Srsf3 (serine and arginine-rich splicing factor 3) - Rat Genome Database

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Gene: Srsf3 (serine and arginine-rich splicing factor 3) Mus musculus
Analyze
Symbol: Srsf3
Name: serine and arginine-rich splicing factor 3
RGD ID: 1319460
MGI Page MGI
Description: Enables phospholipase binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in nuclear speck. Is expressed in brain; cerebral cortex; cerebral cortex ventricular layer; and lung mesenchyme. Orthologous to human SRSF3 (serine and arginine rich splicing factor 3).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AL024116; pre-mRNA-splicing factor SRP20; serine/arginine-rich splicing factor 3; Sf; Sfrs3; splicing factor, arginine/serine-rich 3; splicing factor, arginine/serine-rich 3 (SRp20); X16
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm9761   Srsf3-ps  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391729,251,634 - 29,262,346 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1729,251,602 - 29,262,347 (+)EnsemblGRCm39 Ensembl
GRCm381729,032,660 - 29,043,372 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1729,032,628 - 29,043,373 (+)EnsemblGRCm38mm10GRCm38
MGSCv371729,169,618 - 29,180,311 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361728,760,340 - 28,771,033 (+)NCBIMGSCv36mm8
Celera1729,589,503 - 29,600,185 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.03NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3',5'-cyclic UMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP)
bisphenol A  (ISO)
buspirone  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
carbon nanotube  (EXP)
cisplatin  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
ethylisopropylamiloride  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
gentamycin  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (EXP)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pinosylvin  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
succimer  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
trans-pinosylvin  (ISO)
trichloroethene  (EXP,ISO)
triptonide  (EXP)
trovafloxacin  (ISO)
tungsten  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nuclear speck  (IBA,IDA,ISO)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bile canaliculus morphology  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal cranial neural crest cell morphology  (IAGP)
abnormal endoplasmic reticulum morphology  (IAGP)
abnormal face development  (IAGP)
abnormal facial morphology  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal glucose tolerance  (IAGP)
abnormal hepatobiliary system development  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal hyoid bone greater horn morphology  (IAGP)
abnormal hyoid bone lesser horn morphology  (IAGP)
abnormal hyoid bone morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver sinusoid morphology  (IAGP)
abnormal maxillary frontal process morphology  (IAGP)
abnormal nasal pit morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal palate bone morphology  (IAGP)
abnormal preimplantation embryo development  (IAGP)
abnormal retrotympanic process morphology  (IAGP)
abnormal styloid process morphology  (IAGP)
abnormal temporal bone zygomatic process morphology  (IAGP)
abnormal thymus development  (IAGP)
abnormal tracheal cartilage morphology  (IAGP)
absent frontal bone  (IAGP)
absent maxillary shelf  (IAGP)
absent nasal bone  (IAGP)
absent palatine bone horizontal plate  (IAGP)
absent tympanic ring  (IAGP)
basisphenoid bone hypoplasia  (IAGP)
cricoid cartilage hypoplasia  (IAGP)
decreased B cell number  (IAGP)
decreased body size  (IAGP)
decreased brown adipose tissue amount  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating HDL cholesterol level  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased circulating serum albumin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased cranial neural crest cell apoptosis  (IAGP)
decreased cranial neural crest cell proliferation  (IAGP)
decreased fatty acid oxidation  (IAGP)
decreased liver cholesterol level  (IAGP)
decreased liver glycogen level  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased midbrain size  (IAGP)
decreased pre-B cell number  (IAGP)
decreased pro-B cell number  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
embryonic lethality before implantation, complete penetrance  (IAGP)
enlarged lateral ventricles  (IAGP)
exencephaly  (IAGP)
facial bone hypoplasia  (IAGP)
facial cleft  (IAGP)
failure of blastocyst formation  (IAGP)
hypoglycemia  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating bilirubin level  (IAGP)
increased circulating growth hormone level  (IAGP)
increased forebrain size  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased insulin sensitivity  (IAGP)
internal hemorrhage  (IAGP)
interparietal bone hypoplasia  (IAGP)
lethality throughout fetal growth and development  (IAGP)
mandible hypoplasia  (IAGP)
mandibular coronoid process hypoplasia  (IAGP)
maxilla hypoplasia  (IAGP)
maxillary zygomatic process hypoplasia  (IAGP)
Meckel's cartilage hypoplasia  (IAGP)
microcephaly  (IAGP)
midbrain hypoplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
palatal shelf hypoplasia  (IAGP)
pale liver  (IAGP)
parietal bone hypoplasia  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premaxilla hypoplasia  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
pterygoid bone hypoplasia  (IAGP)
small liver  (IAGP)
small supraoccipital bone  (IAGP)
temporal bone hypoplasia  (IAGP)
thyroid cartilage hypoplasia  (IAGP)
tongue hypoplasia  (IAGP)
wavy neural tube  (IAGP)
zygomatic bone hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
2. Differentially expressed genes after peripheral nerve injury. Gillen C, etal., J Neurosci Res. 1995 Oct 1;42(2):159-71.
3. Alterations in expression pattern of splicing factors in epithelial ovarian cancer and its clinical impact. Iborra S, etal., Int J Gynecol Cancer. 2013 Jul;23(6):990-6. doi: 10.1097/IGC.0b013e31829783e3.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. The spliceosome: design principles of a dynamic RNP machine. Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.
13. Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients. Watanuki T, etal., J Affect Disord. 2008 Sep;110(1-2):62-9. doi: 10.1016/j.jad.2008.01.003. Epub 2008 Feb 20.
Additional References at PubMed
PMID:2030943   PMID:7671812   PMID:8617202   PMID:9154810   PMID:10349636   PMID:10469594   PMID:10640718   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12124942  
PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:15328023   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16940357   PMID:17022104   PMID:17911373  
PMID:18799693   PMID:19159640   PMID:20439489   PMID:20516191   PMID:20639886   PMID:20657840   PMID:21179588   PMID:21873635   PMID:22436691   PMID:22794259   PMID:23233666   PMID:23299886  
PMID:23665500   PMID:23818142   PMID:24457600   PMID:24591653   PMID:25132062   PMID:25921334   PMID:26167872   PMID:26336360   PMID:26435690   PMID:28378742   PMID:29055695   PMID:29241548  
PMID:29459677   PMID:29741478   PMID:29799838   PMID:30068389   PMID:30200638   PMID:30457570   PMID:30550785   PMID:30835716   PMID:31145021   PMID:31393851   PMID:32325033   PMID:32338600  
PMID:32581705   PMID:33706811   PMID:33819356   PMID:34133714   PMID:34184034   PMID:34354569   PMID:34605568   PMID:34852174   PMID:35012549   PMID:35615981   PMID:35739118   PMID:36293380  
PMID:37055407  


Genomics

Comparative Map Data
Srsf3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391729,251,634 - 29,262,346 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1729,251,602 - 29,262,347 (+)EnsemblGRCm39 Ensembl
GRCm381729,032,660 - 29,043,372 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1729,032,628 - 29,043,373 (+)EnsemblGRCm38mm10GRCm38
MGSCv371729,169,618 - 29,180,311 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361728,760,340 - 28,771,033 (+)NCBIMGSCv36mm8
Celera1729,589,503 - 29,600,185 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.03NCBI
SRSF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38636,594,362 - 36,605,600 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl636,594,353 - 36,605,600 (+)EnsemblGRCh38hg38GRCh38
GRCh37636,562,139 - 36,573,377 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36636,670,144 - 36,679,187 (+)NCBINCBI36Build 36hg18NCBI36
Build 34636,670,143 - 36,679,187NCBI
Celera638,117,136 - 38,127,290 (+)NCBICelera
Cytogenetic Map6p21.31-p21.2NCBI
HuRef636,280,649 - 36,290,802 (+)NCBIHuRef
CHM1_1636,563,858 - 36,574,011 (+)NCBICHM1_1
T2T-CHM13v2.0636,415,006 - 36,426,242 (+)NCBIT2T-CHM13v2.0
Srsf3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2207,091,928 - 7,101,860 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl207,091,910 - 7,101,078 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,803,145 - 7,813,066 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0207,165,002 - 7,174,923 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0207,639,798 - 7,649,730 (+)NCBIRnor_WKY
Rnor_6.0206,288,285 - 6,298,218 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,288,267 - 6,298,213 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,534,919 - 8,544,852 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,316,649 - 7,326,580 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1207,316,875 - 7,326,807 (+)NCBI
Celera208,643,622 - 8,653,553 (+)NCBICelera
Cytogenetic Map20p12NCBI
Srsf3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554376,306,151 - 6,314,332 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554376,306,151 - 6,314,332 (-)NCBIChiLan1.0ChiLan1.0
SRSF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1646,932,631 - 46,941,830 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0636,157,321 - 36,165,896 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1637,352,484 - 37,362,196 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl637,352,484 - 37,362,195 (+)Ensemblpanpan1.1panPan2
SRSF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,677,879 - 5,686,220 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,677,907 - 5,684,446 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha125,696,947 - 5,705,330 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0126,026,006 - 6,034,386 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl126,026,034 - 6,035,139 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1125,681,309 - 5,689,692 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0125,760,111 - 5,768,487 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0125,858,304 - 5,866,684 (+)NCBIUU_Cfam_GSD_1.0
Srsf3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494641,160,749 - 41,169,819 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647622,790,411 - 22,799,452 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647622,790,411 - 22,799,498 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRSF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl732,289,480 - 32,298,580 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1732,289,464 - 32,298,652 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2737,191,583 - 37,199,370 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRSF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11735,535,900 - 35,544,852 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604436,534,264 - 36,542,771 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srsf3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475421,163,232 - 21,171,058 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475421,163,232 - 21,171,122 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Srsf3
568 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1163
Count of miRNA genes:524
Interacting mature miRNAs:638
Transcripts:ENSMUST00000037776, ENSMUST00000130216, ENSMUST00000144551, ENSMUST00000147265, ENSMUST00000150157
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13524851Asrq8_macoustic startle response 8 (mouse)17131030170Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17787584329487423Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171683545533819843Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172507658355712970Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172558491443976235Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172640101252911704Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172650533741105037Mouse
12904013Cfq12_mconditioned fear QTL 12 (mouse)172682878130664955Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172771579245622654Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
10045977Tir9_mtrypanosome infection response 9 (mouse)Not determined172787811943885114Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172862240662622654Mouse

Markers in Region
RH136130  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38188,226,205 - 8,226,406UniSTSGRCm38
GRCm381729,042,504 - 29,042,704UniSTSGRCm38
MGSCv37188,226,203 - 8,226,404UniSTSGRCm37
MGSCv371729,179,449 - 29,179,649UniSTSGRCm37
Celera188,269,927 - 8,270,128UniSTS
Celera1729,599,323 - 29,599,523UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map17A3.3UniSTS
RH125488  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38188,226,746 - 8,227,034UniSTSGRCm38
GRCm381729,041,888 - 29,042,164UniSTSGRCm38
MGSCv37188,226,744 - 8,227,032UniSTSGRCm37
MGSCv371729,178,833 - 29,179,109UniSTSGRCm37
Celera188,270,468 - 8,270,756UniSTS
Celera1729,598,707 - 29,598,983UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map17A3.3UniSTS
UniSTS:225320  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381729,042,686 - 29,042,863UniSTSGRCm38
MGSCv371729,179,631 - 29,179,808UniSTSGRCm37
Celera1729,599,505 - 29,599,682UniSTS
Cytogenetic Map17A3.3UniSTS
SFRS3_1875  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381729,042,160 - 29,042,769UniSTSGRCm38
MGSCv371729,179,105 - 29,179,714UniSTSGRCm37
Celera1729,598,979 - 29,599,588UniSTS
Cytogenetic Map17A3.3UniSTS
Sfrs3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381729,035,067 - 29,036,267UniSTSGRCm38
MGSCv371729,172,012 - 29,173,212UniSTSGRCm37
Celera1729,591,898 - 29,593,090UniSTS
Cytogenetic Map17A3.3UniSTS
cM Map1711.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_036613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC167363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB008721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC068111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC071196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY249648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT009662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OP966671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OP966672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OP966673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OP966674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X91656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000037776   ⟹   ENSMUSP00000049025
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1729,251,606 - 29,261,871 (+)Ensembl
GRCm38.p6 Ensembl1729,032,632 - 29,042,897 (+)Ensembl
RefSeq Acc Id: ENSMUST00000130216   ⟹   ENSMUSP00000117045
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1729,251,602 - 29,262,347 (+)Ensembl
GRCm38.p6 Ensembl1729,032,628 - 29,043,373 (+)Ensembl
RefSeq Acc Id: ENSMUST00000144551
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1729,255,353 - 29,259,115 (+)Ensembl
GRCm38.p6 Ensembl1729,036,379 - 29,040,141 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147265
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1729,251,623 - 29,261,217 (+)Ensembl
GRCm38.p6 Ensembl1729,032,649 - 29,042,243 (+)Ensembl
RefSeq Acc Id: ENSMUST00000150157
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1729,258,492 - 29,261,084 (+)Ensembl
GRCm38.p6 Ensembl1729,039,518 - 29,042,110 (+)Ensembl
RefSeq Acc Id: ENSMUST00000233010   ⟹   ENSMUSP00000156504
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1729,258,428 - 29,259,709 (+)Ensembl
GRCm38.p6 Ensembl1729,039,454 - 29,040,735 (+)Ensembl
RefSeq Acc Id: ENSMUST00000233105
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1729,258,668 - 29,260,705 (+)Ensembl
GRCm38.p6 Ensembl1729,039,694 - 29,041,731 (+)Ensembl
RefSeq Acc Id: ENSMUST00000233127
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1729,251,663 - 29,260,227 (+)Ensembl
GRCm38.p6 Ensembl1729,032,689 - 29,041,253 (+)Ensembl
RefSeq Acc Id: ENSMUST00000233209
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1729,251,663 - 29,257,659 (+)Ensembl
GRCm38.p6 Ensembl1729,032,689 - 29,038,685 (+)Ensembl
RefSeq Acc Id: ENSMUST00000233885
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1729,251,647 - 29,254,482 (+)Ensembl
GRCm38.p6 Ensembl1729,032,673 - 29,035,508 (+)Ensembl
RefSeq Acc Id: NM_013663   ⟹   NP_038691
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391729,251,634 - 29,262,346 (+)NCBI
GRCm381729,032,660 - 29,043,372 (+)ENTREZGENE
MGSCv371729,169,618 - 29,180,311 (+)RGD
Celera1729,589,490 - 29,600,191 (+)ENTREZGENE
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_036613
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391729,251,634 - 29,262,346 (+)NCBI
GRCm381729,032,660 - 29,043,372 (+)ENTREZGENE
Celera1729,589,490 - 29,600,191 (+)ENTREZGENE
cM Map17 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_038691   ⟸   NM_013663
- UniProtKB: Q564E9 (UniProtKB/Swiss-Prot),   P84104 (UniProtKB/Swiss-Prot),   A0A6P5RD25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000117045   ⟸   ENSMUST00000130216
RefSeq Acc Id: ENSMUSP00000156504   ⟸   ENSMUST00000233010
RefSeq Acc Id: ENSMUSP00000049025   ⟸   ENSMUST00000037776
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P84104-F1-model_v2 AlphaFold P84104 1-164 view protein structure

Promoters
RGD ID:13675400
Promoter ID:EPDNEW_M21849
Type:multiple initiation site
Name:Srsf3_1
Description:Mus musculus serine/arginine-rich splicing factor 3 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381729,032,673 - 29,032,733EPDNEW
RGD ID:6828697
Promoter ID:MM_KWN:22911
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000097356,   ENSMUST00000114717,   NM_013663,   OTTMUST00000078434,   UC008BSE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361729,169,276 - 29,170,002 (+)MPROMDB
RGD ID:6828677
Promoter ID:MM_KWN:22912
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   ES_Cell,   MEF_B6
Transcripts:OTTMUST00000078435
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361729,172,511 - 29,173,712 (+)MPROMDB
RGD ID:6828676
Promoter ID:MM_KWN:22913
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day4,   BoneMarrow_0Hour,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:OTTMUST00000078436
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361729,176,656 - 29,177,562 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98285 AgrOrtholog
Ensembl Genes ENSMUSG00000071172 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000049025.9 UniProtKB/Swiss-Prot
  ENSMUSP00000117045 ENTREZGENE
  ENSMUSP00000117045.2 UniProtKB/Swiss-Prot
  ENSMUSP00000156504.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000037776 ENTREZGENE
  ENSMUST00000037776.16 UniProtKB/Swiss-Prot
  ENSMUST00000130216 ENTREZGENE
  ENSMUST00000130216.3 UniProtKB/Swiss-Prot
  ENSMUST00000233010.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20383 UniProtKB/Swiss-Prot
MGD MGI:98285 ENTREZGENE
NCBI Gene 20383 ENTREZGENE
PANTHER RRM DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  SERINE/ARGININE RICH SPLICING FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/ARGININE-RICH SPLICING FACTOR 3 UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Srsf3 PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3B2W3M9_MOUSE UniProtKB/TrEMBL
  A0A6P5RD25 ENTREZGENE
  P84104 ENTREZGENE
  Q3U781_MOUSE UniProtKB/TrEMBL
  Q564E9 ENTREZGENE
  Q9D6W4_MOUSE UniProtKB/TrEMBL
  SRSF3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary O08831 UniProtKB/Swiss-Prot
  P23152 UniProtKB/Swiss-Prot
  Q564E9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-27 Srsf3  serine and arginine-rich splicing factor 3  Srsf3  serine/arginine-rich splicing factor 3  Symbol and/or name change 5135510 APPROVED
2011-07-27 Srsf3  serine/arginine-rich splicing factor 3  Sfrs3  splicing factor, arginine/serine-rich 3 (SRp20)  Symbol and/or name change 5135510 APPROVED