Nek1 (NIMA (never in mitosis gene a)-related expressed kinase 1) - Rat Genome Database

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Gene: Nek1 (NIMA (never in mitosis gene a)-related expressed kinase 1) Mus musculus
Analyze
Symbol: Nek1
Name: NIMA (never in mitosis gene a)-related expressed kinase 1
RGD ID: 1319691
MGI Page MGI
Description: Enables 14-3-3 protein binding activity. Involved in regulation of DNA damage checkpoint. Acts upstream of or within several processes, including DNA damage response; response to ionizing radiation; and spermatogenesis. Located in centrosome and nucleus. Is expressed in several structures, including ganglia; gut; hemolymphoid system gland; metanephros; and reproductive system. Used to study autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 24; asphyxiating thoracic dystrophy; orofaciodigital syndrome II; and short-rib thoracic dysplasia 6 with or without polydactyly. Orthologous to human NEK1 (NIMA related kinase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D8Ertd790; D8Ertd790e; ka; kat; kidney, anemia and testis; MGC189817; Nek1 serine/threonine- and tyrosine-specific protein kinase; never in mitosis A-related kinase 1; NIMA-related kinase 1; nimA-related protein kinase 1; NY-REN-55 antigen; serine/threonine-protein kinase Nek1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39861,446,184 - 61,584,383 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl861,446,229 - 61,584,380 (+)EnsemblGRCm39 Ensembl
GRCm38860,993,157 - 61,131,349 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl860,993,195 - 61,131,346 (+)EnsemblGRCm38mm10GRCm38
MGSCv37863,472,017 - 63,609,031 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36863,885,335 - 64,023,496 (+)NCBIMGSCv36mm8
Celera863,560,390 - 63,696,381 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map830.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. NEK1 and DYNC2H1 are both involved in short rib polydactyly Majewski type but not in Beemer Langer cases. El Hokayem J, etal., J Med Genet. 2012 Apr;49(4):227-33. doi: 10.1136/jmedgenet-2011-100717.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11. NEK1 mutations cause short-rib polydactyly syndrome type majewski. Thiel C, etal., Am J Hum Genet. 2011 Jan 7;88(1):106-14. doi: 10.1016/j.ajhg.2010.12.004.
Additional References at PubMed
PMID:1382974   PMID:9070925   PMID:9434622   PMID:9583679   PMID:10349636   PMID:10366444   PMID:10393247   PMID:10589692   PMID:10618398   PMID:11042159   PMID:11076861   PMID:12204287  
PMID:12819135   PMID:14600027   PMID:15345747   PMID:15368895   PMID:15371535   PMID:15604234   PMID:15965785   PMID:16141072   PMID:16141073   PMID:16267153   PMID:16603261   PMID:18387364  
PMID:18533026   PMID:18827223   PMID:18843199   PMID:19699716   PMID:21214959   PMID:21267068   PMID:21301226   PMID:21474562   PMID:21873635   PMID:24236097   PMID:25030234   PMID:26496610  
PMID:27760328   PMID:28235073   PMID:28982183   PMID:29891719   PMID:30928383   PMID:32325033   PMID:34376696   PMID:38355793   PMID:39227882  


Genomics

Comparative Map Data
Nek1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39861,446,184 - 61,584,383 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl861,446,229 - 61,584,380 (+)EnsemblGRCm39 Ensembl
GRCm38860,993,157 - 61,131,349 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl860,993,195 - 61,131,346 (+)EnsemblGRCm38mm10GRCm38
MGSCv37863,472,017 - 63,609,031 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36863,885,335 - 64,023,496 (+)NCBIMGSCv36mm8
Celera863,560,390 - 63,696,381 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map830.91NCBI
NEK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384169,392,809 - 169,612,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4169,369,704 - 169,612,632 (-)EnsemblGRCh38hg38GRCh38
GRCh374170,313,960 - 170,533,734 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364170,551,004 - 170,770,189 (-)NCBINCBI36Build 36hg18NCBI36
Build 344170,689,158 - 170,908,344NCBI
Celera4167,647,120 - 167,866,584 (-)NCBICelera
Cytogenetic Map4q33NCBI
HuRef4166,069,151 - 166,288,552 (-)NCBIHuRef
CHM1_14170,290,871 - 170,510,372 (-)NCBICHM1_1
T2T-CHM13v2.04172,752,512 - 172,972,332 (-)NCBIT2T-CHM13v2.0
Nek1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81634,009,092 - 34,137,418 (-)NCBIGRCr8
mRatBN7.21628,998,229 - 29,125,426 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1628,998,231 - 29,117,723 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1632,593,117 - 32,712,602 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01636,026,844 - 36,146,328 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01632,228,326 - 32,347,844 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01632,321,010 - 32,439,421 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1632,321,010 - 32,439,421 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01632,155,914 - 32,274,325 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01631,025,718 - 31,032,968 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41632,317,987 - 32,438,010 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11632,320,904 - 32,431,386 (-)NCBI
Celera1628,993,115 - 29,112,552 (-)NCBICelera
Cytogenetic Map16p12NCBI
Nek1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540336,720,162 - 36,881,891 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540336,710,248 - 36,878,901 (+)NCBIChiLan1.0ChiLan1.0
NEK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23167,174,897 - 167,388,951 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14167,530,541 - 167,744,594 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04161,618,181 - 161,830,332 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14173,690,074 - 173,902,100 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4173,690,074 - 173,902,100 (-)Ensemblpanpan1.1panPan2
NEK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12520,297,190 - 20,528,537 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2520,299,079 - 20,518,483 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2520,934,647 - 21,153,217 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02520,475,506 - 20,704,356 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2520,475,503 - 20,694,127 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12520,318,819 - 20,578,371 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02520,295,186 - 20,524,672 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02520,394,714 - 20,624,101 (-)NCBIUU_Cfam_GSD_1.0
Nek1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494321,094,565 - 21,252,579 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365161,508,811 - 1,666,869 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365161,508,800 - 1,666,841 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1420,144,659 - 20,332,245 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11420,144,631 - 20,332,248 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21421,439,141 - 21,626,347 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17115,621,917 - 115,819,349 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7115,621,916 - 115,819,291 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603795,560,952 - 95,765,438 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nek1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624769945,644 - 1,147,246 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624769945,788 - 1,146,921 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nek1
5515 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:988
Count of miRNA genes:484
Interacting mature miRNAs:556
Transcripts:ENSMUST00000034065, ENSMUST00000120689, ENSMUST00000125717, ENSMUST00000140444, ENSMUST00000142601, ENSMUST00000154313, ENSMUST00000155664
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3250657271740637Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84809006482090180Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84924559183245673Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
14746987Manh64_mmandible shape 64 (mouse)85050595884505958Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3250657271740637Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85474046188740637Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84809006482090180Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84819016882190288Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85515925889159407Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3250657271740637Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85050595884505958Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85913640493136404Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85629887290298872Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83429039768290537Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83250657271740637Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85233484386334843Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84474791478748059Mouse

Markers in Region
28.MMHAP96FLB4.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38861,102,077 - 61,102,238UniSTSGRCm38
MGSCv37863,580,874 - 63,581,035UniSTSGRCm37
Celera863,668,216 - 63,668,377UniSTS
Cytogenetic Map8B3.1UniSTS
Whitehead_YAC8 UniSTS
D8Ertd124e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38861,091,165 - 61,091,379UniSTSGRCm38
MGSCv37863,569,962 - 63,570,176UniSTSGRCm37
Cytogenetic Map8B3.1UniSTS
cM Map831.5UniSTS
D8Ertd790e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38861,131,061 - 61,131,260UniSTSGRCm38
MGSCv37863,609,858 - 63,610,057UniSTSGRCm37
Celera863,697,207 - 63,697,406UniSTS
Cytogenetic Map8B3.1UniSTS
cM Map831.5UniSTS
cM Map832.0UniSTS
PMC26643P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38861,019,839 - 61,019,917UniSTSGRCm38
MGSCv37863,498,636 - 63,498,714UniSTSGRCm37
Celera863,587,026 - 63,587,104UniSTS
Cytogenetic Map8B3.1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001293637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001293638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001293639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_175089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030243340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC134339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC159302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEKQ02141728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK029963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK173292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY850065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC157939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC158009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC172091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX237035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000034065   ⟹   ENSMUSP00000034065
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,446,229 - 61,584,380 (+)Ensembl
GRCm38.p6 Ensembl860,993,195 - 61,131,346 (+)Ensembl
Ensembl Acc Id: ENSMUST00000120689   ⟹   ENSMUSP00000113932
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,446,229 - 61,584,373 (+)Ensembl
GRCm38.p6 Ensembl860,993,195 - 61,131,339 (+)Ensembl
Ensembl Acc Id: ENSMUST00000125717
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,446,234 - 61,497,577 (+)Ensembl
GRCm38.p6 Ensembl860,993,200 - 61,044,543 (+)Ensembl
Ensembl Acc Id: ENSMUST00000140444
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,446,275 - 61,483,093 (+)Ensembl
GRCm38.p6 Ensembl860,993,241 - 61,030,059 (+)Ensembl
Ensembl Acc Id: ENSMUST00000142601
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,502,869 - 61,542,489 (+)Ensembl
GRCm38.p6 Ensembl861,049,835 - 61,089,455 (+)Ensembl
Ensembl Acc Id: ENSMUST00000154313
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,446,275 - 61,483,634 (+)Ensembl
GRCm38.p6 Ensembl860,993,241 - 61,030,600 (+)Ensembl
Ensembl Acc Id: ENSMUST00000155664
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,446,273 - 61,560,385 (+)Ensembl
GRCm38.p6 Ensembl860,993,239 - 61,107,351 (+)Ensembl
Ensembl Acc Id: ENSMUST00000211256   ⟹   ENSMUSP00000147258
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,446,299 - 61,583,934 (+)Ensembl
GRCm38.p6 Ensembl860,993,265 - 61,130,900 (+)Ensembl
Ensembl Acc Id: ENSMUST00000211672   ⟹   ENSMUSP00000147809
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl861,446,299 - 61,583,942 (+)Ensembl
GRCm38.p6 Ensembl860,993,265 - 61,130,908 (+)Ensembl
RefSeq Acc Id: NM_001293637   ⟹   NP_001280566
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,446,227 - 61,584,380 (+)NCBI
GRCm38860,993,193 - 61,131,346 (+)NCBI
Celera863,560,363 - 63,697,492 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001293638   ⟹   NP_001280567
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,446,227 - 61,584,380 (+)NCBI
GRCm38860,993,193 - 61,131,346 (+)NCBI
Celera863,560,363 - 63,697,492 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001293639   ⟹   NP_001280568
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,446,227 - 61,584,380 (+)NCBI
GRCm38860,993,193 - 61,131,346 (+)NCBI
Celera863,560,363 - 63,697,492 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001414226   ⟹   NP_001401155
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,446,227 - 61,584,380 (+)NCBI
RefSeq Acc Id: NM_001414227   ⟹   NP_001401156
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,446,227 - 61,584,380 (+)NCBI
RefSeq Acc Id: NM_001414228   ⟹   NP_001401157
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,446,227 - 61,584,380 (+)NCBI
RefSeq Acc Id: NM_001414229   ⟹   NP_001401158
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,446,227 - 61,584,380 (+)NCBI
RefSeq Acc Id: NM_001414230   ⟹   NP_001401159
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,446,227 - 61,584,380 (+)NCBI
RefSeq Acc Id: NM_175089   ⟹   NP_780298
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,446,227 - 61,584,380 (+)NCBI
GRCm38860,993,193 - 61,131,346 (+)NCBI
MGSCv37863,472,017 - 63,609,031 (+)RGD
Celera863,560,363 - 63,697,492 (+)NCBI
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030243340   ⟹   XP_030099200
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,446,195 - 61,584,383 (+)NCBI
GRCm38860,993,157 - 61,131,349 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036153794   ⟹   XP_036009687
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,446,184 - 61,525,866 (+)NCBI
Sequence:
RefSeq Acc Id: NP_780298   ⟸   NM_175089
- Peptide Label: isoform 3
- UniProtKB: P51954 (UniProtKB/Swiss-Prot),   Q69Z74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001280566   ⟸   NM_001293637
- Peptide Label: isoform 1
- UniProtKB: B2RXX0 (UniProtKB/TrEMBL),   Q69Z74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001280567   ⟸   NM_001293638
- Peptide Label: isoform 2
- UniProtKB: B7ZWK0 (UniProtKB/TrEMBL),   Q69Z74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001280568   ⟸   NM_001293639
- Peptide Label: isoform 4
- UniProtKB: B2RXQ4 (UniProtKB/TrEMBL),   Q69Z74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030099200   ⟸   XM_030243340
- Peptide Label: isoform X5
- UniProtKB: Q69Z74 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000147809   ⟸   ENSMUST00000211672
Ensembl Acc Id: ENSMUSP00000034065   ⟸   ENSMUST00000034065
Ensembl Acc Id: ENSMUSP00000147258   ⟸   ENSMUST00000211256
Ensembl Acc Id: ENSMUSP00000113932   ⟸   ENSMUST00000120689
RefSeq Acc Id: XP_036009687   ⟸   XM_036153794
- Peptide Label: isoform X7
RefSeq Acc Id: NP_001401156   ⟸   NM_001414227
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001401159   ⟸   NM_001414230
- Peptide Label: isoform 9
RefSeq Acc Id: NP_001401155   ⟸   NM_001414226
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001401158   ⟸   NM_001414229
- Peptide Label: isoform 8
RefSeq Acc Id: NP_001401157   ⟸   NM_001414228
- Peptide Label: isoform 7
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51954-F1-model_v2 AlphaFold P51954 1-1203 view protein structure

Promoters
RGD ID:8667147
Promoter ID:EPDNEW_M11604
Type:initiation region
Name:Nek1_1
Description:Mus musculus NIMA -related expressed kinase 1 , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38860,993,241 - 60,993,301EPDNEW
RGD ID:6843537
Promoter ID:MM_KWN:54493
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000036594,   ENSMUST00000120689,   OTTMUST00000077868,   OTTMUST00000077870,   OTTMUST00000077871,   OTTMUST00000077873,   UC009LTR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36863,471,376 - 63,472,167 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97303 AgrOrtholog
Ensembl Genes ENSMUSG00000031644 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034065 ENTREZGENE
  ENSMUST00000034065.14 UniProtKB/Swiss-Prot
  ENSMUST00000120689 ENTREZGENE
  ENSMUST00000120689.8 UniProtKB/TrEMBL
  ENSMUST00000211256 ENTREZGENE
  ENSMUST00000211256.2 UniProtKB/TrEMBL
  ENSMUST00000211672 ENTREZGENE
  ENSMUST00000211672.2 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEK_Ser/Thr_kinase_NIMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97303 ENTREZGENE
NCBI Gene Nek1 ENTREZGENE
PANTHER CAMK FAMILY PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE NEK1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nek1 PhenoGen
PIRSF Integrin-linked_kinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RXQ4 ENTREZGENE, UniProtKB/TrEMBL
  B2RXX0 ENTREZGENE, UniProtKB/TrEMBL
  B7ZWK0 ENTREZGENE, UniProtKB/TrEMBL
  NEK1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UXI0_MOUSE UniProtKB/TrEMBL
  Q69Z74 ENTREZGENE, UniProtKB/TrEMBL
  Q811L2_MOUSE UniProtKB/TrEMBL
  Q8BSB6_MOUSE UniProtKB/TrEMBL
  Q8CD72_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Nek1  NIMA (never in mitosis gene a)-related expressed kinase 1  kat  kidney, anemia and testis  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 kat  kidney, anemia and testis  Nek1  NIMA (never in mitosis gene a)-related expressed kinase 1  Symbol and/or name change 5135510 APPROVED