Cyba<sup>mesSdi</sup> (cytochrome b-245 alpha chain;mutant 1,Sdi) - Rat Genome Database

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Gene: CybamesSdi (cytochrome b-245 alpha chain;mutant 1,Sdi) Rattus norvegicus
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Symbol: CybamesSdi
Name: cytochrome b-245 alpha chain;mutant 1,Sdi
RGD ID: 13209000
Description: This allele was identified in the MES rat strain that spontaneously develops severe blood eosinophilia as a hereditary trait. It carries a deletion of four nucleotides, including the 5' splice donor GpT of intron 4 of the Cyba gene.
ASSOCIATED WITH absent otoliths; decreased NAD(P)H oxidase activity; ASSOCIATED WITH Eosinophilia
Type: allele  of Cyba  
Previously known as: Cybam1Sdi; Cybames; Cybames/Sdi; Cyba^[mesSdi]; Cybam1Sdi
Is Marker For: Strains:   MES/Slc   F344.MES-Cybames/Shmo   BN.MES-Cyba/Sna   SHRSP.MES-CybaMES/Izm  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View
Eosinophilia  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Pivotal Advance: Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba). Mori M, etal., J Leukoc Biol. 2009 Sep;86(3):473-8. doi: 10.1189/jlb.1108715. Epub 2009 Apr 30.
2. BN.MES-Cyba(mes) congenic rats manifest focal necrosis with eosinophilic infiltration in the liver without blood eosinophilia. Tomozawa H, etal., Exp Anim. 2010;59(4):469-78.
3. Genes for difference in eosinophilic phenotype between MES and BN.MES-Cyba(mes) rats are on chromosomes 9, 5, and 1. Tomozawa H, etal., Exp Anim. 2011;60(2):151-60.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
CybamesSdi-var1 chr19 50489921 50489924 TCAC - deletion mRatBN7.2
CybamesSdi-var1 chr19 55252024 55252027 TCAC - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to CybamesSdi
BN.MES-Cyba/Sna     F344.MES-Cybames/Shmo     MES/Slc     SHRSP.MES-CybaMES/Izm    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-03-31 CybamesSdi  cytochrome b-245 alpha chain;mutant 1,Sdi  Cybames/Sdi  cytochrome b-245 alpha chain;mutant 1,Sdi  Symbol changed 629549 APPROVED
2025-03-31 Cybames/Sdi  cytochrome b-245 alpha chain;mutant 1,Sdi  Cybames  cytochrome b-245 alpha chain;mutant 1,Sdi  Symbol changed 629549 APPROVED
2025-03-31 Cybames  cytochrome b-245 alpha chain;mutant 1,Sdi  Cybames/Sdi  cytochrome b-245 alpha chain;mutant 1,Sdi  Symbol changed 629549 APPROVED
2025-03-31 Cybames/Sdi  cytochrome b-245 alpha chain;mutant 1,Sdi  Cybam1Sdi  cytochrome b-245 alpha chain;mutant 1,Sdi  Symbol changed 629549 APPROVED