Nhlh2 (nescient helix loop helix 2) - Rat Genome Database

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Gene: Nhlh2 (nescient helix loop helix 2) Mus musculus
Analyze
Symbol: Nhlh2
Name: nescient helix loop helix 2
RGD ID: 1317986
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on apoptotic process; hypothalamus gonadotrophin-releasing hormone neuron development; and peripheral nervous system development. Acts upstream of or within several processes, including cell migration in hindbrain; male gonad development; and male mating behavior. Located in chromatin. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; head mesenchyme derived from neural crest; and sensory organ. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism. Orthologous to human NHLH2 (nescient helix-loop-helix 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6230401I09Rik; bHLHa; bHLHa34; helix-loop-helix protein 2; Hen; HEN-2; Hen2; NS; Nsc; Nscl-2; NSCL2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393101,917,425 - 101,922,808 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3101,917,392 - 101,922,808 (+)EnsemblGRCm39 Ensembl
GRCm383102,010,111 - 102,015,492 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3102,010,076 - 102,015,492 (+)EnsemblGRCm38mm10GRCm38
MGSCv373101,814,068 - 101,819,415 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363102,139,216 - 102,143,567 (+)NCBIMGSCv36mm8
Celera3104,213,826 - 104,219,176 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map344.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IDA)
nucleus  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anogenital distance  (IAGP)
abnormal bone structure  (IEA)
abnormal cholesterol homeostasis  (IEA)
abnormal epididymis morphology  (IEA)
abnormal estrous cycle  (IAGP)
abnormal mating receptivity  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal ovary morphology  (IEA)
abnormal parasympathetic nervous system physiology  (IAGP)
abnormal QT variability  (IAGP)
abnormal reflex  (IAGP)
abnormal seminal vesicle morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal testis morphology  (IEA)
abnormal urinary bladder morphology  (IEA)
abnormal uterus morphology  (IEA)
abnormal vas deferens morphology  (IAGP)
abnormal voluntary movement  (IAGP)
absent corpus luteum  (IAGP)
absent epididymis  (IEA)
absent ovary  (IEA)
absent seminal vesicle  (IEA)
absent testes  (IEA)
azoospermia  (IAGP)
bilateral cryptorchism  (IAGP)
decreased bone mineral content  (IEA)
decreased bone mineral density  (IEA)
decreased circulating estradiol level  (IAGP)
decreased circulating follicle stimulating hormone level  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased core body temperature  (IAGP)
decreased heart rate variability  (IAGP)
decreased kidney weight  (IEA)
decreased lean body mass  (IEA)
decreased Leydig cell number  (IAGP)
decreased litter size  (IAGP)
decreased locomotor activity  (IEA)
decreased male germ cell number  (IAGP)
decreased mean corpuscular hemoglobin concentration  (IEA)
decreased neuron number  (IAGP)
decreased superovulation rate  (IAGP)
decreased uterus weight  (IAGP)
delayed vaginal opening  (IAGP)
early reproductive senescence  (IAGP)
ectopic neuron  (IAGP)
eye hemorrhage  (IEA)
female infertility  (IEA)
impaired glucose tolerance  (IEA)
impaired ovarian folliculogenesis  (IAGP)
increased abdominal adipose tissue amount  (IAGP)
increased body weight  (IAGP)
increased circulating alanine transaminase level  (IEA)
increased circulating aspartate transaminase level  (IEA)
increased mean corpuscular volume  (IEA)
increased neuron number  (IAGP)
increased percent body fat/body weight  (IAGP)
increased spleen weight  (IEA)
increased susceptibility to age related obesity  (IAGP)
increased total body fat amount  (IEA)
increased white adipose tissue amount  (IAGP)
irregular heartbeat  (IAGP)
male infertility  (IAGP)
obese  (IAGP)
polyphagia  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
prolonged diestrus  (IAGP)
prolonged proestrus  (IAGP)
reduced female fertility  (IAGP)
reduced male mating frequency  (IAGP)
seminiferous tubule degeneration  (IAGP)
short estrus  (IAGP)
small epididymis  (IAGP)
small gonad  (IAGP)
small male preputial gland  (IAGP)
small ovary  (IAGP)
small penis  (IAGP)
small seminiferous tubules  (IAGP)
small testis  (IAGP)
small uterus  (IAGP)
ventricular fibrillation  (IAGP)
ventricular premature beat  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1328219   PMID:1528853   PMID:1633105   PMID:8385626   PMID:8889548   PMID:9011755   PMID:9090387   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11825874  
PMID:12077327   PMID:12419415   PMID:12477932   PMID:14578122   PMID:14623245   PMID:14701669   PMID:15226823   PMID:15465527   PMID:15470499   PMID:16141072   PMID:16141073   PMID:16168404  
PMID:16469766   PMID:16602821   PMID:17004922   PMID:17444492   PMID:17573818   PMID:17717072   PMID:18160702   PMID:18287559   PMID:18356286   PMID:18557763   PMID:18815487   PMID:19030180  
PMID:19386638   PMID:19436734   PMID:19777589   PMID:19906978   PMID:20059953   PMID:20436479   PMID:20512592   PMID:20661473   PMID:20808804   PMID:21074524   PMID:21146598   PMID:21192082  
PMID:21267068   PMID:21300888   PMID:21664420   PMID:21873635   PMID:22169038   PMID:23431145   PMID:23614009   PMID:23649822   PMID:23785158   PMID:24131868   PMID:24146773   PMID:24148613  
PMID:24194600   PMID:24486192   PMID:24952961   PMID:26156403   PMID:26516211   PMID:26949938   PMID:27626380   PMID:31171666   PMID:32868762   PMID:32931849   PMID:33760820   PMID:33795231  
PMID:33856031   PMID:34321664   PMID:34494548   PMID:34675088   PMID:36074819   PMID:37298722   PMID:37321213   PMID:38355793   PMID:38781326  


Genomics

Comparative Map Data
Nhlh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393101,917,425 - 101,922,808 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3101,917,392 - 101,922,808 (+)EnsemblGRCm39 Ensembl
GRCm383102,010,111 - 102,015,492 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3102,010,076 - 102,015,492 (+)EnsemblGRCm38mm10GRCm38
MGSCv373101,814,068 - 101,819,415 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363102,139,216 - 102,143,567 (+)NCBIMGSCv36mm8
Celera3104,213,826 - 104,219,176 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map344.3NCBI
NHLH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381115,831,344 - 115,841,126 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1115,836,377 - 115,843,917 (-)EnsemblGRCh38hg38GRCh38
GRCh371116,378,998 - 116,383,747 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361116,180,521 - 116,185,270 (-)NCBINCBI36Build 36hg18NCBI36
Build 341116,091,039 - 116,095,789NCBI
Celera1114,607,811 - 114,612,562 (-)NCBICelera
Cytogenetic Map1p13.1NCBI
HuRef1114,236,931 - 114,241,683 (-)NCBIHuRef
CHM1_11116,493,794 - 116,498,543 (-)NCBICHM1_1
T2T-CHM13v2.01115,837,717 - 115,849,134 (-)NCBIT2T-CHM13v2.0
Nhlh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82192,132,848 - 192,138,186 (+)NCBIGRCr8
mRatBN7.22189,444,287 - 189,449,625 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2189,442,711 - 189,449,625 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2197,077,824 - 197,083,162 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02194,936,235 - 194,941,573 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02189,755,908 - 189,761,246 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02204,427,577 - 204,432,946 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2204,427,608 - 204,432,946 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02223,860,974 - 223,866,312 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42197,099,516 - 197,104,854 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12197,064,770 - 197,065,178 (+)NCBI
Celera2181,878,118 - 181,883,456 (+)NCBICelera
Cytogenetic Map2q34NCBI
Nhlh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543519,068,761 - 19,075,257 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543519,070,715 - 19,073,678 (-)NCBIChiLan1.0ChiLan1.0
NHLH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21108,487,181 - 108,497,028 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11108,086,690 - 108,096,541 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0186,719,650 - 86,727,607 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11121,771,957 - 121,776,934 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1121,774,940 - 121,775,347 (+)Ensemblpanpan1.1panPan2
NHLH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11753,359,275 - 53,363,753 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1753,359,258 - 53,458,795 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1753,009,555 - 53,031,683 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01754,241,618 - 54,263,553 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11753,280,410 - 53,302,487 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01753,315,432 - 53,337,564 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01753,888,717 - 53,910,668 (-)NCBIUU_Cfam_GSD_1.0
Nhlh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505813,353,914 - 13,358,661 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366271,131,807 - 1,135,012 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366271,130,064 - 1,135,092 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NHLH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4104,857,635 - 104,858,042 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14104,852,287 - 104,858,042 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24114,943,248 - 114,949,052 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NHLH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12017,865,226 - 17,869,955 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2017,867,929 - 17,868,336 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603820,575,051 - 20,577,618 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nhlh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477211,611,342 - 11,613,835 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477211,609,825 - 11,614,937 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nhlh2
211 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:769
Count of miRNA genes:443
Interacting mature miRNAs:548
Transcripts:ENSMUST00000066187
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398635284132635383Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100607316137205761Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398635284132635383Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398624041132624197Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined398924105132924250Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
8655600Cia5b_mcollagen induced arthritis QTL 5b (mouse)Not determined3100655184103744779Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse

Markers in Region
Nhlh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F2.2UniSTS
cM Map344.3UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000066187   ⟹   ENSMUSP00000064355
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3101,917,462 - 101,922,808 (+)Ensembl
GRCm38.p6 Ensembl3102,010,146 - 102,015,492 (+)Ensembl
Ensembl Acc Id: ENSMUST00000196324   ⟹   ENSMUSP00000142746
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3101,917,392 - 101,922,033 (+)Ensembl
GRCm38.p6 Ensembl3102,010,076 - 102,014,717 (+)Ensembl
Ensembl Acc Id: ENSMUST00000198675   ⟹   ENSMUSP00000143362
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3101,917,471 - 101,921,822 (+)Ensembl
GRCm38.p6 Ensembl3102,010,155 - 102,014,506 (+)Ensembl
RefSeq Acc Id: NM_178777   ⟹   NP_848892
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393101,917,461 - 101,922,808 (+)NCBI
GRCm383102,010,145 - 102,015,492 (+)NCBI
MGSCv373101,814,068 - 101,819,415 (+)RGD
Celera3104,213,826 - 104,219,176 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006501112   ⟹   XP_006501175
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393101,917,425 - 101,922,033 (+)NCBI
GRCm383102,010,111 - 102,014,717 (+)NCBI
Sequence:
RefSeq Acc Id: NP_848892   ⟸   NM_178777
- UniProtKB: Q8BFV7 (UniProtKB/Swiss-Prot),   Q64221 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006501175   ⟸   XM_006501112
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000143362   ⟸   ENSMUST00000198675
Ensembl Acc Id: ENSMUSP00000064355   ⟸   ENSMUST00000066187
Ensembl Acc Id: ENSMUSP00000142746   ⟸   ENSMUST00000196324
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64221-F1-model_v2 AlphaFold Q64221 1-135 view protein structure

Promoters
RGD ID:6881828
Promoter ID:EPDNEW_M4365
Type:multiple initiation site
Name:Nhlh2_1
Description:Mus musculus nescient helix loop helix 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383102,010,156 - 102,010,216EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97324 AgrOrtholog
Ensembl Genes ENSMUSG00000048540 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000066187.6 UniProtKB/Swiss-Prot
  ENSMUST00000196324 ENTREZGENE
  ENSMUST00000196324.2 UniProtKB/Swiss-Prot
  ENSMUST00000198675.2 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  TAL-like UniProtKB/Swiss-Prot
KEGG Report mmu:18072 UniProtKB/Swiss-Prot
MGD MGI:97324 ENTREZGENE
NCBI Gene 18072 ENTREZGENE
PANTHER HELIX-LOOP-HELIX PROTEIN 2 UniProtKB/Swiss-Prot
  PTHR13864 UniProtKB/Swiss-Prot
Pfam HLH UniProtKB/Swiss-Prot
PhenoGen Nhlh2 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
SMART HLH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
UniProt HEN2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8BFV7 ENTREZGENE
UniProt Secondary Q8BFV7 UniProtKB/Swiss-Prot