Stk11 (serine/threonine kinase 11) - Rat Genome Database

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Gene: Stk11 (serine/threonine kinase 11) Mus musculus
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Symbol: Stk11
Name: serine/threonine kinase 11
RGD ID: 1318549
MGI Page MGI
Description: Enables LRR domain binding activity; protein kinase activator activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular response to UV-B; negative regulation of cold-induced thermogenesis; and positive regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including dendrite extension; regulation of neuron projection development; and regulation of signal transduction. Located in cytosol; membrane; and nucleus. Is expressed in several structures, including alimentary system; blood; genitourinary system; lung; and nervous system. Used to study Peutz-Jeghers syndrome; endometrial cancer; lung cancer; and urinary bladder cancer. Human ortholog(s) of this gene implicated in Peutz-Jeghers syndrome; cervical mucinous adenocarcinoma; familial melanoma; ovarian carcinoma; and pancreatic cancer. Orthologous to human STK11 (serine/threonine kinase 11).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA408040; liver kinase B1 homolog; Lkb; Lkb1; LKB1 short isoform; mLKB1; Pa; Par-4; R75140; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; serine/threonine-protein kinase STK11
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,951,602 - 79,966,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,951,637 - 79,966,516 (+)EnsemblGRCm39 Ensembl
GRCm381080,115,767 - 80,130,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,115,803 - 80,130,682 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,579,281 - 79,593,215 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,519,331 - 79,533,808 (+)NCBIMGSCv36mm8
Celera1081,131,368 - 81,145,302 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
bile duct cancer  (ISO)
brain cancer  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Cardiomegaly  (IEP)
cerebral creatine deficiency syndrome  (ISO)
cervical mucinous adenocarcinoma  (ISO)
colon carcinoma  (ISO)
Cronkhite-Canada syndrome  (ISO)
cyclic hematopoiesis  (ISO)
Distal Arthrogryposis, with Impaired Proprioception and Touch  (ISO)
dysplastic nevus syndrome  (ISO)
embryonal rhabdomyosarcoma  (ISO)
endometrial cancer  (IAGP,ISO)
endometrial carcinoma  (ISO)
familial adenomatous polyposis  (ISO)
familial adenomatous polyposis 1  (ISO)
familial adenomatous polyposis 2  (ISO)
familial melanoma  (ISO)
Familial Pancreatic Carcinoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatoblastoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
Insulin Resistance  (ISO)
juvenile polyposis syndrome  (ISO)
Left Ventricular Hypertrophy  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Marfanoid Mental Retardation Syndrome, Autosomal  (ISO)
melanoma  (ISO)
multiple endocrine neoplasia type 1  (ISO)
obesity  (ISO)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
Peutz-Jeghers syndrome  (IAGP,ISO)
prostate carcinoma in situ  (IAGP)
skin melanoma  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
testicular cancer  (ISO)
testicular germ cell cancer  (ISO)
Testicular Germ Cell Tumor  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-acanthoic acid  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-lipoic acid  (EXP)
1,3-dichloropropan-2-ol  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-deoxy-D-glucose  (ISO)
3',5'-cyclic GMP  (ISO)
3-aminobenzamide  (ISO)
3-bromopyruvic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
5-methyltetrahydrofolic acid  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (EXP)
amitrole  (ISO)
Ammothamnine  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
ATP  (ISO)
bafilomycin A1  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
beta-ionone  (ISO)
bisphenol A  (ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
bortezomib  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
chenodeoxycholic acid  (EXP)
choline  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
corosolic acid  (EXP)
D-glucose  (EXP)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
deoxypodophyllotoxin  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dieldrin  (EXP,ISO)
diosgenin  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
ethanol  (EXP)
fenofibrate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formononetin  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
Gastrodin  (ISO)
geldanamycin  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg2  (ISO)
glucose  (EXP)
hexadecanoic acid  (ISO)
histamine  (ISO)
ionomycin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (ISO)
L-methionine  (EXP)
lactacystin  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP)
lonidamine  (ISO)
maslinic acid  (EXP)
mechlorethamine  (EXP)
metformin  (ISO)
methimazole  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
oleanolic acid  (EXP)
oleic acid  (ISO)
orotic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
Picroside ii  (EXP)
pioglitazone  (ISO)
pterostilbene  (ISO)
quercetin  (EXP)
resveratrol  (EXP,ISO)
rubimaillin  (ISO)
selenium atom  (ISO)
sertraline  (ISO)
silicon atom  (EXP)
simvastatin  (EXP)
sodium arsenate  (EXP)
sucrose  (ISO)
tamoxifen  (EXP)
thymoquinone  (EXP,ISO)
titanium dioxide  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
U-73122  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
anoikis  (IEA,ISO)
apoptotic process  (IEA)
autophagy  (IEA)
axonogenesis  (IGI,IMP,ISO)
cell differentiation  (IEA)
cellular response to UV-B  (IDA,IEA,ISO)
dendrite extension  (IMP)
DNA damage response  (IBA,IEA,IMP,ISO)
epithelial cell proliferation involved in prostate gland development  (IMP)
establishment of cell polarity  (IBA,IEA,IMP,ISO)
G1 to G0 transition  (IEA,ISO)
glucose homeostasis  (IEA,IMP)
Golgi localization  (IMP)
intrinsic apoptotic signaling pathway by p53 class mediator  (IEA,ISO,ISS)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO,ISS)
negative regulation of cell growth  (IDA)
negative regulation of cell population proliferation  (IEA,IMP,ISO)
negative regulation of cold-induced thermogenesis  (IMP)
negative regulation of epithelial cell proliferation involved in prostate gland development  (IMP)
negative regulation of TORC1 signaling  (IEA,ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of autophagy  (IEA,ISO)
positive regulation of axonogenesis  (IGI)
positive regulation of cellular senescence  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of protein localization to nucleus  (IMP)
positive regulation of transforming growth factor beta receptor signaling pathway  (IEA,IMP,ISO)
positive regulation of vesicle transport along microtubule  (IBA,IEA,IMP,ISO)
positive thymic T cell selection  (IMP)
protein autophosphorylation  (IDA,ISO)
protein dephosphorylation  (ISO,ISS)
protein localization to nucleus  (IMP)
protein phosphorylation  (IDA,IMP,ISO,ISS)
regulation of cell growth  (IDA,IEA)
regulation of dendrite morphogenesis  (IMP)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
regulation of Wnt signaling pathway  (IBA,IMP)
response to activity  (ISO)
response to glucagon  (ISO)
response to ionizing radiation  (IDA)
response to lipid  (ISO)
response to peptide hormone  (ISO)
response to thyroid hormone  (ISO)
signal transduction  (IBA)
spermatid development  (IMP)
spermatogenesis  (IEA)
T cell receptor signaling pathway  (IGI,IMP)
tissue homeostasis  (IMP)
vasculature development  (IMP)

Cellular Component
centrosome  (IEA,ISO)
cilium  (IEA,ISO)
cytoplasm  (IBA,IDA,IEA,ISO)
cytosol  (IDA,IEA,ISO)
intracellular protein-containing complex  (IEA,ISO)
membrane  (IDA,IEA)
mitochondrion  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO)
protein-containing complex  (ISO)
serine/threonine protein kinase complex  (IEA,ISO)
Z disc  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal alveolar process morphology  (IAGP)
abnormal axon extension  (IAGP)
abnormal axon morphology  (IAGP)
abnormal basicranium morphology  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal branching involved in lung morphogenesis  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell differentiation  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal embryo turning  (IAGP)
abnormal exocrine pancreas morphology  (IAGP)
abnormal gluconeogenesis  (IAGP)
abnormal glycogen homeostasis  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair shaft morphology  (IAGP)
abnormal head mesenchyme morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal lung bud morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal mammary gland morphology  (IAGP)
abnormal mitotic spindle morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal myometrium morphology  (IAGP)
abnormal nasal bone morphology  (IAGP)
abnormal neural fold formation  (IAGP)
abnormal neural tube closure  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal notochord morphology  (IAGP)
abnormal palatine bone morphology  (IAGP)
abnormal pancreatic acinar cell morphology  (IAGP)
abnormal pancreatic acinus morphology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal placenta development  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
abnormal seminiferous tubule epithelium morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal Sertoli cell morphology  (IAGP)
abnormal somite development  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal sphenoid bone morphology  (IAGP)
abnormal spongiotrophoblast layer morphology  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal testis morphology  (IAGP)
abnormal urinary bladder morphology  (IAGP)
abnormal urinary bladder mucosa morphology  (IAGP)
abnormal urinary bladder urothelium morphology  (IAGP)
abnormal uterus size  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
abnormal vasculogenesis  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent first pharyngeal arch  (IAGP)
absent vitelline blood vessels  (IAGP)
aneuploidy  (IAGP)
cleft secondary palate  (IAGP)
colon polyps  (IAGP)
cornea opacity  (IAGP)
decreased body height  (IAGP)
decreased body size  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone ossification  (IAGP)
decreased embryo size  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased fluid intake  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased male germ cell number  (IAGP)
decreased muscle cell glucose uptake  (IAGP)
decreased pancreatic alpha cell number  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased pancreatic delta cell number  (IAGP)
decreased somite size  (IAGP)
decreased testis weight  (IAGP)
decreased tumor incidence  (IAGP)
decreased tumor latency  (IAGP)
decreased tumor-free survival time  (IAGP)
delayed chorioallantoic fusion  (IAGP)
delayed hair appearance  (IAGP)
distended abdomen  (IAGP)
duodenum polyps  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged liver  (IAGP)
enlarged spleen  (IAGP)
enlarged stomach  (IAGP)
enlarged urinary bladder  (IAGP)
failure of initiation of embryo turning  (IAGP)
first pharyngeal arch hypoplasia  (IAGP)
gastric polyps  (IAGP)
gastrointestinal tract polyps  (IAGP)
hydronephrosis  (IAGP)
impaired glucose tolerance  (IAGP)
improved glucose tolerance  (IAGP)
incomplete embryo turning  (IAGP)
increased adenoma incidence  (IAGP)
increased cell proliferation  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating interleukin-10 level  (IAGP)
increased cutaneous melanoma incidence  (IAGP)
increased endometrial carcinoma incidence  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased hamartoma incidence  (IAGP)
increased hemangioma incidence  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased intestinal adenoma incidence  (IAGP)
increased liver adenoma incidence  (IAGP)
increased liver tumor incidence  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lung large cell carcinoma incidence  (IAGP)
increased lung squamous cell carcinoma incidence  (IAGP)
increased lung tumor incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased macrophage cell number  (IAGP)
increased mammary gland tumor incidence  (IAGP)
increased metastatic potential  (IAGP)
increased mitochondrial fission  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased ovary tumor incidence  (IAGP)
increased pancreas apoptosis  (IAGP)
increased sarcoma incidence  (IAGP)
increased Sertoli cell proliferation  (IAGP)
increased skin nevi incidence  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased tumor incidence  (IAGP)
increased urinary bladder carcinoma incidence  (IAGP)
increased uterus weight  (IAGP)
insulin resistance  (IAGP)
intestinal obstruction  (IAGP)
intestine polyps  (IAGP)
large anterior fontanelle  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
male infertility  (IAGP)
micrognathia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
pancreas cyst  (IAGP)
pancreas fibrosis  (IAGP)
pancreas inflammation  (IAGP)
pancytopenia  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
peritoneal inflammation  (IAGP)
placenta hemorrhage  (IAGP)
premature death  (IAGP)
reddish skin  (IAGP)
sepsis  (IAGP)
short mandible  (IAGP)
short snout  (IAGP)
small basisphenoid bone  (IAGP)
small cranium  (IAGP)
small frontal bone  (IAGP)
small maxilla  (IAGP)
small pancreas  (IAGP)
small pancreatic islets  (IAGP)
small parietal bone  (IAGP)
small placenta  (IAGP)
small premaxilla  (IAGP)
small presphenoid bone  (IAGP)
small temporal bone squamous part  (IAGP)
small testis  (IAGP)
small vomer bone  (IAGP)
sparse hair  (IAGP)
thin cerebral cortex  (IAGP)
thrombocytopenia  (IAGP)
thymus hypoplasia  (IAGP)
urinary bladder obstruction  (IAGP)
visceromegaly  (IAGP)
waved hair  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle. Branvold DJ, etal., J Appl Physiol (1985). 2008 Oct;105(4):1218-27. doi: 10.1152/japplphysiol.00997.2007. Epub 2008 Jul 31.
2. Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas. Contreras CM, etal., Cancer Res. 2008 Feb 1;68(3):759-66.
3. LKB1 protein expression in human breast cancer. Fenton H, etal., Appl Immunohistochem Mol Morphol. 2006 Jun;14(2):146-53.
4. The AMP-activated protein kinase pathway--new players upstream and downstream. Hardie DG J Cell Sci. 2004 Nov 1;117(Pt 23):5479-87.
5. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. Hawley SA, etal., J Biol. 2003;2(4):28. Epub 2003 Sep 24.
6. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
7. Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix. Kuragaki C, etal., Lab Invest. 2003 Jan;83(1):35-45.
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. Mutational analysis of STK11 gene in ovarian carcinomas. Nishioka Y, etal., Jpn J Cancer Res. 1999 Jun;90(6):629-32.
11. Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophy. Noga AA, etal., Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1460-9. Epub 2006 Nov 10.
12. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Lkb1 deficiency causes prostate neoplasia in the mouse. Pearson HB, etal., Cancer Res. 2008 Apr 1;68(7):2223-32.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma. Shen Z, etal., Clin Cancer Res. 2002 Jul;8(7):2085-90.
20. LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training. Sriwijitkamol A, etal., Am J Physiol Endocrinol Metab. 2006 May;290(5):E925-32. Epub 2005 Dec 13.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10381580   PMID:10400995   PMID:10642527   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11297520   PMID:11509733   PMID:11544199   PMID:11741830  
PMID:11853558   PMID:11956081   PMID:12060709   PMID:12183403   PMID:12218179   PMID:12226664   PMID:12234250   PMID:12477932   PMID:12489981   PMID:12520002   PMID:12719437   PMID:12904583  
PMID:14760387   PMID:14985505   PMID:15480979   PMID:15489334   PMID:15731909   PMID:15733851   PMID:15800014   PMID:15831494   PMID:15889149   PMID:15963768   PMID:15987703   PMID:16141072  
PMID:16141073   PMID:16278673   PMID:16308421   PMID:16332922   PMID:16357136   PMID:16817901   PMID:16926377   PMID:16966378   PMID:17083919   PMID:17085580   PMID:17244606   PMID:17244624  
PMID:17482548   PMID:17482549   PMID:17573348   PMID:17676035   PMID:17761947   PMID:17855357   PMID:17925454   PMID:17959818   PMID:18172296   PMID:18202101   PMID:18227155   PMID:18281551  
PMID:18311138   PMID:18387000   PMID:18403917   PMID:18482975   PMID:18483235   PMID:18539926   PMID:18562309   PMID:18687677   PMID:18761009   PMID:18774945   PMID:18840652   PMID:18854309  
PMID:19147279   PMID:19159696   PMID:19165340   PMID:19254698   PMID:19274086   PMID:19434632   PMID:19520843   PMID:19541609   PMID:19671058   PMID:19681070   PMID:19724060   PMID:19808021  
PMID:19808022   PMID:19828446   PMID:19830737   PMID:19833968   PMID:19940131   PMID:19966866   PMID:20029389   PMID:20108250   PMID:20142099   PMID:20142330   PMID:20203304   PMID:20354156  
PMID:20360428   PMID:20363912   PMID:20400510   PMID:20424326   PMID:20441792   PMID:20452353   PMID:20489196   PMID:20541700   PMID:20551175   PMID:20577053   PMID:20592207   PMID:20647423  
PMID:20713714   PMID:20925120   PMID:20956321   PMID:20972424   PMID:20974850   PMID:21073663   PMID:21102522   PMID:21111240   PMID:21118154   PMID:21124450   PMID:21124451   PMID:21124456  
PMID:21135058   PMID:21266325   PMID:21266715   PMID:21272562   PMID:21283818   PMID:21312243   PMID:21341271   PMID:21383064   PMID:21487392   PMID:21606593   PMID:21813469   PMID:21835890  
PMID:21873635   PMID:21876548   PMID:21903876   PMID:21926085   PMID:21930968   PMID:21994947   PMID:22145035   PMID:22287727   PMID:22308451   PMID:22348111   PMID:22425996   PMID:22454291  
PMID:22552116   PMID:22687285   PMID:22698401   PMID:22791749   PMID:22815934   PMID:22844503   PMID:22848740   PMID:22916036   PMID:22983157   PMID:23086944   PMID:23187960   PMID:23241891  
PMID:23266956   PMID:23332765   PMID:23349504   PMID:23352126   PMID:23393134   PMID:23451056   PMID:23465594   PMID:23533675   PMID:23539217   PMID:23587167   PMID:23597566   PMID:23648482  
PMID:23695215   PMID:23715154   PMID:23722652   PMID:23790753   PMID:23791179   PMID:23825589   PMID:23883619   PMID:23928772   PMID:23931756   PMID:23982155   PMID:24086281   PMID:24093678  
PMID:24170201   PMID:24174333   PMID:24218567   PMID:24280377   PMID:24295069   PMID:24319055   PMID:24322983   PMID:24362629   PMID:24367100   PMID:24458094   PMID:24531128   PMID:24550282  
PMID:24594058   PMID:24637557   PMID:24643070   PMID:24768298   PMID:24794706   PMID:24859006   PMID:24859970   PMID:24877601   PMID:24898145   PMID:24953650   PMID:24998845   PMID:25002183  
PMID:25011082   PMID:25042806   PMID:25069613   PMID:25070369   PMID:25071166   PMID:25073924   PMID:25086610   PMID:25088745   PMID:25157091   PMID:25180605   PMID:25190708   PMID:25195104  
PMID:25240456   PMID:25250856   PMID:25251157   PMID:25252692   PMID:25255972   PMID:25256100   PMID:25263448   PMID:25329316   PMID:25366347   PMID:25436981   PMID:25451940   PMID:25488815  
PMID:25519892   PMID:25533675   PMID:25584893   PMID:25588837   PMID:25738506   PMID:25773299   PMID:25830091   PMID:25874445   PMID:25916856   PMID:25936644   PMID:26054542   PMID:26070564  
PMID:26139601   PMID:26178787   PMID:26212320   PMID:26274331   PMID:26329580   PMID:26363011   PMID:26378152   PMID:26413869   PMID:26498531   PMID:26549569   PMID:26574479   PMID:26625127  
PMID:26689699   PMID:26722122   PMID:26745759   PMID:26796753   PMID:26833127   PMID:26856538   PMID:26971467   PMID:27131604   PMID:27429220   PMID:27461402   PMID:27498867   PMID:27527806  
PMID:27643638   PMID:27679742   PMID:27728797   PMID:27760313   PMID:27793977   PMID:27799657   PMID:27824128   PMID:27896618   PMID:28099846   PMID:28159992   PMID:28284717   PMID:28289208  
PMID:28346429   PMID:28381544   PMID:28387316   PMID:28435024   PMID:28493443   PMID:28500773   PMID:28530655   PMID:28542142   PMID:28548087   PMID:28581518   PMID:28621313   PMID:28628912  
PMID:28652249   PMID:28723898   PMID:28743498   PMID:28754670   PMID:28766983   PMID:28847007   PMID:28860163   PMID:28882900   PMID:28945226   PMID:28974424   PMID:29022902   PMID:29032027  
PMID:29109251   PMID:29152604   PMID:29202476   PMID:29233960   PMID:29269398   PMID:29343420   PMID:29352002   PMID:29466728   PMID:29483507   PMID:29514069   PMID:29533739   PMID:29610476  
PMID:29636366   PMID:29688375   PMID:29777910   PMID:29875463   PMID:29925518   PMID:29967064   PMID:30049881   PMID:30107230   PMID:30205046   PMID:30208308   PMID:30279167   PMID:30296566  
PMID:30318987   PMID:30332632   PMID:30415923   PMID:30546010   PMID:30566242   PMID:30692209   PMID:30710502   PMID:30830877   PMID:30911060   PMID:30935996   PMID:31089135   PMID:31091421  
PMID:31154393   PMID:31160601   PMID:31167140   PMID:31204282   PMID:31217475   PMID:31328154   PMID:31350328   PMID:31412252   PMID:31430259   PMID:31563695   PMID:31636950   PMID:31664223  
PMID:31664743   PMID:31666695   PMID:31720081   PMID:31759100   PMID:31930700   PMID:31930988   PMID:32219437   PMID:32325033   PMID:32339642   PMID:32347900   PMID:32378514   PMID:32414840  
PMID:32571479   PMID:32763296   PMID:32779566   PMID:32841502   PMID:32900241   PMID:33077574   PMID:33149301   PMID:33236987   PMID:33257663   PMID:33257678   PMID:33291665   PMID:33338919  
PMID:33358943   PMID:33439550   PMID:33535040   PMID:33579786   PMID:33783473   PMID:33924999   PMID:33968022   PMID:34142658   PMID:34301761   PMID:34321999   PMID:34341533   PMID:34369094  
PMID:34385181   PMID:34516304   PMID:34551310   PMID:34635508   PMID:34856161   PMID:34921639   PMID:34968488   PMID:34995278   PMID:35115536   PMID:35194062   PMID:35228570   PMID:35357082  
PMID:35425962   PMID:35503781   PMID:35504291   PMID:35717902   PMID:35768580   PMID:35858546   PMID:35941104   PMID:36096803   PMID:36171294   PMID:36179691   PMID:36217034   PMID:36261001  
PMID:36377658   PMID:36384136   PMID:36477539   PMID:36515008   PMID:36702816   PMID:36715544   PMID:36781473   PMID:36930164   PMID:37062029   PMID:37092555   PMID:37108413   PMID:37246608  
PMID:37327788   PMID:37427454   PMID:37573301   PMID:37607939   PMID:37669951   PMID:37695905   PMID:37722454   PMID:38136437   PMID:38670109   PMID:38772366   PMID:38786008   PMID:38805014  
PMID:38898113   PMID:38997257   PMID:39139039   PMID:39213022   PMID:39952242   PMID:40148340  


Genomics

Comparative Map Data
Stk11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,951,602 - 79,966,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,951,637 - 79,966,516 (+)EnsemblGRCm39 Ensembl
GRCm381080,115,767 - 80,130,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,115,803 - 80,130,682 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,579,281 - 79,593,215 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,519,331 - 79,533,808 (+)NCBIMGSCv36mm8
Celera1081,131,368 - 81,145,302 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
STK11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,205,778 - 1,228,431 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,177,558 - 1,228,431 (+)EnsemblGRCh38hg38GRCh38
GRCh37191,205,777 - 1,228,430 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,156,798 - 1,179,434 (+)NCBINCBI36Build 36hg18NCBI36
Build 34191,156,797 - 1,179,434NCBI
Celera191,140,029 - 1,162,667 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19981,572 - 1,004,116 (+)NCBIHuRef
CHM1_1191,205,350 - 1,228,397 (+)NCBICHM1_1
T2T-CHM13v2.0191,174,325 - 1,196,989 (+)NCBIT2T-CHM13v2.0
Stk11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,225,204 - 10,241,965 (-)NCBIGRCr8
GRCr8 Ensembl710,225,204 - 10,241,965 (-)EnsemblGRCr8 Ensembl
mRatBN7.279,574,553 - 9,591,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,575,269 - 9,591,315 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,457,505 - 12,474,280 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,332,844 - 14,349,619 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,193,941 - 12,210,702 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,440,751 - 12,457,513 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,440,751 - 12,457,513 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,610,856 - 12,627,616 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,086,760 - 11,103,522 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera77,750,545 - 7,767,310 (-)NCBICelera
RGSC_v3.1711,089,427 - 11,103,113 (-)NCBI
Cytogenetic Map7q11NCBI
Stk11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,678,195 - 6,699,058 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,678,195 - 6,699,408 (-)NCBIChiLan1.0ChiLan1.0
STK11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,548,808 - 5,570,145 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,784,506 - 4,806,946 (+)NCBINHGRI_mPanPan1
PanPan1.1191,188,537 - 1,210,677 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl191,188,537 - 1,210,677 (+)Ensemblpanpan1.1panPan2
STK11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,558,966 - 57,579,163 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,559,424 - 57,579,118 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,361,634 - 57,381,897 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,301,527 - 58,321,790 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,301,538 - 58,321,845 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,357,343 - 57,377,554 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,836,582 - 57,856,814 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,039,595 - 58,059,787 (-)NCBIUU_Cfam_GSD_1.0
Stk11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,234,125 - 217,254,944 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588579,816 - 603,654 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588579,816 - 601,033 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,230,372 - 77,249,327 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,229,888 - 77,249,322 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,814,541 - 77,823,643 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STK11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16973,033 - 996,857 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6974,144 - 995,136 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660817,866,551 - 7,890,682 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stk11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,445,069 - 7,467,298 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,444,339 - 7,466,926 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stk11
321 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:2605
Count of miRNA genes:731
Interacting mature miRNAs:963
Transcripts:ENSMUST00000003152, ENSMUST00000105370, ENSMUST00000105371, ENSMUST00000128992, ENSMUST00000129235, ENSMUST00000144108, ENSMUST00000144119, ENSMUST00000144883, ENSMUST00000152592
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7398721682491121Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078381268112381268Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse

Markers in Region
Stk11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381080,137,642 - 80,137,771UniSTSGRCm38
MGSCv371079,600,387 - 79,600,516UniSTSGRCm37
Celera1081,152,474 - 81,152,603UniSTS
Cytogenetic Map10C1UniSTS
cM Map10 UniSTS
RH125172  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381080,130,363 - 80,130,658UniSTSGRCm38
MGSCv371079,593,108 - 79,593,403UniSTSGRCm37
Celera1081,145,195 - 81,145,490UniSTS
Cytogenetic Map10C1UniSTS
RH125759  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381080,130,437 - 80,130,573UniSTSGRCm38
MGSCv371079,593,182 - 79,593,318UniSTSGRCm37
Celera1081,145,269 - 81,145,405UniSTS
Cytogenetic Map10C1UniSTS
PMC124396P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381080,126,335 - 80,126,738UniSTSGRCm38
MGSCv371079,589,080 - 79,589,483UniSTSGRCm37
Celera1081,141,167 - 81,141,570UniSTS
Cytogenetic Map10C1UniSTS
MARC_3363-3364:991937109:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381080,126,253 - 80,126,702UniSTSGRCm38
MGSCv371079,588,998 - 79,589,447UniSTSGRCm37
Celera1081,141,085 - 81,141,534UniSTS
Cytogenetic Map10C1UniSTS
Stk11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10C1UniSTS
Stk11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10C1UniSTS
Stk11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10C1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001301853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_126043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003948638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB015801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB026255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC159999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF129870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF145287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF145697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF151711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH008186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE951985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF468348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD565465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ229363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO424479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU730638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY779728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000003152   ⟹   ENSMUSP00000003152
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,951,637 - 79,966,516 (+)Ensembl
GRCm38.p6 Ensembl1080,115,803 - 80,130,682 (+)Ensembl
Ensembl Acc Id: ENSMUST00000105370   ⟹   ENSMUSP00000101009
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,961,209 - 79,966,509 (+)Ensembl
GRCm38.p6 Ensembl1080,125,375 - 80,130,675 (+)Ensembl
Ensembl Acc Id: ENSMUST00000105371   ⟹   ENSMUSP00000101010
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,952,181 - 79,966,304 (+)Ensembl
GRCm38.p6 Ensembl1080,116,347 - 80,130,470 (+)Ensembl
Ensembl Acc Id: ENSMUST00000128992
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,952,188 - 79,953,648 (+)Ensembl
GRCm38.p6 Ensembl1080,116,354 - 80,117,814 (+)Ensembl
Ensembl Acc Id: ENSMUST00000129235
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,961,209 - 79,962,343 (+)Ensembl
GRCm38.p6 Ensembl1080,125,375 - 80,126,509 (+)Ensembl
Ensembl Acc Id: ENSMUST00000144108
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,962,220 - 79,964,033 (+)Ensembl
GRCm38.p6 Ensembl1080,126,386 - 80,128,199 (+)Ensembl
Ensembl Acc Id: ENSMUST00000144119
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,960,653 - 79,965,809 (+)Ensembl
GRCm38.p6 Ensembl1080,124,819 - 80,129,975 (+)Ensembl
Ensembl Acc Id: ENSMUST00000144883   ⟹   ENSMUSP00000114195
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,951,637 - 79,966,303 (+)Ensembl
GRCm38.p6 Ensembl1080,115,803 - 80,130,469 (+)Ensembl
Ensembl Acc Id: ENSMUST00000152592   ⟹   ENSMUSP00000118853
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,962,516 - 79,966,304 (+)Ensembl
GRCm38.p6 Ensembl1080,126,682 - 80,130,470 (+)Ensembl
RefSeq Acc Id: NM_001301853   ⟹   NP_001288782
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391079,951,629 - 79,964,397 (+)NCBI
GRCm381080,115,795 - 80,128,563 (+)NCBI
Celera1081,130,635 - 81,145,517 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001301854   ⟹   NP_001288783
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391079,951,629 - 79,966,513 (+)NCBI
GRCm381080,115,795 - 80,130,679 (+)NCBI
Celera1081,130,635 - 81,145,517 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011492   ⟹   NP_035622
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391079,951,629 - 79,966,513 (+)NCBI
GRCm381080,115,795 - 80,130,679 (+)NCBI
MGSCv371079,579,281 - 79,593,215 (+)RGD
Celera1081,130,635 - 81,145,517 (+)NCBI
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_126043
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391079,951,629 - 79,966,513 (+)NCBI
GRCm381080,115,795 - 80,130,679 (+)NCBI
Celera1081,130,635 - 81,145,517 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006513439   ⟹   XP_006513502
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391079,953,148 - 79,966,513 (+)NCBI
GRCm381080,117,309 - 80,130,679 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003948638
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391079,951,602 - 79,966,513 (+)NCBI
GRCm381080,115,775 - 80,130,679 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004936136
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391079,951,610 - 79,966,513 (+)NCBI
Sequence:
RefSeq Acc Id: NP_035622   ⟸   NM_011492
- Peptide Label: isoform L
- UniProtKB: B3VBP0 (UniProtKB/Swiss-Prot),   A0A2L1DGD8 (UniProtKB/Swiss-Prot),   Q3TAE0 (UniProtKB/Swiss-Prot),   Q9WTK7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006513502   ⟸   XM_006513439
- Peptide Label: isoform X1
- UniProtKB: Q9R0P1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001288783   ⟸   NM_001301854
- Peptide Label: isoform 3
- UniProtKB: E9Q811 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001288782   ⟸   NM_001301853
- Peptide Label: isoform S
- UniProtKB: Q9WTK7 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000114195   ⟸   ENSMUST00000144883
Ensembl Acc Id: ENSMUSP00000101009   ⟸   ENSMUST00000105370
Ensembl Acc Id: ENSMUSP00000101010   ⟸   ENSMUST00000105371
Ensembl Acc Id: ENSMUSP00000118853   ⟸   ENSMUST00000152592
Ensembl Acc Id: ENSMUSP00000003152   ⟸   ENSMUST00000003152
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTK7-F1-model_v2 AlphaFold Q9WTK7 1-436 view protein structure

Promoters
RGD ID:6819553
Promoter ID:MM_KWN:4826
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000099495,   OTTMUST00000045747,   OTTMUST00000045748,   OTTMUST00000045750,   OTTMUST00000045751,   UC007GBT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361079,577,556 - 79,579,632 (+)MPROMDB
RGD ID:6819558
Promoter ID:MM_KWN:4827
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000105370,   OTTMUST00000045753,   OTTMUST00000045754,   UC007GBV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361079,586,571 - 79,587,912 (+)MPROMDB
RGD ID:6819975
Promoter ID:MM_KWN:4828
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Kidney,   Liver,   Lung,   Spleen
Transcripts:OTTMUST00000045752,   OTTMUST00000045755
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361079,588,371 - 79,589,172 (+)MPROMDB
RGD ID:6846790
Promoter ID:MM_ACW:5349
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung
Transcripts:STK11.LSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361079,590,826 - 79,591,326 (+)MPROMDB
RGD ID:8672608
Promoter ID:EPDNEW_M14335
Type:multiple initiation site
Name:Stk11_1
Description:Mus musculus serine/threonine kinase 11 , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14336  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381080,115,813 - 80,115,873EPDNEW
RGD ID:8672610
Promoter ID:EPDNEW_M14336
Type:initiation region
Name:Stk11_2
Description:Mus musculus serine/threonine kinase 11 , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14335  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381080,116,251 - 80,116,311EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1341870 AgrOrtholog
Ensembl Genes ENSMUSG00000003068 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000003152 ENTREZGENE
  ENSMUST00000003152.14 UniProtKB/Swiss-Prot
  ENSMUST00000105370 ENTREZGENE
  ENSMUST00000144883 ENTREZGENE
  ENSMUST00000144883.8 UniProtKB/Swiss-Prot
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  LKB1_c UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report mmu:20869 UniProtKB/Swiss-Prot
MGD MGI:1341870 ENTREZGENE
NCBI Gene 20869 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/Swiss-Prot
  NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Stk11 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A2L1DGD8 ENTREZGENE
  B3VBP0 ENTREZGENE
  D6RGT4_MOUSE UniProtKB/TrEMBL
  E9Q811 ENTREZGENE, UniProtKB/TrEMBL
  F6WNS2_MOUSE UniProtKB/TrEMBL
  Q3TAE0 ENTREZGENE
  Q3V4A1_MOUSE UniProtKB/TrEMBL
  Q9R0P1 ENTREZGENE, UniProtKB/TrEMBL
  Q9WTK7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A2L1DGD8 UniProtKB/Swiss-Prot
  B3VBP0 UniProtKB/Swiss-Prot
  Q3TAE0 UniProtKB/Swiss-Prot