Card11 (caspase recruitment domain family, member 11) - Rat Genome Database

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Gene: Card11 (caspase recruitment domain family, member 11) Mus musculus
Analyze
Symbol: Card11
Name: caspase recruitment domain family, member 11
RGD ID: 1319686
MGI Page MGI
Description: Predicted to enable CARD domain binding activity. Involved in positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell receptor signaling pathway; and positive regulation of canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including lymphocyte differentiation; positive regulation of interleukin-2 production; and regulation of lymphocyte activation. Located in immunological synapse. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma; immunodeficiency 11A; and immunodeficiency 11B. Orthologous to human CARD11 (caspase recruitment domain family member 11).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 0610008L17Rik; 2410011D02Rik; BIM; BIMP3; CAR; CARD-containing MAGUK protein 1; carma 1; CARMA1; caspase recruitment domain-containing protein 11
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395140,858,109 - 140,986,398 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5140,858,745 - 140,986,337 (-)EnsemblGRCm39 Ensembl
GRCm385140,872,999 - 141,000,596 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5140,872,990 - 141,000,582 (-)EnsemblGRCm38mm10GRCm38
MGSCv375141,348,953 - 141,476,550 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365141,125,473 - 141,252,966 (-)NCBIMGSCv36mm8
Celera5137,928,048 - 138,050,352 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map579.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal B cell proliferation  (IAGP)
abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal cytotoxic T cell physiology  (IEA)
abnormal double-negative T cell morphology  (IAGP)
abnormal germinal center B cell morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal interleukin-2 secretion  (IAGP)
abnormal lymphocyte morphology  (IAGP)
abnormal NK cell physiology  (IEA)
abnormal plasma cell differentiation  (IAGP)
abnormal spleen morphology  (IEA)
abnormal T cell activation  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell proliferation  (IAGP)
abnormal T-helper 2 cell differentiation  (IAGP)
abnormal testis morphology  (IEA)
abnormal thymus morphology  (IEA)
abnormal uterus morphology  (IEA)
absent B-1a cells  (IAGP)
absent immature B cells  (IAGP)
decreased airway responsiveness  (IAGP)
decreased B cell number  (IEA)
decreased B cell proliferation  (IAGP)
decreased B-1 B cell number  (IAGP)
decreased B-1a cell number  (IAGP)
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number  (IEA)
decreased central memory CD4-positive, alpha-beta T cell number  (IEA)
decreased circulating alkaline phosphatase level  (IEA)
decreased circulating interleukin-4 level  (IAGP)
decreased circulating interleukin-5 level  (IAGP)
decreased effector memory CD4-positive, alpha-beta T cell number  (IEA)
decreased effector memory CD8-positive, alpha-beta T cell number  (IEA)
decreased effector memory T-helper cell number  (IEA)
decreased gamma-delta T cell number  (IAGP)
decreased germinal center B cell number  (IAGP)
decreased IgA level  (IAGP)
decreased IgE level  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG2c level  (IAGP)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased interferon-gamma secretion  (IEA)
decreased interleukin-2 secretion  (IEA)
decreased locomotor activity  (IEA)
decreased marginal zone B cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased memory T cell number  (IAGP)
decreased NK cell number  (IAGP)
decreased NK T cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased response to antigen  (IEA)
decreased spleen weight  (IEA)
decreased T cell proliferation  (IAGP)
decreased transitional stage T1 B cell number  (IAGP)
decreased transitional stage T3 B cell number  (IAGP)
dermatitis  (IAGP)
enlarged spleen  (IAGP)
enlarged thymus  (IEA)
erythroderma  (IAGP)
hydrometra  (IEA)
impaired humoral immune response  (IAGP)
increased alpha-beta T cell number  (IEA)
increased B cell proliferation  (IAGP)
increased B-1 B cell number  (IAGP)
increased B-1a cell number  (IAGP)
increased B-1b cell number  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, naive alpha-beta T cell number  (IEA)
increased follicular B cell number  (IAGP)
increased freezing behavior  (IEA)
increased germinal center B cell number  (IAGP)
increased IgE level  (IAGP)
increased immunoglobulin level  (IAGP)
increased inflammatory response  (IAGP)
increased leukocyte cell number  (IEA)
increased lymphocyte cell number  (IEA)
increased marginal zone B cell number  (IAGP)
increased NK T cell number  (IEA)
increased pre-B cell number  (IAGP)
increased T cell number  (IEA)
increased T-helper cell number  (IEA)
increased transitional stage T2 B cell number  (IAGP)
lung inflammation  (IAGP)
lymph node hyperplasia  (IAGP)
respiratory system inflammation  (IAGP)
small spleen  (IEA)
small testis  (IEA)
spleen hyperplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. Lenz G, etal., Science. 2008 Mar 21;319(5870):1676-9. doi: 10.1126/science.1153629. Epub 2008 Mar 6.
3. Characteristics of CARMA1-BCL10-MALT1-A20-NF-kappaB expression in T cell-acute lymphocytic leukemia. Ma Y, etal., Eur J Med Res. 2014 Nov 11;19:62. doi: 10.1186/s40001-014-0062-8.
4. CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma. Medoff BD, etal., J Immunol. 2006 Jun 15;176(12):7272-7.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Comparative analysis of apoptosis and inflammation genes of mice and humans. Reed JC, etal., Genome Res 2003 Jun;13(6B):1376-88.
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Congenital B cell lymphocytosis explained by novel germline CARD11 mutations. Snow AL, etal., J Exp Med. 2012 Nov 19;209(12):2247-61. doi: 10.1084/jem.20120831. Epub 2012 Nov 5.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12154356   PMID:12356734   PMID:12477932   PMID:12818157   PMID:12818158   PMID:12867037   PMID:12867038   PMID:14610273   PMID:15449545  
PMID:15520247   PMID:16141072   PMID:16141073   PMID:16301747   PMID:16356855   PMID:16889948   PMID:17048267   PMID:17189706   PMID:17428801   PMID:17462996   PMID:17478723   PMID:17486093  
PMID:18192506   PMID:18227156   PMID:18446227   PMID:18606643   PMID:18625728   PMID:18829987   PMID:19118383   PMID:19130560   PMID:19260764   PMID:19454668   PMID:19815501   PMID:20008554  
PMID:20064449   PMID:20164171   PMID:20233721   PMID:20668237   PMID:21157432   PMID:21267068   PMID:21282629   PMID:21320717   PMID:21411734   PMID:21771792   PMID:21873635   PMID:22075698  
PMID:22323537   PMID:22371397   PMID:22547705   PMID:22880103   PMID:22896637   PMID:23027925   PMID:23091043   PMID:23337809   PMID:23525237   PMID:23793062   PMID:24036998   PMID:24224005  
PMID:24345681   PMID:24383645   PMID:24443940   PMID:24792914   PMID:24917592   PMID:25602919   PMID:25606824   PMID:25973755   PMID:26936881   PMID:27166870   PMID:27560392   PMID:28362433  
PMID:29649481   PMID:30127060   PMID:31087793   PMID:31092922   PMID:31138793   PMID:31391255   PMID:31784498   PMID:32325033   PMID:32401674   PMID:33230847   PMID:34341167   PMID:34348992  
PMID:36334349   PMID:36446869   PMID:36878279   PMID:36960072   PMID:38355793  


Genomics

Comparative Map Data
Card11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395140,858,109 - 140,986,398 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5140,858,745 - 140,986,337 (-)EnsemblGRCm39 Ensembl
GRCm385140,872,999 - 141,000,596 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5140,872,990 - 141,000,582 (-)EnsemblGRCm38mm10GRCm38
MGSCv375141,348,953 - 141,476,550 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365141,125,473 - 141,252,966 (-)NCBIMGSCv36mm8
Celera5137,928,048 - 138,050,352 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map579.42NCBI
CARD11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3872,906,142 - 3,043,867 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl72,906,142 - 3,044,228 (-)EnsemblGRCh38hg38GRCh38
GRCh3772,945,776 - 3,083,501 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3672,912,295 - 3,050,105 (-)NCBINCBI36Build 36hg18NCBI36
Build 3472,719,023 - 2,856,711NCBI
Celera72,914,379 - 3,052,190 (-)NCBICelera
Cytogenetic Map7p22.2NCBI
HuRef72,863,784 - 3,002,087 (-)NCBIHuRef
CHM1_172,945,368 - 3,083,717 (-)NCBICHM1_1
T2T-CHM13v2.073,019,747 - 3,157,416 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v272,993,579 - 3,131,390 (-)NCBI
Card11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81218,735,088 - 18,872,045 (+)NCBIGRCr8
mRatBN7.21213,621,140 - 13,758,115 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1213,621,087 - 13,758,112 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01215,700,600 - 15,844,512 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,700,825 - 15,844,512 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01217,780,109 - 17,843,748 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41214,165,040 - 14,229,267 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1215,382,300 - 15,519,160 (+)NCBICelera
Cytogenetic Map12q11NCBI
Card11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546012,368,918 - 12,490,041 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546012,368,987 - 12,487,675 (+)NCBIChiLan1.0ChiLan1.0
CARD11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v267,863,477 - 8,001,993 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1756,188,181 - 56,326,694 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v073,166,788 - 3,304,729 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.173,258,736 - 3,395,626 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl73,258,736 - 3,332,999 (-)Ensemblpanpan1.1panPan2
CARD11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1614,273,115 - 14,331,029 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl614,210,114 - 14,332,094 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha615,666,400 - 15,792,761 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0614,329,524 - 14,455,900 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl614,335,283 - 14,455,892 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1614,134,984 - 14,261,297 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0614,061,830 - 14,188,602 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0614,347,905 - 14,474,301 (+)NCBIUU_Cfam_GSD_1.0
Card11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344142,360,008 - 142,471,017 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936823581,955 - 621,208 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936823580,438 - 621,298 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CARD11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl32,145,178 - 2,266,355 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.132,145,178 - 2,266,377 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103246958
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12818,657,941 - 18,714,202 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660903,151,200 - 3,325,501 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Card11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474029,974,689 - 30,085,981 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474029,974,707 - 30,085,498 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Card11
4559 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:198
Count of miRNA genes:175
Interacting mature miRNAs:185
Transcripts:ENSMUST00000085786
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125178229141700466Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
13504737Ifvrq5_minfluenza virus resistance QTL 5 (mouse)5139509801151658149Mouse
13504734Ifvrq4_minfluenza virus resistance QTL 4 (mouse)5139985755151658149Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
13504735Ifvrq7_minfluenza virus resistance QTL 7 (mouse)5139509801151658149Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse

Markers in Region
D5Dcr3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385140,922,037 - 140,922,134UniSTSGRCm38
MGSCv375141,397,991 - 141,398,088UniSTSGRCm37
Celera5137,973,409 - 137,973,512UniSTS
Cytogenetic Map5G2UniSTS
cM Map5 UniSTS
cM Map5 UniSTS
D5Dcr4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385140,957,425 - 140,957,526UniSTSGRCm38
MGSCv375141,433,379 - 141,433,480UniSTSGRCm37
Celera5138,006,779 - 138,006,886UniSTS
Cytogenetic Map5G2UniSTS
cM Map5 UniSTS
D5Mit99  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385140,957,413 - 140,957,611UniSTSGRCm38
MGSCv375141,433,367 - 141,433,565UniSTSGRCm37
Celera5138,006,767 - 138,006,971UniSTS
Cytogenetic Map5G2UniSTS
cM Map580.0UniSTS
Whitehead Genetic573.2UniSTS
Whitehead_YAC5 UniSTS
Card11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385140,877,768 - 140,878,111UniSTSGRCm38
MGSCv375141,353,722 - 141,354,065UniSTSGRCm37
Celera5137,932,821 - 137,933,164UniSTS
Cytogenetic Map5G2UniSTS
cM Map5 UniSTS
D5Dcr27  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385140,908,731 - 140,908,835UniSTSGRCm38
MGSCv375141,384,685 - 141,384,789UniSTSGRCm37
Celera5137,960,088 - 137,960,192UniSTS
Cytogenetic Map5G2UniSTS
cM Map5 UniSTS
D5Dcr29  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385140,994,339 - 140,994,443UniSTSGRCm38
MGSCv375141,470,293 - 141,470,397UniSTSGRCm37
Celera5138,044,095 - 138,044,199UniSTS
Cytogenetic Map5G2UniSTS
cM Map5 UniSTS
D5Dcr3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385140,920,014 - 140,920,113UniSTSGRCm38
MGSCv375141,395,968 - 141,396,067UniSTSGRCm37
Celera5137,971,381 - 137,971,480UniSTS
Cytogenetic Map5G2UniSTS
cM Map5 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000085786   ⟹   ENSMUSP00000082941
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5140,858,745 - 140,986,337 (-)Ensembl
GRCm38.p6 Ensembl5140,872,990 - 141,000,582 (-)Ensembl
Ensembl Acc Id: ENSMUST00000196169
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5140,858,747 - 140,867,960 (-)Ensembl
GRCm38.p6 Ensembl5140,872,992 - 140,882,205 (-)Ensembl
Ensembl Acc Id: ENSMUST00000199091
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5140,898,302 - 140,986,226 (-)Ensembl
GRCm38.p6 Ensembl5140,912,547 - 141,000,471 (-)Ensembl
RefSeq Acc Id: NM_001419862   ⟹   NP_001406791
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395140,858,109 - 140,986,398 (-)NCBI
RefSeq Acc Id: NM_175362   ⟹   NP_780571
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395140,858,109 - 140,986,398 (-)NCBI
GRCm385140,872,999 - 141,000,596 (-)ENTREZGENE
MGSCv375141,348,953 - 141,476,550 (-)RGD
Celera5137,928,048 - 138,050,352 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_780571   ⟸   NM_175362
- Peptide Label: isoform 1
- UniProtKB: Q8CIS0 (UniProtKB/Swiss-Prot),   Q8BYV0 (UniProtKB/Swiss-Prot),   Q6KAS3 (UniProtKB/Swiss-Prot),   Q4VA14 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000082941   ⟸   ENSMUST00000085786
RefSeq Acc Id: NP_001406791   ⟸   NM_001419862
- Peptide Label: isoform 2
Protein Domains
CARD   Guanylate kinase-like   PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CIS0-F1-model_v2 AlphaFold Q8CIS0 1-1159 view protein structure

Promoters
RGD ID:6888616
Promoter ID:EPDNEW_M7759
Type:initiation region
Name:Card11_2
Description:Mus musculus caspase recruitment domain family, member 11 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7760  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385140,995,834 - 140,995,894EPDNEW
RGD ID:6888618
Promoter ID:EPDNEW_M7760
Type:initiation region
Name:Card11_1
Description:Mus musculus caspase recruitment domain family, member 11 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7759  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385141,000,640 - 141,000,700EPDNEW
RGD ID:6837216
Promoter ID:MM_KWN:44675
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:ENSMUST00000085786,   NM_175362
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365141,476,171 - 141,476,671 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916978 AgrOrtholog
Ensembl Genes ENSMUSG00000036526 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000085786 ENTREZGENE
  ENSMUST00000085786.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot
  2.30.42.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot
InterPro CARD UniProtKB/Swiss-Prot
  CARD_CARD11 UniProtKB/Swiss-Prot
  DEATH-like_dom_sf UniProtKB/Swiss-Prot
  MAGUK_Signaling_Regulators UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
KEGG Report mmu:108723 UniProtKB/Swiss-Prot
MGD MGI:1916978 ENTREZGENE
NCBI Gene Card11 ENTREZGENE
PANTHER CASPASE RECRUITMENT DOMAIN FAMILY UniProtKB/Swiss-Prot
  DISKS LARGE HOMOLOG 5 UniProtKB/TrEMBL
  DISKS LARGE HOMOLOG 5 UniProtKB/TrEMBL
  PTHR14559:SF4 UniProtKB/Swiss-Prot
Pfam CARD UniProtKB/Swiss-Prot
PhenoGen Card11 PhenoGen
PROSITE CARD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CAR11_MOUSE UniProtKB/Swiss-Prot
  Q4VA14 ENTREZGENE
  Q6KAS3 ENTREZGENE
  Q8BVX8_MOUSE UniProtKB/TrEMBL
  Q8BYV0 ENTREZGENE
  Q8CIS0 ENTREZGENE
UniProt Secondary Q4VA14 UniProtKB/Swiss-Prot
  Q6KAS3 UniProtKB/Swiss-Prot
  Q8BYV0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Card11  caspase recruitment domain family, member 11  2410011D02Rik  RIKEN cDNA 2410011D02 gene  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 2410011D02Rik  RIKEN cDNA 2410011D02 gene  Card11  caspase recruitment domain family, member 11  Symbol and/or name change 5135510 APPROVED