Dicer1 (dicer 1, ribonuclease type III) - Rat Genome Database

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Gene: Dicer1 (dicer 1, ribonuclease type III) Mus musculus
Symbol: Dicer1
Name: dicer 1, ribonuclease type III
RGD ID: 1319700
Description: Enables miRNA binding activity. Involved in several processes, including nervous system development; regulation of gene expression; and regulation of nervous system development. Acts upstream of or within several processes, including circulatory system development; nervous system development; and regulation of gene expression. Located in cytoplasm. Part of RISC complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study DiGeorge syndrome; dilated cardiomyopathy; and ovarian cancer. Human ortholog(s) of this gene implicated in DICER1 syndrome; gastrointestinal system cancer (multiple); multinodular goiter; nephroma; and pleuropulmonary blastoma. Orthologous to human DICER1 (dicer 1, ribonuclease III).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110006F08Rik; aviD; D12Ertd7; D12Ertd7e; Dice; Dicer1, Dcr-1 homolog; double-strand-specific ribonuclease mDCR-1; endoribonuclease Dicer; mKIAA0928
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3912104,654,001 - 104,718,331 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12104,654,001 - 104,718,211 (-)EnsemblGRCm39 Ensembl
GRCm3812104,687,740 - 104,751,968 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12104,687,742 - 104,751,952 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712105,925,952 - 105,990,162 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612105,092,486 - 105,153,002 (-)NCBIMGSCv36mm8
Celera12105,918,245 - 105,982,441 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1254.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-D  (EXP)
2,5-hexanedione  (EXP)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
aflatoxin B1  (EXP,ISO)
amphetamine  (ISO)
amphotericin B  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
butyric acid  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calyculin a  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
chrysene  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (ISO)
glucaric acid  (EXP)
GSK343  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
nickel dichloride  (ISO)
nicotinamide  (EXP)
oxaliplatin  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sucrose  (EXP)
sunitinib  (ISO)
thiram  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
tungsten  (EXP)
tunicamycin  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IMP)
apoptotic DNA fragmentation  (IBA)
branching morphogenesis of an epithelial tube  (IMP)
cardiac muscle cell development  (IMP)
cardiac neural crest cell development involved in outflow tract morphogenesis  (IMP)
cartilage development  (IMP)
cell population proliferation  (IMP)
cellular response to glucose stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to tumor necrosis factor  (ISO)
cerebral cortex development  (IMP)
defense response to virus  (IMP)
digestive tract development  (IMP)
embryonic hindlimb morphogenesis  (IMP)
embryonic limb morphogenesis  (IMP)
epidermis morphogenesis  (IMP)
ganglion development  (IMP)
gene expression  (IMP)
global gene silencing by mRNA cleavage  (ISO)
hair follicle cell proliferation  (IMP)
hair follicle development  (IMP)
hair follicle morphogenesis  (IMP)
inner ear receptor cell development  (IMP)
intestinal epithelial cell development  (IGI)
lung development  (IMP)
meiotic spindle organization  (IMP)
miRNA processing  (IMP,ISO)
mRNA stabilization  (IMP)
multicellular organism growth  (IMP)
myoblast differentiation involved in skeletal muscle regeneration  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of glial cell proliferation  (IMP)
negative regulation of Schwann cell proliferation  (IMP)
negative regulation of transcription by RNA polymerase II  (IMP)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
nerve development  (IMP)
neuron projection morphogenesis  (IMP)
olfactory bulb interneuron differentiation  (IMP)
pericentric heterochromatin formation  (IMP)
peripheral nervous system myelin formation  (IMP)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell-matrix adhesion via fibronectin  (ISO)
positive regulation of establishment of endothelial barrier  (ISO)
positive regulation of gene expression  (IMP)
positive regulation of hepatic stellate cell proliferation  (ISO)
positive regulation of miRNA metabolic process  (IMP)
positive regulation of myelination  (IMP)
positive regulation of Schwann cell differentiation  (IMP)
positive regulation of transcription by RNA polymerase II  (IMP)
positive regulation of vascular endothelial cell proliferation  (ISO)
post-embryonic development  (IMP)
pre-miRNA processing  (IBA,IDA,ISO)
regulation of cell cycle  (IMP)
regulation of enamel mineralization  (IMP)
regulation of epithelial cell differentiation  (IMP)
regulation of gene expression  (IMP)
regulation of inflammatory response  (IMP)
regulation of miRNA metabolic process  (IMP)
regulation of muscle cell apoptotic process  (IMP)
regulation of myelination  (IMP)
regulation of neurogenesis  (IMP)
regulation of neuron differentiation  (IMP)
regulation of Notch signaling pathway  (IC)
regulation of odontogenesis of dentin-containing tooth  (IMP)
regulation of oligodendrocyte differentiation  (IMP)
regulation of protein phosphorylation  (IMP)
regulation of regulatory T cell differentiation  (IMP)
regulation of RNA metabolic process  (IMP)
regulation of stem cell differentiation  (IMP)
regulation of viral genome replication  (IMP)
regulatory ncRNA-mediated gene silencing  (IEA)
regulatory ncRNA-mediated post-transcriptional gene silencing  (IMP)
reproductive structure development  (IMP)
RISC complex assembly  (ISO)
RNA processing  (IDA,IMP)
rRNA processing  (IEA)
siRNA processing  (IBA,IDA,IMP,ISO)
spermatogonial cell division  (IMP)
spinal cord motor neuron differentiation  (IMP)
spindle assembly  (IMP)
spleen development  (IMP)
stem cell population maintenance  (IMP)
trophectodermal cell proliferation  (IMP)
zygote asymmetric cell division  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal acrosome morphology  (IAGP)
abnormal angiogenesis  (IAGP)
abnormal aortic arch development  (IAGP)
abnormal atrial thrombosis  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal basicranium morphology  (IAGP)
abnormal basisphenoid bone morphology  (IAGP)
abnormal behavior  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal bone structure  (IAGP)
abnormal branching involved in lung morphogenesis  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal CD4-positive, alpha-beta T cell physiology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal coat/ hair morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cytotoxic T cell physiology  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal effector T cell morphology  (IAGP)
abnormal efferent ductules of testis morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal epididymis epithelium morphology  (IAGP)
abnormal epididymis morphology  (IAGP)
abnormal female meiosis  (IAGP)
abnormal first pharyngeal arch morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal frontal bone morphology  (IAGP)
abnormal germinal center B cell physiology  (IAGP)
abnormal Golgi apparatus morphology  (IAGP)
abnormal granulocyte differentiation  (IAGP)
abnormal hair cycle  (IAGP)
abnormal hair cycle catagen phase  (IAGP)
abnormal hair follicle bulge morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle inner root sheath morphology  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair follicle orientation  (IAGP)
abnormal hair follicle regression  (IAGP)
abnormal hair growth  (IAGP)
abnormal hair shaft morphology  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal immunoglobulin V(D)J recombination  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal limb development  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal lung epithelium morphology  (IAGP)
abnormal lung-associated mesenchyme development  (IAGP)
abnormal lymph node cell ratio  (IAGP)
abnormal male germ cell morphology  (IAGP)
abnormal manchette morphology  (IAGP)
abnormal maxillary frontal process morphology  (IAGP)
abnormal megakaryocyte differentiation  (IAGP)
abnormal megakaryocyte morphology  (IAGP)
abnormal meiotic spindle morphology  (IAGP)
abnormal mitosis  (IAGP)
abnormal myeloid leukocyte morphology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal neutrophil morphology  (IAGP)
abnormal oocyte morphology  (IAGP)
abnormal oviduct morphology  (IAGP)
abnormal oviduct transport  (IAGP)
abnormal palatal shelf bone ossification  (IAGP)
abnormal palatal shelf morphology  (IAGP)
abnormal positive T cell selection  (IAGP)
abnormal pregnancy  (IAGP)
abnormal regulatory T cell morphology  (IAGP)
abnormal regulatory T cell physiology  (IAGP)
abnormal renal corpuscle morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal tubule epithelial cell primary cilium morphology  (IAGP)
abnormal retina layer morphology  (IAGP)
abnormal retina morphology  (IEA)
abnormal retina photoreceptor morphology  (IAGP)
abnormal sarcomere morphology  (IAGP)
abnormal secondary palate development  (IAGP)
abnormal seminiferous tubule epithelium morphology  (IAGP)
abnormal Sertoli cell morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skin appearance  (IAGP)
abnormal skin physiology  (IAGP)
abnormal sperm flagellum morphology  (IAGP)
abnormal sperm head morphology  (IAGP)
abnormal sperm midpiece morphology  (IAGP)
abnormal sperm mitochondrial sheath morphology  (IAGP)
abnormal sperm nucleus morphology  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal spermiogenesis  (IAGP)
abnormal spindle assembly in female meiosis  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal sympathetic ganglion morphology  (IAGP)
abnormal T-helper 1 physiology  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
abnormal thymus cortex morphology  (IAGP)
abnormal thymus development  (IAGP)
abnormal thymus epithelium morphology  (IAGP)
abnormal thymus involution  (IAGP)
abnormal thymus medulla morphology  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal thymus physiology  (IAGP)
abnormal uterus morphology  (IAGP)
abnormal ventricular thrombosis  (IAGP)
abnormal vibrissa morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
absent alisphenoid bone  (IAGP)
absent eyelids  (IAGP)
absent memory B cells  (IAGP)
absent orbitosphenoid bone  (IAGP)
absent palatine bone  (IAGP)
absent plasma cells  (IAGP)
absent presphenoid bone  (IAGP)
absent sperm fibrous sheath  (IAGP)
absent sperm mitochondrial sheath  (IAGP)
absent spleen  (IEA)
absent temporal bone squamous part  (IAGP)
absent vitelline blood vessels  (IAGP)
absent zygomatic bone  (IAGP)
albuminuria  (IAGP)
alopecia  (IAGP)
anemia  (IAGP)
arrested B cell differentiation  (IAGP)
ascites  (IAGP)
athymia  (IAGP)
azoospermia  (IAGP)
blood vessel inflammation  (IAGP)
cachexia  (IAGP)
cleft secondary palate  (IAGP)
congestive heart failure  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased B cell number  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased cell proliferation  (IAGP)
decreased circulating progesterone level  (IAGP)
decreased DNA replication  (IAGP)
decreased embryo size  (IAGP)
decreased endometrial gland number  (IAGP)
decreased germinal center B cell number  (IAGP)
decreased grip strength  (IEA)
decreased hair follicle cell proliferation  (IAGP)
decreased hair follicle number  (IAGP)
decreased heart rate  (IAGP)
decreased heart ventricle muscle contractility  (IAGP)
decreased immature B cell number  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased kidney collecting duct number  (IAGP)
decreased kidney weight  (IAGP)
decreased lean body mass  (IEA)
decreased leukocyte cell number  (IAGP)
decreased locomotor activity  (IAGP)
decreased male germ cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased neutrophil cell number  (IEA)
decreased osteoblast cell number  (IAGP)
decreased ovary weight  (IAGP)
decreased ovulation rate  (IAGP)
decreased palatal shelf size  (IAGP)
decreased plasma cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased red blood cell distribution width  (IEA)
decreased regulatory T cell number  (IAGP)
decreased renal glomerular filtration rate  (IAGP)
decreased single-positive T cell number  (IEA)
decreased superovulation rate  (IAGP)
decreased susceptibility to kidney reperfusion injury  (IAGP)
decreased susceptibility to Riboviria infection  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
decreased testis weight  (IAGP)
decreased thymocyte number  (IAGP)
decreased tumor-free survival time  (IAGP)
decreased tympanic ring size  (IAGP)
decreased urine osmolality  (IAGP)
decreased uterus weight  (IAGP)
dehydration  (IAGP)
delayed endochondral bone ossification  (IAGP)
delayed hair appearance  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated efferent ductule of testis  (IAGP)
dilated heart left ventricle  (IAGP)
dilated renal glomerular capsule  (IAGP)
dilated renal tubule  (IAGP)
disorganized myocardium  (IAGP)
disorganized retina layers  (IAGP)
double outlet right ventricle  (IAGP)
dry skin  (IAGP)
early cellular replicative senescence  (IAGP)
ectopic manchette  (IAGP)
ectopic Sertoli cells  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality prior to organogenesis  (IEA)
embryonic lethality prior to tooth bud stage  (IEA)
embryonic lethality, complete penetrance  (IAGP)
enlarged heart  (IAGP)
enlarged lung  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
epidermal cyst  (IAGP)
epidermal hyperplasia  (IAGP)
exophthalmos  (IAGP)
extramedullary hematopoiesis  (IAGP)
failure of embryo implantation  (IAGP)
failure of palatal shelf elevation  (IAGP)
female infertility  (IAGP)
fetal cardiomyocyte disarray  (IAGP)
forelimb oligodactyly  (IAGP)
frontal bossing  (IAGP)
giant platelets  (IAGP)
hair follicle degeneration  (IAGP)
hypergranulosis  (IAGP)
impaired hematopoiesis  (IAGP)
impaired skeletal muscle regeneration  (IAGP)
increased apoptosis  (IAGP)
increased B-1 B cell number  (IEA)
increased basal cell carcinoma incidence  (IAGP)
increased bone marrow cell number  (IAGP)
increased carcinoma incidence  (IAGP)
increased cardiomyocyte apoptosis  (IAGP)
increased cell proliferation  (IAGP)
increased central memory CD8 positive, alpha-beta T cell number  (IEA)
increased circulating alkaline phosphatase level  (IEA)
increased compact bone volume  (IAGP)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased effector memory CD8-positive, alpha-beta T cell number  (IEA)
increased epididymal epithelium cell proliferation  (IAGP)
increased facial tumor incidence  (IAGP)
increased fluid intake  (IAGP)
increased gamma-delta T cell number  (IAGP)
increased hemolymphoid system tumor incidence  (IAGP)
increased kidney apoptosis  (IAGP)
increased kidney cell proliferation  (IAGP)
increased leukemia incidence  (IAGP)
increased Leydig cell number  (IAGP)
increased male germ cell apoptosis  (IAGP)
increased mesenchymal cell proliferation involved in lung development  (IAGP)
increased metastatic potential  (IAGP)
increased myeloid sarcoma incidence  (IAGP)
increased ovarian carcinoma incidence  (IAGP)
increased pro-B cell number  (IAGP)
increased Sertoli cell proliferation  (IAGP)
increased skin squamous cell carcinoma incidence  (IAGP)
increased skin tumor incidence  (IAGP)
increased susceptibility to age-related retinal degeneration  (IAGP)
increased susceptibility to Herpesvirales infection  (IAGP)
increased susceptibility to induced arthritis  (IAGP)
increased susceptibility to Riboviria infection  (IAGP)
increased T cell apoptosis  (IAGP)
increased urine protein level  (IAGP)
intracerebral hemorrhage  (IAGP)
isosthenuria  (IAGP)
kidney cortex cyst  (IAGP)
kinked sperm flagellum  (IAGP)
kyphosis  (IAGP)
lethality throughout fetal growth and development  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
liver inflammation  (IAGP)
loss of vibrissae  (IAGP)
lung cyst  (IAGP)
lung inflammation  (IAGP)
male infertility  (IAGP)
micrognathia  (IAGP)
midface hypoplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
oligozoospermia  (IAGP)
palatal shelves fail to meet at midline  (IAGP)
pale kidney  (IAGP)
pericardial edema  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
persistent truncus arteriosus  (IAGP)
pinhead sperm  (IAGP)
polyuria  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
progressive hair loss  (IAGP)
renal interstitial fibrosis  (IAGP)
retina gliosis  (IAGP)
retina photoreceptor degeneration  (IAGP)
scaly skin  (IAGP)
seminiferous tubule degeneration  (IAGP)
shallow orbits  (IAGP)
short oviduct  (IAGP)
short rostral-caudal axis  (IAGP)
short uterine horn  (IAGP)
small epididymis  (IAGP)
small hair follicle bulb  (IAGP)
small hair follicles  (IAGP)
small liver  (IAGP)
small lung lobe  (IAGP)
small mandible  (IAGP)
small neurocranium  (IAGP)
small seminiferous tubules  (IAGP)
small sperm head  (IAGP)
small testis  (IAGP)
small uterus  (IAGP)
small vomer bone  (IAGP)
spina bifida  (IAGP)
teratozoospermia  (IAGP)
testis degeneration  (IAGP)
thick epidermis  (IAGP)
thin myometrium  (IAGP)
thin retina outer nuclear layer  (IAGP)
thin sperm flagellum  (IAGP)
thin ventricle myocardium compact layer  (IAGP)
thrombocytopenia  (IAGP)
ventricular septal defect  (IAGP)
waved hair  (IAGP)
weight loss  (IAGP)

References - curated
# Reference Title Reference Citation
1. Clinicopathological and prognostic significance of the microRNA processing enzyme DICER1 mRNA expression in colorectal cancer patients. Akahane T, Mol Clin Oncol. 2013 Mar;1(2):267-273. doi: 10.3892/mco.2012.43. Epub 2012 Nov 22.
2. DICER1 mutations in childhood cystic nephroma and its relationship to DICER1-renal sarcoma. Doros LA, etal., Mod Pathol. 2014 Sep;27(9):1267-80. doi: 10.1038/modpathol.2013.242. Epub 2014 Jan 31.
3. DICER1 mutations in familial pleuropulmonary blastoma. Hill DA, etal., Science. 2009 Aug 21;325(5943):965. doi: 10.1126/science.1174334. Epub 2009 Jun 25.
4. Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus. Kalis M, etal., PLoS One. 2011;6(12):e29166. doi: 10.1371/journal.pone.0029166. Epub 2011 Dec 27.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Dietary Lutein Plus Zeaxanthin Intake and DICER1 rs3742330 A > G Polymorphism Relative to Colorectal Cancer Risk. Kim J, etal., Sci Rep. 2019 Mar 4;9(1):3406. doi: 10.1038/s41598-019-39747-5.
7. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
8. The widespread regulation of microRNA biogenesis, function and decay. Krol J, etal., Nat Rev Genet. 2010 Sep;11(9):597-610. Epub 2010 Jul 27.
9. Dicer1 functions as a haploinsufficient tumor suppressor. Kumar MS, etal., Genes Dev. 2009 Dec 1;23(23):2700-4. doi: 10.1101/gad.1848209. Epub 2009 Nov 10.
10. Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo. Lambertz I, etal., Cell Death Differ. 2010 Apr;17(4):633-41. doi: 10.1038/cdd.2009.202. Epub 2009 Dec 18.
11. MicroRNA-107 contributes to post-stroke angiogenesis by targeting Dicer-1. Li Y, etal., Sci Rep. 2015 Aug 21;5:13316. doi: 10.1038/srep13316.
12. Potentially functional genetic variants in microRNA processing genes and risk of HBV-related hepatocellular carcinoma. Liu L, etal., Mol Carcinog. 2013 Nov;52 Suppl 1:E148-54. doi: 10.1002/mc.22062. Epub 2013 Jul 19.
13. MGDs mouse GO annotations MGD data from the GO Consortium
15. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, etal., DNA Res 2003 Aug 31;10(4):167-80.
16. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Mouse MP Annotation Import Pipeline RGD automated import pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Cell- and developmental stage-specific Dicer1 ablation in the lung epithelium models cystic pleuropulmonary blastoma. Wagh PK, etal., J Pathol. 2015 May;236(1):41-52. doi: 10.1002/path.4500. Epub 2015 Jan 20.
22. Gonadotrope-specific deletion of Dicer results in severely suppressed gonadotropins and fertility defects. Wang H, etal., J Biol Chem. 2015 Jan 30;290(5):2699-714. doi: 10.1074/jbc.M114.621565. Epub 2014 Dec 18.
23. Downregulated expression of Dicer1 predicts inferior survival in primary gastrointestinal diffuse large B-cell lymphoma treated with CHOP-like regimen and rituximab. Zhao H, etal., Med Oncol. 2014 Oct;31(10):206. doi: 10.1007/s12032-014-0206-2. Epub 2014 Sep 7.
24. Decreased expression of DICER1 in gastric cancer. Zheng ZH, etal., Chin Med J (Engl). 2007 Dec 5;120(23):2099-104.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10512203   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11889553   PMID:12477932   PMID:12520002   PMID:12526743   PMID:14528307   PMID:14610273  
PMID:14681479   PMID:15033168   PMID:15081373   PMID:15576842   PMID:15613470   PMID:15713842   PMID:15840001   PMID:15867090   PMID:16009718   PMID:16036130   PMID:16040801   PMID:16092937  
PMID:16099834   PMID:16141072   PMID:16141073   PMID:16182285   PMID:16319892   PMID:16397794   PMID:16452165   PMID:16462742   PMID:16575173   PMID:16682203   PMID:16938833   PMID:17060477  
PMID:17113034   PMID:17135486   PMID:17369397   PMID:17369401   PMID:17397913   PMID:17401365   PMID:17452327   PMID:17606634   PMID:17613256   PMID:17679093   PMID:17761882   PMID:17804764  
PMID:17936265   PMID:17989215   PMID:18157120   PMID:18184563   PMID:18238902   PMID:18256189   PMID:18268334   PMID:18320056   PMID:18329371   PMID:18385371   PMID:18398510   PMID:18404146  
PMID:18404147   PMID:18410515   PMID:18434510   PMID:18463241   PMID:18535243   PMID:18554416   PMID:18591425   PMID:18604195   PMID:18633141   PMID:18687735   PMID:18703631   PMID:18725525  
PMID:18725526   PMID:18725527   PMID:18776119   PMID:18776121   PMID:18779589   PMID:18799693   PMID:18809798   PMID:18988856   PMID:18997113   PMID:19059913   PMID:19071104   PMID:19114655  
PMID:19118902   PMID:19127519   PMID:19129368   PMID:19144718   PMID:19148298   PMID:19164542   PMID:19169742   PMID:19197916   PMID:19272382   PMID:19349980   PMID:19389351   PMID:19416898  
PMID:19422693   PMID:19509335   PMID:19625646   PMID:19646895   PMID:19681134   PMID:19718708   PMID:19799966   PMID:19806666   PMID:19876815   PMID:19898466   PMID:20018673   PMID:20035504  
PMID:20039311   PMID:20056748   PMID:20079730   PMID:20102707   PMID:20103535   PMID:20116252   PMID:20144605   PMID:20167638   PMID:20211135   PMID:20223197   PMID:20223198   PMID:20237275  
PMID:20299448   PMID:20305640   PMID:20353723   PMID:20360310   PMID:20378849   PMID:20386732   PMID:20452309   PMID:20457670   PMID:20463238   PMID:20504959   PMID:20517984   PMID:20519547  
PMID:20530258   PMID:20540774   PMID:20550935   PMID:20554876   PMID:20569692   PMID:20587524   PMID:20596657   PMID:20603000   PMID:20616003   PMID:20616011   PMID:20643829   PMID:20659473  
PMID:20660113   PMID:20699384   PMID:20702715   PMID:20708584   PMID:20713509   PMID:20730047   PMID:20805417   PMID:20805985   PMID:20807761   PMID:20827505   PMID:20852262   PMID:20852728  
PMID:20884876   PMID:20944551   PMID:20945399   PMID:20956382   PMID:20962848   PMID:20975942   PMID:20976144   PMID:21048142   PMID:21048966   PMID:21062284   PMID:21093320   PMID:21098294  
PMID:21098571   PMID:21138975   PMID:21149603   PMID:21225654   PMID:21256124   PMID:21256960   PMID:21267068   PMID:21273303   PMID:21273552   PMID:21278735   PMID:21285947   PMID:21297615  
PMID:21307095   PMID:21338882   PMID:21360794   PMID:21371421   PMID:21447562   PMID:21501592   PMID:21526127   PMID:21533178   PMID:21542136   PMID:21544061   PMID:21573140   PMID:21632951  
PMID:21677750   PMID:21712401   PMID:21730146   PMID:21731673   PMID:21788498   PMID:21796153   PMID:21807765   PMID:21826226   PMID:21841785   PMID:21873635   PMID:21911408   PMID:21945074  
PMID:21949761   PMID:21969379   PMID:21984007   PMID:21991391   PMID:21998645   PMID:22053081   PMID:22106413   PMID:22113163   PMID:22117047   PMID:22131398   PMID:22132122   PMID:22179202  
PMID:22198669   PMID:22225602   PMID:22242190   PMID:22270084   PMID:22308344   PMID:22313051   PMID:22326846   PMID:22331912   PMID:22353998   PMID:22358842   PMID:22379031   PMID:22379033  
PMID:22434867   PMID:22447776   PMID:22474261   PMID:22475483   PMID:22492706   PMID:22503104   PMID:22504928   PMID:22508726   PMID:22521588   PMID:22541070   PMID:22558254   PMID:22564735  
PMID:22580128   PMID:22615744   PMID:22629237   PMID:22661094   PMID:22665486   PMID:22665768   PMID:22684508   PMID:22698408   PMID:22701646   PMID:22706270   PMID:22737231   PMID:22753148  
PMID:22778034   PMID:22796409   PMID:22798293   PMID:22801545   PMID:22819339   PMID:22836445   PMID:22836757   PMID:22844247   PMID:22854828   PMID:22858543   PMID:22864477   PMID:22869729  
PMID:22869792   PMID:22874921   PMID:22898830   PMID:22916300   PMID:22918229   PMID:22925886   PMID:22952873   PMID:22958919   PMID:22969435   PMID:22972926   PMID:22982054   PMID:22991506  
PMID:22993445   PMID:23011138   PMID:23056286   PMID:23063653   PMID:23132766   PMID:23138483   PMID:23141545   PMID:23152916   PMID:23284137   PMID:23311378   PMID:23321074   PMID:23349485  
PMID:23382448   PMID:23427252   PMID:23498953   PMID:23518926   PMID:23569256   PMID:23622242   PMID:23684747   PMID:23716939   PMID:23733098   PMID:23754433   PMID:23840532   PMID:23851498  
PMID:23895693   PMID:23918385   PMID:23935075   PMID:23949802   PMID:23961995   PMID:23974039   PMID:24012747   PMID:24023722   PMID:24040281   PMID:24062642   PMID:24094851   PMID:24142921  
PMID:24163352   PMID:24184162   PMID:24194600   PMID:24199146   PMID:24209619   PMID:24233972   PMID:24244599   PMID:24287487   PMID:24381269   PMID:24395757   PMID:24451661   PMID:24497637  
PMID:24500693   PMID:24526444   PMID:24664281   PMID:24690185   PMID:24769236   PMID:24788257   PMID:24794437   PMID:24812086   PMID:24835278   PMID:24840646   PMID:24945770   PMID:24971698  
PMID:24979267   PMID:24983316   PMID:24990804   PMID:25043492   PMID:25100599   PMID:25131933   PMID:25172909   PMID:25184675   PMID:25201754   PMID:25244517   PMID:25329700   PMID:25349431  
PMID:25366345   PMID:25369991   PMID:25383518   PMID:25405615   PMID:25448413   PMID:25457613   PMID:25557550   PMID:25587068   PMID:25594698   PMID:25595182   PMID:25629159   PMID:25643827  
PMID:25651362   PMID:25661788   PMID:25695507   PMID:25714103   PMID:25783852   PMID:25799508   PMID:25815421   PMID:25887159   PMID:25910616   PMID:25934699   PMID:25962146   PMID:25978641  
PMID:25979949   PMID:25995211   PMID:26000482   PMID:26000566   PMID:26032504   PMID:26033159   PMID:26038943   PMID:26041499   PMID:26054367   PMID:26062936   PMID:26074697   PMID:26091048  
PMID:26120830   PMID:26180185   PMID:26329601   PMID:26387953   PMID:26437240   PMID:26438731   PMID:26466203   PMID:26472536   PMID:26496610   PMID:26510868   PMID:26556063   PMID:26565905  
PMID:26639063   PMID:26718009   PMID:26748703   PMID:26773046   PMID:26773048   PMID:26802803   PMID:26837267   PMID:26882526   PMID:26900752   PMID:27064596   PMID:27135215   PMID:27150236  
PMID:27159635   PMID:27166376   PMID:27195970   PMID:27254021   PMID:27278750   PMID:27295554   PMID:27332731   PMID:27346348   PMID:27545503   PMID:27554624   PMID:27600805   PMID:27602775  
PMID:27607422   PMID:27622243   PMID:27626380   PMID:27627450   PMID:27695046   PMID:27716060   PMID:27880894   PMID:27880903   PMID:28003412   PMID:28104803   PMID:28115634   PMID:28199304  
PMID:28232457   PMID:28232627   PMID:28337978   PMID:28446592   PMID:28542144   PMID:28636953   PMID:28653618   PMID:28704808   PMID:28777373   PMID:28794184   PMID:28870694   PMID:28916654  
PMID:28982684   PMID:29021386   PMID:29066312   PMID:29091291   PMID:29117535   PMID:29150673   PMID:29199004   PMID:29232705   PMID:29251629   PMID:29374161   PMID:29394246   PMID:29704636  
PMID:29726608   PMID:29860390   PMID:29925675   PMID:29980665   PMID:30213595   PMID:30215742   PMID:30280598   PMID:30295958   PMID:30311908   PMID:30540495   PMID:30593561   PMID:30653268  
PMID:30760705   PMID:30783126   PMID:30914430   PMID:30940834   PMID:31013297   PMID:31080058   PMID:31138677   PMID:31306658   PMID:31330130   PMID:31703292   PMID:31766249   PMID:31860668  
PMID:31873194   PMID:31964819   PMID:32015493   PMID:32129540   PMID:32286280   PMID:32290105   PMID:32325033   PMID:32478074   PMID:32483416   PMID:32484548   PMID:32497036   PMID:32520726  
PMID:32677148   PMID:32737764   PMID:32843721   PMID:32900951   PMID:32985705   PMID:33052800   PMID:33144601   PMID:33232872   PMID:33262282   PMID:33268364   PMID:33450179   PMID:33503410  
PMID:33727367   PMID:33837743   PMID:34106403   PMID:34242585   PMID:34244417   PMID:34383714   PMID:34531379   PMID:34572101   PMID:34695450   PMID:34847178   PMID:35045290   PMID:35067718  
PMID:35165388   PMID:35240143   PMID:35490865   PMID:35533808   PMID:35784484   PMID:35921818   PMID:35945211   PMID:36601302   PMID:37494452   PMID:37494476   PMID:37525425   PMID:38207077  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3912104,654,001 - 104,718,331 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12104,654,001 - 104,718,211 (-)EnsemblGRCm39 Ensembl
GRCm3812104,687,740 - 104,751,968 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12104,687,742 - 104,751,952 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712105,925,952 - 105,990,162 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612105,092,486 - 105,153,002 (-)NCBIMGSCv36mm8
Celera12105,918,245 - 105,982,441 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1254.83NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381495,086,228 - 95,158,010 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1495,086,228 - 95,158,010 (-)EnsemblGRCh38hg38GRCh38
GRCh371495,552,565 - 95,624,347 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361494,622,319 - 94,693,512 (-)NCBINCBI36Build 36hg18NCBI36
Build 341494,622,318 - 94,693,512NCBI
Celera1475,608,684 - 75,679,876 (-)NCBICelera
Cytogenetic Map14q32.13NCBI
HuRef1475,736,521 - 75,807,615 (-)NCBIHuRef
CHM1_11495,490,915 - 95,561,989 (-)NCBICHM1_1
T2T-CHM13v2.01489,316,445 - 89,388,228 (-)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr86129,392,298 - 129,457,252 (-)NCBIGRCr8
mRatBN7.26123,627,529 - 123,692,278 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,631,250 - 123,693,965 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.06128,388,084 - 128,453,234 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6128,388,053 - 128,434,183 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06137,586,335 - 137,633,706 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46128,777,468 - 128,838,780 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16128,781,378 - 128,842,495 (-)NCBI
Celera6121,106,680 - 121,167,957 (-)NCBICelera
Cytogenetic Map6q32NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495543817,382,493 - 17,431,797 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543817,374,899 - 17,431,599 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21596,234,748 - 96,307,196 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11495,451,254 - 95,523,061 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01475,709,029 - 75,780,779 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11495,036,385 - 95,107,940 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1495,036,385 - 95,107,940 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1863,970,245 - 64,029,438 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl863,972,027 - 64,019,879 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha863,546,706 - 63,619,316 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0864,236,992 - 64,309,618 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl864,238,043 - 64,309,589 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1863,912,041 - 63,984,637 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0863,970,646 - 64,043,228 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0864,295,524 - 64,368,151 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440864010,443,874 - 10,504,962 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936846532,972 - 575,689 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936846528,768 - 584,599 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl7116,365,802 - 116,411,224 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17116,361,630 - 116,436,471 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27123,581,725 - 123,652,553 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12472,915,550 - 72,986,658 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2472,915,499 - 72,963,006 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605360,107,379 - 60,178,341 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247347,608,273 - 7,651,819 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247347,604,049 - 7,681,481 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Dicer1
1994 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1206
Count of miRNA genes:663
Interacting mature miRNAs:810
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
12910790Pwgrq7_mpre-weaning growth rate QTL 7 (mouse)1290937367108645308Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
25823169Hrsq8_mhost response to SARS QTL 8, log titer (mouse)1281696245108495368Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
11039526Ccc1_mcolitis susceptibility in the Collaborative Cross 1 (mouse)1293528334111028223Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
25394546Skmw76_mskeletal muscle weight 76, TA (mouse)12102593095106941888Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
10412192Bbaa27_mB.burgdorferi-associated arthritis 27 (mouse)Not determined1291254220107308393Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812104,691,475 - 104,691,575UniSTSGRCm38
MGSCv3712105,929,685 - 105,929,785UniSTSGRCm37
Celera12105,921,978 - 105,922,078UniSTS
Cytogenetic Map12E-F1UniSTS
cM Map12 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812104,687,916 - 104,688,026UniSTSGRCm38
MGSCv3712105,926,126 - 105,926,236UniSTSGRCm37
Celera12105,918,419 - 105,918,529UniSTS
Cytogenetic Map12E-F1UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812104,687,744 - 104,687,971UniSTSGRCm38
MGSCv3712105,925,954 - 105,926,181UniSTSGRCm37
Celera12105,918,247 - 105,918,474UniSTS
Cytogenetic Map12E-F1UniSTS
cM Map1251.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12E-F1UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12E-F1UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812104,731,076 - 104,731,916UniSTSGRCm38
MGSCv3712105,969,286 - 105,970,126UniSTSGRCm37
Celera12105,961,564 - 105,962,404UniSTS
Cytogenetic Map12E-F1UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12E-F1UniSTS



Nucleotide Sequences
RefSeq Transcripts NM_001411829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_148948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB081470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF430845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF484523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF484524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MZ209414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000041987   ⟹   ENSMUSP00000043676
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12104,654,001 - 104,718,211 (-)Ensembl
GRCm38.p6 Ensembl12104,687,742 - 104,751,952 (-)Ensembl
RefSeq Acc Id: ENSMUST00000221293
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12104,688,016 - 104,696,423 (-)Ensembl
GRCm38.p6 Ensembl12104,721,757 - 104,730,164 (-)Ensembl
RefSeq Acc Id: ENSMUST00000222002   ⟹   ENSMUSP00000152413
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12104,688,343 - 104,705,096 (-)Ensembl
GRCm38.p6 Ensembl12104,722,084 - 104,738,837 (-)Ensembl
RefSeq Acc Id: ENSMUST00000222115
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12104,657,702 - 104,666,761 (-)Ensembl
GRCm38.p6 Ensembl12104,691,443 - 104,700,502 (-)Ensembl
RefSeq Acc Id: ENSMUST00000222519
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12104,663,605 - 104,666,761 (-)Ensembl
GRCm38.p6 Ensembl12104,697,346 - 104,700,502 (-)Ensembl
RefSeq Acc Id: ENSMUST00000222528
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12104,657,687 - 104,688,311 (-)Ensembl
GRCm38.p6 Ensembl12104,691,428 - 104,722,052 (-)Ensembl
RefSeq Acc Id: ENSMUST00020183808
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12104,673,145 - 104,679,287 (-)Ensembl
RefSeq Acc Id: ENSMUST00020183809   ⟹   ENSMUSP00001091668
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12104,697,413 - 104,718,169 (-)Ensembl
RefSeq Acc Id: ENSMUST00020183813
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12104,657,492 - 104,660,825 (-)Ensembl
RefSeq Acc Id: NM_001411829   ⟹   NP_001398758
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm3912104,654,001 - 104,718,331 (-)NCBI
RefSeq Acc Id: ENSMUSP00000152413   ⟸   ENSMUST00000222002
RefSeq Acc Id: ENSMUSP00000043676   ⟸   ENSMUST00000041987
RefSeq Acc Id: ENSMUSP00001091668   ⟸   ENSMUST00020183809
RefSeq Acc Id: NP_001398758   ⟸   NM_001411829
- Peptide Label: isoform 1
- UniProtKB: F8VQ54 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R418-F1-model_v2 AlphaFold Q8R418 1-1916 view protein structure

RGD ID:8679146
Promoter ID:EPDNEW_M17604
Type:initiation region
Description:Mus musculus dicer 1, ribonuclease type III , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm3812104,752,045 - 104,752,105EPDNEW
RGD ID:6822845
Promoter ID:MM_KWN:12613
SO ACC ID:SO:0000170
Tissues & Cell Lines:Kidney
Mouse AssemblyChrPosition (strand)Source
MGSCv3612105,967,726 - 105,968,226 (-)MPROMDB
RGD ID:6822862
Promoter ID:MM_KWN:12615
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK134511_6230426M11RIK,   NM_148948
Mouse AssemblyChrPosition (strand)Source
MGSCv3612105,989,351 - 105,990,557 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2177178 AgrOrtholog
Ensembl Genes ENSMUSG00000041415 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000041987 ENTREZGENE
  ENSMUST00000041987.8 UniProtKB/TrEMBL
  ENSMUST00000222002.3 UniProtKB/TrEMBL
  ENSMUST00020183809.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  paz domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dicer_dimer_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dicer_dimerisation_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DICER_DSRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dicer_PBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dicer_platform UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  dsRBD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase/UvrB_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNase_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNase_III_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNase_III_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DICER-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Dicer_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dicer_dsRBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dicer_PBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dicer_platform UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ResIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribonuclease_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dicer1 PhenoGen
  DS_RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICASE_ATP_BIND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNASE_3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNASE_3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEXDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DSRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBOc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP dsRNA-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF101690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DICER_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q8R419 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-22 Dicer1  dicer 1, ribonuclease type III  Dicer1  Dicer1, Dcr-1 homolog (Drosophila)  Symbol and/or name change 5135510 APPROVED