Adam24 (ADAM metallopeptidase domain 24) - Rat Genome Database

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Gene: Adam24 (ADAM metallopeptidase domain 24) Mus musculus
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Symbol: Adam24
Name: ADAM metallopeptidase domain 24
RGD ID: 1319199
MGI Page MGI
Description: Predicted to enable integrin binding activity and metalloendopeptidase activity. Acts upstream of or within prevention of polyspermy. Located in external side of plasma membrane and sperm head plasma membrane. Is expressed in genitourinary system. Orthologous to human ADAM24P (ADAM metallopeptidase domain 24, pseudogene).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: a disintegrin and metallopeptidase domain 24 (testase 1); a disintegrin and metalloproteinase domain 24 (testase 1); ADAM 24; disintegrin 5; disintegrin and metalloproteinase domain-containing protein 24; Dtgn; Dtgn5; testase 1; testase-1
RGD Orthologs
Human
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39841,128,118 - 41,135,238 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl841,128,118 - 41,135,238 (+)EnsemblGRCm39 Ensembl
GRCm38840,675,077 - 40,682,199 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl840,675,077 - 40,682,199 (+)EnsemblGRCm38mm10GRCm38
MGSCv37841,760,448 - 41,767,553 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36842,173,911 - 42,181,016 (+)NCBIMGSCv36mm8
Celera843,321,556 - 43,328,596 (+)NCBICelera
Cytogenetic Map8A4NCBI
cM Map823.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8146185   PMID:10349636   PMID:10395895   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11309208   PMID:12477932   PMID:16141072   PMID:16141073   PMID:18287559   PMID:19129510  
PMID:19334288   PMID:19670298   PMID:21267068   PMID:21873635   PMID:24079728  


Genomics

Comparative Map Data
Adam24
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39841,128,118 - 41,135,238 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl841,128,118 - 41,135,238 (+)EnsemblGRCm39 Ensembl
GRCm38840,675,077 - 40,682,199 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl840,675,077 - 40,682,199 (+)EnsemblGRCm38mm10GRCm38
MGSCv37841,760,448 - 41,767,553 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36842,173,911 - 42,181,016 (+)NCBIMGSCv36mm8
Celera843,321,556 - 43,328,596 (+)NCBICelera
Cytogenetic Map8A4NCBI
cM Map823.89NCBI
NPIPB11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381629,381,167 - 29,406,711 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1629,381,310 - 29,406,711 (-)EnsemblGRCh38hg38GRCh38
GRCh371629,392,631 - 29,418,032 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361629,300,268 - 29,322,624 (-)NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map16p11.2NCBI
CHM1_11630,404,474 - 30,433,500 (-)NCBICHM1_1
T2T-CHM13v2.01629,663,351 - 29,688,504 (-)NCBIT2T-CHM13v2.0
Adam24
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81658,281,748 - 58,287,735 (-)NCBIGRCr8
mRatBN7.21651,578,278 - 51,584,265 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1651,578,277 - 51,584,312 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01654,625,789 - 54,631,824 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1654,625,847 - 54,628,458 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01654,333,065 - 54,339,049 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41654,916,429 - 54,918,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11654,916,503 - 54,918,726 (-)NCBI
Celera1649,470,643 - 49,476,678 (-)NCBICelera
Cytogenetic Map16q12.1NCBI

Variants

.
Variants in Adam24
237 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:88
Interacting mature miRNAs:88
Transcripts:ENSMUST00000051614
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301139Lmr10_mleishmaniasis resistance 10 (mouse)Not determined83532109757797633Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
11049577Lmr10b_mleishmaniasis resistance 10b (mouse)83532109757797633Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3250657271740637Mouse
11049578Lmr10c_mleishmaniasis resistance 10c (mouse)83532109757797633Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
11041902Lmr10a_mleishmaniasis resistance 10a (mouse)83532109757797633Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3250657271740637Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
10043990Hbnr12_mHeligmosomoides bakeri nematode resistance 12 (mouse)Not determined83327701651290537Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3250657271740637Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
1301196Mnif1_mmacronutrient intake (mouse)Not determined83510993045305872Mouse
10043974Obq30_mobesity QTL 30 (mouse)Not determined82658332260583322Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83429039768290537Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
13524525Bodwtq7_mbody wweight QTL 7 (mouse)82824955647027681Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83250657271740637Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000051614   ⟹   ENSMUSP00000050727
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl841,128,118 - 41,135,238 (+)Ensembl
GRCm38.p6 Ensembl840,675,077 - 40,682,199 (+)Ensembl
RefSeq Acc Id: NM_010086   ⟹   NP_034216
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39841,128,118 - 41,135,238 (+)NCBI
GRCm38840,675,077 - 40,682,199 (+)NCBI
MGSCv37841,760,448 - 41,767,553 (+)RGD
Celera843,321,556 - 43,328,596 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509261   ⟹   XP_006509324
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39841,128,930 - 41,135,166 (+)NCBI
GRCm38840,675,890 - 40,682,127 (+)NCBI
Sequence:
RefSeq Acc Id: NP_034216   ⟸   NM_010086
- Peptide Label: preproprotein
- UniProtKB: A6H683 (UniProtKB/Swiss-Prot),   E9QL68 (UniProtKB/Swiss-Prot),   Q9R160 (UniProtKB/Swiss-Prot),   Q8CDV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509324   ⟸   XM_006509261
- Peptide Label: isoform X1
- UniProtKB: A6H683 (UniProtKB/Swiss-Prot),   E9QL68 (UniProtKB/Swiss-Prot),   Q9R160 (UniProtKB/Swiss-Prot),   Q8CDV3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000050727   ⟸   ENSMUST00000051614
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R160-F1-model_v2 AlphaFold Q9R160 1-761 view protein structure

Promoters
RGD ID:8666935
Promoter ID:EPDNEW_M11499
Type:multiple initiation site
Name:Adam24_1
Description:Mus musculus a disintegrin and metallopeptidase domain 24 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38840,675,065 - 40,675,125EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105984 AgrOrtholog
Ensembl Genes ENSMUSG00000046723 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000051614 ENTREZGENE
  ENSMUST00000051614.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13526 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:105984 ENTREZGENE
NCBI Gene 13526 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11905:SF118 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adam24 PhenoGen
PROSITE ADAM_MEPRO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART ACR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57552 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6H683 ENTREZGENE
  ADA24_MOUSE UniProtKB/Swiss-Prot
  E9QL68 ENTREZGENE
  Q60624_MOUSE UniProtKB/TrEMBL
  Q8CDV3 ENTREZGENE, UniProtKB/TrEMBL
  Q9R160 ENTREZGENE
UniProt Secondary A6H683 UniProtKB/Swiss-Prot
  E9QL68 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Adam24  ADAM metallopeptidase domain 24  Adam24  a disintegrin and metallopeptidase domain 24 (testase 1)  Symbol and/or name change 5135510 APPROVED