Dicer1 (dicer 1, ribonuclease type III)

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Gene: Dicer1 (dicer 1, ribonuclease type III) Mus musculus

Analyze

Symbol:

Dicer1

Name:

dicer 1, ribonuclease type III

RGD ID:

1319700

MGI Page

MGI

Description:

Enables miRNA binding activity. Involved in several processes, including nervous system development; regulation of gene expression; and regulation of nervous system development. Acts upstream of or within several processes, including circulatory system development; negative regulation of macromolecule metabolic process; and nervous system development. Located in cytoplasm. Part of RISC complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study DiGeorge syndrome; dilated cardiomyopathy; and ovarian cancer. Human ortholog(s) of this gene implicated in DICER1 syndrome; gastrointestinal system cancer (multiple); multinodular goiter; nephroma; and pleuropulmonary blastoma. Orthologous to human DICER1 (dicer 1, ribonuclease III).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

1110006F08Rik; aviD; D12Ertd7; D12Ertd7e; Dice; Dicer1, Dcr-1 homolog; double-strand-specific ribonuclease mDCR-1; endoribonuclease Dicer; mKIAA0928

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DICER1 (dicer 1, ribonuclease III)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Dicer1 (dicer 1 ribonuclease III)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dicer1 (dicer 1, ribonuclease III)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DICER1 (dicer 1, ribonuclease III)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DICER1 (dicer 1, ribonuclease III)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dicer1 (dicer 1, ribonuclease III)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DICER1 (dicer 1, ribonuclease III)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DICER1 (dicer 1, ribonuclease III)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dicer1 (dicer 1, ribonuclease III)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Dicer1 (dicer 1 ribonuclease III)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	DICER1 (dicer 1, ribonuclease III)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dicer1 (dicer 1, ribonuclease type III)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	Dcr-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dcr-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dicer1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	104,654,001 - 104,718,331 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	104,654,001 - 104,718,211 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	104,687,740 - 104,751,968 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	104,687,742 - 104,751,952 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	105,925,952 - 105,990,162 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	105,092,486 - 105,153,002 (-)	NCBI		MGSCv36	mm8
Celera	12	105,918,245 - 105,982,441 (-)	NCBI		Celera
Cytogenetic Map	12	E	NCBI
cM Map	12	54.83	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

breast cancer (ISO)

Breast Neoplasms (ISO)

colorectal cancer (ISO)

diabetes mellitus (IMP)

DICER1 syndrome (ISO)

diffuse large B-cell lymphoma (ISO)

DiGeorge syndrome (IAGP)

dilated cardiomyopathy (IAGP)

Embryonal Rhabdomyosarcoma 2 (ISO)

endometriosis (ISO)

genetic disease (ISO)

Global Developmental Delay, Lung Cysts, Overgrowth, and Wilms Tumor (ISO)

hepatocellular carcinoma (ISO)

Hereditary Neoplastic Syndromes (ISO)

infertility (IMP)

Liver Neoplasms (ISO)

lung cancer (IMP)

medulloblastoma (ISO)

middle cerebral artery infarction (ISO)

Multinodular Goiter 1 (ISO)

nephroblastoma (ISO)

nephroma (ISO)

oligospermia (ISO)

ovarian cancer (ISO)

pineoblastoma (ISO)

pleuropulmonary blastoma (IMP,ISO)

retinoblastoma (IMP)

rhabdomyosarcoma (ISO)

stomach cancer (ISO)

supratentorial primitive neuroectodermal tumor (ISO)

syndromic microphthalmia 5 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2,5-hexanedione (EXP)

5-chloro-7-iodoquinolin-8-ol (ISO)

5-fluorouracil (ISO)

7,12-dimethyltetraphene (EXP)

aflatoxin B1 (EXP,ISO)

amphetamine (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

butyric acid (EXP)

cadmium dichloride (ISO)

caffeine (ISO)

calyculin a (EXP)

CGP 52608 (ISO)

choline (EXP)

chrysene (EXP)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

desferrioxamine B (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP)

dioxygen (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

enzyme inhibitor (ISO)

ethyl methanesulfonate (ISO)

flutamide (ISO)

folic acid (EXP)

formaldehyde (ISO)

gentamycin (ISO)

glucaric acid (EXP)

GSK343 (ISO)

ivermectin (ISO)

L-methionine (EXP)

methamphetamine (EXP)

methyl methanesulfonate (ISO)

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (ISO)

N-ethyl-N-nitrosourea (EXP)

nickel dichloride (ISO)

nicotinamide (EXP)

oxaliplatin (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

progesterone (EXP)

raloxifene (ISO)

resveratrol (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

topotecan (ISO)

trichloroethene (ISO)

tungsten (EXP)

tunicamycin (EXP)

urethane (ISO)

valproic acid (EXP,ISO)

vitamin E (ISO)

zinc dichloride (ISO)

zinc sulfate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anatomical structure development (IMP)

angiogenesis (IMP)

apoptotic DNA fragmentation (IBA)

branching morphogenesis of an epithelial tube (IMP)

cardiac muscle cell development (IMP)

cardiac neural crest cell development involved in outflow tract morphogenesis (IMP)

cartilage development (IMP)

cell population proliferation (IMP)

cellular response to glucose stimulus (ISO)

cellular response to hydrogen peroxide (ISO)

cellular response to oxygen-glucose deprivation (ISO)

cellular response to tumor necrosis factor (ISO)

cerebral cortex development (IMP)

defense response to virus (IMP)

digestive tract development (IMP)

embryonic hindlimb morphogenesis (IMP)

embryonic limb morphogenesis (IMP)

epidermis morphogenesis (IMP)

ganglion development (IMP)

gene expression (IMP)

global gene silencing by mRNA cleavage (ISO)

hair follicle cell proliferation (IMP)

hair follicle development (IMP)

hair follicle morphogenesis (IMP)

inner ear receptor cell development (IMP)

intestinal epithelial cell development (IGI)

lung development (IMP)

meiotic spindle organization (IMP)

miRNA processing (IMP,ISO)

mRNA stabilization (IMP)

multicellular organism growth (IMP)

myoblast differentiation involved in skeletal muscle regeneration (IMP)

ncRNA-mediated post-transcriptional gene silencing (IMP)

negative regulation of gene expression (ISO)

negative regulation of glial cell proliferation (IMP)

negative regulation of Schwann cell proliferation (IMP)

negative regulation of transcription by RNA polymerase II (IMP)

negative regulation of tumor necrosis factor production (ISO)

nerve development (IMP)

neuron projection morphogenesis (IMP)

NIK/NF-kappaB signaling (ISO)

olfactory bulb interneuron differentiation (IMP)

pericentric heterochromatin formation (IMP)

peripheral nervous system myelin formation (IMP)

positive regulation of collagen biosynthetic process (ISO)

positive regulation of endothelial cell migration (ISO)

positive regulation of endothelial cell-matrix adhesion via fibronectin (ISO)

positive regulation of establishment of endothelial barrier (ISO)

positive regulation of gene expression (IMP)

positive regulation of hepatic stellate cell proliferation (ISO)

positive regulation of miRNA metabolic process (IMP)

positive regulation of myelination (IMP)

positive regulation of Schwann cell differentiation (IMP)

positive regulation of transcription by RNA polymerase II (IMP)

positive regulation of vascular endothelial cell proliferation (ISO)

post-embryonic development (IMP)

pre-miRNA processing (IBA,IDA,ISO)

regulation of cell cycle (IMP)

regulation of enamel mineralization (IMP)

regulation of epithelial cell differentiation (IMP)

regulation of gene expression (IMP)

regulation of inflammatory response (IMP)

regulation of miRNA metabolic process (IMP)

regulation of muscle cell apoptotic process (IMP)

regulation of myelination (IMP)

regulation of neurogenesis (IMP)

regulation of neuron differentiation (IMP)

regulation of Notch signaling pathway (IC)

regulation of odontogenesis of dentin-containing tooth (IMP)

regulation of oligodendrocyte differentiation (IMP)

regulation of protein phosphorylation (IMP)

regulation of regulatory T cell differentiation (IMP)

regulation of RNA metabolic process (IMP)

regulation of stem cell differentiation (IMP)

regulation of viral genome replication (IMP)

reproductive structure development (IMP)

RISC complex assembly (ISO)

RNA processing (IDA,IMP)

RNA-mediated gene silencing (IEA)

rRNA processing (IEA)

siRNA processing (IBA,IDA,IMP,ISO)

spermatogonial cell division (IMP)

spinal cord motor neuron differentiation (IMP)

spindle assembly (IMP)

spleen development (IMP)

stem cell population maintenance (IMP)

trophectodermal cell proliferation (IMP)

zygote asymmetric cell division (IMP)

Cellular Component

axon (ISO)

cytoplasm (IBA,IDA)

cytosol (TAS)

dendrite (ISO)

endoplasmic reticulum-Golgi intermediate compartment (ISO)

extracellular exosome (ISO)

glutamatergic synapse (IDA)

growth cone (ISO)

nucleus (IBA)

perinuclear region of cytoplasm (ISO)

postsynaptic density, intracellular component (IDA)

RISC complex (IBA,IDA,ISO)

RISC-loading complex (ISO)

Molecular Function

ATP binding (IEA)

deoxyribonuclease I activity (IBA)

DNA binding (IEA)

double-stranded RNA binding (ISO)

endonuclease activity (IEA)

helicase activity (IEA)

hydrolase activity (IEA)

metal ion binding (IEA)

miRNA binding (IDA)

nuclease activity (IEA)

nucleotide binding (IEA)

pre-miRNA binding (ISO)

protein binding (IPI)

protein domain specific binding (ISO)

ribonuclease III activity (IBA,ISO,TAS)

RNA binding (IBA)

RNA endonuclease activity (ISO)

RNA endonuclease activity, producing 5'-phosphomonoesters (IEA)

siRNA binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

microRNA pathway (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal acrosome morphology (IAGP)

abnormal angiogenesis (IAGP)

abnormal aortic arch development (IAGP)

abnormal atrial thrombosis (IAGP)

abnormal B cell differentiation (IAGP)

abnormal basicranium morphology (IAGP)

abnormal basisphenoid bone morphology (IAGP)

abnormal behavior (IAGP)

abnormal blood vessel morphology (IAGP)

abnormal bone marrow morphology (IAGP)

abnormal bone structure (IAGP)

abnormal branching involved in lung morphogenesis (IAGP)

abnormal cardiovascular system morphology (IAGP)

abnormal cardiovascular system physiology (IAGP)

abnormal cartilage morphology (IAGP)

abnormal CD4-positive, alpha-beta T cell physiology (IAGP)

abnormal cell physiology (IAGP)

abnormal coat/ hair morphology (IAGP)

abnormal craniofacial bone morphology (IAGP)

abnormal craniofacial development (IAGP)

abnormal craniofacial morphology (IAGP)

abnormal cytotoxic T cell physiology (IAGP)

abnormal dorsal root ganglion morphology (IAGP)

abnormal effector T cell morphology (IAGP)

abnormal efferent ductules of testis morphology (IAGP)

abnormal embryo development (IAGP)

abnormal epidermal layer morphology (IAGP)

abnormal epidermis stratum basale morphology (IAGP)

abnormal epididymis epithelium morphology (IAGP)

abnormal epididymis morphology (IAGP)

abnormal female meiosis (IAGP)

abnormal fetal cardiomyocyte morphology (IAGP)

abnormal first pharyngeal arch morphology (IAGP)

abnormal forelimb morphology (IAGP)

abnormal frontal bone morphology (IAGP)

abnormal germinal center B cell physiology (IAGP)

abnormal Golgi apparatus morphology (IAGP)

abnormal granulocyte differentiation (IAGP)

abnormal hair cycle (IAGP)

abnormal hair cycle catagen phase (IAGP)

abnormal hair follicle bulge morphology (IAGP)

abnormal hair follicle development (IAGP)

abnormal hair follicle inner root sheath morphology (IAGP)

abnormal hair follicle morphology (IAGP)

abnormal hair follicle orientation (IAGP)

abnormal hair follicle regression (IAGP)

abnormal hair growth (IAGP)

abnormal hair shaft morphology (IAGP)

abnormal heart echocardiography feature (IAGP)

abnormal hindlimb morphology (IAGP)

abnormal humoral immune response (IAGP)

abnormal immunoglobulin V(D)J recombination (IAGP)

abnormal kidney morphology (IAGP)

abnormal limb development (IAGP)

abnormal long bone morphology (IAGP)

abnormal lung development (IAGP)

abnormal lung epithelium morphology (IAGP)

abnormal lung-associated mesenchyme development (IAGP)

abnormal lymph node cell ratio (IAGP)

abnormal male germ cell morphology (IAGP)

abnormal manchette morphology (IAGP)

abnormal maxillary frontal process morphology (IAGP)

abnormal megakaryocyte differentiation (IAGP)

abnormal megakaryocyte morphology (IAGP)

abnormal meiotic spindle morphology (IAGP)

abnormal mitosis (IAGP)

abnormal myeloid leukocyte morphology (IAGP)

abnormal myocardial fiber morphology (IAGP)

abnormal myocardium layer morphology (IAGP)

abnormal neutrophil morphology (IAGP)

abnormal oocyte morphology (IAGP)

abnormal oviduct morphology (IAGP)

abnormal oviduct transport (IAGP)

abnormal palatal shelf bone ossification (IAGP)

abnormal palatal shelf morphology (IAGP)

abnormal positive T cell selection (IAGP)

abnormal pregnancy (IAGP)

abnormal regulatory T cell morphology (IAGP)

abnormal regulatory T cell physiology (IAGP)

abnormal renal corpuscle morphology (IAGP)

abnormal renal glomerulus morphology (IAGP)

abnormal renal tubule epithelial cell primary cilium morphology (IAGP)

abnormal retina layer morphology (IAGP)

abnormal retina morphology (IEA)

abnormal retina photoreceptor morphology (IAGP)

abnormal sarcomere morphology (IAGP)

abnormal secondary palate development (IAGP)

abnormal seminiferous tubule epithelium morphology (IAGP)

abnormal Sertoli cell morphology (IAGP)

abnormal skeleton development (IAGP)

abnormal skin appearance (IAGP)

abnormal skin physiology (IAGP)

abnormal sperm flagellum morphology (IAGP)

abnormal sperm head morphology (IAGP)

abnormal sperm midpiece morphology (IAGP)

abnormal sperm mitochondrial sheath morphology (IAGP)

abnormal sperm nucleus morphology (IAGP)

abnormal spermatid morphology (IAGP)

abnormal spermatogenesis (IAGP)

abnormal spermiogenesis (IAGP)

abnormal splenic cell ratio (IAGP)

abnormal sympathetic ganglion morphology (IAGP)

abnormal T-helper 1 physiology (IAGP)

abnormal T-helper 2 physiology (IAGP)

abnormal thymus cortex morphology (IAGP)

abnormal thymus development (IAGP)

abnormal thymus epithelium morphology (IAGP)

abnormal thymus involution (IAGP)

abnormal thymus medulla morphology (IAGP)

abnormal thymus morphology (IAGP)

abnormal thymus physiology (IAGP)

abnormal uterus morphology (IAGP)

abnormal ventricular thrombosis (IAGP)

abnormal vibrissa morphology (IAGP)

abnormal vitelline vascular remodeling (IAGP)

absent alisphenoid bone (IAGP)

absent eyelids (IAGP)

absent memory B cells (IAGP)

absent orbitosphenoid bone (IAGP)

absent palatine bone (IAGP)

absent plasma cells (IAGP)

absent presphenoid bone (IAGP)

absent sperm fibrous sheath (IAGP)

absent sperm mitochondrial sheath (IAGP)

absent spleen (IEA)

absent temporal bone squamous part (IAGP)

absent vitelline blood vessels (IAGP)

absent zygomatic bone (IAGP)

albuminuria (IAGP)

alopecia (IAGP)

anemia (IAGP)

arrested B cell differentiation (IAGP)

ascites (IAGP)

athymia (IAGP)

azoospermia (IAGP)

blood vessel inflammation (IAGP)

cachexia (IAGP)

cleft secondary palate (IAGP)

congestive heart failure (IAGP)

decreased a-wave amplitude (IAGP)

decreased B cell number (IAGP)

decreased b-wave amplitude (IAGP)

decreased body size (IAGP)

decreased body weight (IAGP)

decreased cardiac muscle contractility (IAGP)

decreased CD4-positive, alpha-beta T cell number (IAGP)

decreased CD8-positive, alpha-beta T cell number (IAGP)

decreased CD8-positive, naive alpha-beta T cell number (IEA)

decreased cell proliferation (IAGP)

decreased circulating progesterone level (IAGP)

decreased DNA replication (IAGP)

decreased embryo size (IAGP)

decreased endometrial gland number (IAGP)

decreased germinal center B cell number (IAGP)

decreased grip strength (IEA)

decreased hair follicle cell proliferation (IAGP)

decreased hair follicle number (IAGP)

decreased heart rate (IAGP)

decreased immature B cell number (IAGP)

decreased immunoglobulin level (IAGP)

decreased kidney collecting duct number (IAGP)

decreased kidney weight (IAGP)

decreased lean body mass (IEA)

decreased leukocyte cell number (IAGP)

decreased locomotor activity (IAGP)

decreased male germ cell number (IAGP)

decreased mature B cell number (IAGP)

decreased neutrophil cell number (IEA)

decreased osteoblast cell number (IAGP)

decreased ovary weight (IAGP)

decreased ovulation rate (IAGP)

decreased palatal shelf size (IAGP)

decreased plasma cell number (IAGP)

decreased pre-B cell number (IAGP)

decreased red blood cell distribution width (IEA)

decreased regulatory T cell number (IAGP)

decreased renal glomerular filtration rate (IAGP)

decreased single-positive T cell number (IEA)

decreased superovulation rate (IAGP)

decreased susceptibility to kidney reperfusion injury (IAGP)

decreased susceptibility to Riboviria infection (IAGP)

decreased T cell number (IAGP)

decreased T cell proliferation (IAGP)

decreased testis weight (IAGP)

decreased thymocyte number (IAGP)

decreased tympanic ring size (IAGP)

decreased urine osmolality (IAGP)

decreased uterus weight (IAGP)

dehydration (IAGP)

delayed endochondral bone ossification (IAGP)

delayed hair appearance (IAGP)

dilated cardiomyopathy (IAGP)

dilated efferent ductule of testis (IAGP)

dilated heart left ventricle (IAGP)

dilated renal glomerular capsule (IAGP)

dilated renal tubule (IAGP)

disorganized myocardium (IAGP)

disorganized retina layers (IAGP)

dry skin (IAGP)

early cellular replicative senescence (IAGP)

ectopic manchette (IAGP)

ectopic Sertoli cells (IAGP)

embryonic growth arrest (IAGP)

embryonic lethality between implantation and somite formation, complete penetrance (IAGP)

embryonic lethality during organogenesis, complete penetrance (IAGP)

embryonic lethality during organogenesis, incomplete penetrance (IAGP)

embryonic lethality prior to organogenesis (IEA)

embryonic lethality prior to tooth bud stage (IEA)

embryonic lethality, complete penetrance (IAGP)

enlarged heart (IAGP)

enlarged lung (IAGP)

enlarged lymph nodes (IAGP)

enlarged spleen (IAGP)

epidermal cyst (IAGP)

epidermal hyperplasia (IAGP)

exophthalmos (IAGP)

extramedullary hematopoiesis (IAGP)

failure of embryo implantation (IAGP)

failure of palatal shelf elevation (IAGP)

female infertility (IAGP)

frontal bossing (IAGP)

giant platelets (IAGP)

hair follicle degeneration (IAGP)

hypergranulosis (IAGP)

impaired hematopoiesis (IAGP)

impaired skeletal muscle regeneration (IAGP)

increased apoptosis (IAGP)

increased B-1 B cell number (IEA)

increased basal cell carcinoma incidence (IAGP)

increased bone marrow cell number (IAGP)

increased carcinoma incidence (IAGP)

increased cardiomyocyte apoptosis (IAGP)

increased cell proliferation (IAGP)

increased central memory CD8 positive, alpha-beta T cell number (IEA)

increased circulating alkaline phosphatase level (IEA)

increased compact bone volume (IAGP)

increased effector memory CD4-positive, alpha-beta T cell number (IEA)

increased effector memory CD8-positive, alpha-beta T cell number (IEA)

increased epididymal epithelium cell proliferation (IAGP)

increased facial tumor incidence (IAGP)

increased fluid intake (IAGP)

increased gamma-delta T cell number (IAGP)

increased hemolymphoid system tumor incidence (IAGP)

increased kidney apoptosis (IAGP)

increased kidney cell proliferation (IAGP)

increased leukemia incidence (IAGP)

increased Leydig cell number (IAGP)

increased male germ cell apoptosis (IAGP)

increased mesenchymal cell proliferation involved in lung development (IAGP)

increased metastatic potential (IAGP)

increased myeloid sarcoma incidence (IAGP)

increased ovarian carcinoma incidence (IAGP)

increased pro-B cell number (IAGP)

increased Sertoli cell proliferation (IAGP)

increased skin squamous cell carcinoma incidence (IAGP)

increased skin tumor incidence (IAGP)

increased susceptibility to Herpesvirales infection (IAGP)

increased susceptibility to induced arthritis (IAGP)

increased susceptibility to Riboviria infection (IAGP)

increased T cell apoptosis (IAGP)

increased urine protein level (IAGP)

intracerebral hemorrhage (IAGP)

isosthenuria (IAGP)

kidney cortex cyst (IAGP)

kinked sperm flagellum (IAGP)

kyphosis (IAGP)

lethality throughout fetal growth and development (IAGP)

lethality throughout fetal growth and development, complete penetrance (IAGP)

liver inflammation (IAGP)

loss of vibrissae (IAGP)

lung cyst (IAGP)

lung inflammation (IAGP)

male infertility (IAGP)

micrognathia (IAGP)

midface hypoplasia (IAGP)

no abnormal phenotype detected (IAGP)

oligodactyly (IAGP)

oligozoospermia (IAGP)

palatal shelves fail to meet at midline (IAGP)

pale kidney (IAGP)

pericardial edema (IAGP)

perinatal lethality, complete penetrance (IAGP)

perinatal lethality, incomplete penetrance (IAGP)

persistent truncus arteriosis (IAGP)

pinhead sperm (IAGP)

polyuria (IAGP)

postnatal growth retardation (IAGP)

postnatal lethality, complete penetrance (IAGP)

postnatal lethality, incomplete penetrance (IAGP)

premature death (IAGP)

preweaning lethality, complete penetrance (IEA)

progressive hair loss (IAGP)

renal interstitial fibrosis (IAGP)

retina degeneration (IAGP)

retina gliosis (IAGP)

retina photoreceptor degeneration (IAGP)

scaly skin (IAGP)

seminiferous tubule degeneration (IAGP)

shallow orbits (IAGP)

short oviduct (IAGP)

short rostral-caudal axis (IAGP)

short uterine horn (IAGP)

small epididymis (IAGP)

small hair follicle bulb (IAGP)

small hair follicles (IAGP)

small liver (IAGP)

small lung lobe (IAGP)

small mandible (IAGP)

small neurocranium (IAGP)

small seminiferous tubules (IAGP)

small sperm head (IAGP)

small testis (IAGP)

small uterus (IAGP)

small vomer bone (IAGP)

spina bifida (IAGP)

teratozoospermia (IAGP)

testis degeneration (IAGP)

thick epidermis (IAGP)

thin myometrium (IAGP)

thin retina outer nuclear layer (IAGP)

thin sperm flagellum (IAGP)

thrombocytopenia (IAGP)

ventricular septal defect (IAGP)

waved hair (IAGP)

weight loss (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Clinicopathological and prognostic significance of the microRNA processing enzyme DICER1 mRNA expression in colorectal cancer patients.	Akahane T, Mol Clin Oncol. 2013 Mar;1(2):267-273. doi: 10.3892/mco.2012.43. Epub 2012 Nov 22.
2.	DICER1 mutations in childhood cystic nephroma and its relationship to DICER1-renal sarcoma.	Doros LA, etal., Mod Pathol. 2014 Sep;27(9):1267-80. doi: 10.1038/modpathol.2013.242. Epub 2014 Jan 31.
3.	DICER1 mutations in familial pleuropulmonary blastoma.	Hill DA, etal., Science. 2009 Aug 21;325(5943):965. doi: 10.1126/science.1174334. Epub 2009 Jun 25.
4.	Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus.	Kalis M, etal., PLoS One. 2011;6(12):e29166. doi: 10.1371/journal.pone.0029166. Epub 2011 Dec 27.
5.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6.	Dietary Lutein Plus Zeaxanthin Intake and DICER1 rs3742330 A > G Polymorphism Relative to Colorectal Cancer Risk.	Kim J, etal., Sci Rep. 2019 Mar 4;9(1):3406. doi: 10.1038/s41598-019-39747-5.
7.	Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.	Ko MS, etal., Development 2000 Apr;127(8):1737-49.
8.	The widespread regulation of microRNA biogenesis, function and decay.	Krol J, etal., Nat Rev Genet. 2010 Sep;11(9):597-610. Epub 2010 Jul 27.
9.	Dicer1 functions as a haploinsufficient tumor suppressor.	Kumar MS, etal., Genes Dev. 2009 Dec 1;23(23):2700-4. doi: 10.1101/gad.1848209. Epub 2009 Nov 10.
10.	Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo.	Lambertz I, etal., Cell Death Differ. 2010 Apr;17(4):633-41. doi: 10.1038/cdd.2009.202. Epub 2009 Dec 18.
11.	MicroRNA-107 contributes to post-stroke angiogenesis by targeting Dicer-1.	Li Y, etal., Sci Rep. 2015 Aug 21;5:13316. doi: 10.1038/srep13316.
12.	Potentially functional genetic variants in microRNA processing genes and risk of HBV-related hepatocellular carcinoma.	Liu L, etal., Mol Carcinog. 2013 Nov;52 Suppl 1:E148-54. doi: 10.1002/mc.22062. Epub 2013 Jul 19.
13.	MGDs mouse GO annotations	MGD data from the GO Consortium
14.	MGD IEA	MGD IEA
15.	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	Okazaki N, etal., DNA Res 2003 Aug 31;10(4):167-80.
16.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
17.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
18.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
19.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
21.	Cell- and developmental stage-specific Dicer1 ablation in the lung epithelium models cystic pleuropulmonary blastoma.	Wagh PK, etal., J Pathol. 2015 May;236(1):41-52. doi: 10.1002/path.4500. Epub 2015 Jan 20.
22.	Gonadotrope-specific deletion of Dicer results in severely suppressed gonadotropins and fertility defects.	Wang H, etal., J Biol Chem. 2015 Jan 30;290(5):2699-714. doi: 10.1074/jbc.M114.621565. Epub 2014 Dec 18.
23.	Downregulated expression of Dicer1 predicts inferior survival in primary gastrointestinal diffuse large B-cell lymphoma treated with CHOP-like regimen and rituximab.	Zhao H, etal., Med Oncol. 2014 Oct;31(10):206. doi: 10.1007/s12032-014-0206-2. Epub 2014 Sep 7.
24.	Decreased expression of DICER1 in gastric cancer.	Zheng ZH, etal., Chin Med J (Engl). 2007 Dec 5;120(23):2099-104.

Additional References at PubMed

PMID:8889548	PMID:10349636	PMID:10512203	PMID:10922068	PMID:11042159	PMID:11076861	PMID:11889553	PMID:12477932	PMID:12520002	PMID:12526743	PMID:14528307	PMID:14610273
PMID:14681479	PMID:15033168	PMID:15081373	PMID:15576842	PMID:15613470	PMID:15713842	PMID:15840001	PMID:15867090	PMID:16009718	PMID:16036130	PMID:16040801	PMID:16092937
PMID:16099834	PMID:16141072	PMID:16141073	PMID:16182285	PMID:16319892	PMID:16397794	PMID:16452165	PMID:16462742	PMID:16575173	PMID:16682203	PMID:16938833	PMID:17060477
PMID:17113034	PMID:17135486	PMID:17369397	PMID:17369401	PMID:17397913	PMID:17401365	PMID:17452327	PMID:17606634	PMID:17613256	PMID:17679093	PMID:17761882	PMID:17804764
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PMID:34847178	PMID:35045290	PMID:35067718	PMID:35165388	PMID:35240143	PMID:35490865	PMID:35533808	PMID:35784484	PMID:35921818	PMID:35945211	PMID:36601302

Genomics

Comparative Map Data

Dicer1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	104,654,001 - 104,718,331 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	104,654,001 - 104,718,211 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	104,687,740 - 104,751,968 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	104,687,742 - 104,751,952 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	105,925,952 - 105,990,162 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	105,092,486 - 105,153,002 (-)	NCBI		MGSCv36	mm8
Celera	12	105,918,245 - 105,982,441 (-)	NCBI		Celera
Cytogenetic Map	12	E	NCBI
cM Map	12	54.83	NCBI

DICER1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	95,086,228 - 95,158,010 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	14	95,086,228 - 95,158,010 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	95,552,565 - 95,624,347 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	94,622,319 - 94,693,512 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	94,622,318 - 94,693,512	NCBI
Celera	14	75,608,684 - 75,679,876 (-)	NCBI		Celera
Cytogenetic Map	14	q32.13	NCBI
HuRef	14	75,736,521 - 75,807,615 (-)	NCBI		HuRef
CHM1_1	14	95,490,915 - 95,561,989 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	89,316,445 - 89,388,228 (-)	NCBI		T2T-CHM13v2.0

Dicer1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	123,627,529 - 123,692,278 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	123,631,250 - 123,693,965 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	6	128,388,084 - 128,453,234 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	128,388,053 - 128,434,183 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	137,586,335 - 137,633,706 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	128,777,468 - 128,838,780 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	128,781,378 - 128,842,495 (-)	NCBI
Celera	6	121,106,680 - 121,167,957 (-)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

Dicer1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955438	17,382,493 - 17,431,797 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955438	17,374,899 - 17,431,599 (+)	NCBI	ChiLan1.0	ChiLan1.0

DICER1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	14	95,451,254 - 95,523,012 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	75,709,029 - 75,780,779 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	95,036,385 - 95,107,940 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	95,036,385 - 95,107,940 (-)	Ensembl	panpan1.1		panPan2

DICER1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	63,970,245 - 64,029,438 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	63,972,027 - 64,019,879 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	63,546,706 - 63,619,316 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	64,236,992 - 64,309,618 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	64,238,043 - 64,309,589 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	63,912,041 - 63,984,637 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	63,970,646 - 64,043,228 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	64,295,524 - 64,368,151 (-)	NCBI		UU_Cfam_GSD_1.0

Dicer1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	10,443,874 - 10,504,962 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936846	532,972 - 575,689 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936846	528,768 - 584,599 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DICER1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	116,365,802 - 116,411,224 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	116,361,630 - 116,436,471 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	123,581,725 - 123,652,553 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DICER1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	72,915,550 - 72,986,658 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	72,915,499 - 72,963,006 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	60,107,379 - 60,178,341 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dicer1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	7,608,273 - 7,651,819 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	7,604,049 - 7,681,481 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dicer1
1994 total Variants

miRNA Target Status

Confirmed Target Of

miRNA Gene	Mature miRNA	Method Name	Result Type	Data Type	Support Type	PMID
Mirlet7a-1	mmu-let-7a-5p	OncomiRDB	external_info	NA	NA	18700235
Mir130b	mmu-miR-130b-3p	OncomiRDB	external_info	NA	NA	23392577
Mirlet7f-2	mmu-let-7f-5p	OncomiRDB	external_info	NA	NA	18700235
Mir222	mmu-miR-222-3p	OncomiRDB	external_info	NA	NA	21761362
Mirlet7c-2	mmu-let-7c-5p	OncomiRDB	external_info	NA	NA	18700235
Mirlet7a-2	mmu-let-7a-5p	OncomiRDB	external_info	NA	NA	18700235
Mir18	mmu-miR-18a-5p	OncomiRDB	external_info	NA	NA	23097559
Mir18	mmu-miR-18a-5p	OncomiRDB	external_info	NA	NA	21935572
Mirlet7g	mmu-let-7g-5p	OncomiRDB	external_info	NA	NA	18700235
Mir107	mmu-miR-107-3p	OncomiRDB	external_info	NA	NA	21029372
Mir107	mmu-miR-107-3p	OncomiRDB	external_info	NA	NA	20603000
Mir221	mmu-miR-221-3p	OncomiRDB	external_info	NA	NA	21761362
Mirlet7b	mmu-let-7b-5p	OncomiRDB	external_info	NA	NA	18700235
Mir9-3	mmu-miR-9-5p	OncomiRDB	external_info	NA	NA	22310293
Mirlet7d	mmu-let-7d-5p	OncomiRDB	external_info	NA	NA	18700235
Mir29a	mmu-miR-29a-3p	OncomiRDB	external_info	NA	NA	21761362
Mirlet7i	mmu-let-7i-5p	OncomiRDB	external_info	NA	NA	18700235
Mirlet7e	mmu-let-7e-5p	OncomiRDB	external_info	NA	NA	18700235
Mirlet7c-1	mmu-let-7c-5p	OncomiRDB	external_info	NA	NA	18700235

Predicted Target Of

	Summary Value
Count of predictions:	1206
Count of miRNA genes:	663
Interacting mature miRNAs:	810
Transcripts:	ENSMUST00000041987
Prediction methods:	Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4142002	Tbqt3_m	tibia bone quality traits 3 (mouse)			Not determined		12	35285496	109936243	Mouse
27226793	Feml10_m	femur length 10, 5 week (mouse)					12	68346774	113363620	Mouse
4141738	Tgq23_m	triglyceride QTL 23 (mouse)			Not determined			72112877	106112877	Mouse
1301926	Adip6_m	adiposity 6 (mouse)			Not determined		12	73887422	107887526	Mouse
1301689	Skull18_m	skull morphology 18 (mouse)			Not determined		12	73887422	107887526	Mouse
13524842	Ppiq10a_m	prepulse inhibition QTL 10a (mouse)					12	77512220	111512220	Mouse
4141610	Tailaq1_m	tail length adjusted QTL 1 (mouse)			Not determined			80956708	113383533	Mouse
4142401	Egq10_m	early growth QTL 10 (mouse)			Not determined			80956708	113383533	Mouse
4141335	W6q10_m	weight 6 weeks QTL 10 (mouse)			Not determined			80956708	113383533	Mouse
39128213	Lwq23_m	liver weight QTL 10 (mouse)					12	80956708	113383533	Mouse
13524849	Ppiq11a_m	prepulse inhibition QTL 11a (mouse)					12	80989143	114989143	Mouse
25823169	Hrsq8_m	host response to SARS QTL 8, log titer (mouse)					12	81696245	108495368	Mouse
13524846	Ppiq11_m	prepulse inhibition QTL 11 (mouse)					12	82666396	116666396	Mouse
1301492	Dbsty3_m	diabesity 3 (mouse)			Not determined		12	83532075	117532224	Mouse
1301879	Insq10_m	insulin QTL 10 (mouse)			Not determined		12	83532075	117532224	Mouse
1300883	Ath21_m	atherosclerosis 21 (mouse)			Not determined		12	85961579	119961683	Mouse
10412156	Nociq3_m	nociceptive sensitivity inflammatory QTL 3 (mouse)			Not determined		12	86396075	114831653	Mouse
4142007	Chlq17_m	circulating hormone level QTL 17 (mouse)			Not determined		12	88052874	120092757	Mouse
1300545	Lifespan3_m	life span 3 (mouse)			Not determined		12	88052874	120092757	Mouse
1301308	Prdt4_m	prion disease incubation time 4 (mouse)			Not determined		12	88308354	120092757	Mouse
5491194	Mobq3_m	multigenic obesity QTL 3 (mouse)			Not determined		12	89664071	120092757	Mouse
1301836	Heal5_m	wound healing/regeneration 5 (mouse)			Not determined		12	89939031	120092757	Mouse
1301922	Bbaa6_m	B.burgdorferi-associated arthritis 6 (mouse)			Not determined		12	90308268	120092757	Mouse
12910790	Pwgrq7_m	pre-weaning growth rate QTL 7 (mouse)					12	90937367	108645308	Mouse
10402491	Dipa4_m	drug induced psychomotor activation 4 (mouse)			Not determined		12	91222515	120092757	Mouse
10412192	Bbaa27_m	B.burgdorferi-associated arthritis 27 (mouse)			Not determined		12	91254220	107308393	Mouse
12910532	Nrq10a_m	noise-induced hearing loss resistant QTL 10a (mouse)					12	92750025	120092757	Mouse
12910533	Nrq10_m	noise-induced hearing loss resistant QTL 10 (mouse)					12	92750025	120092757	Mouse
1357463	Vtbt14_m	vertebral trabecular bone trait 14 (mouse)			Not determined		12	92936097	120092757	Mouse
1300973	Abmm_m	antibody mediated myocarditis (mouse)			Not determined		12	93264461	120092757	Mouse
11039526	Ccc1_m	colitis susceptibility in the Collaborative Cross 1 (mouse)					12	93528334	111028223	Mouse
1302177	Dps2_m	delta power in slow-wave sleep 2 (mouse)			Not determined		12	94146064	120092757	Mouse
1302138	Im6_m	immunoregulatory 6 (mouse)			Not determined		12	96860337	120092757	Mouse
1301269	Sluc12_m	susceptibility to lung cancer 12 (mouse)			Not determined		12	96860337	120092757	Mouse
10412075	Nils1_m	neointima lesion size 1 (mouse)			Not determined		12	102024665	120092757	Mouse
25394546	Skmw76_m	skeletal muscle weight 76, TA (mouse)					12	102593095	106941888	Mouse

Markers in Region

Dicer1

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	12	104,691,475 - 104,691,575	UniSTS	GRCm38
MGSCv37	12	105,929,685 - 105,929,785	UniSTS	GRCm37
Celera	12	105,921,978 - 105,922,078	UniSTS
Cytogenetic Map	12	E-F1	UniSTS
cM Map	12		UniSTS

C76324

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	12	104,687,916 - 104,688,026	UniSTS	GRCm38
MGSCv37	12	105,926,126 - 105,926,236	UniSTS	GRCm37
Celera	12	105,918,419 - 105,918,529	UniSTS
Cytogenetic Map	12	E-F1	UniSTS
Whitehead/MRC_RH	12	959.48	UniSTS

RH125953

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	12	104,687,744 - 104,687,971	UniSTS	GRCm38
MGSCv37	12	105,925,954 - 105,926,181	UniSTS	GRCm37
Celera	12	105,918,247 - 105,918,474	UniSTS
Cytogenetic Map	12	E-F1	UniSTS
cM Map	12	51.0	UniSTS
Whitehead/MRC_RH	12	1003.2	UniSTS

Dicer1

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	12	E-F1	UniSTS

Dicer1

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	12	E-F1	UniSTS

Dicer1

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	12	104,731,076 - 104,731,916	UniSTS	GRCm38
MGSCv37	12	105,969,286 - 105,970,126	UniSTS	GRCm37
Celera	12	105,961,564 - 105,962,404	UniSTS
Cytogenetic Map	12	E-F1	UniSTS

Dicer1

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	12	E-F1	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001411829	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_148948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB081470	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC124364	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF430845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF484523	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF484524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK003494	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK033198	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK035253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK129241	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK137929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC019805	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC023863	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC029665	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061198	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC100374	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466549	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	MZ209414	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000041987 ⟹ ENSMUSP00000043676

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	12	104,654,001 - 104,718,211 (-)	Ensembl
GRCm38.p6 Ensembl	12	104,687,742 - 104,751,952 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000221293

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	12	104,688,016 - 104,696,423 (-)	Ensembl
GRCm38.p6 Ensembl	12	104,721,757 - 104,730,164 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000222002 ⟹ ENSMUSP00000152413

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	12	104,688,343 - 104,705,096 (-)	Ensembl
GRCm38.p6 Ensembl	12	104,722,084 - 104,738,837 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000222115

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	12	104,657,702 - 104,666,761 (-)	Ensembl
GRCm38.p6 Ensembl	12	104,691,443 - 104,700,502 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000222519

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	12	104,663,605 - 104,666,761 (-)	Ensembl
GRCm38.p6 Ensembl	12	104,697,346 - 104,700,502 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000222528

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	12	104,657,687 - 104,688,311 (-)	Ensembl
GRCm38.p6 Ensembl	12	104,691,428 - 104,722,052 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00020183808

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	12	104,673,145 - 104,679,287 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00020183809 ⟹ ENSMUSP00001091668

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	12	104,697,413 - 104,718,169 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00020183813

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	12	104,657,492 - 104,660,825 (-)	Ensembl

RefSeq Acc Id:

NM_001411829 ⟹ NP_001398758

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	12	104,654,001 - 104,718,331 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001398758	(Get FASTA)	NCBI Sequence Viewer
	NP_683750	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH19805	(Get FASTA)	NCBI Sequence Viewer
	AAH61198	(Get FASTA)	NCBI Sequence Viewer
	AAL84637	(Get FASTA)	NCBI Sequence Viewer
	AAL84638	(Get FASTA)	NCBI Sequence Viewer
	AAM21495	(Get FASTA)	NCBI Sequence Viewer
	BAC15765	(Get FASTA)	NCBI Sequence Viewer
	BAC29002	(Get FASTA)	NCBI Sequence Viewer
	BAC98051	(Get FASTA)	NCBI Sequence Viewer
	BAE23515	(Get FASTA)	NCBI Sequence Viewer
	EDL18787	(Get FASTA)	NCBI Sequence Viewer
	EDL18788	(Get FASTA)	NCBI Sequence Viewer
	Q8R418	(Get FASTA)	NCBI Sequence Viewer
	QXP50135	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

ENSMUSP00000152413 ⟸ ENSMUST00000222002

RefSeq Acc Id:

ENSMUSP00000043676 ⟸ ENSMUST00000041987

RefSeq Acc Id:

ENSMUSP00001091668 ⟸ ENSMUST00020183809

RefSeq Acc Id:	NP_001398758 ⟸ NM_001411829
- Peptide Label:	isoform 1

Protein Domains

Dicer dsRNA-binding fold DRBM Helicase ATP-binding Helicase C-terminal PAZ RNase III

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8R418-F1-model_v2	AlphaFold	Q8R418	1-1916	view protein structure

Promoters

RGD ID:

8679146

Promoter ID:

EPDNEW_M17604

Type:

initiation region

Name:

Dicer1_1

Description:

Mus musculus dicer 1, ribonuclease type III , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	12	104,752,045 - 104,752,105	EPDNEW

RGD ID:

6822845

Promoter ID:

MM_KWN:12613

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Kidney

Transcripts:

UC007OXK.1

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	12	105,967,726 - 105,968,226 (-)	MPROMDB

RGD ID:

6822862

Promoter ID:

MM_KWN:12615

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

AK134511_6230426M11RIK, NM_148948

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	12	105,989,351 - 105,990,557 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2177178	AgrOrtholog
Ensembl Genes	ENSMUSG00000041415	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000043676	ENTREZGENE
	ENSMUSP00000043676.8	UniProtKB/TrEMBL
	ENSMUSP00000152413.3	UniProtKB/TrEMBL
	ENSMUSP00001091668.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000041987	ENTREZGENE
	ENSMUST00000041987.8	UniProtKB/TrEMBL
	ENSMUST00000222002.3	UniProtKB/TrEMBL
	ENSMUST00020183809.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1520.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.160.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.160.380	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	paz domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Dicer_dimer_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dicer_dimerisation_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DICER_DSRM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	dsRBD_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Helicase/UvrB_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Helicase_ATP-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Helicase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAZ_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAZ_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RNase_III	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RNase_III_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RNase_III_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:2177178	ENTREZGENE
NCBI Gene	192119	ENTREZGENE
PANTHER	ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I	UniProtKB/TrEMBL
	DICER-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENDORIBONUCLEASE DICER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HELICASE WITH DEATH DOMAIN-RELATED	UniProtKB/TrEMBL
Pfam	Dicer_dimer	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Helicase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAZ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ResIII	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ribonuclease_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Dicer1	PhenoGen
PROSITE	DICER_DSRBF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DS_RBD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HELICASE_ATP_BIND_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HELICASE_CTER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAZ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RNASE_3_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RNASE_3_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	DEXDc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DSRM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HELICc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PAZ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RIBOc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	dsRNA-binding domain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF101690	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF69065	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A1Y7VJD6_MOUSE	UniProtKB/TrEMBL
	A0A8F5XVB9_MOUSE	UniProtKB/TrEMBL
	A0A8I4YZW9_MOUSE	UniProtKB/TrEMBL
	DICER_MOUSE	UniProtKB/Swiss-Prot
	F8VQ54	ENTREZGENE, UniProtKB/TrEMBL
	Q05CY3_MOUSE	UniProtKB/TrEMBL
	Q3UUV8_MOUSE	UniProtKB/TrEMBL
	Q6P8L5_MOUSE	UniProtKB/TrEMBL
	Q6ZQ23_MOUSE	UniProtKB/TrEMBL
	Q8CBU8_MOUSE	UniProtKB/TrEMBL
	Q8R418	ENTREZGENE
UniProt Secondary	Q8R419	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-05-22	Dicer1	dicer 1, ribonuclease type III	Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - OMIM

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