Rorc (RAR-related orphan receptor gamma) - Rat Genome Database

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Gene: Rorc (RAR-related orphan receptor gamma) Mus musculus
Analyze
Symbol: Rorc
Name: RAR-related orphan receptor gamma
RGD ID: 1317897
MGI Page MGI
Description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription coactivator binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of thymocyte apoptotic process; and regulation of gene expression. Acts upstream of or within several processes, including T cell differentiation; mucosa-associated lymphoid tissue development; and regulation of gamma-delta T cell differentiation. Located in external side of plasma membrane and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system; and sensory organ. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in immunodeficiency 42. Orthologous to human RORC (RAR related orphan receptor C).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Nr1f3; nuclear receptor ROR-gamma; nuclear receptor RZR-gamma; nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; retinoid-related orphan receptor-gamma; ROR; RORgamma; Th; Thor; thymus orphan receptor; TOR
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39394,280,106 - 94,305,583 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl394,280,101 - 94,305,583 (+)EnsemblGRCm39 Ensembl
GRCm38394,372,794 - 94,398,276 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl394,372,794 - 94,398,276 (+)EnsemblGRCm38mm10GRCm38
MGSCv37394,176,748 - 94,202,161 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36394,458,190 - 94,483,992 (+)NCBIMGSCv36mm8
Celera395,819,177 - 95,843,048 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-tert-butylhydroquinone  (EXP)
25-hydroxycholesterol  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-phenoxybenzoic acid  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
aflatoxin B1  (ISO)
alloxan  (EXP)
alpha-galactosylceramide  (EXP)
alpha-Zearalanol  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bifenthrin  (ISO)
biochanin A  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bromuconazole  (ISO)
buspirone  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
calcitriol  (ISO)
cannabidiol  (EXP)
carbamazepine  (EXP)
carbon nanotube  (EXP)
chloroprene  (EXP)
chlorpyrifos  (EXP,ISO)
chrysene  (EXP)
chrysin  (EXP)
clofibrate  (EXP)
copper(II) chloride  (ISO)
cyclophosphamide  (EXP)
cycloprothrin  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
diclofenac  (EXP)
digoxigenin  (ISO)
digoxin  (EXP)
dihydroouabain  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
flucloxacillin  (EXP)
flutamide  (ISO)
fluvalinate  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fragrance  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glyphosate  (ISO)
helveticoside  (ISO)
hexaconazole  (EXP)
hydroxysafflor yellow A  (EXP)
imidacloprid  (ISO)
imiquimod  (EXP)
indoxyl sulfate  (EXP)
lead diacetate  (ISO)
lead(0)  (EXP)
leflunomide  (EXP)
levamisole  (EXP)
methamphetamine  (EXP,ISO)
mevalonic acid  (ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
O-methyleugenol  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
pioglitazone  (EXP)
pirinixic acid  (EXP)
platycodin D  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
prostaglandin D2  (EXP)
prostaglandin E2  (ISO)
rofecoxib  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
strophanthidin  (ISO)
sulforaphane  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thiabendazole  (ISO)
thioacetamide  (ISO)
thymoquinone  (EXP)
tofacitinib  (EXP)
toluene 2,4-diisocyanate  (EXP)
trichloroethene  (EXP)
triflumizole  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
triptonide  (EXP)
Tryptanthrine  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal CD4-positive, alpha beta T cell morphology  (IEA)
abnormal CD4-positive, alpha-beta intraepithelial T cell morphology  (IAGP)
abnormal CD8 positive, alpha-beta intraepithelial T cell morphology  (IAGP)
abnormal CD8-positive, alpha-beta T cell differentiation  (IAGP)
abnormal cell cycle  (IAGP)
abnormal colon morphology  (IAGP)
abnormal gut-associated lymphoid tissue morphology  (IAGP)
abnormal immune system cell morphology  (IAGP)
abnormal interleukin level  (IAGP)
abnormal lymph organ development  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T-helper 17 cell differentiation  (IAGP)
absent lymph nodes  (IAGP)
absent Peyer's patches  (IAGP)
colitis  (IAGP)
colonic necrosis  (IAGP)
decreased B-2 B cell number  (IEA)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased IgG level  (IEA)
decreased IgM level  (IEA)
decreased NK cell number  (IAGP)
decreased response to antigen  (IEA)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased T cell number  (IAGP)
decreased thymocyte number  (IAGP)
decreased thymus weight  (IAGP)
enlarged spleen  (IAGP)
impaired humoral immune response  (IEA)
increased B-1a cell number  (IEA)
increased B-1b cell number  (IEA)
increased CD8-positive, alpha-beta T cell number  (IEA)
increased double-negative T cell number  (IAGP)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased effector memory CD8-positive, alpha-beta T cell number  (IEA)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased T cell apoptosis  (IAGP)
increased thymocyte apoptosis  (IAGP)
small inguinal lymph nodes  (IAGP)
thymus hypoplasia  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Regulatory T cell activity is partly inhibited in a mouse model of chronic Pseudomonas aeruginosa lung infection. Ding FM, etal., Exp Lung Res. 2015 Feb;41(1):44-55. doi: 10.3109/01902148.2014.964351. Epub 2014 Nov 14.
2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Bupi Hewei decoction ameliorates 5-fluorouracil-induced intestinal dysbiosis in rats through T helper 17/T regulatory cell signaling pathway. Sun Z, etal., J Tradit Chin Med. 2020 Feb;40(1):38-48.
11. The Treg/Th17 imbalance in Toxoplasma gondii-infected pregnant mice. Zhang H, etal., Am J Reprod Immunol. 2012 Feb;67(2):112-21. doi: 10.1111/j.1600-0897.2011.01065.x. Epub 2011 Sep 19.
12. Fibrinogen-like protein-2 causes deterioration in cardiac function in experimental autoimmune myocarditis rats through regulation of programmed death-1 and inflammatory cytokines. Zheng Z, etal., Immunology. 2018 Feb;153(2):246-252. doi: 10.1111/imm.12837. Epub 2017 Oct 16.
Additional References at PubMed
PMID:7811290   PMID:8614404   PMID:8973331   PMID:9403063   PMID:9543393   PMID:9881970   PMID:10349636   PMID:10602018   PMID:10875923   PMID:10963675   PMID:11042159   PMID:11076861  
PMID:11801629   PMID:12223510   PMID:12477932   PMID:12902464   PMID:14691482   PMID:14966198   PMID:15010863   PMID:15078980   PMID:15144897   PMID:15247480   PMID:15489334   PMID:15591166  
PMID:15792999   PMID:15806105   PMID:15963785   PMID:16141072   PMID:16141073   PMID:16148126   PMID:16971476   PMID:16990136   PMID:17210914   PMID:17312169   PMID:17476214   PMID:17521585  
PMID:17581537   PMID:17581589   PMID:17601883   PMID:17609113   PMID:17666523   PMID:17675483   PMID:17882258   PMID:18086663   PMID:18164222   PMID:18287559   PMID:18350550   PMID:18368049  
PMID:18390697   PMID:18434325   PMID:18489764   PMID:18585065   PMID:18599325   PMID:18656387   PMID:18694395   PMID:18792410   PMID:18799150   PMID:18992745   PMID:19029903   PMID:19029904  
PMID:19050256   PMID:19057011   PMID:19060331   PMID:19076641   PMID:19079179   PMID:19084435   PMID:19088203   PMID:19270712   PMID:19286559   PMID:19303389   PMID:19362022   PMID:19366986  
PMID:19427241   PMID:19494260   PMID:19587013   PMID:19596803   PMID:19635901   PMID:19741597   PMID:19783990   PMID:19808254   PMID:19822644   PMID:19890042   PMID:19965867   PMID:20017902  
PMID:20023630   PMID:20059953   PMID:20142358   PMID:20207995   PMID:20211142   PMID:20226692   PMID:20237296   PMID:20339029   PMID:20383124   PMID:20393462   PMID:20667820   PMID:20818394  
PMID:20932939   PMID:20935648   PMID:21076063   PMID:21093318   PMID:21173107   PMID:21178013   PMID:21183590   PMID:21249177   PMID:21266776   PMID:21267068   PMID:21317191   PMID:21325057  
PMID:21336274   PMID:21391996   PMID:21419662   PMID:21505191   PMID:21516111   PMID:21516112   PMID:21519551   PMID:21540300   PMID:21560493   PMID:21566134   PMID:21606479   PMID:21622681  
PMID:21628546   PMID:21637854   PMID:21737317   PMID:21853531   PMID:21856864   PMID:21871655   PMID:21873635   PMID:21909092   PMID:22006976   PMID:22033518   PMID:22039299   PMID:22101730  
PMID:22177117   PMID:22244845   PMID:22291094   PMID:22383805   PMID:22406269   PMID:22425250   PMID:22430492   PMID:22539787   PMID:22546855   PMID:22623033   PMID:22753030   PMID:22768117  
PMID:22770220   PMID:22772464   PMID:22772566   PMID:22778391   PMID:22855506   PMID:22942422   PMID:22981535   PMID:22984619   PMID:22988430   PMID:23021777   PMID:23022186   PMID:23034280  
PMID:23063333   PMID:23086144   PMID:23174342   PMID:23241743   PMID:23255360   PMID:23278668   PMID:23293351   PMID:23334414   PMID:23345426   PMID:23362310   PMID:23363980   PMID:23447682  
PMID:23453631   PMID:23467085   PMID:23475182   PMID:23489689   PMID:23623381   PMID:23626860   PMID:23670188   PMID:23698371   PMID:23723244   PMID:23740948   PMID:23903754   PMID:23954130  
PMID:23960240   PMID:23995235   PMID:24038093   PMID:24058178   PMID:24064669   PMID:24150244   PMID:24202171   PMID:24292710   PMID:24315996   PMID:24356888   PMID:24362892   PMID:24367096  
PMID:24412612   PMID:24412614   PMID:24419270   PMID:24516202   PMID:24562309   PMID:24574339   PMID:24586521   PMID:24625929   PMID:24631024   PMID:24631157   PMID:24670648   PMID:24718324  
PMID:24742125   PMID:24745332   PMID:24792964   PMID:24812667   PMID:24831725   PMID:24842756   PMID:24952961   PMID:25001511   PMID:25024136   PMID:25073789   PMID:25092873   PMID:25136120  
PMID:25143535   PMID:25212631   PMID:25274297   PMID:25305313   PMID:25310240   PMID:25411202   PMID:25456160   PMID:25470037   PMID:25491772   PMID:25501629   PMID:25527718   PMID:25560829  
PMID:25575242   PMID:25604624   PMID:25607885   PMID:25629265   PMID:25769926   PMID:25801035   PMID:25820779   PMID:25902484   PMID:25918343   PMID:25928901   PMID:26038559   PMID:26044300  
PMID:26147686   PMID:26149470   PMID:26154056   PMID:26156402   PMID:26160380   PMID:26163773   PMID:26170390   PMID:26193821   PMID:26223651   PMID:26261005   PMID:26267538   PMID:26272906  
PMID:26307665   PMID:26320657   PMID:26341825   PMID:26414766   PMID:26431948   PMID:26458769   PMID:26474535   PMID:26499265   PMID:26523865   PMID:26595886   PMID:26595889   PMID:26640126  
PMID:26690704   PMID:26694902   PMID:26784959   PMID:26822608   PMID:26878233   PMID:27022145   PMID:27043409   PMID:27055905   PMID:27096318   PMID:27099134   PMID:27183623   PMID:27193261  
PMID:27322655   PMID:27430721   PMID:27438771   PMID:27479084   PMID:27643385   PMID:27725632   PMID:27791279   PMID:27880975   PMID:28009290   PMID:28088699   PMID:28098217   PMID:28100680  
PMID:28290453   PMID:28319097   PMID:28438638   PMID:28455312   PMID:28504697   PMID:28514662   PMID:28589939   PMID:28607488   PMID:28612841   PMID:28667162   PMID:28698286   PMID:28709801  
PMID:28723549   PMID:28747429   PMID:28751470   PMID:28827845   PMID:28846085   PMID:28860383   PMID:28943467   PMID:28978473   PMID:29072299   PMID:29120746   PMID:29166603   PMID:29186687  
PMID:29282318   PMID:29364878   PMID:29500225   PMID:29514953   PMID:29625134   PMID:29651155   PMID:29769201   PMID:29791844   PMID:29851080   PMID:29910804   PMID:29949760   PMID:29975009  
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PMID:30824326   PMID:30918005   PMID:30955884   PMID:31053612   PMID:31132747   PMID:31142588   PMID:31235962   PMID:31269440   PMID:31269441   PMID:31350179   PMID:31398665   PMID:31451397  
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PMID:32161123   PMID:32169841   PMID:32240600   PMID:32314428   PMID:32434140   PMID:32532834   PMID:32601220   PMID:32627520   PMID:32640223   PMID:32698011   PMID:32731813   PMID:32827457  
PMID:33104170   PMID:33107570   PMID:33113356   PMID:33207209   PMID:33397953   PMID:33547295   PMID:33547881   PMID:33589625   PMID:33619092   PMID:33724364   PMID:33739023   PMID:33806085  
PMID:33894128   PMID:34135062   PMID:34305911   PMID:34320346   PMID:34324837   PMID:34348118   PMID:34407392   PMID:34462459   PMID:34504008   PMID:34549726   PMID:34822777   PMID:35246617  
PMID:35294872   PMID:35379749   PMID:35597802   PMID:35613048   PMID:35709248   PMID:35720414   PMID:35794484   PMID:35845169   PMID:35857588   PMID:36041436   PMID:36070798   PMID:36103814  
PMID:36243007   PMID:36269826   PMID:36640762   PMID:36685040   PMID:36791105   PMID:36792629   PMID:36883358   PMID:36917985   PMID:36933213   PMID:36969227   PMID:37366299   PMID:37367944  
PMID:37443284   PMID:37549024   PMID:37616368   PMID:37815917   PMID:37950867   PMID:38019650   PMID:38125026   PMID:38166152   PMID:38363684   PMID:38489350   PMID:38512959   PMID:38722677  
PMID:38723629   PMID:38781073   PMID:38815582  


Genomics

Comparative Map Data
Rorc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39394,280,106 - 94,305,583 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl394,280,101 - 94,305,583 (+)EnsemblGRCm39 Ensembl
GRCm38394,372,794 - 94,398,276 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl394,372,794 - 94,398,276 (+)EnsemblGRCm38mm10GRCm38
MGSCv37394,176,748 - 94,202,161 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36394,458,190 - 94,483,992 (+)NCBIMGSCv36mm8
Celera395,819,177 - 95,843,048 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.56NCBI
RORC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381151,806,071 - 151,831,802 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1151,806,071 - 151,831,845 (-)EnsemblGRCh38hg38GRCh38
GRCh371151,778,547 - 151,804,278 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361150,045,171 - 150,070,972 (-)NCBINCBI36Build 36hg18NCBI36
Build 341148,591,621 - 148,617,421NCBI
Celera1124,893,230 - 124,919,042 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1123,155,515 - 123,181,337 (-)NCBIHuRef
CHM1_11153,173,871 - 153,199,672 (-)NCBICHM1_1
T2T-CHM13v2.01150,929,559 - 150,955,307 (-)NCBIT2T-CHM13v2.0
Rorc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82184,698,779 - 184,723,942 (+)NCBIGRCr8
mRatBN7.22182,009,707 - 182,034,910 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2182,009,286 - 182,034,907 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02195,612,471 - 195,636,797 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2195,617,021 - 195,637,630 (+)EnsemblRnor6.0rn6Rnor6.0
RGSC_v3.42189,345,134 - 189,369,442 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2174,560,165 - 174,584,474 (+)NCBICelera
Cytogenetic Map2q34NCBI
Rorc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955589590,743 - 616,694 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955589590,653 - 616,784 (+)NCBIChiLan1.0ChiLan1.0
RORC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2197,991,871 - 98,017,622 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,743,055 - 97,768,831 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01127,164,725 - 127,190,479 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11130,808,705 - 130,834,490 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1130,808,705 - 130,834,490 (-)Ensemblpanpan1.1panPan2
RORC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11760,821,498 - 60,842,485 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1760,821,981 - 60,842,453 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1760,263,366 - 60,285,188 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01761,838,557 - 61,860,379 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1761,837,962 - 61,860,343 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11760,665,332 - 60,687,158 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01760,751,477 - 60,773,308 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01761,480,593 - 61,502,436 (-)NCBIUU_Cfam_GSD_1.0
Rorc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505822,967,256 - 22,990,222 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365801,997,640 - 2,020,649 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365801,997,640 - 2,020,649 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RORC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl497,375,136 - 97,400,209 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1497,374,672 - 97,399,017 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24106,397,490 - 106,421,980 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RORC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12011,854,911 - 11,880,221 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2011,855,005 - 11,879,717 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603811,414,109 - 11,440,149 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rorc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477219,477,093 - 19,501,169 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477219,478,403 - 19,501,184 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rorc
462 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:952
Count of miRNA genes:369
Interacting mature miRNAs:430
Transcripts:ENSMUST00000029795, ENSMUST00000098877, ENSMUST00000107292, ENSMUST00000126783
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390511217100464137Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse

Markers in Region
U39071  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38394,397,514 - 94,397,666UniSTSGRCm38
MGSCv37394,201,436 - 94,201,588UniSTSGRCm37
Celera395,842,323 - 95,842,475UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map3F2.1UniSTS
Whitehead_YAC3 UniSTS
Rorc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F2UniSTS
cM Map340.56UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001293734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_121656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC164562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF163668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ131723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ132394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF019665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ098183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U39071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U43508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000029795   ⟹   ENSMUSP00000029795
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl394,280,101 - 94,305,147 (+)Ensembl
GRCm38.p6 Ensembl394,372,794 - 94,397,840 (+)Ensembl
Ensembl Acc Id: ENSMUST00000197040   ⟹   ENSMUSP00000143763
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl394,284,739 - 94,305,583 (+)Ensembl
GRCm38.p6 Ensembl394,377,432 - 94,398,276 (+)Ensembl
Ensembl Acc Id: ENSMUST00000198793
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl394,284,767 - 94,304,953 (+)Ensembl
GRCm38.p6 Ensembl394,377,460 - 94,397,646 (+)Ensembl
Ensembl Acc Id: ENSMUST00000200009   ⟹   ENSMUSP00000143610
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl394,284,823 - 94,304,955 (+)Ensembl
GRCm38.p6 Ensembl394,377,516 - 94,397,648 (+)Ensembl
RefSeq Acc Id: NM_001293734   ⟹   NP_001280663
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39394,284,739 - 94,305,583 (+)NCBI
GRCm38394,377,432 - 94,398,276 (+)NCBI
Celera395,819,145 - 95,843,085 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011281   ⟹   NP_035411
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39394,280,145 - 94,305,142 (+)NCBI
GRCm38394,372,794 - 94,398,276 (+)NCBI
MGSCv37394,176,748 - 94,202,161 (+)RGD
Celera395,819,145 - 95,843,085 (+)NCBI
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_121656
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39394,284,739 - 94,305,583 (+)NCBI
GRCm38394,377,432 - 94,398,276 (+)NCBI
Celera395,819,145 - 95,843,085 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006501162   ⟹   XP_006501225
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39394,295,479 - 94,305,146 (+)NCBI
GRCm38394,388,178 - 94,397,839 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006501163   ⟹   XP_006501226
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39394,280,106 - 94,305,146 (+)NCBI
GRCm38394,372,799 - 94,397,836 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006501164   ⟹   XP_006501227
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39394,280,106 - 94,298,474 (+)NCBI
GRCm38394,372,799 - 94,391,167 (+)NCBI
Sequence:
RefSeq Acc Id: NP_035411   ⟸   NM_011281
- Peptide Label: isoform 1
- UniProtKB: Q9R177 (UniProtKB/Swiss-Prot),   Q9QXD9 (UniProtKB/Swiss-Prot),   Q91YT5 (UniProtKB/Swiss-Prot),   Q61027 (UniProtKB/Swiss-Prot),   Q3U513 (UniProtKB/Swiss-Prot),   E9Q8I1 (UniProtKB/Swiss-Prot),   P51450 (UniProtKB/Swiss-Prot),   A0A0R4J096 (UniProtKB/TrEMBL),   Q3TVH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501226   ⟸   XM_006501163
- Peptide Label: isoform X2
- UniProtKB: Q3UUW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501227   ⟸   XM_006501164
- Peptide Label: isoform X3
- UniProtKB: Q3UUW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501225   ⟸   XM_006501162
- Peptide Label: isoform X1
- UniProtKB: Q9R177 (UniProtKB/Swiss-Prot),   Q9QXD9 (UniProtKB/Swiss-Prot),   Q91YT5 (UniProtKB/Swiss-Prot),   Q61027 (UniProtKB/Swiss-Prot),   Q3U513 (UniProtKB/Swiss-Prot),   P51450 (UniProtKB/Swiss-Prot),   E9Q8I1 (UniProtKB/Swiss-Prot),   Q3TVH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001280663   ⟸   NM_001293734
- Peptide Label: isoform 2
- UniProtKB: Q9R177 (UniProtKB/Swiss-Prot),   Q9QXD9 (UniProtKB/Swiss-Prot),   Q91YT5 (UniProtKB/Swiss-Prot),   Q61027 (UniProtKB/Swiss-Prot),   Q3U513 (UniProtKB/Swiss-Prot),   E9Q8I1 (UniProtKB/Swiss-Prot),   P51450 (UniProtKB/Swiss-Prot),   A0A0G2JGZ6 (UniProtKB/TrEMBL),   Q3TVH3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000143763   ⟸   ENSMUST00000197040
Ensembl Acc Id: ENSMUSP00000029795   ⟸   ENSMUST00000029795
Ensembl Acc Id: ENSMUSP00000143610   ⟸   ENSMUST00000200009
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51450-F1-model_v2 AlphaFold P51450 1-516 view protein structure

Promoters
RGD ID:6834363
Promoter ID:MM_KWN:35195
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:ENSMUST00000029795
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36394,176,696 - 94,177,196 (+)MPROMDB
RGD ID:6834373
Promoter ID:MM_KWN:35196
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000098877,   OTTMUST00000054426,   UC008QFX.1,   UC008QFZ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36394,180,921 - 94,181,822 (+)MPROMDB
RGD ID:6834365
Promoter ID:MM_KWN:35197
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000096195
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36394,187,671 - 94,188,472 (+)MPROMDB
RGD ID:6834366
Promoter ID:MM_KWN:35198
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000107290
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36394,190,021 - 94,191,172 (+)MPROMDB
RGD ID:6881488
Promoter ID:EPDNEW_M4195
Type:initiation region
Name:Rorc_1
Description:Mus musculus RAR-related orphan receptor gamma , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38394,372,838 - 94,372,898EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104856 AgrOrtholog
Ensembl Genes ENSMUSG00000028150 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029795 ENTREZGENE
  ENSMUST00000029795.10 UniProtKB/TrEMBL
  ENSMUST00000197040 ENTREZGENE
  ENSMUST00000197040.5 UniProtKB/TrEMBL
  ENSMUST00000200009.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NR_DBD_ROR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ROR_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19885 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104856 ENTREZGENE
NCBI Gene 19885 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR HR3-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR RECEPTOR ROR-GAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rorc PhenoGen
PRINTS RORNUCRECPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JGZ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A0R4J096 ENTREZGENE, UniProtKB/TrEMBL
  E9Q8I1 ENTREZGENE
  P51450 ENTREZGENE
  Q3TVH3 ENTREZGENE, UniProtKB/TrEMBL
  Q3U513 ENTREZGENE
  Q3UUW3 ENTREZGENE, UniProtKB/TrEMBL
  Q61027 ENTREZGENE
  Q91YT5 ENTREZGENE
  Q9QXD9 ENTREZGENE
  Q9R177 ENTREZGENE
  RORG_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary E9Q8I1 UniProtKB/Swiss-Prot
  Q3U513 UniProtKB/Swiss-Prot
  Q61027 UniProtKB/Swiss-Prot
  Q91YT5 UniProtKB/Swiss-Prot
  Q9QXD9 UniProtKB/Swiss-Prot
  Q9R177 UniProtKB/Swiss-Prot