Cul3 (cullin 3) - Rat Genome Database

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Gene: Cul3 (cullin 3) Mus musculus
Analyze
Symbol: Cul3
Name: cullin 3
RGD ID: 1317825
MGI Page MGI
Description: Enables cyclin binding activity and identical protein binding activity. Involved in several processes, including embryonic cleavage; integrin-mediated signaling pathway; and regulation protein catabolic process at postsynapse. Acts upstream of or within with a positive effect on protein polyubiquitination. Acts upstream of or within several processes, including embryonic morphogenesis; fibroblast apoptotic process; and liver morphogenesis. Located in Golgi apparatus and nucleus. Is active in glutamatergic synapse. Is expressed in several structures, including cerebral cortex; extraembryonic component; gonad; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI467304; AW146203; CUL-3; cullin-3; KIAA0617; mKIAA0617
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39180,242,640 - 80,318,426 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl180,242,640 - 80,318,197 (-)EnsemblGRCm39 Ensembl
GRCm38180,264,923 - 80,340,690 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl180,264,923 - 80,340,480 (-)EnsemblGRCm38mm10GRCm38
MGSCv37180,263,393 - 80,337,005 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36180,145,842 - 80,219,467 (-)NCBIMGSCv36mm8
Celera180,291,823 - 80,365,420 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map141.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
auramine O  (ISO)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
clozapine  (ISO)
curcumin  (ISO)
decabromodiphenyl ether  (ISO)
diallyl trisulfide  (ISO)
diazinon  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethanol  (EXP)
folic acid  (EXP,ISO)
FR900359  (ISO)
furan  (ISO)
gentamycin  (ISO)
inulin  (EXP)
ivermectin  (ISO)
leflunomide  (ISO)
melphalan  (ISO)
mercury dibromide  (ISO)
methylmercury chloride  (ISO)
motexafin gadolinium  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenylmercury acetate  (ISO)
pyrogallol  (EXP)
resveratrol  (ISO)
rimonabant  (EXP)
salvianolic acid B  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
solanesol  (ISO)
succimer  (EXP)
sulforaphane  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (EXP)
valproic acid  (ISO)
vancomycin  (EXP)
vitamin E  (ISO)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anaphase-promoting complex-dependent catabolic process  (ISS)
cell division  (IEA)
cell migration  (ISO,ISS)
cell morphogenesis  (IMP)
cell projection organization  (IEA)
cellular response to amino acid stimulus  (ISO)
COPII vesicle coating  (ISO)
embryonic cleavage  (IMP)
endoplasmic reticulum to Golgi vesicle-mediated transport  (ISO,ISS)
fibroblast apoptotic process  (IMP)
gastrulation  (IMP)
gene expression  (IMP)
in utero embryonic development  (IMP)
inflammatory response  (IMP)
integrin-mediated signaling pathway  (IMP)
liver morphogenesis  (IMP)
mitotic cell cycle  (IMP)
mitotic metaphase chromosome alignment  (ISO,ISS)
negative regulation of Rho protein signal transduction  (ISO)
negative regulation of transcription by RNA polymerase II  (IMP)
negative regulation of type I interferon production  (ISO)
nuclear protein quality control by the ubiquitin-proteasome system  (ISO)
positive regulation of cytokinesis  (ISO,ISS)
positive regulation of mitotic cell cycle phase transition  (ISO,ISS)
positive regulation of mitotic metaphase/anaphase transition  (ISO,ISS)
positive regulation of protein ubiquitination  (IEA,ISO)
positive regulation of TORC1 signaling  (IEA,ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IGI,ISO)
protein autoubiquitination  (IEA,ISO)
protein catabolic process  (IMP)
protein destabilization  (IEA,ISO)
protein K48-linked ubiquitination  (ISO,ISS)
protein monoubiquitination  (ISO,ISS)
protein polyubiquitination  (IDA,ISO,ISS)
protein ubiquitination  (IBA,IMP,ISO,ISS)
regulation of cellular response to insulin stimulus  (ISO)
regulation of transcription by RNA polymerase II  (IGI)
regulation protein catabolic process at postsynapse  (IDA,IEP,IMP)
stem cell division  (IMP)
stress fiber assembly  (ISO)
trophectodermal cellular morphogenesis  (IMP)
ubiquitin-dependent protein catabolic process  (ISO)
vesicle-mediated transport  (IEA)
Wnt signaling pathway  (IDA)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal actin cytoskeleton morphology  (IAGP)
abnormal action potential  (IAGP)
abnormal blood vessel physiology  (IAGP)
abnormal brain morphology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal CNS synaptic transmission  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal entorhinal cortex morphology  (IAGP)
abnormal extraembryonic ectoderm morphology  (IAGP)
abnormal fear/anxiety-related behavior  (IAGP)
abnormal gastrulation  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal pH regulation  (IAGP)
abnormal response to novel object  (IAGP)
abnormal response to social novelty  (IAGP)
abnormal somatosensory cortex morphology  (IAGP)
abnormal stratification in cerebral cortex  (IAGP)
abnormal trophectoderm morphology  (IAGP)
abnormal trophoblast giant cell morphology  (IAGP)
abnormal visual cortex morphology  (IAGP)
absent amnion  (IAGP)
absent corpus callosum  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain size  (IAGP)
decreased brain weight  (IAGP)
decreased corpus callosum size  (IAGP)
decreased dendritic spine length  (IAGP)
decreased dentate gyrus size  (IAGP)
decreased embryo size  (IAGP)
decreased paired-pulse facilitation  (IAGP)
disorganized extraembryonic tissue  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
hyperactivity  (IAGP)
hyperkalemia  (IAGP)
hypertension  (IAGP)
hypothalamus hyperplasia  (IAGP)
impaired righting response  (IAGP)
increased anxiety-related response  (IAGP)
increased aorta wall thickness  (IAGP)
increased circulating aldosterone level  (IAGP)
increased circulating chloride level  (IAGP)
increased circulating magnesium level  (IAGP)
increased circulating phosphate level  (IAGP)
increased dendritic spine density  (IAGP)
increased fibroblast apoptosis  (IAGP)
increased liver weight  (IAGP)
increased miniature excitatory postsynaptic current frequency  (IAGP)
increased miniature inhibitory postsynaptic current frequency  (IAGP)
increased thigmotaxis  (IAGP)
increased vasoconstriction  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality, complete penetrance  (IAGP)
metabolic acidosis  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preweaning lethality  (IAGP)
small cerebellum  (IAGP)
small olfactory bulb  (IAGP)
thin cerebral cortex  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Furukawa M and Xiong Y, Mol Cell Biol. 2005 Jan;25(1):162-71.
2. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans. Pintard L, etal., Curr Biol. 2003 May 27;13(11):911-21.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10500095   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11700028   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:14621295  
PMID:15489334   PMID:16141072   PMID:16141073   PMID:16162871   PMID:16785233   PMID:17062563   PMID:17339333   PMID:17967808   PMID:18303015   PMID:18799693   PMID:19056892   PMID:19261606  
PMID:20081843   PMID:20360068   PMID:20452971   PMID:20811152   PMID:20978349   PMID:21549840   PMID:21677750   PMID:21873635   PMID:22167182   PMID:22358839   PMID:22405651   PMID:22709582  
PMID:22922362   PMID:23040068   PMID:23055941   PMID:23086144   PMID:24361185   PMID:24457600   PMID:24844779   PMID:24863065   PMID:25250572   PMID:25311533   PMID:25401743   PMID:25888806  
PMID:26286618   PMID:26320660   PMID:26490675   PMID:26496610   PMID:26607111   PMID:26687681   PMID:27000625   PMID:27378813   PMID:27477274   PMID:27507650   PMID:27697860   PMID:27708159  
PMID:27882355   PMID:28190767   PMID:28280036   PMID:28499918   PMID:28620047   PMID:28671696   PMID:28706196   PMID:28794184   PMID:28887507   PMID:29263298   PMID:29653945   PMID:29777060  
PMID:29869755   PMID:29897280   PMID:30126895   PMID:30261176   PMID:30872636   PMID:30967423   PMID:31184598   PMID:31296559   PMID:31455858   PMID:31696965   PMID:31780330   PMID:32325033  
PMID:32341059   PMID:32716006   PMID:33727673   PMID:33825963   PMID:34031387   PMID:34321999   PMID:34491895   PMID:34518307   PMID:35064051   PMID:35115401   PMID:35493997   PMID:35715796  
PMID:36007890   PMID:36198437   PMID:36693858   PMID:37142655   PMID:37428799   PMID:37558490   PMID:37913946  


Genomics

Comparative Map Data
Cul3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39180,242,640 - 80,318,426 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl180,242,640 - 80,318,197 (-)EnsemblGRCm39 Ensembl
GRCm38180,264,923 - 80,340,690 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl180,264,923 - 80,340,480 (-)EnsemblGRCm38mm10GRCm38
MGSCv37180,263,393 - 80,337,005 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36180,145,842 - 80,219,467 (-)NCBIMGSCv36mm8
Celera180,291,823 - 80,365,420 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map141.24NCBI
CUL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382224,470,150 - 224,585,363 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2224,470,150 - 224,585,397 (-)EnsemblGRCh38hg38GRCh38
GRCh372225,334,867 - 225,450,080 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362225,043,113 - 225,158,358 (-)NCBINCBI36Build 36hg18NCBI36
Build 342225,160,373 - 225,275,619NCBI
Celera2219,099,731 - 219,215,637 (-)NCBICelera
Cytogenetic Map2q36.2NCBI
HuRef2217,186,560 - 217,301,844 (-)NCBIHuRef
CHM1_12225,341,500 - 225,456,770 (-)NCBICHM1_1
T2T-CHM13v2.02224,952,401 - 225,067,578 (-)NCBIT2T-CHM13v2.0
Cul3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8989,040,987 - 89,118,775 (-)NCBIGRCr8
mRatBN7.2981,592,641 - 81,670,428 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl981,592,641 - 81,670,462 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx990,022,642 - 90,100,355 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0995,151,541 - 95,229,253 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0993,534,067 - 93,611,783 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0986,044,485 - 86,129,066 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl986,044,485 - 86,129,329 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0985,794,367 - 85,853,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4979,574,062 - 79,634,396 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1979,757,935 - 79,837,198 (-)NCBI
Celera979,070,793 - 79,129,030 (-)NCBICelera
Cytogenetic Map9q34NCBI
Cul3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554539,564,522 - 9,629,976 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554539,546,554 - 9,629,976 (+)NCBIChiLan1.0ChiLan1.0
CUL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213127,089,437 - 127,200,964 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B127,104,406 - 127,215,480 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B111,714,533 - 111,827,080 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B230,289,195 - 230,373,537 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B230,289,195 - 230,378,991 (-)Ensemblpanpan1.1panPan2
CUL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12537,730,903 - 37,819,851 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2537,733,229 - 37,800,886 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2538,338,004 - 38,427,804 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02537,967,156 - 38,056,983 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2537,968,235 - 38,057,261 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12537,907,667 - 37,997,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02537,748,392 - 37,838,350 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02537,923,140 - 38,012,960 (-)NCBIUU_Cfam_GSD_1.0
Cul3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303179,724,396 - 179,788,614 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365696,065,367 - 6,132,316 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365696,067,230 - 6,131,467 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CUL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15126,189,851 - 126,287,005 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115126,191,605 - 126,287,148 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215139,621,601 - 139,781,465 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CUL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110110,425,895 - 110,541,431 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10110,425,076 - 110,541,538 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604088,866,367 - 88,980,363 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cul3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624823766,780 - 852,727 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624823767,347 - 854,065 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cul3
2280 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:921
Count of miRNA genes:499
Interacting mature miRNAs:585
Transcripts:ENSMUST00000163119, ENSMUST00000164108, ENSMUST00000167293, ENSMUST00000167794, ENSMUST00000168372, ENSMUST00000170897
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73615692107615830Mouse
4141625Emo4_memotionality 4 (mouse)Not determined6807134586235027Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177123115110536075Mouse
14697705Stsl3b_mSalmonella typhimurium susceptibility locus 3b (mouse)17413915981777715Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17747663795827725Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170133533104139557Mouse
14696691Malq1_mmean attack latency QTL 1 (mouse)17797663787927722Mouse
14696693Avd2q1_mattack value day 2 QTL 1 (mouse)17897771790927722Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15794135191941351Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15799197791992080Mouse
4141725Wbcq4_mwhite blood cell quantitative locus 4 (mouse)Not determined179858683113858791Mouse
12050069Nabq1_mnasal bone morphology QTL 1 (mouse)179858683113858791Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15089021684890216Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14889234582892485Mouse
10413880Mota1_mmotor activity 1 (mouse)17993637380247924Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180245593126386517Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15672692290727077Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173615692107615830Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15854919192549443Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14888900682889210Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15597494889975057Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15799197791992080Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15626621490266360Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15672692290727077Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
1300821Lore1_mloss of righting induced by ethanol 1 (mouse)Not determined17554919192941077Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15626621490266360Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15854919192549443Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
14747009Manh49_mmandible shape 49 (mouse)15794135191941351Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14685469080854839Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173266214108838414Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)175976637128527737Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14734989481350013Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
1302119Cia15_mcollagen induced arthritis 15 (mouse)Not determined16588900688496101Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14685469080854839Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15799197791992080Mouse

Markers in Region
AI467304  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38180,266,567 - 80,266,646UniSTSGRCm38
MGSCv37180,263,142 - 80,263,221UniSTSGRCm37
Celera180,291,572 - 80,291,651UniSTS
Cytogenetic Map1C4UniSTS
Whitehead/MRC_RH11170.51UniSTS
AW146203  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38180,265,953 - 80,266,088UniSTSGRCm38
MGSCv37180,262,528 - 80,262,663UniSTSGRCm37
Celera180,290,958 - 80,291,093UniSTS
Cytogenetic Map1C4UniSTS
Whitehead/MRC_RH11166.12UniSTS
D1Mit134  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38180,267,876 - 80,268,019UniSTSGRCm38
MGSCv37180,264,451 - 80,264,594UniSTSGRCm37
Celera180,292,881 - 80,293,024UniSTS
Cytogenetic Map1C4UniSTS
cM Map149.0UniSTS
Whitehead Genetic147.0UniSTS
Whitehead/MRC_RH11170.18UniSTS
AI072520  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38180,265,896 - 80,266,092UniSTSGRCm38
MGSCv37180,262,471 - 80,262,667UniSTSGRCm37
Celera180,290,901 - 80,291,097UniSTS
Cytogenetic Map1C4UniSTS
CUL3-1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38180,280,888 - 80,281,435UniSTSGRCm38
MGSCv37180,277,463 - 80,278,010UniSTSGRCm37
Celera180,305,893 - 80,306,440UniSTS
Cytogenetic Map1C4UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001313728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001421384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001421385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030254438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030254443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC161416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC166157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF129738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE991461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM899470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK634506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000163119   ⟹   ENSMUSP00000130738
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl180,242,640 - 80,318,197 (-)Ensembl
GRCm38.p6 Ensembl180,264,923 - 80,340,480 (-)Ensembl
Ensembl Acc Id: ENSMUST00000164108   ⟹   ENSMUSP00000131891
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl180,244,540 - 80,318,028 (-)Ensembl
GRCm38.p6 Ensembl180,266,823 - 80,340,311 (-)Ensembl
Ensembl Acc Id: ENSMUST00000167293   ⟹   ENSMUSP00000126630
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl180,266,548 - 80,317,996 (-)Ensembl
GRCm38.p6 Ensembl180,288,831 - 80,340,279 (-)Ensembl
Ensembl Acc Id: ENSMUST00000167794
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl180,244,959 - 80,254,283 (-)Ensembl
GRCm38.p6 Ensembl180,267,242 - 80,276,566 (-)Ensembl
Ensembl Acc Id: ENSMUST00000168372   ⟹   ENSMUSP00000132485
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl180,244,664 - 80,255,158 (-)Ensembl
GRCm38.p6 Ensembl180,266,947 - 80,277,441 (-)Ensembl
Ensembl Acc Id: ENSMUST00000170897   ⟹   ENSMUSP00000130010
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl180,264,767 - 80,318,024 (-)Ensembl
GRCm38.p6 Ensembl180,287,050 - 80,340,307 (-)Ensembl
RefSeq Acc Id: NM_001313728   ⟹   NP_001300657
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39180,242,640 - 80,318,426 (-)NCBI
GRCm38180,264,923 - 80,340,690 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001421384   ⟹   NP_001408313
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39180,242,640 - 80,318,426 (-)NCBI
RefSeq Acc Id: NM_001421385   ⟹   NP_001408314
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39180,242,640 - 80,318,426 (-)NCBI
RefSeq Acc Id: NM_016716   ⟹   NP_057925
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39180,242,640 - 80,318,426 (-)NCBI
GRCm38180,264,923 - 80,340,690 (-)NCBI
MGSCv37180,263,393 - 80,337,005 (-)RGD
Celera180,291,823 - 80,365,420 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030254438   ⟹   XP_030110298
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39180,243,327 - 80,300,773 (-)NCBI
GRCm38180,265,610 - 80,322,997 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030254443   ⟹   XP_030110303
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39180,243,327 - 80,300,689 (-)NCBI
GRCm38180,265,610 - 80,308,585 (-)NCBI
Sequence:
RefSeq Acc Id: NP_057925   ⟸   NM_016716
- Peptide Label: isoform 1
- UniProtKB: Q9JLV5 (UniProtKB/Swiss-Prot),   Q6ZQ84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300657   ⟸   NM_001313728
- Peptide Label: isoform 2 precursor
- UniProtKB: E9Q4T8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030110298   ⟸   XM_030254438
- Peptide Label: isoform X1
- UniProtKB: E9Q4T8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030110303   ⟸   XM_030254443
- Peptide Label: isoform X2
- UniProtKB: E9Q4T8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000131891   ⟸   ENSMUST00000164108
Ensembl Acc Id: ENSMUSP00000130738   ⟸   ENSMUST00000163119
Ensembl Acc Id: ENSMUSP00000130010   ⟸   ENSMUST00000170897
Ensembl Acc Id: ENSMUSP00000132485   ⟸   ENSMUST00000168372
Ensembl Acc Id: ENSMUSP00000126630   ⟸   ENSMUST00000167293
RefSeq Acc Id: NP_001408314   ⟸   NM_001421385
- Peptide Label: isoform 3
- UniProtKB: E9Q4T8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001408313   ⟸   NM_001421384
- Peptide Label: isoform 2 precursor
- UniProtKB: E9Q4T8 (UniProtKB/TrEMBL)
Protein Domains
Cullin family profile   Cullin N-terminal   Cullin protein neddylation

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JLV5-F1-model_v2 AlphaFold Q9JLV5 1-768 view protein structure

Promoters
RGD ID:6817566
Promoter ID:MM_KWN:1310
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000004478,   UC007BRD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36180,336,876 - 80,337,847 (-)MPROMDB
RGD ID:6874214
Promoter ID:EPDNEW_M558
Type:initiation region
Name:Cul3_1
Description:Mus musculus cullin 3 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38180,340,641 - 80,340,701EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1347360 AgrOrtholog
Ensembl Genes ENSMUSG00000004364 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000163119 ENTREZGENE
  ENSMUST00000163119.8 UniProtKB/Swiss-Prot
  ENSMUST00000164108 ENTREZGENE
  ENSMUST00000164108.8 UniProtKB/TrEMBL
  ENSMUST00000167293.2 UniProtKB/TrEMBL
  ENSMUST00000168372.2 UniProtKB/TrEMBL
  ENSMUST00000170897.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin Repeats UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cullin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_homology UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_homology_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_neddylation_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:26554 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1347360 ENTREZGENE
NCBI Gene 26554 ENTREZGENE
PANTHER CULLIN-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11932 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cullin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_Nedd8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cul3 PhenoGen
PROSITE CULLIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CULLIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CULLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cullin_Nedd8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF74788 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF75632 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CUL3_MOUSE UniProtKB/Swiss-Prot
  E9Q4T8 ENTREZGENE, UniProtKB/TrEMBL
  F6R0N8_MOUSE UniProtKB/TrEMBL
  F6UY44_MOUSE UniProtKB/TrEMBL
  F6ZZK0_MOUSE UniProtKB/TrEMBL
  Q6ZQ84 ENTREZGENE, UniProtKB/TrEMBL
  Q9CTE0_MOUSE UniProtKB/TrEMBL
  Q9JLV5 ENTREZGENE