Map3k7 (mitogen-activated protein kinase kinase kinase 7) - Rat Genome Database

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Gene: Map3k7 (mitogen-activated protein kinase kinase kinase 7) Mus musculus
Symbol: Map3k7
Name: mitogen-activated protein kinase kinase kinase 7
RGD ID: 1319783
Description: Enables MAP kinase kinase activity; MAP kinase kinase kinase kinase activity; and receptor tyrosine kinase binding activity. Involved in several processes, including JNK cascade; anoikis; and negative regulation of necroptotic process. Acts upstream of or within several processes, including intracellular signal transduction; positive regulation of intracellular signal transduction; and tube morphogenesis. Located in postsynaptic density. Is expressed in several structures, including central nervous system; gut; male reproductive gland or organ; metanephros; and respiratory system. Used to study Wolff-Parkinson-White syndrome. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia 2 and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B430101B05; C87327; mitogen activated protein kinase kinase kinase 7; Tak; Tak1; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor beta-activated kinase 1; transforming growth factor-beta-activated kinase 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm8188  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39431,963,659 - 32,023,470 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl431,964,097 - 32,023,467 (+)EnsemblGRCm39 Ensembl
GRCm38431,963,492 - 32,023,470 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl431,964,097 - 32,023,467 (+)EnsemblGRCm38mm10GRCm38
MGSCv37432,051,082 - 32,110,442 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36432,292,735 - 32,349,405 (+)NCBIMGSCv36mm8
Celera431,710,402 - 31,768,496 (+)NCBICelera
Cytogenetic Map4A5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
5Z-7-oxozeaenol  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
albiflorin  (ISO)
alpha-Chaconine  (EXP)
angiotensin II  (ISO)
antirheumatic drug  (ISO)
arjunolic acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
casticin  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
coumarin  (ISO)
cyclosporin A  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dihydrolipoic acid  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (EXP)
fasudil  (EXP)
filipin III  (ISO)
flutamide  (ISO)
formaldehyde  (ISO)
hexadecanoic acid  (ISO)
hypochlorous acid  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
kaempferol  (ISO)
lipopolysaccharide  (EXP)
manganese(II) chloride  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methylparaben  (ISO)
monocrotaline  (ISO)
myricetin  (EXP)
N-phosphocreatine  (ISO)
nickel dichloride  (ISO)
nonanoic acid  (EXP)
o-anisidine  (ISO)
oligomycin  (ISO)
olmesartan  (ISO)
omega-3 fatty acid  (ISO)
oxazepam  (EXP)
oxidised LDL  (ISO)
paclitaxel  (ISO)
paeoniflorin  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
Pentoxifylline  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (EXP)
pirinixic acid  (EXP)
quercetin  (EXP)
rac-lactic acid  (ISO)
reactive oxygen species  (EXP)
resveratrol  (ISO)
rosmarinic acid  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
sulfates  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
toluene 2,4-diisocyanate  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
tunicamycin  (EXP)
valproic acid  (EXP,ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of NF-kappaB-inducing kinase activity  (ISO)
angiogenesis  (IMP)
anoikis  (IMP)
apoptotic process  (IEA)
apoptotic signaling pathway  (IGI,IMP)
bone development  (IMP)
cellular response to angiotensin  (ISO)
cellular response to oxygen-glucose deprivation  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
histone H3 acetylation  (ISO)
I-kappaB kinase/NF-kappaB signaling  (IGI,ISO)
I-kappaB phosphorylation  (IGI,ISO)
inflammatory response  (ISO)
interleukin-17A-mediated signaling pathway  (ISO)
JNK cascade  (IBA,IDA,IGI,ISO)
MAPK cascade  (IDA,IMP,ISO)
negative regulation of apoptotic signaling pathway  (IGI,IMP)
negative regulation of gene expression  (ISO)
negative regulation of necroptotic process  (IMP)
negative regulation of reactive oxygen species metabolic process  (IMP)
negative regulation of ripoptosome assembly involved in necroptotic process  (IGI)
negative regulation of voltage-gated calcium channel activity  (ISO)
neural tube formation  (IMP)
osteoblast differentiation  (IMP)
peptidyl-threonine phosphorylation  (IDA)
phosphorylation  (IEA)
positive regulation of autophagy  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of cell size  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IBA,IGI,ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of JNK cascade  (IGI)
positive regulation of JUN kinase activity  (ISO)
positive regulation of macroautophagy  (IMP)
positive regulation of MAPK cascade  (ISO)
positive regulation of T cell cytokine production  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
protein phosphorylation  (IDA,ISO)
regulation of reactive oxygen species metabolic process  (IMP)
response to angiotensin  (ISO)
response to hypoxia  (ISO)
signal transduction  (IEA)
stress-activated MAPK cascade  (ISO)
transforming growth factor beta receptor signaling pathway  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal alpha-beta intraepithelial T cell morphology  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal bile duct morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal CD4-positive, alpha-beta T cell physiology  (IAGP)
abnormal colon morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cytokine level  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal intestinal epithelium physiology  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal intraepithelial T cell number  (IAGP)
abnormal lens morphology  (IEA)
abnormal liver morphology  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal pharyngeal arch artery morphology  (IAGP)
abnormal regulatory T cell number  (IAGP)
abnormal regulatory T cell physiology  (IAGP)
abnormal secondary palate development  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal vascular development  (IAGP)
abnormal vascular regression  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent fibroblast proliferation  (IAGP)
absent regulatory T cells  (IAGP)
bile duct proliferation  (IAGP)
chronic diarrhea  (IAGP)
cleft secondary palate  (IAGP)
colitis  (IAGP)
decreased angiogenesis  (IAGP)
decreased B cell proliferation  (IAGP)
decreased B-1 B cell number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased circulating interleukin-10 level  (IAGP)
decreased cranium height  (IAGP)
decreased embryo size  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG3 level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased interleukin-10 secretion  (IAGP)
decreased interleukin-12b secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased locomotor activity  (IAGP)
decreased macrophage cell number  (IAGP)
decreased NK T cell number  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
dilated vasculature  (IAGP)
edema  (IAGP)
embryo tissue necrosis  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality prior to tooth bud stage  (IEA)
enlarged axillary lymph nodes  (IAGP)
enlarged inguinal lymph nodes  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
failure of palatal shelf elevation  (IAGP)
focal hepatic necrosis  (IAGP)
hemorrhage  (IAGP)
impaired febrile response  (IAGP)
increased apoptosis  (IAGP)
increased B cell number  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating bilirubin level  (IAGP)
increased circulating glutamate dehydrogenase level  (IAGP)
increased circulating interleukin-1 beta level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased gamma-delta intraepithelial T cell number  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased hepatocyte proliferation  (IAGP)
increased inflammatory response  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased interleukin-10 secretion  (IAGP)
increased interleukin-17 secretion  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased lymphocyte cell number  (IAGP)
increased memory T cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased splenocyte number  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased thymocyte apoptosis  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
intestinal ulcer  (IAGP)
intrahepatic cholestasis  (IAGP)
lethargy  (IAGP)
liver fibrosis  (IAGP)
liver inflammation  (IAGP)
microcephaly  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
open neural tube  (IAGP)
palatal shelf hypoplasia  (IAGP)
pericardial edema  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
rectal prolapse  (IAGP)
short mandible  (IAGP)
short maxilla  (IAGP)
short tail  (IAGP)
small heart  (IAGP)
spleen hyperplasia  (IAGP)
thin myocardium compact layer  (IAGP)
wavy neural tube  (IAGP)
weight loss  (IAGP)

References - curated
# Reference Title Reference Citation
1. Arjunolic acid, a peroxisome proliferator-activated receptor α agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-β signaling. Bansal T, etal., J Biol Chem. 2017 Oct 6;292(40):16440-16462. doi: 10.1074/jbc.M117.788299. Epub 2017 Aug 18.
2. Tripartite Motif 8 Contributes to Pathological Cardiac Hypertrophy Through Enhancing Transforming Growth Factor β-Activated Kinase 1-Dependent Signaling Pathways. Chen L, etal., Hypertension. 2017 Feb;69(2):249-258. doi: 10.1161/HYPERTENSIONAHA.116.07741. Epub 2016 Dec 12.
3. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
4. p38 MAP-kinases pathway regulation, function and role in human diseases. Cuenda A and Rousseau S, Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24.
5. Growth/differentiation factor 15 causes TGFβ-activated kinase 1-dependent muscle atrophy in pulmonary arterial hypertension. Garfield BE, etal., Thorax. 2019 Feb;74(2):164-176. doi: 10.1136/thoraxjnl-2017-211440. Epub 2018 Dec 15.
6. Erythropoietin Abrogates Post-Ischemic Activation of the NLRP3, NLRC4, and AIM2 Inflammasomes in Microglia/Macrophages in a TAK1-Dependent Manner. Heinisch O, etal., Transl Stroke Res. 2022 Jun;13(3):462-482. doi: 10.1007/s12975-021-00948-8. Epub 2021 Oct 9.
7. FBXW5 acts as a negative regulator of pathological cardiac hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic members of the MAPK signaling pathway. Hui X, etal., J Mol Cell Cardiol. 2021 Feb;151:31-43. doi: 10.1016/j.yjmcc.2020.09.008. Epub 2020 Sep 22.
8. The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling. Ji YX, etal., Nat Commun. 2016 Jun 1;7:11267. doi: 10.1038/ncomms11267.
9. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
10. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
11. Genetic mapping of allelic loss on chromosome 6q within heterogeneous prostate carcinoma. Konishi N, etal., Cancer Sci. 2003 Sep;94(9):764-8.
12. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
13. Modulation of AT-1R/AMPK-MAPK cascade plays crucial role for the pathogenesis of diabetic cardiomyopathy in transgenic type 2 diabetic (Spontaneous Diabetic Torii) rats. Lakshmanan AP, etal., Biochem Pharmacol. 2012 Mar 1;83(5):653-60. doi: 10.1016/j.bcp.2011.11.018. Epub 2011 Nov 28.
14. Heterozygous Mutations in MAP3K7, Encoding TGF-beta-Activated Kinase 1, Cause Cardiospondylocarpofacial Syndrome. Le Goff C, etal., Am J Hum Genet. 2016 Aug 4;99(2):407-13. doi: 10.1016/j.ajhg.2016.06.005. Epub 2016 Jul 14.
15. Farnesoid X receptor activation inhibits TGFBR1/TAK1-mediated vascular inflammation and calcification via miR-135a-5p. Li C, etal., Commun Biol. 2020 Jun 24;3(1):327. doi: 10.1038/s42003-020-1058-2.
16. Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway. Li CY, etal., Basic Res Cardiol. 2016 Mar;111(2):19. doi: 10.1007/s00395-016-0536-7. Epub 2016 Feb 18.
17. GCN5-mediated regulation of pathological cardiac hypertrophy via activation of the TAK1-JNK/p38 signaling pathway. Li J, etal., Cell Death Dis. 2022 Apr 30;13(4):421. doi: 10.1038/s41419-022-04881-y.
18. Transforming growth factor beta-activated kinase 1 signaling pathway critically regulates myocardial survival and remodeling. Li L, etal., Circulation. 2014 Dec 9;130(24):2162-72. doi: 10.1161/CIRCULATIONAHA.114.011195. Epub 2014 Oct 2.
19. microRNA-149-5p mediates the PM2.5-induced inflammatory response by targeting TAB2 via MAPK and NF-κB signaling pathways in vivo and in vitro. Li Q, etal., Cell Biol Toxicol. 2021 Jul 31. pii: 10.1007/s10565-021-09638-5. doi: 10.1007/s10565-021-09638-5.
20. Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway. Liao HH, etal., Oxid Med Cell Longev. 2019 Dec 6;2019:6304058. doi: 10.1155/2019/6304058. eCollection 2019.
21. Expanding role of ubiquitination in NF-kappaB signaling. Liu S and Chen ZJ, Cell Res. 2011 Jan;21(1):6-21. Epub 2010 Dec 7.
22. Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers. Liu W, etal., Clin Cancer Res. 2007 Sep 1;13(17):5028-33.
23. Albiflorin Alleviates Ox-LDL-Induced Human Umbilical Vein Endothelial Cell Injury through IRAK1/TAK1 Pathway. Liu Y, etal., Biomed Res Int. 2022 May 13;2022:6584645. doi: 10.1155/2022/6584645. eCollection 2022.
24. Inhibition of TGFβ-activated kinase 1 promotes inflammation-resolving microglial/macrophage responses and recovery after stroke in ovariectomized female mice. Liu Y, etal., Neurobiol Dis. 2021 Apr;151:105257. doi: 10.1016/j.nbd.2021.105257. Epub 2021 Jan 9.
25. C1q-tumour necrosis factor-related protein-3 exacerbates cardiac hypertrophy in mice. Ma ZG, etal., Cardiovasc Res. 2019 May 1;115(6):1067-1077. doi: 10.1093/cvr/cvy279.
26. Activation of TGF-beta1-TAK1-p38 MAPK pathway in spared cardiomyocytes is involved in left ventricular remodeling after myocardial infarction in rats. Matsumoto-Ida M, etal., Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H709-15. Epub 2005 Sep 23.
27. MGDs mouse GO annotations MGD data from the GO Consortium
28. TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. Morioka S, etal., Blood. 2012 Nov 1;120(18):3846-57. doi: 10.1182/blood-2012-03-416198. Epub 2012 Sep 12.
29. BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFβ-TAK1-MAPK pathways in PAH. Nasim MT, etal., Hum Mol Genet. 2012 Jun 1;21(11):2548-58. doi: 10.1093/hmg/dds073. Epub 2012 Mar 2.
30. Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia. Neubert M, etal., Cell Death Differ. 2011 Sep;18(9):1521-30. doi: 10.1038/cdd.2011.29. Epub 2011 Apr 8.
31. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
32. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
33. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
34. Mouse MP Annotation Import Pipeline RGD automated import pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Brain endothelial TAK1 and NEMO safeguard the neurovascular unit. Ridder DA, etal., J Exp Med. 2015 Sep 21;212(10):1529-49. doi: 10.1084/jem.20150165. Epub 2015 Sep 7.
38. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Verstrepen L, etal., Cell Mol Life Sci. 2008 Oct;65(19):2964-78.
39. Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia. Wade EM, etal., Am J Hum Genet. 2016 Aug 4;99(2):392-406. doi: 10.1016/j.ajhg.2016.05.024. Epub 2016 Jul 15.
40. NG25, an inhibitor of transforming growth factor‑β‑activated kinase 1, ameliorates neuronal apoptosis in neonatal hypoxic‑ischemic rats. Wang H, etal., Mol Med Rep. 2018 Jan;17(1):1710-1716. doi: 10.3892/mmr.2017.8024. Epub 2017 Nov 10.
41. Transforming Growth Factor Beta-Activated Kinase 1-Dependent Microglial and Macrophage Responses Aggravate Long-Term Outcomes After Ischemic Stroke. Wang R, etal., Stroke. 2020 Mar;51(3):975-985. doi: 10.1161/STROKEAHA.119.028398. Epub 2020 Feb 12.
42. Interleukin-1 (IL-1) pathway. Weber A, etal., Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1.
43. Olmesartan ameliorates pressure overload-induced cardiac remodeling through inhibition of TAK1/p38 signaling in mice. Wu L, etal., Life Sci. 2016 Jan 15;145:121-6. doi: 10.1016/j.lfs.2015.12.034. Epub 2015 Dec 17.
44. CARD3 Promotes Cerebral Ischemia-Reperfusion Injury Via Activation of TAK1. Wu X, etal., J Am Heart Assoc. 2020 May 5;9(9):e014920. doi: 10.1161/JAHA.119.014920. Epub 2020 Apr 30.
45. [Mobilization of Bone Marrow Mesenchymal Stem Cells Inhibits TGF-β Non-classical Pathway Against Myocardial Fibrosis in Rats]. Xia WQ, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2020 May;51(3):344-349. doi: 10.12182/20200560503.
46. Simvastatin ameliorates ventricular remodeling via the TGFbeta1 signaling pathway in rats following myocardial infarction. Xiao X, etal., Mol Med Rep. 2016 Apr 25. doi: 10.3892/mmr.2016.5178.
47. A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. Xie M, etal., Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17378-83. doi: 10.1073/pnas.0604708103. Epub 2006 Nov 3.
48. A20 prevents obesity-induced development of cardiac dysfunction. Xu W, etal., J Mol Med (Berl). 2018 Feb;96(2):159-172. doi: 10.1007/s00109-017-1608-3. Epub 2017 Nov 16.
49. Sialyltransferase7A promotes angiotensin II-induced cardiomyocyte hypertrophy via HIF-1α-TAK1 signalling pathway. Yan X, etal., Cardiovasc Res. 2020 Jan 1;116(1):114-126. doi: 10.1093/cvr/cvz064.
50. Overexpression of miR-146b-5p Ameliorates Neonatal Hypoxic Ischemic Encephalopathy by Inhibiting IRAK1/TRAF6/TAK1/NF-αB Signaling. Yang G and Zhao Y, Yonsei Med J. 2020 Aug;61(8):660-669. doi: 10.3349/ymj.2020.61.8.660.
51. Cardiomyocyte-Specific RIP2 Overexpression Exacerbated Pathologic Remodeling and Contributed to Spontaneous Cardiac Hypertrophy. Yang JJ, etal., Front Cell Dev Biol. 2021 Oct 18;9:688238. doi: 10.3389/fcell.2021.688238. eCollection 2021.
52. Creg in Hepatocytes Ameliorates Liver Ischemia/Reperfusion Injury in a TAK1-Dependent Manner in Mice. Yang L, etal., Hepatology. 2019 Jan;69(1):294-313. doi: 10.1002/hep.30203.
53. TAK1-AMPK Pathway in Macrophages Regulates Hypothyroid Atherosclerosis. Yang Y, etal., Cardiovasc Drugs Ther. 2021 Jun;35(3):599-612. doi: 10.1007/s10557-020-06996-w.
54. Inhibitory effects of omega-3 fatty acids on early brain injury after subarachnoid hemorrhage in rats: Possible involvement of G protein-coupled receptor 120/β-arrestin2/TGF-β activated kinase-1 binding protein-1 signaling pathway. Yin J, etal., Int J Biochem Cell Biol. 2016 Jun;75:11-22. doi: 10.1016/j.biocel.2016.03.008. Epub 2016 Mar 18.
55. Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing TAK1-MAPK/NF-κB pathways. Yu M, etal., Int J Med Sci. 2022 Mar 28;19(4):681-694. doi: 10.7150/ijms.69289. eCollection 2022.
56. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, etal., Cardiovasc Res. 2022 Mar 30:cvac039. doi: 10.1093/cvr/cvac039.
57. Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke. Zeyen T, etal., J Mol Med (Berl). 2020 Jun;98(6):833-847. doi: 10.1007/s00109-020-01916-9. Epub 2020 May 7.
58. TGFβ-activated Kinase 1 (TAK1) Inhibition by 5Z-7-Oxozeaenol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage. Zhang D, etal., J Biol Chem. 2015 Aug 7;290(32):19900-9. doi: 10.1074/jbc.M115.636795. Epub 2015 Jun 22.
59. TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice. Zhang D, etal., Nat Med. 2000 May;6(5):556-63. doi: 10.1038/75037.
60. The E3 ubiquitin ligase TRIM31 plays a critical role in hypertensive nephropathy by promoting proteasomal degradation of MAP3K7 in the TGF-β1 signaling pathway. Zhang J, etal., Cell Death Differ. 2022 Mar;29(3):556-567. doi: 10.1038/s41418-021-00874-0. Epub 2021 Sep 28.
61. TAK1 accelerates transplant arteriosclerosis in rat aortic allografts by inducing autophagy in vascular smooth muscle cells. Zheng X, etal., Atherosclerosis. 2022 Feb;343:10-19. doi: 10.1016/j.atherosclerosis.2022.01.009. Epub 2022 Jan 19.
62. USP4 deficiency exacerbates hepatic ischaemia/reperfusion injury via TAK1 signalling. Zhou J, etal., Clin Sci (Lond). 2019 Jan 30;133(2):335-349. doi: 10.1042/CS20180959. Print 2019 Jan 31.
63. Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat. Zhou K, etal., Stroke. 2018 Jan;49(1):175-183. doi: 10.1161/STROKEAHA.117.018593.
64. TRAF3 mediates neuronal apoptosis in early brain injury following subarachnoid hemorrhage via targeting TAK1-dependent MAPKs and NF-κB pathways. Zhou Y, etal., Cell Death Dis. 2021 Jan 7;12(1):10. doi: 10.1038/s41419-020-03278-z.
Additional References at PubMed
PMID:8533096   PMID:10349636   PMID:10757786   PMID:10882101   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11356033   PMID:11585904   PMID:12464436   PMID:12477932  
PMID:12520002   PMID:12545162   PMID:12556533   PMID:12711537   PMID:12805214   PMID:12842894   PMID:12904583   PMID:14592977   PMID:14610273   PMID:15218018   PMID:15226265   PMID:15647289  
PMID:15761153   PMID:15782199   PMID:15837794   PMID:15894542   PMID:15911626   PMID:16141072   PMID:16141073   PMID:16145668   PMID:16157589   PMID:16186825   PMID:16260493   PMID:16301747  
PMID:16339560   PMID:16360132   PMID:16385569   PMID:16446357   PMID:16498455   PMID:16556914   PMID:16675448   PMID:16754690   PMID:16799562   PMID:16831874   PMID:16835226   PMID:16857737  
PMID:16919269   PMID:16940043   PMID:17114649   PMID:17158449   PMID:17197697   PMID:17276978   PMID:17384642   PMID:17679097   PMID:17709393   PMID:17855357   PMID:17897957   PMID:17965022  
PMID:17967808   PMID:18021073   PMID:18079694   PMID:18206350   PMID:18287559   PMID:18299321   PMID:18316610   PMID:18573910   PMID:18606667   PMID:18606807   PMID:18617512   PMID:18635759  
PMID:18682563   PMID:18762249   PMID:18799693   PMID:18805969   PMID:18818394   PMID:18829460   PMID:18855897   PMID:18984593   PMID:19026643   PMID:19116914   PMID:19136967   PMID:19196865  
PMID:19197243   PMID:19201899   PMID:19213760   PMID:19224920   PMID:19224984   PMID:19234607   PMID:19268530   PMID:19419968   PMID:19421137   PMID:19536134   PMID:19556242   PMID:19675569  
PMID:19774455   PMID:19793887   PMID:19793892   PMID:19820695   PMID:19843958   PMID:19898473   PMID:19927120   PMID:19955178   PMID:20014292   PMID:20037141   PMID:20037161   PMID:20038579  
PMID:20062539   PMID:20064449   PMID:20065289   PMID:20080763   PMID:20164171   PMID:20194509   PMID:20213696   PMID:20392264   PMID:20478530   PMID:20538596   PMID:20551513   PMID:20585657  
PMID:20615388   PMID:20696287   PMID:20813258   PMID:20855879   PMID:20932476   PMID:20959492   PMID:21052097   PMID:21267068   PMID:21335610   PMID:21367917   PMID:21371434   PMID:21383695  
PMID:21471444   PMID:21472480   PMID:21552285   PMID:21566132   PMID:21606198   PMID:21677750   PMID:21771792   PMID:21789165   PMID:21873635   PMID:21896478   PMID:21953618   PMID:21979919  
PMID:21989986   PMID:22016814   PMID:22057290   PMID:22069318   PMID:22080947   PMID:22143887   PMID:22167179   PMID:22173278   PMID:22219364   PMID:22226633   PMID:22307082   PMID:22308391  
PMID:22326956   PMID:22331902   PMID:22337877   PMID:22348103   PMID:22365665   PMID:22411628   PMID:22467172   PMID:22520462   PMID:22590573   PMID:22637723   PMID:22649194   PMID:22683931  
PMID:22698400   PMID:22860133   PMID:22941947   PMID:23148225   PMID:23166301   PMID:23226465   PMID:23251462   PMID:23298137   PMID:23322300   PMID:23340735   PMID:23391818   PMID:23422957  
PMID:23460641   PMID:23483698   PMID:23505428   PMID:23546880   PMID:23776175   PMID:23778976   PMID:23790753   PMID:23825189   PMID:23892723   PMID:23960234   PMID:23962979   PMID:23972991  
PMID:23973329   PMID:23982205   PMID:23994637   PMID:24036998   PMID:24072697   PMID:24077561   PMID:24114841   PMID:24120137   PMID:24144697   PMID:24194600   PMID:24270572   PMID:24277938  
PMID:24319055   PMID:24498425   PMID:24534530   PMID:24535827   PMID:24558484   PMID:24633226   PMID:24652804   PMID:24751651   PMID:24832470   PMID:24833394   PMID:24874739   PMID:24952961  
PMID:24963009   PMID:24980047   PMID:24983318   PMID:25050617   PMID:25086610   PMID:25146924   PMID:25418008   PMID:25452303   PMID:25521315   PMID:25523394   PMID:25535389   PMID:25725788  
PMID:25729924   PMID:25828701   PMID:25891214   PMID:26092120   PMID:26102028   PMID:26132627   PMID:26189595   PMID:26269654   PMID:26322481   PMID:26353931   PMID:26371508   PMID:26381601  
PMID:26391398   PMID:26474655   PMID:26564789   PMID:26634297   PMID:26648529   PMID:26882989   PMID:26973245   PMID:26985063   PMID:27026702   PMID:27043411   PMID:27121163   PMID:27230958  
PMID:27245349   PMID:27246297   PMID:27293199   PMID:27473013   PMID:27601471   PMID:27626380   PMID:27685625   PMID:27695001   PMID:27696624   PMID:27768832   PMID:27777970   PMID:27981609  
PMID:27995356   PMID:28013046   PMID:28045080   PMID:28182011   PMID:28190767   PMID:28220341   PMID:28410990   PMID:28530714   PMID:28842570   PMID:28875549   PMID:28898696   PMID:28974699  
PMID:29024853   PMID:29027124   PMID:29107558   PMID:29196442   PMID:29228365   PMID:29247325   PMID:29281682   PMID:29291351   PMID:29292386   PMID:29411501   PMID:29415881   PMID:29475001  
PMID:29500178   PMID:29504713   PMID:29558367   PMID:29661023   PMID:29667914   PMID:29676259   PMID:29703898   PMID:29796309   PMID:29855498   PMID:29894692   PMID:30146158   PMID:30361383  
PMID:30451876   PMID:30582764   PMID:30639056   PMID:30683914   PMID:30765691   PMID:30975711   PMID:30988397   PMID:31127032   PMID:31162944   PMID:31241461   PMID:31243089   PMID:31301769  
PMID:31311865   PMID:31387937   PMID:31393024   PMID:31461199   PMID:31519887   PMID:31545406   PMID:31668971   PMID:31758827   PMID:31813254   PMID:31847895   PMID:31869420   PMID:31982140  
PMID:32071228   PMID:32108376   PMID:32273474   PMID:32378287   PMID:32451485   PMID:32460580   PMID:32513687   PMID:32622875   PMID:32798288   PMID:32865519   PMID:32979244   PMID:33133065  
PMID:33139544   PMID:33378226   PMID:33436499   PMID:33522247   PMID:33549727   PMID:33894128   PMID:34052945   PMID:34161265   PMID:35750050   PMID:35842423   PMID:35948397   PMID:35959632  
PMID:36062803   PMID:36417873   PMID:36862288   PMID:36912451   PMID:36974751  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39431,963,659 - 32,023,470 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl431,964,097 - 32,023,467 (+)EnsemblGRCm39 Ensembl
GRCm38431,963,492 - 32,023,470 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl431,964,097 - 32,023,467 (+)EnsemblGRCm38mm10GRCm38
MGSCv37432,051,082 - 32,110,442 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36432,292,735 - 32,349,405 (+)NCBIMGSCv36mm8
Celera431,710,402 - 31,768,496 (+)NCBICelera
Cytogenetic Map4A5NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38690,513,579 - 90,587,072 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl690,513,573 - 90,587,086 (-)EnsemblGRCh38hg38GRCh38
GRCh37691,223,298 - 91,296,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36691,282,074 - 91,353,628 (-)NCBINCBI36Build 36hg18NCBI36
Celera691,646,249 - 91,717,462 (-)NCBICelera
Cytogenetic Map6q15NCBI
HuRef688,442,517 - 88,515,844 (-)NCBIHuRef
CHM1_1691,320,725 - 91,394,113 (-)NCBICHM1_1
T2T-CHM13v2.0691,725,183 - 91,798,324 (-)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2546,356,973 - 46,415,597 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl546,357,931 - 46,415,597 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx548,494,947 - 48,552,846 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0550,094,119 - 50,152,018 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0550,043,393 - 50,101,289 (+)NCBIRnor_WKY
Rnor_6.0547,183,142 - 47,244,424 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl547,186,558 - 47,244,416 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl9114,022,137 - 114,079,089 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0551,793,737 - 51,852,677 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4548,252,637 - 48,308,820 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1548,252,815 - 48,309,011 (+)NCBI
Celera545,121,067 - 45,178,378 (+)NCBICelera
Cytogenetic Map5q21NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541117,177,335 - 17,229,957 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541117,177,335 - 17,229,957 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan16108,504,996 - 108,581,339 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0688,398,329 - 88,470,926 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1691,664,263 - 91,737,468 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl691,664,263 - 91,737,468 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11249,669,849 - 49,740,039 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1249,672,389 - 49,739,850 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1249,477,606 - 49,546,370 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01250,481,094 - 50,549,843 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1250,481,149 - 50,549,837 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11249,798,234 - 49,867,173 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01249,697,121 - 49,766,116 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01249,887,662 - 49,956,849 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494684,634,746 - 84,697,875 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365101,772,971 - 1,837,765 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365101,772,971 - 1,836,075 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl158,481,956 - 58,548,057 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1158,482,046 - 58,548,087 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2165,479,754 - 65,542,430 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11315,284,927 - 15,360,539 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1315,284,923 - 15,360,832 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040191,671,798 - 191,744,917 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247993,554,678 - 3,622,289 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247993,554,644 - 3,623,317 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Map3k7
1873 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4748
Count of miRNA genes:788
Interacting mature miRNAs:1002
Transcripts:ENSMUST00000037607, ENSMUST00000080933, ENSMUST00000108183, ENSMUST00000108184, ENSMUST00000126632, ENSMUST00000131114, ENSMUST00000131310, ENSMUST00000143138, ENSMUST00000147462
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
1302010Wta1_mweight adult 1 (mouse)Not determined4868324042683429Mouse
1558992Ses8_msalmonella enteritidis susceptibility 8 (mouse)Not determined4868324042683429Mouse
1301473Triglq1_mtriglyceride QTL 1 (mouse)Not determined4868324042683429Mouse
1302125Lxw1_mlupus BXSB x NZW 1 (mouse)Not determined4868324042683429Mouse
4141302Ssrq5_mstress response QTL 5 (mouse)Not determined868324042683430Mouse
10401905Sicd3_mseizure-induced cell death 3 (mouse)Not determined4939552543760862Mouse
10401115Pgia35_mproteoglycan induced arthritis 35 (mouse)Not determined41256237746562509Mouse
12880405Jcdq1_mjoint cartilage degeneration QTL 1 (mouse)41256237746562509Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
1301203Alcp8_malcohol preference locus 8 (mouse)Not determined41739516051395290Mouse
1301237Alcp7_malcohol preference locus 7 (mouse)Not determined41739516051395290Mouse
4141555Nbwa2_mNZB and NZW autoimmunity 2 (mouse)Not determined41789251551892635Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
25440481Moaq1_mmodifier of alien QTL 1 (mouse)41950000046000000Mouse
1302058Hrtfm3_mheart failure modifier 3 (mouse)Not determined42211194456112145Mouse
1300769Pcyts2_mplasmacytoma susceptibility 2 (mouse)Not determined42211194456112145Mouse
1301437Scon1_msucrose consumption 1 (mouse)Not determined42237344856373612Mouse
1302075Bdln6_mbody length 6 (mouse)Not determined42237344856373612Mouse
1301697Sluc18_msusceptibility to lung cancer 18 (mouse)Not determined42237344856373612Mouse
1302184Aaom1_mautoimmune aoritis in MRL mice 1 (mouse)Not determined42432229946332776Mouse
1300574Im2_mimmunoregulatory 2 (mouse)Not determined42807768262077816Mouse
1301586Stheal3_msoft tissue heal 3 (mouse)Not determined42865844262658566Mouse
1357877Synch1_msynechia 1 (mouse)Not determined42870992562710107Mouse
1301990Arvm1_mautoimmune renal vasculitis 1 (mouse)Not determined42933264663332776Mouse
12903995Opfaq2_mopen field activity QTL 2 (mouse)43034341933824057Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38431,962,676 - 31,962,882UniSTSGRCm38
MGSCv37432,049,651 - 32,049,857UniSTSGRCm37
Cytogenetic Map4A5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38431,962,838 - 31,962,950UniSTSGRCm38
MGSCv37432,049,813 - 32,049,925UniSTSGRCm37
Celera431,709,142 - 31,709,254UniSTS
Cytogenetic Map4A5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38432,019,857 - 32,020,018UniSTSGRCm38
MGSCv37432,106,832 - 32,106,993UniSTSGRCm37
Celera431,764,937 - 31,765,098UniSTS
Cytogenetic Map4A5UniSTS
Whitehead_YAC4 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38432,020,282 - 32,020,534UniSTSGRCm38
MGSCv37432,107,257 - 32,107,509UniSTSGRCm37
Celera431,765,362 - 31,765,614UniSTS
Cytogenetic Map4A5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38432,022,425 - 32,022,734UniSTSGRCm38
MGSCv37432,109,400 - 32,109,709UniSTSGRCm37
Cytogenetic Map4A5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38432,021,575 - 32,021,787UniSTSGRCm38
MGSCv37432,108,550 - 32,108,762UniSTSGRCm37
Celera431,766,650 - 31,766,862UniSTS
Cytogenetic Map4A5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381082,431,380 - 82,432,375UniSTSGRCm38
MGSCv371081,894,125 - 81,895,120UniSTSGRCm37
Celera1084,351,133 - 84,352,128UniSTS
Cytogenetic Map4A5UniSTS
Cytogenetic Map10C1UniSTS
cM Map4 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38432,020,134 - 32,020,546UniSTSGRCm38
MGSCv37432,107,109 - 32,107,521UniSTSGRCm37
Celera431,765,214 - 31,765,626UniSTS
Cytogenetic Map4A5UniSTS
cM Map4 UniSTS



Nucleotide Sequences
RefSeq Transcripts NM_009316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_172688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006537948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004941907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004941908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004941909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_390323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK046565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL833781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV559615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D76446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000037607   ⟹   ENSMUSP00000040307
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl431,964,097 - 32,023,467 (+)Ensembl
GRCm38.p6 Ensembl431,964,097 - 32,023,467 (+)Ensembl
RefSeq Acc Id: ENSMUST00000080933   ⟹   ENSMUSP00000079734
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl431,964,120 - 32,023,467 (+)Ensembl
GRCm38.p6 Ensembl431,964,120 - 32,023,467 (+)Ensembl
RefSeq Acc Id: ENSMUST00000108183   ⟹   ENSMUSP00000103818
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl431,964,257 - 32,023,467 (+)Ensembl
GRCm38.p6 Ensembl431,964,257 - 32,023,467 (+)Ensembl
RefSeq Acc Id: ENSMUST00000108184   ⟹   ENSMUSP00000103819
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl431,964,263 - 32,023,467 (+)Ensembl
GRCm38.p6 Ensembl431,964,263 - 32,023,467 (+)Ensembl
RefSeq Acc Id: ENSMUST00000126632
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl431,981,576 - 31,992,775 (+)Ensembl
GRCm38.p6 Ensembl431,981,576 - 31,992,775 (+)Ensembl
RefSeq Acc Id: ENSMUST00000131114
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl431,977,348 - 31,988,641 (+)Ensembl
GRCm38.p6 Ensembl431,977,348 - 31,988,641 (+)Ensembl
RefSeq Acc Id: ENSMUST00000131310
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl431,992,473 - 32,019,560 (+)Ensembl
GRCm38.p6 Ensembl431,992,473 - 32,019,560 (+)Ensembl
RefSeq Acc Id: ENSMUST00000143138
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl431,979,498 - 31,985,721 (+)Ensembl
GRCm38.p6 Ensembl431,979,498 - 31,985,721 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147462
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl431,985,667 - 32,015,970 (+)Ensembl
GRCm38.p6 Ensembl431,985,667 - 32,015,970 (+)Ensembl
RefSeq Acc Id: NM_009316   ⟹   NP_033342
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39431,964,107 - 32,023,467 (+)NCBI
GRCm38431,964,107 - 32,023,467 (+)NCBI
MGSCv37432,051,082 - 32,110,442 (+)RGD
Celera431,710,402 - 31,768,496 (+)RGD
RefSeq Acc Id: NM_172688   ⟹   NP_766276
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39431,964,107 - 32,023,467 (+)NCBI
GRCm38431,964,107 - 32,023,467 (+)NCBI
MGSCv37432,051,082 - 32,110,442 (+)RGD
Celera431,710,402 - 31,768,496 (+)RGD
RefSeq Acc Id: XM_006537948   ⟹   XP_006538011
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39431,978,455 - 32,023,470 (+)NCBI
GRCm38431,978,449 - 32,023,470 (+)NCBI
RefSeq Acc Id: XR_004941907
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39431,963,659 - 32,023,470 (+)NCBI
RefSeq Acc Id: XR_004941908
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39431,963,659 - 32,023,470 (+)NCBI
RefSeq Acc Id: XR_004941909
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39431,963,659 - 32,023,470 (+)NCBI
RefSeq Acc Id: XR_390323
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39431,963,659 - 32,023,470 (+)NCBI
GRCm38431,963,492 - 32,023,470 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_766276   ⟸   NM_172688
- Peptide Label: isoform A
- UniProtKB: Q62073 (UniProtKB/Swiss-Prot),   Q543B5 (UniProtKB/TrEMBL),   A0A6P5PIU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_033342   ⟸   NM_009316
- Peptide Label: isoform B
- UniProtKB: Q543B5 (UniProtKB/TrEMBL),   Q923A8 (UniProtKB/TrEMBL),   A0A6P5PKD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006538011   ⟸   XM_006537948
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000103819   ⟸   ENSMUST00000108184
RefSeq Acc Id: ENSMUSP00000103818   ⟸   ENSMUST00000108183
RefSeq Acc Id: ENSMUSP00000040307   ⟸   ENSMUST00000037607
RefSeq Acc Id: ENSMUSP00000079734   ⟸   ENSMUST00000080933
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62073-F1-model_v2 AlphaFold Q62073 1-579 view protein structure

RGD ID:6882956
Promoter ID:EPDNEW_M4929
Type:initiation region
Description:Mus musculus mitogen-activated protein kinase kinase kinase 7, transcript variant A, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38431,964,128 - 31,964,188EPDNEW
RGD ID:6834679
Promoter ID:MM_KWN:36942
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK011347_2610008G14RIK,   ENSMUST00000108183,   OTTMUST00000010919,   OTTMUST00000010920,   OTTMUST00000010922,   UC008SEO.1
Mouse AssemblyChrPosition (strand)Source
MGSCv36432,049,551 - 32,051,127 (-)MPROMDB
RGD ID:6835626
Promoter ID:MM_KWN:36945
SO ACC ID:SO:0000170
Tissues & Cell Lines:Brain
Mouse AssemblyChrPosition (strand)Source
MGSCv36432,068,621 - 32,069,121 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1346877 AgrOrtholog
Ensembl Genes ENSMUSG00000028284 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000040307 ENTREZGENE
  ENSMUSP00000040307.5 UniProtKB/TrEMBL
  ENSMUSP00000079734.7 UniProtKB/Swiss-Prot
  ENSMUSP00000103818.2 UniProtKB/TrEMBL
  ENSMUSP00000103819.3 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000037607 ENTREZGENE
  ENSMUST00000037607.11 UniProtKB/TrEMBL
  ENSMUST00000080933.13 UniProtKB/Swiss-Prot
  ENSMUST00000108183.8 UniProtKB/TrEMBL
  ENSMUST00000108184.3 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPKKK7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:26409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46716 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Map3k7 PhenoGen
PIRSF MAPKKK7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M3K7_MOUSE UniProtKB/Swiss-Prot