Ermn (ermin, ERM-like protein) - Rat Genome Database

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Gene: Ermn (ermin, ERM-like protein) Mus musculus
Analyze
Symbol: Ermn
Name: ermin, ERM-like protein
RGD ID: 1318096
MGI Page MGI
Description: Enables actin filament binding activity. Acts upstream of or within several processes, including actin filament organization; morphogenesis of a branching structure; and regulation of cell shape. Located in several cellular components, including filopodium; glial cell projection; and main axon. Orthologous to human ERMN (ermin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A330104H05Rik; AI854460; ermin; JN; juxtanodin; KIAA1189; MGC107206; mKIAA1189; RP23-255J22.2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39257,874,920 - 57,942,962 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl257,935,125 - 57,942,876 (-)EnsemblGRCm39 Ensembl
GRCm38258,045,115 - 58,052,864 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl258,045,113 - 58,052,864 (-)EnsemblGRCm38mm10GRCm38
MGSCv37257,897,526 - 57,905,163 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36257,860,501 - 57,868,138 (-)NCBIMGSCv36mm8
Celera259,806,673 - 59,814,324 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map232.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell cortex  (IBA,IEA,ISO)
cytoplasm  (ISO)
cytoskeleton  (IEA)
filopodium  (IBA,IDA)
glial cell projection  (IDA)
internode region of axon  (IBA,IDA,ISO)
myelin sheath  (IBA,IDA)
neuronal cell body  (IBA,IDA)
paranode region of axon  (IBA,IDA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16421295   PMID:16602821   PMID:21565611  
PMID:21873635   PMID:24427155   PMID:26928066   PMID:28815590   PMID:29459677   PMID:32325033   PMID:32530539   PMID:33601422   PMID:37142655   PMID:38355793  


Genomics

Comparative Map Data
Ermn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39257,874,920 - 57,942,962 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl257,935,125 - 57,942,876 (-)EnsemblGRCm39 Ensembl
GRCm38258,045,115 - 58,052,864 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl258,045,113 - 58,052,864 (-)EnsemblGRCm38mm10GRCm38
MGSCv37257,897,526 - 57,905,163 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36257,860,501 - 57,868,138 (-)NCBIMGSCv36mm8
Celera259,806,673 - 59,814,324 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map232.99NCBI
ERMN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382157,318,631 - 157,327,712 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2157,318,631 - 157,327,713 (-)EnsemblGRCh38hg38GRCh38
GRCh372158,175,143 - 158,184,224 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362157,883,371 - 157,892,392 (-)NCBINCBI36Build 36hg18NCBI36
Celera2151,788,269 - 151,797,290 (-)NCBICelera
Cytogenetic Map2q24.1NCBI
HuRef2150,060,700 - 150,069,721 (-)NCBIHuRef
CHM1_12158,181,143 - 158,190,164 (-)NCBICHM1_1
T2T-CHM13v2.02157,771,771 - 157,780,852 (-)NCBIT2T-CHM13v2.0
Ermn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8363,037,001 - 63,042,657 (-)NCBIGRCr8
mRatBN7.2342,628,160 - 42,633,816 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl342,626,309 - 42,633,744 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx345,959,546 - 45,965,202 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0354,555,965 - 54,561,629 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0352,335,697 - 52,341,346 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0344,080,350 - 44,086,006 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl344,068,057 - 44,086,022 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0349,193,350 - 49,199,006 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4339,822,600 - 39,828,256 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1339,718,973 - 39,724,628 (-)NCBI
Celera340,696,717 - 40,702,373 (-)NCBICelera
Cytogenetic Map3q21NCBI
Ermn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544916,057,595 - 16,061,861 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544916,056,735 - 16,064,734 (+)NCBIChiLan1.0ChiLan1.0
ERMN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21359,989,035 - 59,996,320 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B60,004,009 - 60,011,294 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B44,583,336 - 44,590,623 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B161,823,765 - 161,831,104 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B161,823,765 - 161,831,104 (-)Ensemblpanpan1.1panPan2
ERMN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1363,355,519 - 3,363,214 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl363,358,125 - 3,363,129 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha363,493,085 - 3,500,771 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0363,477,897 - 3,485,582 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl363,477,898 - 3,485,488 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1363,480,234 - 3,487,919 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0363,539,981 - 3,547,675 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0363,577,877 - 3,585,565 (-)NCBIUU_Cfam_GSD_1.0
Ermn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303120,500,905 - 120,507,928 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646921,109,752 - 21,116,909 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646921,109,812 - 21,116,815 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERMN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1564,286,054 - 64,293,154 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11564,286,038 - 64,293,270 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21571,280,941 - 71,285,638 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ERMN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11042,732,155 - 42,745,664 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1042,729,668 - 42,737,379 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040156,838,321 - 156,845,714 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ermn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247328,486,421 - 8,491,118 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247328,486,514 - 8,493,085 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ermn
3674 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:708
Count of miRNA genes:437
Interacting mature miRNAs:526
Transcripts:ENSMUST00000090940
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13464141Hbbcq3_mhemoglobin concentration QTL 3 (mouse)25244801986448136Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
14746979Manh51_mmandible shape 51 (mouse)22896112962961129Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
11038703Ltpr1_mLeishmania tropica response 1 (mouse)23997166573971811Mouse
1301402Ap2q_malcohol preference 2 QTL (mouse)Not determined24352061277520756Mouse
4142133Pbwg1.6_mpostnatal body weight growth 1.6 (mouse)Not determined3579732469797406Mouse
1300761Lgth1_mbody length 1 (mouse)Not determined25170327685703425Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
1300568Hdl1_mhigh density lipoprotein (HDL) level 1 (mouse)Not determined24826974682269934Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1559001Eae33_mexperimental allergic encephalomyelitis susceptibility 33 (mouse)Not determined23599167971609412Mouse
4142447Pbwg1.7_mpostnatal body weight growth 1.7 (mouse)Not determined3579732469797406Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
14746997Mancz2_mmandible centroid size 2 (mouse)22896112962961129Mouse
4142185Pbwg1.3_mpostnatal body weight growth 1.3 (mouse)Not determined5718712365132495Mouse
1300875Taste1_mtaste-saccharin preference 1 (mouse)Not determined25092317584923278Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
10449151Hdl8_mhigh density lipoprotein (HDL) level 8 (mouse)23812972567072607Mouse
1301747Eae21_mexperimental allergic encephalomyelitis 21 (mouse)Not determined24826974682269934Mouse
1301235Alcw4_malcohol withdrawal 4 (mouse)Not determined24826974682269934Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
10449150Pvldlc1_mplasma VLDL-cholesterol 1 (mouse)23812972567072607Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25752411791524288Mouse
10755526Lymph1_mlymphocyte differential 1 (mouse)25081931484819314Mouse
13463471Hctq6_mhematocrit QTL 6 (mouse)25244801986448136Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
10449145Lanq1_mlanosterol level QTL 1 (mouse)23812972567072607Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
1300788Cia2_mcollagen induced arthritis QTL 2 (mouse)Not determined24352061277520756Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
10755532Lymph5_mlymphocyte differential 5 (mouse)24419901778199017Mouse
11532740Pbwg1.10_mpostnatal body weight growth 1.10 (mouse)24813241282132495Mouse
1300671Cia4_mcollagen induced arthritis QTL 4 (mouse)Not determined24352061277520756Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1301411Pitm1_mprion incubation time 1 (mouse)Not determined24352061277520756Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
4141069Pbwg1.5_mpostnatal body weight growth 1.5 (mouse)Not determined4352061277520756Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
1558820Moo1_mmodifier of Odc1 (mouse)Not determined174826974682269934Mouse
1300645Alcp1_malcohol preference locus 1 (mouse)Not determined24522812867838868Mouse
1301480Pbwg1_mpostnatal body weight growth 1 (mouse)Not determined24182071975820843Mouse
4141186Pbwg1.8_mpostnatal body weight growth 1.8 (mouse)Not determined3579732469797406Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25791999191919991Mouse

Markers in Region
AI854460  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38258,045,397 - 58,045,501UniSTSGRCm38
MGSCv37257,897,808 - 57,897,912UniSTSGRCm37
Celera259,806,959 - 59,807,063UniSTS
Cytogenetic Map2C2UniSTS
Whitehead/MRC_RH2949.96UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000090940   ⟹   ENSMUSP00000088458
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl257,935,125 - 57,942,876 (-)Ensembl
GRCm38.p6 Ensembl258,045,113 - 58,052,864 (-)Ensembl
RefSeq Acc Id: NM_029972   ⟹   NP_084248
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39257,935,127 - 57,942,876 (-)NCBI
GRCm38258,045,115 - 58,052,864 (-)NCBI
MGSCv37257,897,526 - 57,905,163 (-)RGD
Celera259,806,673 - 59,814,324 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036162717   ⟹   XP_036018610
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39257,874,920 - 57,942,962 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036162718   ⟹   XP_036018611
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39257,875,930 - 57,942,962 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036162719   ⟹   XP_036018612
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39257,875,930 - 57,942,962 (-)NCBI
Sequence:
RefSeq Acc Id: NP_084248   ⟸   NM_029972
- UniProtKB: Q8C5L8 (UniProtKB/Swiss-Prot),   Q5DTZ8 (UniProtKB/Swiss-Prot),   Q3UVY3 (UniProtKB/Swiss-Prot),   Q9CTR3 (UniProtKB/Swiss-Prot),   Q5EBJ4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000088458   ⟸   ENSMUST00000090940
RefSeq Acc Id: XP_036018610   ⟸   XM_036162717
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036018612   ⟸   XM_036162719
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036018611   ⟸   XM_036162718
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5EBJ4-F1-model_v2 AlphaFold Q5EBJ4 1-281 view protein structure

Promoters
RGD ID:6877350
Promoter ID:EPDNEW_M2126
Type:initiation region
Name:Ermn_1
Description:Mus musculus ermin, ERM-like protein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38258,052,817 - 58,052,877EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1925017 AgrOrtholog
Ensembl Genes ENSMUSG00000026830 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000090940 ENTREZGENE
  ENSMUST00000090940.6 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.360.10 UniProtKB/Swiss-Prot
InterPro Ermin UniProtKB/Swiss-Prot
  Moesin_tail_sf UniProtKB/Swiss-Prot
KEGG Report mmu:77767 UniProtKB/Swiss-Prot
MGD MGI:1925017 ENTREZGENE
NCBI Gene 77767 ENTREZGENE
PANTHER ERMIN UniProtKB/Swiss-Prot
  PTHR47137 UniProtKB/Swiss-Prot
Pfam Ermin UniProtKB/Swiss-Prot
PhenoGen Ermn PhenoGen
Superfamily-SCOP SSF48678 UniProtKB/Swiss-Prot
UniProt ERMIN_MOUSE UniProtKB/Swiss-Prot
  Q3UVY3 ENTREZGENE
  Q5DTZ8 ENTREZGENE
  Q5EBJ4 ENTREZGENE
  Q8C5L8 ENTREZGENE
  Q9CTR3 ENTREZGENE
UniProt Secondary Q3UVY3 UniProtKB/Swiss-Prot
  Q5DTZ8 UniProtKB/Swiss-Prot
  Q8C5L8 UniProtKB/Swiss-Prot
  Q9CTR3 UniProtKB/Swiss-Prot