Uros (uroporphyrinogen III synthase) - Rat Genome Database

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Gene: Uros (uroporphyrinogen III synthase) Mus musculus
Analyze
Symbol: Uros
Name: uroporphyrinogen III synthase
RGD ID: 1321279
MGI Page MGI
Description: Enables uroporphyrinogen-III synthase activity. Acts upstream of or within porphyrin-containing compound biosynthetic process. Located in mitochondrion. Is expressed in several structures, including genitourinary system; nervous system; respiratory system; sensory organ; and skeleton. Used to study cutaneous porphyria. Human ortholog(s) of this gene implicated in cutaneous porphyria. Orthologous to human UROS (uroporphyrinogen III synthase).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AI415298; hydroxymethylbilane hydrolyase (cyclizing); Ur; URO-synthase; UROIIIS; uroporphyrinogen-III cosynthase; uroporphyrinogen-III cosynthetase; uroporphyrinogen-III synthase; Uros3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397133,287,871 - 133,312,176 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7133,287,972 - 133,311,801 (-)EnsemblGRCm39 Ensembl
GRCm387133,686,142 - 133,710,467 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7133,686,243 - 133,710,072 (-)EnsemblGRCm38mm10GRCm38
MGSCv377140,878,013 - 140,900,978 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367133,524,673 - 133,547,638 (-)NCBIMGSCv36mm8
Celera7133,491,254 - 133,514,229 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map777.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,ISO)
cytosol  (ISO)
mitochondrion  (HDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Biosynthesis of heme in mammals. Ajioka RS, etal., Biochim Biophys Acta. 2006 Jul;1763(7):723-36. Epub 2006 Jun 3.
2. Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors. Barupala DP, etal., Arch Biochem Biophys. 2016 Feb 15;592:60-75. doi: 10.1016/j.abb.2016.01.010. Epub 2016 Jan 16.
3. Point mutations in the uroporphyrinogen III synthase gene in congenital erythropoietic porphyria (Gunther's disease). Deybach JC, etal., Blood. 1990 May 1;75(9):1763-5.
4. GenMAPP: Gene Map Annotator and Pathway Profiler GenMAPP
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Alterations in renal heme biosynthesis during metal nephrotoxicity. Oskarsson A and Fowler BA, Ann N Y Acad Sci. 1987;514:268-77.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Congenital erythropoietic porphyria and erythropoietic protoporphyria: Identification of 7 uroporphyrinogen III synthase and 20 ferrochelatase novel mutations. Weiss Y, etal., Mol Genet Metab. 2019 Nov;128(3):358-362. doi: 10.1016/j.ymgme.2018.08.015. Epub 2018 Aug 31.
Additional References at PubMed
PMID:7607680   PMID:7873885   PMID:8889548   PMID:10349636   PMID:10644678   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11112350   PMID:12477932   PMID:14610273   PMID:14651853  
PMID:14681479   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16314073   PMID:16532394   PMID:17967808   PMID:18179890   PMID:18799693   PMID:20508144   PMID:21267068   PMID:21365124  
PMID:21677750   PMID:21873635   PMID:22556427   PMID:24145442   PMID:30232228   PMID:31601421   PMID:32325033  


Genomics

Comparative Map Data
Uros
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397133,287,871 - 133,312,176 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7133,287,972 - 133,311,801 (-)EnsemblGRCm39 Ensembl
GRCm387133,686,142 - 133,710,467 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7133,686,243 - 133,710,072 (-)EnsemblGRCm38mm10GRCm38
MGSCv377140,878,013 - 140,900,978 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367133,524,673 - 133,547,638 (-)NCBIMGSCv36mm8
Celera7133,491,254 - 133,514,229 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map777.26NCBI
UROS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810125,784,980 - 125,823,258 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10125,784,980 - 125,823,258 (-)EnsemblGRCh38hg38GRCh38
GRCh3710127,473,549 - 127,511,827 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610127,467,142 - 127,501,757 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410127,467,141 - 127,501,757NCBI
Celera10121,252,582 - 121,287,272 (-)NCBICelera
Cytogenetic Map10q26.2NCBI
HuRef10121,166,434 - 121,201,129 (-)NCBIHuRef
CHM1_110127,758,882 - 127,793,568 (-)NCBICHM1_1
T2T-CHM13v2.010126,667,433 - 126,705,719 (-)NCBIT2T-CHM13v2.0
Uros
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21188,490,832 - 188,513,659 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1188,490,323 - 188,512,249 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1196,841,463 - 196,861,991 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01204,018,077 - 204,038,605 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01196,691,597 - 196,712,125 (-)NCBIRnor_WKY
Rnor_6.01205,755,766 - 205,778,170 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1205,756,640 - 205,777,167 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01212,704,834 - 212,727,235 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41193,184,946 - 193,205,475 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11193,334,828 - 193,355,356 (-)NCBI
Celera1186,229,349 - 186,249,866 (-)NCBICelera
Cytogenetic Map1q41NCBI
Uros
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554773,673,532 - 3,707,760 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554773,673,583 - 3,707,761 (-)NCBIChiLan1.0ChiLan1.0
UROS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110126,610,621 - 126,648,363 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10126,613,732 - 126,648,363 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v010122,346,072 - 122,384,405 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
UROS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12834,952,074 - 34,983,532 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2834,948,003 - 34,983,532 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2835,010,678 - 35,042,131 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02835,509,930 - 35,540,636 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2835,504,435 - 35,540,634 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12835,063,739 - 35,095,183 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02835,055,275 - 35,086,722 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02835,315,163 - 35,346,614 (-)NCBIUU_Cfam_GSD_1.0
Uros
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721311,744,646 - 11,770,000 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648613,791,286 - 13,817,238 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493648613,792,354 - 13,816,744 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UROS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14135,101,610 - 135,131,072 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114135,101,609 - 135,131,082 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214146,730,875 - 146,760,513 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UROS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19118,405,674 - 118,450,544 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9118,410,802 - 118,440,915 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604879,769,188 - 79,808,154 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uros
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473721,340,193 - 21,383,452 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir122mmu-miR-122-5pMirtarbaseexternal_infoMicroarrayNon-Functional MTI (Weak)21364282
Mir122mmu-miR-122-5pTarbaseexternal_infoMicroarrayNEGATIVE

Predicted Target Of
Summary Value
Count of predictions:1652
Count of miRNA genes:510
Interacting mature miRNAs:610
Transcripts:ENSMUST00000033276, ENSMUST00000106144, ENSMUST00000106145, ENSMUST00000106146, ENSMUST00000124759, ENSMUST00000135760, ENSMUST00000144789, ENSMUST00000151348, ENSMUST00000153698
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117199227134101729Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
1301903Tlsm1_mthymic lymphoma susceptible 1 (mouse)Not determined7122250663135170901Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse

Markers in Region
AI415298  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387133,692,349 - 133,692,429UniSTSGRCm38
MGSCv377140,884,032 - 140,884,112UniSTSGRCm37
Celera7133,497,273 - 133,497,353UniSTS
Cytogenetic Map7F3UniSTS
cM Map763.0UniSTS
Whitehead/MRC_RH71358.75UniSTS
U18867  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387133,686,660 - 133,686,828UniSTSGRCm38
MGSCv377140,878,343 - 140,878,511UniSTSGRCm37
Celera7133,491,584 - 133,491,752UniSTS
Cytogenetic Map7F3UniSTS
cM Map763.0UniSTS
Whitehead_YAC7 UniSTS
U16216  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387133,686,743 - 133,686,861UniSTSGRCm38
MGSCv377140,878,426 - 140,878,544UniSTSGRCm37
Celera7133,491,667 - 133,491,785UniSTS
Cytogenetic Map7F3UniSTS
cM Map763.0UniSTS
Whitehead/MRC_RH71358.85UniSTS
Uros  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F3UniSTS
cM Map763.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001302085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001360164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_153415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_153416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030242379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030242381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030242383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030242384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036152915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003946436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004934058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004934059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA272198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC127348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF133257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF133258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI839008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC068161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY128487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO044764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U04439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U16216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U18867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000033276   ⟹   ENSMUSP00000033276
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7133,288,094 - 133,311,010 (-)Ensembl
GRCm38.p6 Ensembl7133,686,365 - 133,709,281 (-)Ensembl
RefSeq Acc Id: ENSMUST00000106144   ⟹   ENSMUSP00000101750
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7133,293,863 - 133,310,788 (-)Ensembl
GRCm38.p6 Ensembl7133,692,134 - 133,709,059 (-)Ensembl
RefSeq Acc Id: ENSMUST00000106145   ⟹   ENSMUSP00000101751
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7133,288,085 - 133,310,798 (-)Ensembl
GRCm38.p6 Ensembl7133,686,356 - 133,709,069 (-)Ensembl
RefSeq Acc Id: ENSMUST00000106146   ⟹   ENSMUSP00000101752
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7133,288,085 - 133,310,687 (-)Ensembl
GRCm38.p6 Ensembl7133,686,356 - 133,708,958 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124759   ⟹   ENSMUSP00000119179
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7133,303,622 - 133,310,786 (-)Ensembl
GRCm38.p6 Ensembl7133,701,893 - 133,709,057 (-)Ensembl
RefSeq Acc Id: ENSMUST00000135760
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7133,287,972 - 133,310,823 (-)Ensembl
GRCm38.p6 Ensembl7133,686,243 - 133,709,094 (-)Ensembl
RefSeq Acc Id: ENSMUST00000144789
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7133,288,690 - 133,299,809 (-)Ensembl
GRCm38.p6 Ensembl7133,686,961 - 133,698,080 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151348   ⟹   ENSMUSP00000121763
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7133,303,624 - 133,311,801 (-)Ensembl
GRCm38.p6 Ensembl7133,701,895 - 133,710,072 (-)Ensembl
RefSeq Acc Id: ENSMUST00000153698   ⟹   ENSMUSP00000117187
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7133,303,568 - 133,304,345 (-)Ensembl
GRCm38.p6 Ensembl7133,701,839 - 133,702,616 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209636   ⟹   ENSMUSP00000147433
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7133,300,931 - 133,304,267 (-)Ensembl
GRCm38.p6 Ensembl7133,699,202 - 133,702,538 (-)Ensembl
RefSeq Acc Id: NM_001302085   ⟹   NP_001289014
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397133,288,084 - 133,311,024 (-)NCBI
GRCm387133,686,355 - 133,709,295 (-)NCBI
Celera7133,491,279 - 133,514,229 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001302086   ⟹   NP_001289015
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397133,293,863 - 133,311,024 (-)NCBI
GRCm387133,692,134 - 133,709,295 (-)NCBI
Celera7133,491,279 - 133,514,229 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001302087   ⟹   NP_001289016
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397133,288,084 - 133,304,229 (-)NCBI
GRCm387133,686,355 - 133,702,500 (-)NCBI
Celera7133,491,279 - 133,514,229 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001360164   ⟹   NP_001347093
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397133,288,084 - 133,312,176 (-)NCBI
GRCm387133,686,355 - 133,710,447 (-)NCBI
Sequence:
RefSeq Acc Id: NM_009479   ⟹   NP_033505
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397133,288,084 - 133,311,024 (-)NCBI
GRCm387133,686,355 - 133,709,295 (-)NCBI
MGSCv377140,878,013 - 140,900,978 (-)RGD
Celera7133,491,279 - 133,514,229 (-)NCBI
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_153415
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397133,288,084 - 133,312,176 (-)NCBI
GRCm387133,686,355 - 133,710,447 (-)NCBI
Sequence:
RefSeq Acc Id: NR_153416
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397133,288,084 - 133,311,024 (-)NCBI
GRCm387133,686,355 - 133,709,295 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030242379   ⟹   XP_030098239
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397133,287,871 - 133,310,823 (-)NCBI
GRCm387133,686,142 - 133,709,094 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030242381   ⟹   XP_030098241
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397133,287,871 - 133,310,808 (-)NCBI
GRCm387133,686,142 - 133,709,055 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030242383   ⟹   XP_030098243
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397133,293,861 - 133,310,789 (-)NCBI
GRCm387133,692,132 - 133,709,060 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030242384   ⟹   XP_030098244
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397133,293,861 - 133,310,646 (-)NCBI
GRCm387133,692,132 - 133,710,467 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036152915   ⟹   XP_036008808
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397133,287,871 - 133,310,321 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003946436
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397133,287,871 - 133,311,040 (-)NCBI
GRCm387133,686,142 - 133,709,311 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004934058
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397133,287,871 - 133,311,040 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004934059
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397133,287,871 - 133,310,788 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033505   ⟸   NM_009479
- Peptide Label: isoform 1
- UniProtKB: P51163 (UniProtKB/Swiss-Prot),   Q3UG55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289014   ⟸   NM_001302085
- Peptide Label: isoform 1
- UniProtKB: P51163 (UniProtKB/Swiss-Prot),   Q3UG55 (UniProtKB/TrEMBL),   Q3UKR3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289016   ⟸   NM_001302087
- Peptide Label: isoform 1
- UniProtKB: P51163 (UniProtKB/Swiss-Prot),   Q3UG55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289015   ⟸   NM_001302086
- Peptide Label: isoform 2
- UniProtKB: Q3TPL3 (UniProtKB/TrEMBL),   Q3UG55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030098239   ⟸   XM_030242379
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030098241   ⟸   XM_030242381
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001347093   ⟸   NM_001360164
- Peptide Label: isoform 1
- UniProtKB: P51163 (UniProtKB/Swiss-Prot),   Q3UG55 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030098244   ⟸   XM_030242384
- Peptide Label: isoform X2
- UniProtKB: Q3TPL3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030098243   ⟸   XM_030242383
- Peptide Label: isoform X2
- UniProtKB: Q3TPL3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000119179   ⟸   ENSMUST00000124759
RefSeq Acc Id: ENSMUSP00000033276   ⟸   ENSMUST00000033276
RefSeq Acc Id: ENSMUSP00000101750   ⟸   ENSMUST00000106144
RefSeq Acc Id: ENSMUSP00000101752   ⟸   ENSMUST00000106146
RefSeq Acc Id: ENSMUSP00000101751   ⟸   ENSMUST00000106145
RefSeq Acc Id: ENSMUSP00000121763   ⟸   ENSMUST00000151348
RefSeq Acc Id: ENSMUSP00000117187   ⟸   ENSMUST00000153698
RefSeq Acc Id: ENSMUSP00000147433   ⟸   ENSMUST00000209636
RefSeq Acc Id: XP_036008808   ⟸   XM_036152915
- Peptide Label: isoform X1
Protein Domains
Tetrapyrrole biosynthesis uroporphyrinogen III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51163-F1-model_v2 AlphaFold P51163 1-265 view protein structure

Promoters
RGD ID:8665877
Promoter ID:EPDNEW_M10970
Type:initiation region
Name:Uros_1
Description:Mus musculus uroporphyrinogen III synthase , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10971  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387133,702,501 - 133,702,561EPDNEW
RGD ID:8665879
Promoter ID:EPDNEW_M10971
Type:initiation region
Name:Uros_2
Description:Mus musculus uroporphyrinogen III synthase , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10970  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387133,709,059 - 133,709,119EPDNEW
RGD ID:6842309
Promoter ID:MM_KWN:53024
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000106146,   NM_009479,   OTTMUST00000063228,   OTTMUST00000063230,   OTTMUST00000063231,   UC009KDF.1,   UC009KDH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367140,900,621 - 140,902,187 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98917 AgrOrtholog
Ensembl Genes ENSMUSG00000030979 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000033276 ENTREZGENE
  ENSMUSP00000033276.5 UniProtKB/Swiss-Prot
  ENSMUSP00000101750 ENTREZGENE
  ENSMUSP00000101750.2 UniProtKB/TrEMBL
  ENSMUSP00000101751 ENTREZGENE
  ENSMUSP00000101751.4 UniProtKB/Swiss-Prot
  ENSMUSP00000101752 ENTREZGENE
  ENSMUSP00000101752.2 UniProtKB/Swiss-Prot
  ENSMUSP00000117187.2 UniProtKB/TrEMBL
  ENSMUSP00000119179.2 UniProtKB/TrEMBL
  ENSMUSP00000121763.2 UniProtKB/TrEMBL
  ENSMUSP00000147433.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033276 ENTREZGENE
  ENSMUST00000033276.11 UniProtKB/Swiss-Prot
  ENSMUST00000106144 ENTREZGENE
  ENSMUST00000106144.8 UniProtKB/TrEMBL
  ENSMUST00000106145 ENTREZGENE
  ENSMUST00000106145.10 UniProtKB/Swiss-Prot
  ENSMUST00000106146 ENTREZGENE
  ENSMUST00000106146.8 UniProtKB/Swiss-Prot
  ENSMUST00000124759.2 UniProtKB/TrEMBL
  ENSMUST00000151348.2 UniProtKB/TrEMBL
  ENSMUST00000153698.3 UniProtKB/TrEMBL
  ENSMUST00000209636.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10090 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4pyrrol_syn_uPrphyn_synt_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4pyrrol_synth_uPrphyn_synth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UROS/Hem4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22276 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98917 ENTREZGENE
NCBI Gene 22276 ENTREZGENE
PANTHER PTHR12390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UROPORPHYRINOGEN-III SYNTHASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HEM4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Uros PhenoGen
Superfamily-SCOP SSF69618 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1B0GR97_MOUSE UniProtKB/TrEMBL
  E9PYC9_MOUSE UniProtKB/TrEMBL
  E9Q8N3_MOUSE UniProtKB/TrEMBL
  E9Q9B5_MOUSE UniProtKB/TrEMBL
  HEM4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TPL3 ENTREZGENE, UniProtKB/TrEMBL
  Q3UG55 ENTREZGENE, UniProtKB/TrEMBL
  Q3UKR3 ENTREZGENE, UniProtKB/TrEMBL
  Q9CW78_MOUSE UniProtKB/TrEMBL