SIRT1 (sirtuin 1) - Rat Genome Database

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Gene: SIRT1 (sirtuin 1) Homo sapiens
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Symbol: SIRT1
Name: sirtuin 1
RGD ID: 1318374
HGNC Page HGNC:14929
Description: Enables several functions, including DNA-binding transcription factor binding activity; HLH domain binding activity; and NAD-dependent protein lysine deacetylase activity. Involved in several processes, including DNA repair; negative regulation of intracellular signal transduction; and regulation of macromolecule metabolic process. Located in several cellular components, including chromatin; nuclear inner membrane; and nuclear lumen. Part of eNoSc complex. Is active in cytosol. Implicated in Huntington's disease. Biomarker of several diseases, including Huntington's disease; macular degeneration; metabolic dysfunction-associated steatotic liver disease; prostate cancer; and senile cataract.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: hSIR2; hSIRT1; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacylase sirtuin-1; regulatory protein SIR2 homolog 1; SIR2; sir2-like 1; SIR2-like protein 1; SIR2alpha; SIR2L1; sirtuin; sirtuin type 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381067,884,656 - 67,918,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1067,884,656 - 67,918,390 (+)EnsemblGRCh38hg38GRCh38
GRCh371069,644,414 - 69,678,147 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361069,314,433 - 69,348,149 (+)NCBINCBI36Build 36hg18NCBI36
Build 341069,314,432 - 69,348,147NCBI
Celera1062,919,307 - 62,953,016 (+)NCBICelera
Cytogenetic Map10q21.3NCBI
HuRef1063,643,871 - 63,677,731 (+)NCBIHuRef
CHM1_11069,926,404 - 69,960,153 (+)NCBICHM1_1
T2T-CHM13v2.01068,753,401 - 68,787,131 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (EXP,ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
atherosclerosis  (EXP,ISO)
atrial fibrillation  (EXP)
autoimmune disease  (EXP)
Autosomal Dominant Intellectual Developmental Disorder 70  (IAGP)
Binge Drinking  (ISO)
brain infarction  (EXP)
Brain Injuries  (ISO)
Brain Neoplasms  (EXP)
Breast Neoplasms  (EXP)
Cardiomegaly  (ISO)
Carotid Atherosclerosis  (IEP)
cocaine dependence  (ISO)
colitis  (EXP)
congestive heart failure  (EXP)
demyelinating disease  (EXP)
diabetes mellitus  (EXP)
diabetic retinopathy  (EXP)
endocrine system disease  (EXP)
epilepsy  (IEP)
Experimental Autoimmune Encephalomyelitis  (EXP)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (EXP,ISO)
Experimental Liver Cirrhosis  (EXP)
Fibrosis  (EXP)
Genomic Instability  (EXP)
glucose intolerance  (EXP)
heart disease  (EXP)
Hemorrhagic Shock  (ISO)
human immunodeficiency virus infectious disease  (EXP)
Huntington's disease  (IAGP,IEP,ISO)
Hypertrophy  (EXP)
impotence  (ISO)
Insulin Resistance  (EXP,ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
Lung Injury  (EXP)
macular degeneration  (IEP)
metabolic dysfunction-associated steatotic liver disease  (EXP,IEP,ISO)
Metabolic Syndrome  (EXP,ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (EXP)
Neoplasm Metastasis  (EXP)
nephrogenic diabetes insipidus  (ISS)
Nerve Degeneration  (EXP)
neurodegenerative disease  (EXP)
neuronal ceroid lipofuscinosis 1  (EXP)
obesity  (EXP,ISO)
osteoporosis  (ISO)
osteosarcoma  (EXP)
Paralysis  (EXP)
Pneumococcal Pneumonia  (EXP)
pneumonia  (EXP)
prostate cancer  (IEP)
Prostatic Neoplasms  (EXP)
retinal disease  (EXP)
senile cataract  (IEP)
steatotic liver disease  (EXP,ISO,ISS)
systemic scleroderma  (EXP)
thrombosis  (EXP)
type 2 diabetes mellitus  (EXP,ISO)
Ventricular Dysfunction, Left  (EXP)
Wallerian Degeneration  (EXP)