Mrpl50 (mitochondrial ribosomal protein L50) - Rat Genome Database

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Gene: Mrpl50 (mitochondrial ribosomal protein L50) Mus musculus
Analyze
Symbol: Mrpl50
Name: mitochondrial ribosomal protein L50
RGD ID: 1317531
MGI Page MGI
Description: Predicted to be involved in mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL50 (mitochondrial ribosomal protein L50).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 39S ribosomal protein L50, mitochondrial; AA408971; AI317351; D4Wsu125; D4Wsu125e; L50mt; large ribosomal subunit protein mL50; MRP-L50
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39449,512,597 - 49,521,083 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl449,512,596 - 49,521,093 (-)EnsemblGRCm39 Ensembl
GRCm38449,512,597 - 49,521,083 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl449,512,596 - 49,521,093 (-)EnsemblGRCm38mm10GRCm38
MGSCv37449,525,469 - 49,533,955 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36449,533,697 - 49,542,183 (-)NCBIMGSCv36mm8
Celera449,540,851 - 49,549,337 (-)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7671812   PMID:8889548   PMID:9811942   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:14651853  
PMID:15489334   PMID:16141072   PMID:16141073   PMID:18614015   PMID:18799693   PMID:21267068   PMID:21873635   PMID:25278503   PMID:27023846   PMID:30418981   PMID:32325033   PMID:32987154  


Genomics

Comparative Map Data
Mrpl50
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39449,512,597 - 49,521,083 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl449,512,596 - 49,521,093 (-)EnsemblGRCm39 Ensembl
GRCm38449,512,597 - 49,521,083 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl449,512,596 - 49,521,093 (-)EnsemblGRCm38mm10GRCm38
MGSCv37449,525,469 - 49,533,955 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36449,533,697 - 49,542,183 (-)NCBIMGSCv36mm8
Celera449,540,851 - 49,549,337 (-)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.54NCBI
MRPL50
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389101,387,633 - 101,398,618 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9101,387,633 - 101,398,618 (-)EnsemblGRCh38hg38GRCh38
GRCh379104,149,915 - 104,160,900 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369103,192,070 - 103,200,717 (-)NCBINCBI36Build 36hg18NCBI36
Build 349101,231,803 - 101,240,451NCBI
Celera974,665,854 - 74,674,524 (-)NCBICelera
Cytogenetic Map9q31.1NCBI
HuRef973,751,699 - 73,760,369 (-)NCBIHuRef
CHM1_19104,298,663 - 104,307,332 (-)NCBICHM1_1
T2T-CHM13v2.09113,559,613 - 113,570,593 (-)NCBIT2T-CHM13v2.0
Mrpl50
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8568,662,933 - 68,668,087 (-)NCBIGRCr8
mRatBN7.2563,867,437 - 63,872,591 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx565,798,163 - 65,803,310 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0567,617,495 - 67,622,642 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0567,586,875 - 67,592,022 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0564,784,164 - 64,789,318 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl564,784,170 - 64,789,318 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0569,275,573 - 69,280,730 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4566,261,553 - 66,266,710 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1566,267,116 - 66,271,803 (-)NCBI
Celera563,735,392 - 63,740,545 (+)NCBICelera
Cytogenetic Map5q22NCBI
Mrpl50
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541924,416,556 - 24,425,288 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541924,416,556 - 24,425,288 (+)NCBIChiLan1.0ChiLan1.0
MRPL50
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21137,963,998 - 37,974,042 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1937,966,381 - 37,976,417 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0972,598,030 - 72,607,297 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19100,592,607 - 100,601,435 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9100,592,607 - 100,601,435 (-)Ensemblpanpan1.1panPan2
MRPL50
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11158,126,242 - 58,129,171 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1158,126,547 - 58,129,123 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1156,571,953 - 56,574,915 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01159,263,004 - 59,265,966 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1159,263,072 - 59,265,911 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11157,772,750 - 57,775,710 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01157,785,796 - 57,788,783 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01158,483,375 - 58,486,338 (-)NCBIUU_Cfam_GSD_1.0
Mrpl50
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947173,010,718 - 173,016,859 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365249,558,835 - 9,564,452 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365249,558,298 - 9,564,414 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRPL50
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1243,100,372 - 243,107,084 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11243,100,365 - 243,106,831 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21271,655,691 - 271,660,590 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MRPL50
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11238,042,285 - 38,050,896 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1238,042,317 - 38,050,527 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660354,503,857 - 4,511,616 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrpl50
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247589,901,143 - 9,916,504 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247589,901,076 - 9,915,639 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mrpl50
375 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:442
Count of miRNA genes:352
Interacting mature miRNAs:374
Transcripts:ENSMUST00000057829
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301203Alcp8_malcohol preference locus 8 (mouse)Not determined41739516051395290Mouse
1301586Stheal3_msoft tissue heal 3 (mouse)Not determined42865844262658566Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
25314308Mlh1fc1_mMLH1 foci count 1 (mouse)44850000076918237Mouse
1301786Bpq3_mblood pressure QTL 3 (mouse)Not determined44240224076402381Mouse
4141555Nbwa2_mNZB and NZW autoimmunity 2 (mouse)Not determined41789251551892635Mouse
10412178Habiir2_mhyperoxic acute lung injury imprinted region 2 (mouse)Not determined43945212663283678Mouse
1300574Im2_mimmunoregulatory 2 (mouse)Not determined42807768262077816Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
1301697Sluc18_msusceptibility to lung cancer 18 (mouse)Not determined42237344856373612Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
1558794Agnm1_mautoimmune glomerulonephritis in MRL 1 (mouse)Not determined44633264655755867Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
1357877Synch1_msynechia 1 (mouse)Not determined42870992562710107Mouse
10449022Aanq1_maristolochic acid nephrotoxicity QTL 1 (mouse)44660382680603826Mouse
1300977Mopkd1_mmodifier of polycystic kidney disease progression 1 (mouse)Not determined43655083970550967Mouse
1301237Alcp7_malcohol preference locus 7 (mouse)Not determined41739516051395290Mouse
1301941Mmtg1_mmodifier of mammary tumor growth 1 (mouse)Not determined44565844283099157Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
1302075Bdln6_mbody length 6 (mouse)Not determined42237344856373612Mouse
12879977Bod2_mbone length and organs 2 (mouse)44628353180283678Mouse
1301437Scon1_msucrose consumption 1 (mouse)Not determined42237344856373612Mouse
10043880Adip23_madiposity 23 (mouse)Not determined44628353180283678Mouse
1300769Pcyts2_mplasmacytoma susceptibility 2 (mouse)Not determined42211194456112145Mouse
1301792Hdlq10_mHDL QTL 10 (mouse)Not determined43585970769859853Mouse
1558948Ath8_matherosclerosis 8 (mouse)Not determined445658442105156995Mouse
1301990Arvm1_mautoimmune renal vasculitis 1 (mouse)Not determined42933264663332776Mouse
1300966Pabr2_mplasma apolipoprotein B (human) regulator 2 (mouse)Not determined446332646105801860Mouse
1302116Bbaa1_mB.burgdorferi-associated arthritis 1 (mouse)Not determined43825093072251078Mouse
1302058Hrtfm3_mheart failure modifier 3 (mouse)Not determined42211194456112145Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108357197Mouse
13432176Actres1_mactivity response to ethanol/saline 1 (mouse)44758712850387128Mouse
13432179Acq1_mactivity chamber QTL 1 (mouse)44708712850187128Mouse
11532688Mh_mmodifier of hemostasis (mouse)44830477582304775Mouse

Markers in Region
AI317351  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38449,513,018 - 49,513,126UniSTSGRCm38
MGSCv37449,525,890 - 49,525,998UniSTSGRCm37
Celera449,541,272 - 49,541,380UniSTS
Cytogenetic Map4B1UniSTS
cM Map424.0UniSTS
Whitehead/MRC_RH4793.61UniSTS
RH124800  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38449,512,710 - 49,512,790UniSTSGRCm38
MGSCv37449,525,582 - 49,525,662UniSTSGRCm37
Celera449,540,964 - 49,541,044UniSTS
Cytogenetic Map4B1UniSTS
cM Map424.0UniSTS
RH125648  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38449,514,022 - 49,514,271UniSTSGRCm38
MGSCv37449,526,894 - 49,527,143UniSTSGRCm37
Celera449,542,276 - 49,542,525UniSTS
Cytogenetic Map4B1UniSTS
cM Map424.0UniSTS
Whitehead/MRC_RH4793.61UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000057829   ⟹   ENSMUSP00000062476
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl449,512,596 - 49,521,093 (-)Ensembl
GRCm38.p6 Ensembl449,512,596 - 49,521,093 (-)Ensembl
RefSeq Acc Id: NM_178603   ⟹   NP_848718
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39449,512,597 - 49,521,083 (-)NCBI
GRCm38449,512,597 - 49,521,083 (-)ENTREZGENE
MGSCv37449,525,469 - 49,533,955 (-)RGD
Celera449,540,851 - 49,549,337 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_848718   ⟸   NM_178603
- UniProtKB: Q8VDT9 (UniProtKB/Swiss-Prot),   Q9CR44 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000062476   ⟸   ENSMUST00000057829

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VDT9-F1-model_v2 AlphaFold Q8VDT9 1-159 view protein structure

Promoters
RGD ID:6883416
Promoter ID:EPDNEW_M5159
Type:multiple initiation site
Name:Mrpl50_1
Description:Mus musculus mitochondrial ribosomal protein L50 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38449,521,075 - 49,521,135EPDNEW
RGD ID:6835700
Promoter ID:MM_KWN:37600
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000042964,   NM_145547,   OTTMUST00000018941
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36449,533,716 - 49,534,216 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107329 AgrOrtholog
Ensembl Genes ENSMUSG00000044018 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000057829 ENTREZGENE
  ENSMUST00000057829.4 UniProtKB/Swiss-Prot
InterPro Ribosomal_L50_mt UniProtKB/Swiss-Prot
KEGG Report mmu:28028 UniProtKB/Swiss-Prot
MGD MGI:107329 ENTREZGENE
NCBI Gene 28028 ENTREZGENE
PANTHER 39S RIBOSOMAL PROTEIN L50, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR31542 UniProtKB/Swiss-Prot
Pfam Ribosomal_L50 UniProtKB/Swiss-Prot
PhenoGen Mrpl50 PhenoGen
UniProt Q8VDT9 ENTREZGENE
  Q9CR44 ENTREZGENE
  RM50_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q9CR44 UniProtKB/Swiss-Prot