Cyba<sup>m1Sdi</sup> (cytochrome b-245 alpha chain;mutant 1,Sdi) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Cybam1Sdi (cytochrome b-245 alpha chain;mutant 1,Sdi) Rattus norvegicus
Analyze
Symbol: Cybam1Sdi
Name: cytochrome b-245 alpha chain;mutant 1,Sdi
RGD ID: 13209000
Description: This allele was identified in the MES rat strain that spontaneously develops severe blood eosinophilia as a hereditary trait. It carries a deletion of four nucleotides, including the 5' splice donor GpT of intron 4 of the Cyba gene.
ASSOCIATED WITH absent otoliths; decreased NAD(P)H oxidase activity; increased eosinophil cell number; ASSOCIATED WITH Eosinophilia
Type: allele  of Cyba  
Previously known as: Cybam1Sdi
Is Marker For: Strains:   MES/Slc  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View
Eosinophilia  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Pivotal Advance: Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba). Mori M, etal., J Leukoc Biol. 2009 Sep;86(3):473-8. doi: 10.1189/jlb.1108715. Epub 2009 Apr 30.
2. BN.MES-Cyba(mes) congenic rats manifest focal necrosis with eosinophilic infiltration in the liver without blood eosinophilia. Tomozawa H, etal., Exp Anim. 2010;59(4):469-78.
3. Genes for difference in eosinophilic phenotype between MES and BN.MES-Cyba(mes) rats are on chromosomes 9, 5, and 1. Tomozawa H, etal., Exp Anim. 2011;60(2):151-60.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Cybam1Sdi-var1 chr19 50489921 50489924 TCAC - deletion mRatBN7.2
Cybam1Sdi-var1 chr19 55252024 55252027 TCAC - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Cybam1Sdi


Expression


Sequence

Nucleotide Sequences


Additional Information