PLAC8 (placenta associated 8) - Rat Genome Database

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Gene: PLAC8 (placenta associated 8) Homo sapiens
Analyze
Symbol: PLAC8
Name: placenta associated 8
RGD ID: 1317680
HGNC Page HGNC:19254
Description: Predicted to enable chromatin binding activity. Predicted to be involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including brown fat cell differentiation; defense response to bacterium; and response to cold. Predicted to be located in azurophil granule lumen and extracellular region.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C15; DGIC; onzin; placenta specific 8; placenta-specific 8; placenta-specific gene 8 protein; PNAS-144
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38483,090,048 - 83,114,729 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl483,090,048 - 83,137,075 (-)EnsemblGRCh38hg38GRCh38
GRCh37484,011,201 - 84,035,882 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36484,230,867 - 84,254,913 (-)NCBINCBI36Build 36hg18NCBI36
Build 34484,369,019 - 84,393,068NCBI
Celera481,301,714 - 81,326,359 (-)NCBICelera
Cytogenetic Map4q21.22NCBI
HuRef479,752,244 - 79,779,026 (-)NCBIHuRef
CHM1_1483,987,686 - 84,012,382 (-)NCBICHM1_1
T2T-CHM13v2.0486,419,237 - 86,443,896 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetamiprid  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
antirheumatic drug  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP,ISO)
chloroprene  (ISO)
choline  (ISO)
chrysene  (ISO)
ciglitazone  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
Cuprizon  (ISO)
cyclosporin A  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
diclofenac  (ISO)
dioxygen  (EXP)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (ISO)
ethyl methanesulfonate  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese(II) chloride  (ISO)
methotrexate  (EXP)
methylmercury chloride  (ISO)
Monobutylphthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (EXP)
nitrofen  (ISO)
olanzapine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (EXP)
phenethyl isothiocyanate  (EXP)
phenylmercury acetate  (EXP)
potassium chromate  (EXP)
progesterone  (ISO)
propanal  (EXP)
quinolin-8-ol  (EXP)
rimonabant  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP)
sulforaphane  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trimellitic anhydride  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
urethane  (EXP)
valproic acid  (EXP)
vancomycin  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Plac8-dependent and inducible NO synthase-dependent mechanisms clear Chlamydia muridarum infections from the genital tract. Johnson RM, etal., J Immunol. 2012 Feb 15;188(4):1896-904. doi: 10.4049/jimmunol.1102764. Epub 2012 Jan 11.
2. Impaired host defense in mice lacking ONZIN. Ledford JG, etal., J Immunol. 2007 Apr 15;178(8):5132-43. doi: 10.4049/jimmunol.178.8.5132.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats. Sasaki D, etal., Mamm Genome. 2015 Dec;26(11-12):619-29. doi: 10.1007/s00335-015-9597-4. Epub 2015 Aug 22.
5. Placenta-specific 8 limits IFN╬│ production by CD4 T cells in vitro and promotes establishment of influenza-specific CD8 T cells in vivo. Slade CD, etal., PLoS One. 2020 Jul 8;15(7):e0235706. doi: 10.1371/journal.pone.0235706. eCollection 2020.
Additional References at PubMed
PMID:11042152   PMID:12384430   PMID:12477932   PMID:12758124   PMID:16189514   PMID:18624398   PMID:19322201   PMID:20072156   PMID:21873635   PMID:21982742   PMID:22920440   PMID:23284306  
PMID:23708710   PMID:24691442   PMID:24794439   PMID:25416956   PMID:25720387   PMID:26669866   PMID:27107012   PMID:27322877   PMID:27643556   PMID:28349447   PMID:29361555   PMID:29596836  
PMID:29789534   PMID:30041188   PMID:30404814   PMID:30496758   PMID:31018208   PMID:31272718   PMID:31448883   PMID:31974611   PMID:32296183   PMID:32468683   PMID:33325361   PMID:33570788  
PMID:34117724   PMID:34954560   PMID:35279480   PMID:35497881   PMID:36124427   PMID:36543379  


Genomics

Comparative Map Data
PLAC8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38483,090,048 - 83,114,729 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl483,090,048 - 83,137,075 (-)EnsemblGRCh38hg38GRCh38
GRCh37484,011,201 - 84,035,882 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36484,230,867 - 84,254,913 (-)NCBINCBI36Build 36hg18NCBI36
Build 34484,369,019 - 84,393,068NCBI
Celera481,301,714 - 81,326,359 (-)NCBICelera
Cytogenetic Map4q21.22NCBI
HuRef479,752,244 - 79,779,026 (-)NCBIHuRef
CHM1_1483,987,686 - 84,012,382 (-)NCBICHM1_1
T2T-CHM13v2.0486,419,237 - 86,443,896 (-)NCBIT2T-CHM13v2.0
Plac8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395100,699,455 - 100,720,119 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5100,701,591 - 100,720,111 (-)EnsemblGRCm39 Ensembl
GRCm385100,551,589 - 100,572,253 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5100,553,725 - 100,572,245 (-)EnsemblGRCm38mm10GRCm38
MGSCv375100,982,752 - 101,001,224 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365100,794,035 - 100,812,507 (-)NCBIMGSCv36mm8
Celera597,879,678 - 97,898,791 (-)NCBICelera
Cytogenetic Map5E4NCBI
cM Map548.49NCBI
Plac8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2149,052,601 - 9,074,264 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl149,063,048 - 9,074,264 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx149,024,175 - 9,045,882 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01410,324,037 - 10,345,742 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0149,020,655 - 9,042,362 (+)NCBIRnor_WKY
Rnor_6.01410,692,799 - 10,714,556 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1410,692,764 - 10,714,524 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01410,640,286 - 10,661,811 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41410,302,667 - 10,325,559 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11410,273,445 - 10,325,545 (+)NCBI
Celera149,161,291 - 9,183,206 (+)NCBICelera
Cytogenetic Map14p22NCBI
Plac8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554746,522,204 - 6,534,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554746,518,459 - 6,533,251 (+)NCBIChiLan1.0ChiLan1.0
PLAC8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1446,939,019 - 46,964,131 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl446,943,940 - 46,964,131 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0441,089,847 - 41,115,061 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PLAC8B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1327,004,147 - 7,049,877 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl327,007,753 - 7,029,140 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3234,835,491 - 34,881,280 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0327,025,506 - 7,071,390 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl327,029,110 - 7,050,585 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1327,096,360 - 7,142,074 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0326,964,929 - 7,010,717 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03232,951,037 - 32,996,662 (+)NCBIUU_Cfam_GSD_1.0
Plac8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052855,323,061 - 5,341,351 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367381,484,859 - 1,503,302 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049367381,484,905 - 1,503,181 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLAC8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.18135,250,761 - 135,279,091 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28144,545,594 - 144,573,932 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLAC8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1731,471,166 - 31,496,053 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl731,470,774 - 31,489,432 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603710,049,527 - 10,074,422 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plac8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624900133,889 - 158,050 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624900134,075 - 157,982 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q21.1-21.23(chr4:75453111-84094295)x1 copy number loss See cases [RCV000050786] Chr4:75453111..84094295 [GRCh38]
Chr4:76378321..85015448 [GRCh37]
Chr4:76597345..85234472 [NCBI36]
Chr4:4q21.1-21.23
pathogenic
GRCh38/hg38 4q12-22.3(chr4:51831622-97505618)x3 copy number gain See cases [RCV000051772] Chr4:51831622..97505618 [GRCh38]
Chr4:52697788..98426769 [GRCh37]
Chr4:52392545..98645792 [NCBI36]
Chr4:4q12-22.3
pathogenic
GRCh38/hg38 4q13.2-21.23(chr4:67869564-85517308)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053294]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053294]|See cases [RCV000053294] Chr4:67869564..85517308 [GRCh38]
Chr4:68735282..86438461 [GRCh37]
Chr4:68417877..86657485 [NCBI36]
Chr4:4q13.2-21.23
pathogenic
GRCh38/hg38 4q13.3-22.1(chr4:74031395-90421127)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053296]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053296]|See cases [RCV000053296] Chr4:74031395..90421127 [GRCh38]
Chr4:74897112..91342278 [GRCh37]
Chr4:75115976..91561301 [NCBI36]
Chr4:4q13.3-22.1
pathogenic
GRCh38/hg38 4q21.21-22.1(chr4:79575748-92412449)x1 copy number loss See cases [RCV000053297] Chr4:79575748..92412449 [GRCh38]
Chr4:80496902..93333600 [GRCh37]
Chr4:80715926..93552623 [NCBI36]
Chr4:4q21.21-22.1
pathogenic
GRCh38/hg38 4q21.21-21.23(chr4:81061483-83332595)x1 copy number loss See cases [RCV000053298] Chr4:81061483..83332595 [GRCh38]
Chr4:81982637..84253748 [GRCh37]
Chr4:82201661..84472772 [NCBI36]
Chr4:4q21.21-21.23
pathogenic
GRCh38/hg38 4q21.22-21.23(chr4:81733333-83448842)x1 copy number loss See cases [RCV000053299] Chr4:81733333..83448842 [GRCh38]
Chr4:82654487..84369995 [GRCh37]
Chr4:82873511..84589019 [NCBI36]
Chr4:4q21.22-21.23
pathogenic
GRCh38/hg38 4q21.22-21.23(chr4:81802008-83437114)x1 copy number loss See cases [RCV000053300] Chr4:81802008..83437114 [GRCh38]
Chr4:82723161..84358267 [GRCh37]
Chr4:82942185..84577291 [NCBI36]
Chr4:4q21.22-21.23
pathogenic
GRCh38/hg38 4q21.22-21.3(chr4:82248692-86778340)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053319]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053319]|See cases [RCV000053319] Chr4:82248692..86778340 [GRCh38]
Chr4:83169845..87699493 [GRCh37]
Chr4:83388869..87918517 [NCBI36]
Chr4:4q21.22-21.3
pathogenic
GRCh38/hg38 4q21.21-22.3(chr4:80879777-94809447)x1 copy number loss See cases [RCV000134977] Chr4:80879777..94809447 [GRCh38]
Chr4:81800931..95730598 [GRCh37]
Chr4:82019955..95949621 [NCBI36]
Chr4:4q21.21-22.3
pathogenic
GRCh38/hg38 4q21.21-21.22(chr4:79742612-83153725)x1 copy number loss See cases [RCV000135797] Chr4:79742612..83153725 [GRCh38]
Chr4:80663766..84074878 [GRCh37]
Chr4:80882790..84293902 [NCBI36]
Chr4:4q21.21-21.22
uncertain significance
GRCh38/hg38 4q21.21-21.23(chr4:79786514-85832807)x1 copy number loss See cases [RCV000136865] Chr4:79786514..85832807 [GRCh38]
Chr4:80707668..86753960 [GRCh37]
Chr4:80926692..86972984 [NCBI36]
Chr4:4q21.21-21.23
pathogenic
GRCh38/hg38 4q21.21-24(chr4:80427023-100855441)x1 copy number loss See cases [RCV000137269] Chr4:80427023..100855441 [GRCh38]
Chr4:81348177..101776598 [GRCh37]
Chr4:81567201..101995621 [NCBI36]
Chr4:4q21.21-24
pathogenic
GRCh38/hg38 4q21.21-21.23(chr4:80908016-84329610)x1 copy number loss See cases [RCV000137863] Chr4:80908016..84329610 [GRCh38]
Chr4:81829170..85250763 [GRCh37]
Chr4:82048194..85469787 [NCBI36]
Chr4:4q21.21-21.23
likely pathogenic
GRCh38/hg38 4q13.3-21.3(chr4:72262258-86002147)x3 copy number gain See cases [RCV000138312] Chr4:72262258..86002147 [GRCh38]
Chr4:73127975..86923300 [GRCh37]
Chr4:73346839..87142324 [NCBI36]
Chr4:4q13.3-21.3
pathogenic
GRCh38/hg38 4q21.21-21.3(chr4:80043949-86948317)x1 copy number loss See cases [RCV000140416] Chr4:80043949..86948317 [GRCh38]
Chr4:80965103..87869469 [GRCh37]
Chr4:81184127..88088493 [NCBI36]
Chr4:4q21.21-21.3
pathogenic
GRCh38/hg38 4q21.22-21.23(chr4:81675848-83970410)x1 copy number loss See cases [RCV000143321] Chr4:81675848..83970410 [GRCh38]
Chr4:82597002..84891563 [GRCh37]
Chr4:82816026..85110587 [NCBI36]
Chr4:4q21.22-21.23
likely pathogenic
GRCh38/hg38 4q13.2-22.3(chr4:68686088-95294456)x3 copy number gain See cases [RCV000143458] Chr4:68686088..95294456 [GRCh38]
Chr4:69551806..96215607 [GRCh37]
Chr4:69234401..96434630 [NCBI36]
Chr4:4q13.2-22.3
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q21.21-22.1(chr4:82283358-90341831)x1 copy number loss See cases [RCV000447691] Chr4:82283358..90341831 [GRCh37]
Chr4:4q21.21-22.1
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q21.22-21.23(chr4:83954528-85807754)x1 copy number loss See cases [RCV000510348] Chr4:83954528..85807754 [GRCh37]
Chr4:4q21.22-21.23
uncertain significance
GRCh37/hg19 4q21.21-21.23(chr4:82359656-84155605)x1 copy number loss See cases [RCV000511583] Chr4:82359656..84155605 [GRCh37]
Chr4:4q21.21-21.23
likely pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q21.21-22.3(chr4:81314915-96636651)x1 copy number loss not provided [RCV000682426] Chr4:81314915..96636651 [GRCh37]
Chr4:4q21.21-22.3
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q21.22-21.23(chr4:82593140-85651685)x1 copy number loss not provided [RCV001005566] Chr4:82593140..85651685 [GRCh37]
Chr4:4q21.22-21.23
pathogenic
GRCh37/hg19 4q21.21-22.1(chr4:82043901-88334228) copy number loss not provided [RCV000767792] Chr4:82043901..88334228 [GRCh37]
Chr4:4q21.21-22.1
pathogenic
GRCh37/hg19 4q13.3-21.23(chr4:72680879-86426232)x1 copy number loss not provided [RCV001005556] Chr4:72680879..86426232 [GRCh37]
Chr4:4q13.3-21.23
pathogenic
GRCh37/hg19 4q21.21-22.1(chr4:80482400-92572499)x1 copy number loss See cases [RCV000790579] Chr4:80482400..92572499 [GRCh37]
Chr4:4q21.21-22.1
pathogenic
GRCh37/hg19 4q21.1-21.23(chr4:78769297-84968832)x1 copy number loss not provided [RCV000846933] Chr4:78769297..84968832 [GRCh37]
Chr4:4q21.1-21.23
pathogenic
GRCh37/hg19 4q21.21-21.22(chr4:80199183-84074906)x1 copy number loss not provided [RCV000848187] Chr4:80199183..84074906 [GRCh37]
Chr4:4q21.21-21.22
pathogenic
Single allele deletion Chromosome 4q21 deletion syndrome [RCV001172266] Chr4:83196931..85540706 [GRCh37]
Chr4:4q21.22-21.23
pathogenic
GRCh37/hg19 4q13.3-21.3(chr4:71412409-87920784)x1 copy number loss See cases [RCV001263040] Chr4:71412409..87920784 [GRCh37]
Chr4:4q13.3-21.3
pathogenic
GRCh37/hg19 4q13.3-22.1(chr4:75737340-91131156) copy number gain not specified [RCV002053429] Chr4:75737340..91131156 [GRCh37]
Chr4:4q13.3-22.1
pathogenic
GRCh37/hg19 4q21.21-22.1(chr4:81054789-90667421) copy number loss not specified [RCV002053435] Chr4:81054789..90667421 [GRCh37]
Chr4:4q21.21-22.1
pathogenic
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3 copy number gain not provided [RCV001827738] Chr4:52866944..143582507 [GRCh37]
Chr4:4q12-31.21
pathogenic
GRCh37/hg19 4q21.21-22.2(chr4:79780152-94873225) copy number loss not specified [RCV002053432] Chr4:79780152..94873225 [GRCh37]
Chr4:4q21.21-22.2
pathogenic
GRCh37/hg19 4q21.21-22.1(chr4:80467886-93362064)x1 copy number loss not provided [RCV001829208] Chr4:80467886..93362064 [GRCh37]
Chr4:4q21.21-22.1
pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1648
Count of miRNA genes:715
Interacting mature miRNAs:801
Transcripts:ENST00000311507, ENST00000411416, ENST00000426923, ENST00000505406, ENST00000509973, ENST00000515389
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-86332  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37484,035,568 - 84,035,844UniSTSGRCh37
Build 36484,254,592 - 84,254,868RGDNCBI36
Celera481,326,016 - 81,326,292RGD
Cytogenetic Map4q21.22UniSTS
HuRef479,778,683 - 79,778,959UniSTS
TNG Radiation Hybrid Map449798.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 622 746 33 28 1697 27 7 17 19 15 71 482 4 3 4 1
Low 796 568 1343 518 201 388 1053 231 961 241 800 974 139 1 964 382 2 1
Below cutoff 1018 1665 349 77 49 49 3265 1927 2741 159 588 155 31 237 2388

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001130715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001130716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC073840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF208846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF275812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF279898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ422147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK000140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI824905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ007338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU570985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU570986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ795024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ882405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC767538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC876527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000311507   ⟹   ENSP00000309509
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl483,090,048 - 83,114,729 (-)Ensembl
RefSeq Acc Id: ENST00000411416   ⟹   ENSP00000412230
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl483,090,688 - 83,109,843 (-)Ensembl
RefSeq Acc Id: ENST00000426923   ⟹   ENSP00000399700
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl483,092,861 - 83,114,715 (-)Ensembl
RefSeq Acc Id: ENST00000505406   ⟹   ENSP00000422526
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl483,090,806 - 83,137,075 (-)Ensembl
RefSeq Acc Id: ENST00000509973   ⟹   ENSP00000423459
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl483,090,793 - 83,114,736 (-)Ensembl
RefSeq Acc Id: ENST00000515389
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl483,090,793 - 83,114,736 (-)Ensembl
RefSeq Acc Id: NM_001130715   ⟹   NP_001124187
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38483,092,861 - 83,114,729 (-)NCBI
GRCh37484,011,201 - 84,035,911 (-)RGD
Celera481,301,714 - 81,326,359 (-)RGD
HuRef479,752,244 - 79,779,026 (-)RGD
CHM1_1483,991,793 - 84,012,382 (-)NCBI
T2T-CHM13v2.0486,422,042 - 86,443,896 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001130716   ⟹   NP_001124188
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38483,090,048 - 83,109,889 (-)NCBI
GRCh37484,011,201 - 84,035,911 (-)RGD
Celera481,301,714 - 81,326,359 (-)RGD
HuRef479,752,244 - 79,779,026 (-)RGD
CHM1_1483,987,686 - 84,007,499 (-)NCBI
T2T-CHM13v2.0486,419,237 - 86,439,072 (-)NCBI
Sequence:
RefSeq Acc Id: NM_016619   ⟹   NP_057703
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38483,090,048 - 83,114,729 (-)NCBI
GRCh37484,011,201 - 84,035,911 (-)RGD
Build 36484,230,867 - 84,254,913 (-)NCBI Archive
Celera481,301,714 - 81,326,359 (-)RGD
HuRef479,752,244 - 79,779,026 (-)RGD
CHM1_1483,987,686 - 84,012,382 (-)NCBI
T2T-CHM13v2.0486,419,237 - 86,443,896 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_057703   ⟸   NM_016619
- UniProtKB: C1K3N2 (UniProtKB/Swiss-Prot),   Q9NZF1 (UniProtKB/Swiss-Prot),   X2BQ60 (UniProtKB/TrEMBL),   A0A024RDH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001124188   ⟸   NM_001130716
- UniProtKB: C1K3N2 (UniProtKB/Swiss-Prot),   Q9NZF1 (UniProtKB/Swiss-Prot),   X2BQ60 (UniProtKB/TrEMBL),   A0A024RDH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001124187   ⟸   NM_001130715
- UniProtKB: C1K3N2 (UniProtKB/Swiss-Prot),   Q9NZF1 (UniProtKB/Swiss-Prot),   X2BQ60 (UniProtKB/TrEMBL),   A0A024RDH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000412230   ⟸   ENST00000411416
RefSeq Acc Id: ENSP00000422526   ⟸   ENST00000505406
RefSeq Acc Id: ENSP00000399700   ⟸   ENST00000426923
RefSeq Acc Id: ENSP00000423459   ⟸   ENST00000509973
RefSeq Acc Id: ENSP00000309509   ⟸   ENST00000311507

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9NZF1-F1-model_v2 AlphaFold Q9NZF1 1-115 view protein structure

Promoters
RGD ID:6867880
Promoter ID:EPDNEW_H7105
Type:initiation region
Name:PLAC8_2
Description:placenta specific 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7106  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38483,109,856 - 83,109,916EPDNEW
RGD ID:6867882
Promoter ID:EPDNEW_H7106
Type:initiation region
Name:PLAC8_1
Description:placenta specific 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7105  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38483,114,729 - 83,114,789EPDNEW
RGD ID:6802531
Promoter ID:HG_KWN:48624
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001130716,   UC003HOE.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36484,249,736 - 84,250,472 (-)MPROMDB
RGD ID:6802564
Promoter ID:HG_KWN:48625
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000252637,   UC003HOC.1,   UC003HOD.1,   UC010IJY.1,   UC010IJZ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36484,254,721 - 84,255,221 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:19254 AgrOrtholog
COSMIC PLAC8 COSMIC
Ensembl Genes ENSG00000145287 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000309509 ENTREZGENE
  ENSP00000309509.4 UniProtKB/Swiss-Prot
  ENSP00000399700 ENTREZGENE
  ENSP00000399700.2 UniProtKB/Swiss-Prot
  ENSP00000412230 ENTREZGENE
  ENSP00000412230.2 UniProtKB/Swiss-Prot
  ENSP00000422526.1 UniProtKB/Swiss-Prot
  ENSP00000423459.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000311507 ENTREZGENE
  ENST00000311507.9 UniProtKB/Swiss-Prot
  ENST00000411416 ENTREZGENE
  ENST00000411416.6 UniProtKB/Swiss-Prot
  ENST00000426923 ENTREZGENE
  ENST00000426923.2 UniProtKB/Swiss-Prot
  ENST00000505406.5 UniProtKB/Swiss-Prot
  ENST00000509973.5 UniProtKB/TrEMBL
GTEx ENSG00000145287 GTEx
HGNC ID HGNC:19254 ENTREZGENE
Human Proteome Map PLAC8 Human Proteome Map
InterPro PLAC_motif_containing UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:51316 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 51316 ENTREZGENE
OMIM 607515 OMIM
PANTHER PTHR15907 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PLAC8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134950814 PharmGKB
TIGRFAMs A_thal_Cys_rich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024RDH7 ENTREZGENE
  C1K3N2 ENTREZGENE
  D6RA24_HUMAN UniProtKB/TrEMBL
  PLAC8_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  X2BQ60 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A024RDH7 UniProtKB/TrEMBL
  C1K3N2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-26 PLAC8  placenta associated 8    placenta specific 8  Symbol and/or name change 5135510 APPROVED
2015-12-08 PLAC8  placenta specific 8    placenta-specific 8  Symbol and/or name change 5135510 APPROVED