Hint2 (histidine triad nucleotide binding protein 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Hint2 (histidine triad nucleotide binding protein 2) Mus musculus
Analyze
Symbol: Hint2
Name: histidine triad nucleotide binding protein 2
RGD ID: 1318949
MGI Page MGI
Description: Predicted to enable adenosine 5'-monophosphoramidase activity. Acts upstream of or within lipid catabolic process and negative regulation of peptidyl-lysine acetylation. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including brown fat; liver; lung; metanephros; and spleen. Orthologous to human HINT2 (histidine triad nucleotide binding protein 2).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1190005L05Rik; adenosine 5'-monophosphoramidase HINT2; HINT-2; HINT-3; histidine triad nucleotide-binding protein 2, mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,654,227 - 43,656,445 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,654,227 - 43,656,466 (-)EnsemblGRCm39 Ensembl
GRCm38443,654,227 - 43,656,445 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,654,227 - 43,656,466 (-)EnsemblGRCm38mm10GRCm38
MGSCv37443,667,099 - 43,669,317 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36443,675,327 - 43,677,551 (-)NCBIMGSCv36mm8
Celera443,688,832 - 43,691,050 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
mitochondrial matrix  (IDA)
mitochondrion  (HDA,IBA,IDA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12748294   PMID:16141072   PMID:16141073   PMID:18614015   PMID:18653718   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:22961760   PMID:24010670   PMID:25863250   PMID:26767982   PMID:29199018   PMID:29222160   PMID:29913563   PMID:30550785   PMID:31900976   PMID:32325033   PMID:34914018   PMID:36722640  
PMID:38546629  


Genomics

Comparative Map Data
Hint2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,654,227 - 43,656,445 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,654,227 - 43,656,466 (-)EnsemblGRCm39 Ensembl
GRCm38443,654,227 - 43,656,445 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,654,227 - 43,656,466 (-)EnsemblGRCm38mm10GRCm38
MGSCv37443,667,099 - 43,669,317 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36443,675,327 - 43,677,551 (-)NCBIMGSCv36mm8
Celera443,688,832 - 43,691,050 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.05NCBI
HINT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,812,960 - 35,815,479 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl935,812,960 - 35,815,354 (-)EnsemblGRCh38hg38GRCh38
GRCh37935,812,957 - 35,815,039 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,802,957 - 35,805,042 (-)NCBINCBI36Build 36hg18NCBI36
Build 34935,802,956 - 35,805,042NCBI
Celera935,746,489 - 35,748,574 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,768,969 - 35,771,054 (-)NCBIHuRef
CHM1_1935,813,345 - 35,815,430 (-)NCBICHM1_1
T2T-CHM13v2.0935,833,627 - 35,836,146 (-)NCBIT2T-CHM13v2.0
Hint2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,700,383 - 62,702,638 (-)NCBIGRCr8
mRatBN7.2557,904,613 - 57,906,868 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,904,614 - 57,907,097 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,884,698 - 59,886,953 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,703,512 - 61,705,767 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,674,738 - 61,676,993 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,150,344 - 59,152,599 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,150,345 - 59,152,599 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,675,136 - 63,677,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,130,993 - 60,133,248 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1560,131,171 - 60,133,804 (-)NCBI
Celera556,485,081 - 56,487,336 (-)NCBICelera
Cytogenetic Map5q22NCBI
Hint2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955472500,845 - 503,067 (+)NCBIChiLan1.0ChiLan1.0
HINT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,773,684 - 88,775,887 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,779,754 - 88,781,825 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,663,433 - 35,666,479 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,465,806 - 36,468,325 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,465,806 - 36,468,325 (-)Ensemblpanpan1.1panPan2
HINT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,342,564 - 52,344,994 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,342,567 - 52,344,947 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,910,135 - 50,912,566 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,407,581 - 53,410,013 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,407,584 - 53,409,966 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,952,089 - 51,954,522 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,936,313 - 51,938,949 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,637,771 - 52,640,202 (-)NCBIUU_Cfam_GSD_1.0
HINT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11236,532,316 - 236,535,263 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,257,330 - 264,259,797 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HINT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,790,455 - 44,792,571 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,790,416 - 44,792,625 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603841,894,686 - 41,897,216 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hint2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248684,969,085 - 4,971,336 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248684,969,076 - 4,971,336 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hint2
71 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:748
Count of miRNA genes:346
Interacting mature miRNAs:390
Transcripts:ENSMUST00000030192, ENSMUST00000130593, ENSMUST00000134050, ENSMUST00000134082, ENSMUST00000151238, ENSMUST00000151514, ENSMUST00000155985
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301203Alcp8_malcohol preference locus 8 (mouse)Not determined41739516051395290Mouse
1301586Stheal3_msoft tissue heal 3 (mouse)Not determined42865844262658566Mouse
10401115Pgia35_mproteoglycan induced arthritis 35 (mouse)Not determined41256237746562509Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
1301786Bpq3_mblood pressure QTL 3 (mouse)Not determined44240224076402381Mouse
4141555Nbwa2_mNZB and NZW autoimmunity 2 (mouse)Not determined41789251551892635Mouse
10412178Habiir2_mhyperoxic acute lung injury imprinted region 2 (mouse)Not determined43945212663283678Mouse
1300574Im2_mimmunoregulatory 2 (mouse)Not determined42807768262077816Mouse
12880405Jcdq1_mjoint cartilage degeneration QTL 1 (mouse)41256237746562509Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
1301697Sluc18_msusceptibility to lung cancer 18 (mouse)Not determined42237344856373612Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
1357877Synch1_msynechia 1 (mouse)Not determined42870992562710107Mouse
1300977Mopkd1_mmodifier of polycystic kidney disease progression 1 (mouse)Not determined43655083970550967Mouse
25440481Moaq1_mmodifier of alien QTL 1 (mouse)41950000046000000Mouse
1301237Alcp7_malcohol preference locus 7 (mouse)Not determined41739516051395290Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
1302075Bdln6_mbody length 6 (mouse)Not determined42237344856373612Mouse
4142290Ssrq9_mstress response QTL 9 (mouse)Not determined3439516046332776Mouse
1301437Scon1_msucrose consumption 1 (mouse)Not determined42237344856373612Mouse
10401905Sicd3_mseizure-induced cell death 3 (mouse)Not determined4939552543760862Mouse
1300769Pcyts2_mplasmacytoma susceptibility 2 (mouse)Not determined42211194456112145Mouse
1301792Hdlq10_mHDL QTL 10 (mouse)Not determined43585970769859853Mouse
1301990Arvm1_mautoimmune renal vasculitis 1 (mouse)Not determined42933264663332776Mouse
1302116Bbaa1_mB.burgdorferi-associated arthritis 1 (mouse)Not determined43825093072251078Mouse
1302058Hrtfm3_mheart failure modifier 3 (mouse)Not determined42211194456112145Mouse
1302184Aaom1_mautoimmune aoritis in MRL mice 1 (mouse)Not determined42432229946332776Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108357197Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000030192   ⟹   ENSMUSP00000030192
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl443,654,229 - 43,656,466 (-)Ensembl
GRCm38.p6 Ensembl443,654,229 - 43,656,466 (-)Ensembl
Ensembl Acc Id: ENSMUST00000130593
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl443,654,227 - 43,656,448 (-)Ensembl
GRCm38.p6 Ensembl443,654,227 - 43,656,448 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134050
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl443,654,228 - 43,654,956 (-)Ensembl
GRCm38.p6 Ensembl443,654,228 - 43,654,956 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134082
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl443,654,229 - 43,654,727 (-)Ensembl
GRCm38.p6 Ensembl443,654,229 - 43,654,727 (-)Ensembl
Ensembl Acc Id: ENSMUST00000151238
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl443,654,227 - 43,656,443 (-)Ensembl
GRCm38.p6 Ensembl443,654,227 - 43,656,443 (-)Ensembl
Ensembl Acc Id: ENSMUST00000151514
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl443,654,230 - 43,656,448 (-)Ensembl
GRCm38.p6 Ensembl443,654,230 - 43,656,448 (-)Ensembl
Ensembl Acc Id: ENSMUST00000155985
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl443,654,674 - 43,655,743 (-)Ensembl
GRCm38.p6 Ensembl443,654,674 - 43,655,743 (-)Ensembl
RefSeq Acc Id: NM_026871   ⟹   NP_081147
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39443,654,227 - 43,656,445 (-)NCBI
GRCm38443,654,227 - 43,656,445 (-)NCBI
MGSCv37443,667,099 - 43,669,317 (-)RGD
Celera443,688,832 - 43,691,050 (-)RGD
cM Map4 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_081147 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86940 (Get FASTA)   NCBI Sequence Viewer  
  AAK94774 (Get FASTA)   NCBI Sequence Viewer  
  AAM00220 (Get FASTA)   NCBI Sequence Viewer  
  BAB23334 (Get FASTA)   NCBI Sequence Viewer  
  EDL02454 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000030192
  ENSMUSP00000030192.5
GenBank Protein Q9D0S9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_081147   ⟸   NM_026871
- Peptide Label: precursor
- UniProtKB: Q9D0S9 (UniProtKB/Swiss-Prot),   Q5M9J2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000030192   ⟸   ENSMUST00000030192
Protein Domains
HIT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D0S9-F1-model_v2 AlphaFold Q9D0S9 1-163 view protein structure

Promoters
RGD ID:6883246
Promoter ID:EPDNEW_M5074
Type:multiple initiation site
Name:Hint2_1
Description:Mus musculus histidine triad nucleotide binding protein 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38443,656,451 - 43,656,511EPDNEW
RGD ID:6835466
Promoter ID:MM_KWN:37377
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   BoneMarrow_0Hour,   Brain,   ES_Cell,   Kidney,   Liver,   MEF_B6
Transcripts:OTTMUST00000016321,   OTTMUST00000016322,   OTTMUST00000016326
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36443,668,306 - 43,669,362 (-)MPROMDB
RGD ID:6835468
Promoter ID:MM_KWN:37378
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000016320,   OTTMUST00000016323,   OTTMUST00000016324,   OTTMUST00000016325
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36443,669,046 - 43,669,546 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916167 AgrOrtholog
Ensembl Genes ENSMUSG00000028470 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000030192 ENTREZGENE
  ENSMUST00000030192.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.428.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Histidine_triad_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histidine_triad_HIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIT-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIT-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:68917 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1916167 ENTREZGENE
NCBI Gene 68917 ENTREZGENE
PANTHER HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 2, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23089 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hint2 PhenoGen
PRINTS HISTRIAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HIT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54197 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HINT2_MOUSE UniProtKB/Swiss-Prot
  Q5M9J2 ENTREZGENE, UniProtKB/TrEMBL
  Q9D0S9 ENTREZGENE