Sirt3 (sirtuin 3) - Rat Genome Database

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Gene: Sirt3 (sirtuin 3) Mus musculus
Analyze
Symbol: Sirt3
Name: sirtuin 3
RGD ID: 1318107
MGI Page MGI
Description: Enables NAD-dependent protein lysine deacetylase activity and sequence-specific DNA binding activity. Involved in positive regulation of ceramide biosynthetic process and positive regulation of mitochondrial transcription. Acts upstream of or within negative regulation of peptidyl-lysine acetylation. Located in mitochondrial inner membrane and mitochondrial matrix. Part of protein-containing complex. Is expressed in several structures, including brain; branchial arch; endocrine gland; genitourinary system; and liver and biliary system. Used to study abdominal obesity-metabolic syndrome. Orthologous to human SIRT3 (sirtuin 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2310003L23Rik; AI848213; mitochondrial protein lysine deacetylase; mSIR2L3; NAD-dependent deacetylase sirtuin-3; NAD-dependent protein deacetylase sirtuin-3; regulatory protein SIR2 homolog 3; Si; silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3; SIR2-like protein 3; Sir2l3; SIRT3L mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,443,576 - 140,462,222 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,443,579 - 140,462,222 (-)EnsemblGRCm39 Ensembl
GRCm387140,863,663 - 140,882,309 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,863,666 - 140,882,309 (-)EnsemblGRCm38mm10GRCm38
MGSCv377148,049,562 - 148,068,208 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367140,714,990 - 140,733,629 (-)NCBIMGSCv36mm8
Celera7140,655,950 - 140,674,596 (-)NCBICelera
Cytogenetic Map7F4- F5NCBI
cM Map786.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (EXP)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3,7,9-tetramethyluric acid  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3-chloropropane-1,2-diol  (EXP)
4-hydroxynon-2-enal  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
ADP  (EXP)
aldehydo-D-glucose  (EXP,ISO)
alpha-mangostin  (EXP,ISO)
amitrole  (ISO)
antimycin A  (ISO)
arsenous acid  (ISO)
ATP  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (EXP)
CGS-21680  (ISO)
chloroquine  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP)
D-glucose  (EXP,ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diisononyl phthalate  (ISO)
doxorubicin  (ISO)
estriol  (EXP)
ethanol  (EXP,ISO)
flutamide  (ISO)
folic acid  (EXP)
formononetin  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
hesperetin  (ISO)
hexadecanoic acid  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
icariin  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP)
linalool  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (ISO)
mancozeb  (ISO)
maneb  (ISO)
melatonin  (ISO)
metformin  (EXP,ISO)
methimazole  (ISO)
methotrexate  (EXP)
metiram  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nebivolol  (EXP)
nicotinamide  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (EXP)
propionic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
salvianolic acid B  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
sodium sulfide (anhydrous)  (ISO)
Soman  (ISO)
stavudine  (ISO)
sulfadimethoxine  (ISO)
tenofovir disoproxil fumarate  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
trichloroethene  (ISO)
trilobatin  (ISO)
triptonide  (EXP)
tris(2-chloroethyl) phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vosaroxin  (ISO)
zidovudine  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat offspring at weaning. Borengasser SJ, etal., PLoS One. 2011;6(8):e24068. doi: 10.1371/journal.pone.0024068. Epub 2011 Aug 25.
2. Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients. Caton PW, etal., Diabetologia. 2013 May;56(5):1068-77. doi: 10.1007/s00125-013-2851-y. Epub 2013 Feb 9.
3. Non-histone lysine acetylated proteins in heart failure. Grillon JM, etal., Biochim Biophys Acta. 2012 Apr;1822(4):607-14. doi: 10.1016/j.bbadis.2011.11.016. Epub 2011 Dec 3.
4. Aerobic interval training protects against myocardial infarction-induced oxidative injury by enhancing antioxidase system and mitochondrial biosynthesis. Jiang HK, etal., Clin Exp Pharmacol Physiol. 2014 Mar;41(3):192-201. doi: 10.1111/1440-1681.12211.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
10. Pre-diabetes alters testicular PGC1-alpha/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress. Rato L, etal., Biochim Biophys Acta. 2014 Mar;1837(3):335-44. doi: 10.1016/j.bbabio.2013.12.008. Epub 2013 Dec 20.
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3. Valdecantos MP, etal., Obesity (Silver Spring). 2012 Oct;20(10):1974-83. doi: 10.1038/oby.2012.32. Epub 2012 Feb 13.
15. NAD(+) in aging, metabolism, and neurodegeneration. Verdin E Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.
16. CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease. Weir HJ, etal., PLoS One. 2012;7(11):e48225. doi: 10.1371/journal.pone.0048225. Epub 2012 Nov 6.
17. Age-Related Decrease in the Mitochondrial Sirtuin Deacetylase Sirt3 Expression Associated with ROS Accumulation in the Auditory Cortex of the Mimetic Aging Rat Model. Zeng L, etal., PLoS One. 2014 Feb 4;9(2):e88019. doi: 10.1371/journal.pone.0088019. eCollection 2014.
Additional References at PubMed
PMID:3444409   PMID:8889548   PMID:10349636   PMID:11042159   PMID:11056054   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15489334   PMID:15653680   PMID:16141072   PMID:16141073  
PMID:16602821   PMID:16790548   PMID:17923681   PMID:18054327   PMID:18363549   PMID:18614015   PMID:18710944   PMID:18719589   PMID:18794531   PMID:18799693   PMID:18824292   PMID:19241369  
PMID:19333382   PMID:19410549   PMID:19652361   PMID:19940131   PMID:20000467   PMID:20042612   PMID:20059953   PMID:20129246   PMID:20157566   PMID:20203611   PMID:20235147   PMID:20644252  
PMID:20661474   PMID:20677216   PMID:21044047   PMID:21094524   PMID:21109197   PMID:21109198   PMID:21165558   PMID:21172655   PMID:21212461   PMID:21255725   PMID:21390294   PMID:21397863  
PMID:21449565   PMID:21454513   PMID:21664458   PMID:21677750   PMID:21720390   PMID:21840382   PMID:21856199   PMID:21858060   PMID:21873205   PMID:21873635   PMID:22394676   PMID:22416140  
PMID:22645641   PMID:22956852   PMID:23201123   PMID:23236377   PMID:23283301   PMID:23375372   PMID:23396452   PMID:23508103   PMID:23576753   PMID:23643077   PMID:23767918   PMID:23835326  
PMID:24039710   PMID:24047466   PMID:24051248   PMID:24073283   PMID:24121500   PMID:24194600   PMID:24252090   PMID:24363305   PMID:24370889   PMID:24454908   PMID:24486017   PMID:24748594  
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PMID:25607838   PMID:25681462   PMID:25748450   PMID:25757953   PMID:25759382   PMID:25782072   PMID:25790176   PMID:25811481   PMID:25830335   PMID:25863253   PMID:25871830   PMID:25948682  
PMID:25962702   PMID:26121691   PMID:26319214   PMID:26358839   PMID:26403315   PMID:26464666   PMID:26472659   PMID:26523980   PMID:26524632   PMID:26620563   PMID:26667039   PMID:26698917  
PMID:26767982   PMID:26769382   PMID:26789108   PMID:26868537   PMID:26873966   PMID:26928655   PMID:27000941   PMID:27021965   PMID:27040510   PMID:27047337   PMID:27052737   PMID:27128560  
PMID:27295248   PMID:27304511   PMID:27423420   PMID:27540894   PMID:27613967   PMID:27620507   PMID:27626380   PMID:27681422   PMID:27794418   PMID:27815257   PMID:27880725   PMID:27881304  
PMID:28236057   PMID:28255277   PMID:28258190   PMID:28286268   PMID:28296029   PMID:28369333   PMID:28375738   PMID:28396567   PMID:28437863   PMID:28449871   PMID:28465484   PMID:28480597  
PMID:28500761   PMID:28579116   PMID:28584055   PMID:28603486   PMID:28662362   PMID:28673962   PMID:28684630   PMID:28687409   PMID:28724806   PMID:28808064   PMID:28862956   PMID:28878358  
PMID:28911171   PMID:28914882   PMID:28935506   PMID:29031725   PMID:29076061   PMID:29130578   PMID:29151261   PMID:29198988   PMID:29236713   PMID:29277324   PMID:29302794   PMID:29330215  
PMID:29363727   PMID:29444200   PMID:29466723   PMID:29574628   PMID:29589261   PMID:29634313   PMID:29650970   PMID:29654651   PMID:29674007   PMID:29689547   PMID:29721150   PMID:29765980  
PMID:29777578   PMID:29915018   PMID:29958828   PMID:29972782   PMID:30056271   PMID:30171880   PMID:30219671   PMID:30250024   PMID:30362958   PMID:30368983   PMID:30389773   PMID:30411306  
PMID:30445987   PMID:30487750   PMID:30510203   PMID:30525304   PMID:30545041   PMID:30584213   PMID:30626741   PMID:30726738   PMID:30735837   PMID:30774023   PMID:30794763   PMID:30801823  
PMID:30846716   PMID:30848932   PMID:30849386   PMID:30970248   PMID:30973865   PMID:31015456   PMID:31060926   PMID:31085231   PMID:31160717   PMID:31185214   PMID:31201798   PMID:31208274  
PMID:31269804   PMID:31302001   PMID:31318577   PMID:31340681   PMID:31409767   PMID:31632409   PMID:31641228   PMID:31652451   PMID:31712596   PMID:31773668   PMID:31813822   PMID:31818974  
PMID:31849939   PMID:31852393   PMID:31858519   PMID:31858862   PMID:31876685   PMID:31936019   PMID:31936371   PMID:31991048   PMID:32026628   PMID:32119761   PMID:32212196   PMID:32236798  
PMID:32296036   PMID:32325033   PMID:32439965   PMID:32447338   PMID:32463172   PMID:32468895   PMID:32485218   PMID:32500353   PMID:32524313   PMID:32526680   PMID:32658908   PMID:32721927  
PMID:32722183   PMID:32726464   PMID:32770173   PMID:32835604   PMID:32898015   PMID:32912335   PMID:32933152   PMID:32951306   PMID:33002579   PMID:33006225   PMID:33049518   PMID:33087457  
PMID:33107080   PMID:33131100   PMID:33327751   PMID:33359008   PMID:33371209   PMID:33385630   PMID:33448325   PMID:33531400   PMID:33541361   PMID:33586458   PMID:33634989   PMID:33664465  
PMID:33665656   PMID:33690226   PMID:33744652   PMID:33770326   PMID:33789208   PMID:33805532   PMID:33823364   PMID:33878033   PMID:33900547   PMID:33924115   PMID:33973685   PMID:34119577  
PMID:34122726   PMID:34180125   PMID:34181898   PMID:34202229   PMID:34216536   PMID:34272364   PMID:34370691   PMID:34386777   PMID:34405591   PMID:34478012   PMID:34518519   PMID:34571997  
PMID:34591326   PMID:34597611   PMID:34606850   PMID:34624325   PMID:34630854   PMID:34644302   PMID:34668131   PMID:34695364   PMID:34780879   PMID:34807408   PMID:34849375   PMID:34880332  
PMID:35011652   PMID:35100024   PMID:35167498   PMID:35182747   PMID:35234263   PMID:35367825   PMID:35398277   PMID:35406095   PMID:35418250   PMID:35624490   PMID:35650472   PMID:35749057  
PMID:35793583   PMID:35798229   PMID:35821123   PMID:35902030   PMID:35955472   PMID:36092157   PMID:36100663   PMID:36125675   PMID:36130801   PMID:36134579   PMID:36151131   PMID:36153410  
PMID:36199173   PMID:36211825   PMID:36291179   PMID:36306990   PMID:36336229   PMID:36396721   PMID:36433732   PMID:36435202   PMID:36446868   PMID:36449070   PMID:36460774   PMID:36537765  
PMID:36574062   PMID:36657499   PMID:36692509   PMID:36738799   PMID:36739437   PMID:36759193   PMID:36786945   PMID:36804441   PMID:36815302   PMID:36863620   PMID:36894333   PMID:36905127  
PMID:36906951   PMID:36966803   PMID:37058075   PMID:37068637   PMID:37146925   PMID:37268048   PMID:37275851   PMID:37392543   PMID:37408261   PMID:37417912   PMID:37468929   PMID:37481555  
PMID:37499855   PMID:37536502   PMID:37646156   PMID:37683629   PMID:37705748   PMID:37798514   PMID:37816025   PMID:37840428   PMID:37950995   PMID:38015645   PMID:38150004   PMID:38233193  
PMID:38243371   PMID:38250153   PMID:38270316   PMID:38285890   PMID:38288355   PMID:38354290   PMID:38355793   PMID:38406970   PMID:38430040   PMID:38556109   PMID:38588611   PMID:38625851  
PMID:38635631   PMID:38802337  


Genomics

Comparative Map Data
Sirt3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,443,576 - 140,462,222 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,443,579 - 140,462,222 (-)EnsemblGRCm39 Ensembl
GRCm387140,863,663 - 140,882,309 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,863,666 - 140,882,309 (-)EnsemblGRCm38mm10GRCm38
MGSCv377148,049,562 - 148,068,208 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367140,714,990 - 140,733,629 (-)NCBIMGSCv36mm8
Celera7140,655,950 - 140,674,596 (-)NCBICelera
Cytogenetic Map7F4- F5NCBI
cM Map786.07NCBI
SIRT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811215,030 - 236,931 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11215,030 - 236,931 (-)EnsemblGRCh38hg38GRCh38
GRCh3711215,030 - 236,931 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611205,030 - 226,362 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411206,138 - 226,416NCBI
Celera11322,773 - 343,832 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef1135,047 - 56,030 (-)NCBIHuRef
CHM1_111213,704 - 234,799 (-)NCBICHM1_1
T2T-CHM13v2.011256,228 - 277,937 (-)NCBIT2T-CHM13v2.0
Sirt3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,371,703 - 205,394,145 (-)NCBIGRCr8
mRatBN7.21195,942,066 - 195,964,472 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1195,942,073 - 195,964,808 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,294,536 - 204,318,293 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,421,447 - 211,445,196 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,095,300 - 204,119,047 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,613,502 - 213,636,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,613,513 - 213,635,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,539,132 - 220,561,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,021,391 - 201,043,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,172,601 - 201,193,816 (-)NCBI
Celera1193,586,014 - 193,607,810 (-)NCBICelera
Cytogenetic Map1q41NCBI
Sirt3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,794,951 - 11,826,237 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,794,951 - 11,826,244 (+)NCBIChiLan1.0ChiLan1.0
SIRT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v292,582,959 - 2,605,626 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1111,737,925 - 1,761,366 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011210,052 - 233,969 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111255,191 - 863,031 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11255,191 - 278,732 (-)Ensemblpanpan1.1panPan2
SIRT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11825,369,183 - 25,388,126 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1825,369,382 - 25,388,118 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1825,019,130 - 25,038,115 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01825,895,720 - 25,914,839 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1825,895,722 - 25,914,795 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11825,463,734 - 25,482,834 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,108,512 - 25,127,612 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01825,721,366 - 25,740,351 (-)NCBIUU_Cfam_GSD_1.0
Sirt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494763,131 - 78,513 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493688863,546 - 77,950 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493688863,131 - 78,536 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl238,464 - 55,101 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1238,465 - 55,074 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22162,169,820 - 162,186,214 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1125,740 - 49,471 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl126,927 - 48,944 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603897,040,657 - 97,063,458 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirt3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476622,199,601 - 22,233,933 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476622,199,741 - 22,233,933 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sirt3
814 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:767
Count of miRNA genes:432
Interacting mature miRNAs:519
Transcripts:ENSMUST00000026559, ENSMUST00000106048, ENSMUST00000137024, ENSMUST00000137710, ENSMUST00000147331
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse

Markers in Region
AI848213  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387140,863,885 - 140,864,003UniSTSGRCm38
MGSCv377148,049,784 - 148,049,902UniSTSGRCm37
Celera7140,656,172 - 140,656,290UniSTS
Cytogenetic Map7F4UniSTS
Cytogenetic Map7F5UniSTS
Whitehead/MRC_RH71429.19UniSTS
Sirt3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv377148,062,283 - 148,063,645UniSTSGRCm37
Celera7140,668,671 - 140,670,033UniSTS
cM Map786.07UniSTS
Sirt3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387140,876,384 - 140,877,746UniSTSGRCm38
MGSCv377148,062,283 - 148,063,645UniSTSGRCm37
Celera7140,668,671 - 140,670,033UniSTS
Cytogenetic Map7F4UniSTS
cM Map786.07UniSTS
Sirt3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F4UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001127351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001177804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006536222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006536223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC107815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF299338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF299339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH010003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF681854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB953804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU886466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ621493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000026559   ⟹   ENSMUSP00000026559
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,443,583 - 140,462,222 (-)Ensembl
GRCm38.p6 Ensembl7140,863,670 - 140,882,309 (-)Ensembl
RefSeq Acc Id: ENSMUST00000106048   ⟹   ENSMUSP00000101663
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,443,583 - 140,461,782 (-)Ensembl
GRCm38.p6 Ensembl7140,863,670 - 140,881,869 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137024   ⟹   ENSMUSP00000114247
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,444,933 - 140,458,060 (-)Ensembl
GRCm38.p6 Ensembl7140,865,020 - 140,878,147 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137710   ⟹   ENSMUSP00000115202
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,456,347 - 140,461,782 (-)Ensembl
GRCm38.p6 Ensembl7140,876,434 - 140,881,869 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147331   ⟹   ENSMUSP00000121151
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,449,402 - 140,461,782 (-)Ensembl
GRCm38.p6 Ensembl7140,869,489 - 140,881,869 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210296   ⟹   ENSMUSP00000147504
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,443,579 - 140,462,202 (-)Ensembl
GRCm38.p6 Ensembl7140,863,666 - 140,882,289 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210398
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,460,987 - 140,462,209 (-)Ensembl
GRCm38.p6 Ensembl7140,881,074 - 140,882,296 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210706
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,453,754 - 140,456,959 (-)Ensembl
GRCm38.p6 Ensembl7140,873,841 - 140,877,046 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210974
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,455,583 - 140,461,740 (-)Ensembl
GRCm38.p6 Ensembl7140,875,670 - 140,881,827 (-)Ensembl
RefSeq Acc Id: ENSMUST00000211179   ⟹   ENSMUSP00000147716
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7140,443,583 - 140,462,211 (-)Ensembl
GRCm38.p6 Ensembl7140,863,670 - 140,882,298 (-)Ensembl
RefSeq Acc Id: NM_001127351   ⟹   NP_001120823
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,443,576 - 140,461,782 (-)NCBI
GRCm387140,863,663 - 140,881,869 (-)NCBI
MGSCv377148,049,562 - 148,068,208 (-)RGD
Celera7140,655,950 - 140,674,596 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001177804   ⟹   NP_001171275
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,443,576 - 140,461,782 (-)NCBI
GRCm387140,863,663 - 140,881,869 (-)NCBI
MGSCv377148,049,562 - 148,068,208 (-)RGD
Celera7140,655,950 - 140,674,596 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_022433   ⟹   NP_071878
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,443,576 - 140,462,222 (-)NCBI
GRCm387140,863,663 - 140,882,309 (-)ENTREZGENE
MGSCv377148,049,562 - 148,068,208 (-)RGD
Celera7140,655,950 - 140,674,596 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006536222   ⟹   XP_006536285
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,443,576 - 140,461,808 (-)NCBI
GRCm387140,863,663 - 140,881,898 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006536223   ⟹   XP_006536286
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397140,443,576 - 140,461,795 (-)NCBI
GRCm387140,863,663 - 140,881,877 (-)NCBI
Sequence:
RefSeq Acc Id: NP_071878   ⟸   NM_022433
- Peptide Label: isoform 1
- UniProtKB: Q4FJK3 (UniProtKB/TrEMBL),   A0A1B0GRY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001120823   ⟸   NM_001127351
- Peptide Label: isoform 1
- UniProtKB: Q4FJK3 (UniProtKB/TrEMBL),   A0A1B0GRY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001171275   ⟸   NM_001177804
- Peptide Label: isoform 3
- UniProtKB: C6ZII7 (UniProtKB/Swiss-Prot),   B9W0A9 (UniProtKB/Swiss-Prot),   Q9EPA8 (UniProtKB/Swiss-Prot),   Q8R104 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006536285   ⟸   XM_006536222
- Peptide Label: isoform X1
- UniProtKB: D3YTK6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006536286   ⟸   XM_006536223
- Peptide Label: isoform X2
- UniProtKB: D3YVQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000026559   ⟸   ENSMUST00000026559
RefSeq Acc Id: ENSMUSP00000121151   ⟸   ENSMUST00000147331
RefSeq Acc Id: ENSMUSP00000147716   ⟸   ENSMUST00000211179
RefSeq Acc Id: ENSMUSP00000101663   ⟸   ENSMUST00000106048
RefSeq Acc Id: ENSMUSP00000147504   ⟸   ENSMUST00000210296
RefSeq Acc Id: ENSMUSP00000115202   ⟸   ENSMUST00000137710
RefSeq Acc Id: ENSMUSP00000114247   ⟸   ENSMUST00000137024
Protein Domains
Deacetylase sirtuin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R104-F1-model_v2 AlphaFold Q8R104 1-334 view protein structure

Promoters
RGD ID:8666033
Promoter ID:EPDNEW_M11048
Type:multiple initiation site
Name:Sirt3_1
Description:Mus musculus sirtuin 3 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11049  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387140,881,825 - 140,881,885EPDNEW
RGD ID:8666035
Promoter ID:EPDNEW_M11049
Type:initiation region
Name:Sirt3_2
Description:Mus musculus sirtuin 3 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11048  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387140,882,264 - 140,882,324EPDNEW
RGD ID:6842037
Promoter ID:MM_KWN:53194
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   MEF_B4,   MEF_B6
Transcripts:NM_001127351,   NM_022433,   OTTMUST00000056979,   OTTMUST00000056980
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367148,067,671 - 148,068,202 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1927665 AgrOrtholog
Ensembl Genes ENSMUSG00000025486 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026559 ENTREZGENE
  ENSMUST00000026559.14 UniProtKB/Swiss-Prot
  ENSMUST00000106048 ENTREZGENE
  ENSMUST00000106048.10 UniProtKB/Swiss-Prot
  ENSMUST00000137024 ENTREZGENE
  ENSMUST00000137024.8 UniProtKB/TrEMBL
  ENSMUST00000137710.2 UniProtKB/TrEMBL
  ENSMUST00000147331.9 UniProtKB/TrEMBL
  ENSMUST00000210296.2 UniProtKB/TrEMBL
  ENSMUST00000211179.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1600.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin_cat_small_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin_class_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:64384 UniProtKB/Swiss-Prot
MGD MGI:1927665 ENTREZGENE
NCBI Gene 64384 ENTREZGENE
PANTHER NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SIR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sirt3 PhenoGen
PIRSF SIR2_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SIRTUIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52467 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1B0GRF7_MOUSE UniProtKB/TrEMBL
  A0A1B0GRY5 ENTREZGENE, UniProtKB/TrEMBL
  B9W0A9 ENTREZGENE
  C6ZII7 ENTREZGENE
  D3YTK6 ENTREZGENE, UniProtKB/TrEMBL
  D3YVQ5 ENTREZGENE, UniProtKB/TrEMBL
  D3YWD6_MOUSE UniProtKB/TrEMBL
  Q4FJK3 ENTREZGENE, UniProtKB/TrEMBL
  Q8R104 ENTREZGENE
  Q9EPA8 ENTREZGENE
  SIR3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary B9W0A9 UniProtKB/Swiss-Prot
  C6ZII7 UniProtKB/Swiss-Prot
  Q9EPA8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-06 Sirt3  sirtuin 3    sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED