Wars1 (tryptophanyl-tRNA synthetase1) - Rat Genome Database

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Gene: Wars1 (tryptophanyl-tRNA synthetase1) Mus musculus
Analyze
Symbol: Wars1
Name: tryptophanyl-tRNA synthetase1
RGD ID: 1317962
MGI Page MGI
Description: Enables tryptophan-tRNA ligase activity. Involved in tryptophanyl-tRNA aminoacylation. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: TrpRS; tryptophan--tRNA ligase; tryptophan--tRNA ligase, cytoplasmic; tryptophanyl-tRNA synthetase, cytoplasmic; Wars; WRS
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm18414  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912108,825,956 - 108,860,095 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12108,825,956 - 108,860,100 (-)EnsemblGRCm39 Ensembl
GRCm3812108,860,030 - 108,894,175 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12108,860,030 - 108,894,174 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712110,098,240 - 110,132,384 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612109,307,841 - 109,341,004 (-)NCBIMGSCv36mm8
Celera12110,098,849 - 110,127,409 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1259.66NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dichlorobenzene  (EXP)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
amitrole  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bisphenol A  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chloroacetaldehyde  (ISO)
chlorpromazine  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibric acid  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP,ISO)
DDE  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
estriol  (ISO)
estrone  (ISO)
ethyl methanesulfonate  (ISO)
fenpyroximate  (ISO)
FR900359  (ISO)
furfural  (ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
haloperidol  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lamivudine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
metformin  (ISO)
methimazole  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
N(4)-hydroxycytidine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel atom  (ISO)
Nonylphenol  (ISO)
Nutlin-3  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
piroxicam  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
Propiverine  (ISO)
pyrimidifen  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (EXP)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (IEA,ISO)
nucleus  (IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
tryptophan metabolic pathway  (IEA,ISO)

External Pathway Database Links

KEGG Pathway Tryptophan metabolism

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7515282   PMID:7932716   PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11544199   PMID:12060739   PMID:12477932   PMID:12819125   PMID:14610273  
PMID:14681479   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16575184   PMID:16602821   PMID:17114825   PMID:18799693   PMID:19941862   PMID:21267068   PMID:21873635  
PMID:22083510   PMID:24194600   PMID:24457600   PMID:27626380   PMID:27889896   PMID:28378742   PMID:30196744   PMID:30457570   PMID:32325033   PMID:32554809   PMID:36114006   PMID:36417873  
PMID:37142655   PMID:38177528   PMID:38355793   PMID:38856632  


Genomics

Comparative Map Data
Wars1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912108,825,956 - 108,860,095 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12108,825,956 - 108,860,100 (-)EnsemblGRCm39 Ensembl
GRCm3812108,860,030 - 108,894,175 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12108,860,030 - 108,894,174 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712110,098,240 - 110,132,384 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612109,307,841 - 109,341,004 (-)NCBIMGSCv36mm8
Celera12110,098,849 - 110,127,409 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1259.66NCBI
WARS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814100,333,790 - 100,376,327 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14100,333,790 - 100,376,805 (-)EnsemblGRCh38hg38GRCh38
GRCh3714100,800,127 - 100,842,664 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361499,869,878 - 99,912,433 (-)NCBINCBI36Build 36hg18NCBI36
Build 341499,869,877 - 99,911,680NCBI
Celera1480,854,751 - 80,897,310 (-)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1480,981,470 - 81,024,059 (-)NCBIHuRef
CHM1_114100,737,895 - 100,780,446 (-)NCBICHM1_1
T2T-CHM13v2.01494,566,811 - 94,609,425 (-)NCBIT2T-CHM13v2.0
Wars1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86133,540,463 - 133,571,645 (-)NCBIGRCr8
mRatBN7.26127,776,088 - 127,807,273 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,776,090 - 127,807,269 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6127,899,086 - 127,930,096 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06128,194,132 - 128,225,140 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,553,503 - 127,584,499 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,771,026 - 132,802,262 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,771,021 - 132,802,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06141,941,102 - 141,972,312 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46133,200,866 - 133,232,048 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16133,207,052 - 133,238,235 (-)NCBI
Celera6125,326,985 - 125,358,157 (-)NCBICelera
Cytogenetic Map6q32NCBI
Wars1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543821,414,815 - 21,445,042 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543821,414,878 - 21,445,417 (-)NCBIChiLan1.0ChiLan1.0
WARS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215101,485,389 - 101,526,405 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114100,701,881 - 100,742,894 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01480,954,852 - 80,996,316 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114100,268,845 - 100,310,662 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14100,268,845 - 100,310,662 (-)Ensemblpanpan1.1panPan2
WARS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1868,610,105 - 68,644,616 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl868,610,090 - 68,643,467 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,128,827 - 68,162,983 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0868,893,954 - 68,928,323 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl868,893,953 - 68,928,235 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1868,555,815 - 68,590,006 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0868,621,956 - 68,656,146 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0869,019,419 - 69,053,607 (-)NCBIUU_Cfam_GSD_1.0
Wars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086406,065,559 - 6,097,465 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366043,984,872 - 4,016,911 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366043,985,002 - 4,016,870 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WARS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7121,212,981 - 121,238,113 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17121,212,981 - 121,238,144 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27128,677,569 - 128,702,996 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WARS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12478,296,154 - 78,340,683 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2478,295,741 - 78,339,732 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605365,436,415 - 65,479,619 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wars1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247343,782,733 - 3,817,852 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247343,777,866 - 3,815,369 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wars1
1269 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2787
Count of miRNA genes:668
Interacting mature miRNAs:831
Transcripts:ENSMUST00000109848, ENSMUST00000160477, ENSMUST00000160974, ENSMUST00000161154, ENSMUST00000161410, ENSMUST00000162748, ENSMUST00000162952
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
11039526Ccc1_mcolitis susceptibility in the Collaborative Cross 1 (mouse)1293528334111028223Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse

Markers in Region
40.MMHAP79FLF4.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812108,889,043 - 108,889,200UniSTSGRCm38
MGSCv3712110,127,253 - 110,127,410UniSTSGRCm37
Celera12110,122,301 - 110,122,458UniSTS
Cytogenetic Map12F2UniSTS
Whitehead_YAC12 UniSTS
Wars  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812108,860,117 - 108,860,247UniSTSGRCm38
Celera12110,098,936 - 110,099,066UniSTS
Cytogenetic Map12F2UniSTS
cM Map1259.66UniSTS
Wars  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12F2UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001164314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001164488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001411907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001411908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001411909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001411910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_177976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_177977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006515819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC122811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC152061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK007754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY773669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD563585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF731228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X69656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X69657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000109848   ⟹   ENSMUSP00000105474
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12108,825,956 - 108,860,100 (-)Ensembl
GRCm38.p6 Ensembl12108,860,030 - 108,894,174 (-)Ensembl
Ensembl Acc Id: ENSMUST00000160477   ⟹   ENSMUSP00000124649
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12108,825,956 - 108,860,063 (-)Ensembl
GRCm38.p6 Ensembl12108,860,030 - 108,894,137 (-)Ensembl
Ensembl Acc Id: ENSMUST00000160974
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12108,846,682 - 108,854,343 (-)Ensembl
GRCm38.p6 Ensembl12108,880,756 - 108,888,417 (-)Ensembl
Ensembl Acc Id: ENSMUST00000161154   ⟹   ENSMUSP00000124625
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12108,825,960 - 108,859,123 (-)Ensembl
GRCm38.p6 Ensembl12108,860,034 - 108,893,197 (-)Ensembl
Ensembl Acc Id: ENSMUST00000161410   ⟹   ENSMUSP00000125320
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12108,825,956 - 108,859,124 (-)Ensembl
GRCm38.p6 Ensembl12108,860,030 - 108,893,198 (-)Ensembl
Ensembl Acc Id: ENSMUST00000162748   ⟹   ENSMUSP00000125102
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12108,841,040 - 108,860,027 (-)Ensembl
GRCm38.p6 Ensembl12108,875,114 - 108,894,101 (-)Ensembl
Ensembl Acc Id: ENSMUST00000162952
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12108,831,797 - 108,841,207 (-)Ensembl
GRCm38.p6 Ensembl12108,865,871 - 108,875,281 (-)Ensembl
RefSeq Acc Id: NM_001164314   ⟹   NP_001157786
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912108,825,960 - 108,860,071 (-)NCBI
GRCm3812108,860,030 - 108,894,174 (-)ENTREZGENE
MGSCv3712110,098,240 - 110,132,384 (-)RGD
Celera12110,098,849 - 110,127,409 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001164488   ⟹   NP_001157960
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912108,825,960 - 108,859,132 (-)NCBI
GRCm3812108,860,030 - 108,893,198 (-)NCBI
MGSCv3712110,098,240 - 110,132,384 (-)RGD
Celera12110,098,849 - 110,127,409 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001411907   ⟹   NP_001398836
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912108,825,960 - 108,860,071 (-)NCBI
RefSeq Acc Id: NM_001411908   ⟹   NP_001398837
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912108,825,960 - 108,860,071 (-)NCBI
RefSeq Acc Id: NM_001411909   ⟹   NP_001398838
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912108,825,960 - 108,860,071 (-)NCBI
RefSeq Acc Id: NM_001411910   ⟹   NP_001398839
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912108,825,960 - 108,860,071 (-)NCBI
RefSeq Acc Id: NM_011710   ⟹   NP_035840
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912108,825,960 - 108,859,132 (-)NCBI
GRCm3812108,860,030 - 108,893,211 (-)NCBI
MGSCv3712110,098,240 - 110,132,384 (-)RGD
Celera12110,098,849 - 110,127,409 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_177976
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912108,825,960 - 108,860,071 (-)NCBI
RefSeq Acc Id: NR_177977
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912108,825,960 - 108,860,071 (-)NCBI
RefSeq Acc Id: XM_006515819   ⟹   XP_006515882
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912108,825,956 - 108,860,095 (-)NCBI
GRCm3812108,860,030 - 108,894,175 (-)NCBI
Sequence:
RefSeq Acc Id: NP_035840   ⟸   NM_011710
- Peptide Label: isoform 1
- UniProtKB: Q99J58 (UniProtKB/Swiss-Prot),   Q80ZY4 (UniProtKB/Swiss-Prot),   Q9DC65 (UniProtKB/Swiss-Prot),   P32921 (UniProtKB/Swiss-Prot),   Q4FJZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157786   ⟸   NM_001164314
- Peptide Label: isoform 2
- UniProtKB: Q3U6U7 (UniProtKB/TrEMBL),   Q3UDG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157960   ⟸   NM_001164488
- Peptide Label: isoform 2
- UniProtKB: Q3U6U7 (UniProtKB/TrEMBL),   Q3UDG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006515882   ⟸   XM_006515819
- Peptide Label: isoform X1
- UniProtKB: Q99J58 (UniProtKB/Swiss-Prot),   Q80ZY4 (UniProtKB/Swiss-Prot),   Q9DC65 (UniProtKB/Swiss-Prot),   P32921 (UniProtKB/Swiss-Prot),   Q4FJZ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000124649   ⟸   ENSMUST00000160477
Ensembl Acc Id: ENSMUSP00000105474   ⟸   ENSMUST00000109848
Ensembl Acc Id: ENSMUSP00000125102   ⟸   ENSMUST00000162748
Ensembl Acc Id: ENSMUSP00000125320   ⟸   ENSMUST00000161410
Ensembl Acc Id: ENSMUSP00000124625   ⟸   ENSMUST00000161154
RefSeq Acc Id: NP_001398837   ⟸   NM_001411908
- Peptide Label: isoform 1
- UniProtKB: Q99J58 (UniProtKB/Swiss-Prot),   Q80ZY4 (UniProtKB/Swiss-Prot),   P32921 (UniProtKB/Swiss-Prot),   Q9DC65 (UniProtKB/Swiss-Prot),   Q4FJZ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001398839   ⟸   NM_001411910
- Peptide Label: isoform 3
- UniProtKB: Q4FJZ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001398836   ⟸   NM_001411907
- Peptide Label: isoform 1
- UniProtKB: Q99J58 (UniProtKB/Swiss-Prot),   Q80ZY4 (UniProtKB/Swiss-Prot),   P32921 (UniProtKB/Swiss-Prot),   Q9DC65 (UniProtKB/Swiss-Prot),   Q4FJZ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001398838   ⟸   NM_001411909
- Peptide Label: isoform 1
- UniProtKB: Q99J58 (UniProtKB/Swiss-Prot),   Q80ZY4 (UniProtKB/Swiss-Prot),   P32921 (UniProtKB/Swiss-Prot),   Q9DC65 (UniProtKB/Swiss-Prot),   Q4FJZ4 (UniProtKB/TrEMBL)
Protein Domains
WHEP-TRS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P32921-F1-model_v2 AlphaFold P32921 1-481 view protein structure

Promoters
RGD ID:8679222
Promoter ID:EPDNEW_M17642
Type:multiple initiation site
Name:Wars_2
Description:Mus musculus tryptophanyl-tRNA synthetase , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17643  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812108,893,206 - 108,893,266EPDNEW
RGD ID:8679224
Promoter ID:EPDNEW_M17643
Type:initiation region
Name:Wars_1
Description:Mus musculus tryptophanyl-tRNA synthetase , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17642  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812108,894,137 - 108,894,197EPDNEW
RGD ID:6823534
Promoter ID:MM_KWN:12707
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Liver,   MEF_B6
Transcripts:AK019035_1810056I18RIK,   NM_001164488,   NM_011710
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612110,130,966 - 110,132,012 (-)MPROMDB
RGD ID:6823516
Promoter ID:MM_KWN:12708
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000078788,   NM_001164314,   NM_177602,   UC007PAH.1,   UC007PAK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612110,132,334 - 110,132,834 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104630 AgrOrtholog
Ensembl Genes ENSMUSG00000021266 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000109848 ENTREZGENE
  ENSMUST00000109848.10 UniProtKB/Swiss-Prot
  ENSMUST00000160477.8 UniProtKB/TrEMBL
  ENSMUST00000161154 ENTREZGENE
  ENSMUST00000161154.2 UniProtKB/Swiss-Prot
  ENSMUST00000161410 ENTREZGENE
  ENSMUST00000161410.8 UniProtKB/Swiss-Prot
  ENSMUST00000162748.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.620 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S15/NS1, RNA-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyrosyl-Transfer RNA Synthetase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro aa-tRNA-synth_I_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  aa-tRNA-synth_Ic UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rossmann-like_a/b/a_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S15_NS1_RNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trp-tRNA-ligase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WHEP-TRS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22375 UniProtKB/Swiss-Prot
MGD MGI:104630 ENTREZGENE
NCBI Gene 22375 ENTREZGENE
PANTHER TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPTOPHANYL-TRNA SYNTHETASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam tRNA-synt_1b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WHEP-TRS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wars1 PhenoGen
PRINTS TRNASYNTHTRP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AA_TRNA_LIGASE_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WHEP_TRS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WHEP_TRS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART WHEP-TRS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47060 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E0CXQ4_MOUSE UniProtKB/TrEMBL
  E0CXX4_MOUSE UniProtKB/TrEMBL
  P32921 ENTREZGENE
  Q3U6U7 ENTREZGENE, UniProtKB/TrEMBL
  Q3UDG2 ENTREZGENE, UniProtKB/TrEMBL
  Q4FJZ4 ENTREZGENE, UniProtKB/TrEMBL
  Q80ZY4 ENTREZGENE
  Q99J58 ENTREZGENE
  Q9DC65 ENTREZGENE
  SYWC_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q80ZY4 UniProtKB/Swiss-Prot
  Q99J58 UniProtKB/Swiss-Prot
  Q9DC65 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-06 Wars1  tryptophanyl-tRNA synthetase1  Wars  tryptophanyl-tRNA synthetase  Symbol and/or name updated 27372883 PROVISIONAL