391746,857,764 - 46,869,194 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1746,859,255 - 46,867,101 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381746,546,838 - 46,558,267 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,548,329 - 46,556,175 (-)Ensemblmm10GRCm38
MGSCv371746,683,788 - 46,693,111 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361746,010,028 - 46,019,351 (-)NCBIMGSCv36mm8
Celera1749,982,837 - 49,992,041 (-)NCBICelera
Cytogenetic Map17CNCBI
cM Map1722.9NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (EXP)
8-(4-chlorophenylthio)-cGMP  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
dioxygen  (EXP)
endosulfan  (ISO)
ethanol  (EXP)
folic acid  (EXP)
FR900359  (ISO)
gefitinib  (ISO)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
jaspamide  (ISO)
latrunculin B  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
leflunomide  (EXP,ISO)
mangiferin  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
morphine  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
phencyclidine  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 203580  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
tert-butyl hydroperoxide  (ISO)
Tetrachlorobisphenol A  (EXP,ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trimethyltin  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
wortmannin  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IDA,IMP)
actin filament organization  (IMP)
associative learning  (IMP)
axon extension  (IMP)
bicellular tight junction assembly  (IMP)
branching involved in blood vessel morphogenesis  (IMP)
bronchus cartilage development  (IMP)
cardiac muscle cell myoblast differentiation  (IEA,IGI,ISO)
cardiac myofibril assembly  (IMP)
cardiac vascular smooth muscle cell differentiation  (IMP)
cell migration involved in sprouting angiogenesis  (IEA,IMP,ISO)
cell-cell adhesion  (IMP)
cell-matrix adhesion  (IMP)
cellular response to glucose stimulus  (IEA,ISO)
cellular senescence  (IEA,ISO)
contractile actin filament bundle assembly  (IMP)
developmental growth  (IMP)
dorsal aorta morphogenesis  (IMP)
epithelial cell-cell adhesion  (IMP)
epithelial structure maintenance  (IMP)
erythrocyte development  (IMP)
establishment of skin barrier  (IMP)
eyelid development in camera-type eye  (IMP)
face development  (IMP)
filopodium assembly  (IMP)
forebrain development  (IMP)
gastrulation  (IMP)
heart development  (IMP)
heart looping  (IMP)
heart trabecula formation  (IMP)
hematopoietic stem cell differentiation  (IMP)
hippocampus development  (IMP)
in utero embryonic development  (IEA,IMP)
leukocyte differentiation  (IMP)
long-term memory  (IEA,ISO)
long-term synaptic depression  (IMP)
lung morphogenesis  (IMP)
lung smooth muscle development  (IMP)
megakaryocyte development  (IMP)
mesoderm formation  (IMP)
morphogenesis of an epithelial sheet  (IMP)
muscle cell cellular homeostasis  (IMP)
negative regulation of amyloid-beta clearance  (IEA,ISO)
negative regulation of cell migration  (IEA,ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of miRNA transcription  (IDA)
neuron migration  (IMP)
neuron projection development  (IMP)
platelet activation  (IMP)
platelet formation  (IMP)
positive regulation of axon extension  (IGI,IMP)
positive regulation of cell differentiation  (IEA,ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (IDA,IEA,IMP,ISO)
positive regulation of filopodium assembly  (IMP)
positive regulation of miRNA transcription  (IDA,IEA,ISO)
positive regulation of smooth muscle contraction  (IEA,ISO)
positive regulation of transcription by glucose  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,IGI,IMP,ISO)
positive regulation of transcription initiation by RNA polymerase II  (IEA,ISO)
positive thymic T cell selection  (IMP)
primitive streak formation  (IMP)
regulation of cell adhesion  (IMP)
regulation of DNA-templated transcription  (IDA)
response to cytokine  (IEA,ISO)
response to hormone  (IEA,ISO)
response to hypoxia  (IEA,ISO)
sarcomere organization  (IMP)
skin morphogenesis  (IMP)
stress fiber assembly  (IMP)
tangential migration from the subventricular zone to the olfactory bulb  (IMP)
thymus development  (IMP)
thyroid gland development  (IMP)
trachea cartilage development  (IMP)
transcription by RNA polymerase II  (IGI,IMP)
trophectodermal cell differentiation  (IEA,ISO)
wound healing  (IEA)

Cellular Component
chromatin  (IDA)
cytoplasm  (IDA)
nucleoplasm  (TAS)
nucleus  (IC,IDA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal apoptosis  (IAGP)
abnormal cardiac muscle relaxation  (IAGP)
abnormal diaphragm morphology  (IAGP)
abnormal fetal atrioventricular canal morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal heart shape  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal intercalated disk morphology  (IAGP)
abnormal interventricular groove morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal mature B cell morphology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal pericardium morphology  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal Z line morphology  (IAGP)
absent marginal zone B cells  (IAGP)
absent mesoderm  (IAGP)
absent thyroid gland  (IAGP)
athymia  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
congestive heart failure  (IAGP)
cyanosis  (IAGP)
decreased B cell number  (IAGP)
decreased B-1 B cell number  (IAGP)
decreased birth weight  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased heart left ventricle muscle contractility  (IAGP)
decreased skeletal muscle mass  (IAGP)
decreased T cell number  (IAGP)
decreased thymocyte number  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated heart ventricle  (IAGP)
disorganized myocardium  (IAGP)
distended pericardium  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
failure of primitive streak formation  (IAGP)
increased cardiomyocyte apoptosis  (IAGP)
increased heart left ventricle size  (IAGP)
internal hemorrhage  (IAGP)
irregular heartbeat  (IAGP)
kyphosis  (IAGP)
lethargy  (IAGP)
mandible hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
no spontaneous movement  (IAGP)
pericardial effusion  (IAGP)
persistent truncus arteriosus  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
respiratory failure  (IAGP)
thin interventricular septum  (IAGP)
thin myocardium  (IAGP)
trabecula carnea hypoplasia  (IAGP)
vascular smooth muscle hypotrophy  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Inhibitory cardiac transcription factor, SRF-N, is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading. Chang J, etal., Circulation. 2003 Jul 29;108(4):407-13. Epub 2003 Jul 21.
2. Increased expression of alternatively spliced dominant-negative isoform of SRF in human failing hearts. Davis FJ, etal., Am J Physiol Heart Circ Physiol. 2002 Apr;282(4):H1521-33.
3. A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context. Etkin A, etal., Neuron. 2006 Apr 6;50(1):127-43.
4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
5. Increased Myosin Light Chain Kinase Expression in Hypertension: Regulation by SRF via an Insertion Mutation in the Promoter. Han YJ, etal., Mol Biol Cell. 2006 Jul 5;.
6. Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat. Maeda Y, etal., Cancer Lett. 1997 Nov 11;119(2):137-41.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Restricted inactivation of serum response factor to the cardiovascular system. Miano JM, etal., Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17132-7. Epub 2004 Nov 29.
10. Conditional inactivation of the murine serum response factor in the pancreas leads to severe pancreatitis. Miralles F, etal., Lab Invest. 2006 Oct;86(10):1020-36. Epub 2006 Aug 7.
11. Liver X receptor activation enhances CVB3 viral replication during myocarditis by stimulating lipogenesis. Papageorgiou AP, etal., Cardiovasc Res. 2015 Jul 1;107(1):78-88. doi: 10.1093/cvr/cvv157. Epub 2015 May 21.
12. Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart. Parlakian A, etal., Circulation. 2005 Nov 8;112(19):2930-9. Epub 2005 Oct 31.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. Mouse MP Annotation Import Pipeline RGD automated import pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation. Wei L, etal., Development 2002 Apr;129(7):1705-14.
18. Model of functional cardiac aging: young adult mice with mild overexpression of serum response factor. Zhang X, etal., Am J Physiol Regul Integr Comp Physiol. 2003 Sep;285(3):R552-60.
19. Tissue inhibitor of metalloproteinase-3 downregulation in lymphangioleiomyomatosis: potential consequence of abnormal serum response factor expression. Zhe X, etal., Am J Respir Cell Mol Biol. 2003 Apr;28(4):504-11.
Additional References at PubMed
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PMID:18036521   PMID:18054566   PMID:18054567   PMID:18287559   PMID:18316483   PMID:18334560   PMID:18344281   PMID:18442487   PMID:18458156   PMID:18498732   PMID:18498735   PMID:18501668  
PMID:18511849   PMID:18557893   PMID:18570667   PMID:18586895   PMID:18804439   PMID:18945672   PMID:18952847   PMID:19004760   PMID:19015276   PMID:19079548   PMID:19082443   PMID:19116276  
PMID:19198601   PMID:19205030   PMID:19270689   PMID:19307725   PMID:19329434   PMID:19342595   PMID:19350017   PMID:19357276   PMID:19359245   PMID:19398467   PMID:19578358   PMID:19683494  
PMID:19745164   PMID:19782130   PMID:19783823   PMID:19797053   PMID:19801679   PMID:19953255   PMID:20013655   PMID:20019329   PMID:20047077   PMID:20088824   PMID:20123976   PMID:20139090  
PMID:20223941   PMID:20378849   PMID:20404088   PMID:20412781   PMID:20417598   PMID:20428204   PMID:20436479   PMID:20466732   PMID:20525922   PMID:20534669   PMID:20610412   PMID:20685657  
PMID:20694003   PMID:20709909   PMID:20724380   PMID:20739623   PMID:20842632   PMID:20980616   PMID:21098124   PMID:21135125   PMID:21185285   PMID:21267068   PMID:21289070   PMID:21289071  
PMID:21292826   PMID:21302281   PMID:21303526   PMID:21329726   PMID:21336301   PMID:21379568   PMID:21393865   PMID:21401944   PMID:21479245   PMID:21525490   PMID:21552476   PMID:21573132  
PMID:21637294   PMID:21768101   PMID:21785421   PMID:21799516   PMID:21873635   PMID:22022520   PMID:22046433   PMID:22049076   PMID:22090492   PMID:22106411   PMID:22155005   PMID:22157009  
PMID:22192413   PMID:22207710   PMID:22225874   PMID:22278938   PMID:22356487   PMID:22434656   PMID:22537405   PMID:22563064   PMID:22577142   PMID:22649236   PMID:22674276   PMID:22711842  
PMID:22772757   PMID:22806889   PMID:22927399   PMID:22988430   PMID:22996691   PMID:23028370   PMID:23151848   PMID:23175628   PMID:23264443   PMID:23374345   PMID:23406902   PMID:23426017  
PMID:23436819   PMID:23437181   PMID:23558171   PMID:23563308   PMID:23644458   PMID:23671695   PMID:23674601   PMID:23704920   PMID:23705899   PMID:23771945   PMID:23818299   PMID:23946491  
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PMID:27914009   PMID:27922676   PMID:27930960   PMID:28112683   PMID:28125644   PMID:28152551   PMID:28260872   PMID:28286024   PMID:28342289   PMID:28555077   PMID:28574994   PMID:28576971  
PMID:28607167   PMID:28716058   PMID:29114040   PMID:29187823   PMID:29217642   PMID:29269426   PMID:29284006   PMID:29367466   PMID:29643333   PMID:30026494   PMID:30174314   PMID:30242271  
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PMID:39289869   PMID:39808524  


Genomics

Comparative Map Data
Srf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391746,857,764 - 46,869,194 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1746,859,255 - 46,867,101 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381746,546,838 - 46,558,267 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,548,329 - 46,556,175 (-)Ensemblmm10GRCm38
MGSCv371746,683,788 - 46,693,111 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361746,010,028 - 46,019,351 (-)NCBIMGSCv36mm8
Celera1749,982,837 - 49,992,041 (-)NCBICelera
Cytogenetic Map17CNCBI
cM Map1722.9NCBI
SRF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38643,171,269 - 43,181,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl643,171,269 - 43,181,506 (+)Ensemblhg38GRCh38
GRCh37643,139,007 - 43,149,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36643,246,898 - 43,257,222 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34643,247,014 - 43,257,221NCBI
Celera644,691,142 - 44,701,465 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef642,855,575 - 42,865,934 (+)NCBIHuRef
CHM1_1643,141,808 - 43,152,132 (+)NCBICHM1_1
T2T-CHM13v2.0643,000,031 - 43,010,279 (+)NCBIT2T-CHM13v2.0
Srf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8921,924,050 - 21,933,338 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl921,924,076 - 21,933,337 (+)EnsemblGRCr8
mRatBN7.2914,426,453 - 14,435,734 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,426,472 - 14,435,733 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx923,010,176 - 23,019,436 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0928,073,247 - 28,082,508 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,373,557 - 26,382,817 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0916,737,637 - 16,747,226 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl916,737,642 - 16,747,225 (+)Ensemblrn6Rnor6.0
Rnor_5.0915,642,584 - 15,652,178 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.499,788,378 - 9,797,639 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera912,173,971 - 12,183,234 (+)NCBICelera
Cytogenetic Map9q12NCBI
Srf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,098,968 - 9,107,057 (+)Ensembl
ChiLan1.0NW_0049554379,100,546 - 9,109,305 (+)NCBIChiLan1.0ChiLan1.0
SRF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2557,671,108 - 57,681,467 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1653,541,022 - 53,551,267 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0642,763,099 - 42,773,332 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1644,057,192 - 44,066,768 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl644,057,192 - 44,066,768 (+)EnsemblpanPan2panpan1.1
SRF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11211,664,441 - 11,673,846 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1211,664,527 - 11,671,533 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1211,691,502 - 11,700,834 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01212,146,868 - 12,156,424 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1212,146,882 - 12,156,417 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11211,674,421 - 11,683,753 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01211,758,840 - 11,768,172 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01211,853,634 - 11,862,966 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Srf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494647,170,709 - 47,180,262 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647616,782,233 - 16,789,130 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647616,779,941 - 16,789,499 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl738,213,487 - 38,222,144 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1738,213,300 - 38,223,686 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2743,712,387 - 43,724,048 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11728,983,161 - 28,993,465 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1728,983,002 - 28,992,995 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604443,231,123 - 43,241,353 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475416,371,995 - 16,381,287 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Srf
415 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1178
Count of miRNA genes:517
Interacting mature miRNAs:624
Transcripts:ENSMUST00000015749
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173311897454107028Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173517581770165926Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172862240662622654Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3098790348039703Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174651092682407429Mouse
4141478Hbnr7_mHeligmosomoides bakeri nematode resistance 7 (mouse)Not determined4305118551739122Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173596629469966424Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
10755525Lymph2_mlymphocyte differential 2 (mouse)173880562672805626Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
1300592Pcyts5_mplasmacytoma susceptibility 5 (mouse)Not determined173871288772712970Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3103350065033630Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
10755534Lymph4_mlymphocyte differential 4 (mouse)173880562672805626Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172640101252911704Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
12904951Smmq2_msoleus muscle mass QTL 2 (mouse)173678974370789743Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172507658355712970Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4053444774534623Mouse
26884386Skwq13_mskull length QTL 13, 16 week (mouse)174371089153107028Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174093918774939187Mouse
12903997Cfq4_mconditioned fear QTL 4 (mouse)174501655249366402Mouse
26884390Skwq9_mskull length QTL 9, 10 week (mouse)174371089167806995Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined173013255564132666Mouse

Markers in Region
AW822025  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381746,548,429 - 46,548,676UniSTSGRCm38
MGSCv371746,685,378 - 46,685,625UniSTSGRCm37
Celera1749,984,427 - 49,984,674UniSTS
Cytogenetic Map17CUniSTS
Whitehead/MRC_RH17564.1UniSTS
AW049942  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381746,547,242 - 46,547,331UniSTSGRCm38
MGSCv371746,684,191 - 46,684,280UniSTSGRCm37
Celera1749,983,240 - 49,983,329UniSTS
Cytogenetic Map17CUniSTS
Whitehead/MRC_RH17561.8UniSTS
AW240594  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381746,547,096 - 46,547,180UniSTSGRCm38
MGSCv371746,684,045 - 46,684,129UniSTSGRCm37
Celera1749,983,094 - 49,983,178UniSTS
Cytogenetic Map17CUniSTS
Whitehead/MRC_RH17569.91UniSTS
Srf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381746,548,918 - 46,549,157UniSTSGRCm38
MGSCv371746,685,867 - 46,686,106UniSTSGRCm37
Celera1749,984,916 - 49,985,155UniSTS
Cytogenetic Map17CUniSTS
cM MapUN UniSTS
cM Map17 UniSTS
PMC305791P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381746,554,747 - 46,555,395UniSTSGRCm38
MGSCv371746,691,696 - 46,692,344UniSTSGRCm37
Celera1749,990,626 - 49,991,274UniSTS
Cytogenetic Map17CUniSTS
SRF_3467  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381746,548,301 - 46,549,024UniSTSGRCm38
MGSCv371746,685,250 - 46,685,973UniSTSGRCm37
Celera1749,984,299 - 49,985,022UniSTS
Cytogenetic Map17CUniSTS
Srf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17CUniSTS
Srf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17CUniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000015749   ⟹   ENSMUSP00000015749
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1746,859,255 - 46,867,101 (-)Ensembl
GRCm38.p6 Ensembl1746,548,329 - 46,556,175 (-)Ensembl
Ensembl Acc Id: ENSMUST00000233104   ⟹   ENSMUSP00000156719
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1746,859,925 - 46,861,945 (-)Ensembl
GRCm38.p6 Ensembl1746,548,999 - 46,551,019 (-)Ensembl
Ensembl Acc Id: ENSMUST00000233767
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1746,859,801 - 46,861,026 (-)Ensembl
GRCm38.p6 Ensembl1746,548,875 - 46,550,100 (-)Ensembl
Ensembl Acc Id: ENSMUST00000233797
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1746,861,615 - 46,862,719 (-)Ensembl
GRCm38.p6 Ensembl1746,550,689 - 46,551,793 (-)Ensembl
RefSeq Acc Id: NM_020493   ⟹   NP_065239
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391746,857,765 - 46,867,088 (-)NCBI
GRCm381746,546,839 - 46,556,162 (-)NCBI
MGSCv371746,683,788 - 46,693,111 (-)RGD
Celera1749,982,837 - 49,992,041 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006523957   ⟹   XP_006524020
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391746,857,764 - 46,869,194 (-)NCBI
GRCm381746,546,838 - 46,558,267 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011246336   ⟹   XP_011244638
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391746,857,764 - 46,865,989 (-)NCBI
GRCm381746,546,838 - 46,555,063 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_065239 (Get FASTA)   NCBI Sequence Viewer  
  XP_006524020 (Get FASTA)   NCBI Sequence Viewer  
  XP_011244638 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH51950 (Get FASTA)   NCBI Sequence Viewer  
  BAA92314 (Get FASTA)   NCBI Sequence Viewer  
  EDL23510 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000015749
  ENSMUSP00000015749.6
GenBank Protein Q9JM73 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_065239   ⟸   NM_020493
- UniProtKB: Q9JM73 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006524020   ⟸   XM_006523957
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011244638   ⟸   XM_011246336
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSMUSP00000015749   ⟸   ENSMUST00000015749
Ensembl Acc Id: ENSMUSP00000156719   ⟸   ENSMUST00000233104
Protein Domains
MADS-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JM73-F1-model_v2 AlphaFold Q9JM73 1-504 view protein structure

Promoters
RGD ID:13676230
Promoter ID:EPDNEW_M22264
Type:initiation region
Name:Srf_1
Description:Mus musculus serum response factor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381746,556,169 - 46,556,229EPDNEW
RGD ID:6847463
Promoter ID:MM_ACW:22879
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   Brain,   ES_Cell,   Lung,   MEF_B4
Transcripts:SRF.BSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361746,691,761 - 46,692,261 (-)MPROMDB
RGD ID:6828717
Promoter ID:MM_KWN:23655
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000015749
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361746,692,906 - 46,693,512 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106658 AgrOrtholog
Ensembl Genes ENSMUSG00000015605 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000015749 ENTREZGENE
  ENSMUST00000015749.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.1810.10 UniProtKB/Swiss-Prot
InterPro MADS-box/MEF2_TF UniProtKB/Swiss-Prot
  MADS_SRF-like UniProtKB/Swiss-Prot
  TF_MADSbox UniProtKB/Swiss-Prot
  TF_MADSbox_sf UniProtKB/Swiss-Prot
KEGG Report mmu:20807 UniProtKB/Swiss-Prot
MGD MGI:106658 ENTREZGENE
NCBI Gene 20807 ENTREZGENE
PANTHER SERUM RESPONSE FACTOR HOMOLOG UniProtKB/Swiss-Prot
Pfam SRF-TF UniProtKB/Swiss-Prot
PhenoGen Srf PhenoGen
PRINTS MADSDOMAIN UniProtKB/Swiss-Prot
PROSITE MADS_BOX_1 UniProtKB/Swiss-Prot
  MADS_BOX_2 UniProtKB/Swiss-Prot
SMART MADS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55455 UniProtKB/Swiss-Prot
UniProt A0A3B2WCW1_MOUSE UniProtKB/TrEMBL
  Q9JM73 ENTREZGENE, UniProtKB/Swiss-Prot