Lrrk1 (leucine-rich repeat kinase 1) - Rat Genome Database

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Gene: Lrrk1 (leucine-rich repeat kinase 1) Mus musculus
Analyze
Symbol: Lrrk1
Name: leucine-rich repeat kinase 1
RGD ID: 1317517
MGI Page MGI
Description: Predicted to enable identical protein binding activity and protein kinase activity. Acts upstream of or within several processes, including bone resorption; osteoclast development; and regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in cytosol and mitochondrion. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Used to study osteopetrosis. Human ortholog(s) of this gene implicated in osteosclerotic metaphyseal dysplasia. Orthologous to human LRRK1 (leucine rich repeat kinase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW319595; C230002E15Rik; D130026O16Rik; leucine-rich repeat serine/threonine-protein kinase 1; MGC28646; mKIAA1790
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39765,908,493 - 66,038,089 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl765,876,660 - 66,038,098 (-)EnsemblGRCm39 Ensembl
GRCm38766,258,745 - 66,388,341 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl766,226,912 - 66,388,350 (-)EnsemblGRCm38mm10GRCm38
MGSCv37773,403,631 - 73,533,227 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36755,670,181 - 55,799,947 (-)NCBIMGSCv36mm8
MGSCv36766,137,695 - 66,267,291 (-)NCBIMGSCv36mm8
Celera763,712,568 - 63,843,036 (-)NCBICelera
Celera759,723,311 - 59,724,078 (-)NCBICelera
Cytogenetic Map7CNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (ISO)
mitochondrion  (ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone marrow cavity morphology  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal clavicle morphology  (IEA)
abnormal eyelid morphology  (IEA)
abnormal facial morphology  (IAGP)
abnormal femur morphology  (IEA)
abnormal fibula morphology  (IEA)
abnormal gait  (IEA)
abnormal humerus morphology  (IEA)
abnormal joint morphology  (IEA)
abnormal locomotor behavior  (IEA)
abnormal long bone metaphysis morphology  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal mandible morphology  (IEA)
abnormal maxilla morphology  (IEA)
abnormal osteoclast physiology  (IAGP)
abnormal pelvic girdle bone morphology  (IEA)
abnormal radius morphology  (IEA)
abnormal rib morphology  (IEA)
abnormal snout morphology  (IEA)
abnormal tibia morphology  (IEA)
abnormal tooth morphology  (IEA)
abnormal trabecular bone morphology  (IAGP)
abnormal ulna morphology  (IEA)
abnormal vertebrae morphology  (IEA)
abnormal zygomatic bone morphology  (IEA)
absent teeth  (IEA)
decreased body height  (IAGP)
decreased bone resorption  (IAGP)
decreased circulating alkaline phosphatase level  (IAGP)
decreased eosinophil cell number  (IEA)
decreased lean body mass  (IEA)
decreased leukocyte cell number  (IEA)
decreased lymphocyte cell number  (IEA)
decreased susceptibility to osteoporosis  (IAGP)
increased bone mineral content  (IEA)
increased bone mineral density  (IAGP)
increased bone trabecula number  (IAGP)
increased circulating aspartate transaminase level  (IEA)
increased circulating cholesterol level  (IEA)
increased circulating creatine kinase level  (IEA)
increased circulating HDL cholesterol level  (IEA)
increased circulating iron level  (IEA)
increased circulating phosphate level  (IEA)
increased compact bone thickness  (IAGP)
increased neutrophil cell number  (IEA)
increased osteoclast cell number  (IAGP)
increased red blood cell distribution width  (IEA)
increased total body fat amount  (IEA)
increased trabecular bone thickness  (IAGP)
increased trabecular bone volume  (IAGP)
osteopetrosis  (IAGP)
osteosclerosis  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
short femur  (IAGP)
short tibia  (IAGP)
small pubis  (IAGP)
thrombocytopenia  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, etal., DNA Res 2003 Aug 31;10(4):167-80.
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:18045479   PMID:18799693   PMID:20403420  
PMID:20697350   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23526378   PMID:23675505   PMID:24046356   PMID:24194600   PMID:25455687   PMID:25917818   PMID:26100023   PMID:27166870  
PMID:27600824   PMID:27626380   PMID:29056298   PMID:30136304   PMID:32325033   PMID:33459343   PMID:33905568  


Genomics

Comparative Map Data
Lrrk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39765,908,493 - 66,038,089 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl765,876,660 - 66,038,098 (-)EnsemblGRCm39 Ensembl
GRCm38766,258,745 - 66,388,341 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl766,226,912 - 66,388,350 (-)EnsemblGRCm38mm10GRCm38
MGSCv37773,403,631 - 73,533,227 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36755,670,181 - 55,799,947 (-)NCBIMGSCv36mm8
MGSCv36766,137,695 - 66,267,291 (-)NCBIMGSCv36mm8
Celera763,712,568 - 63,843,036 (-)NCBICelera
Celera759,723,311 - 59,724,078 (-)NCBICelera
Cytogenetic Map7CNCBI
LRRK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3815100,919,357 - 101,078,257 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl15100,919,327 - 101,078,257 (+)EnsemblGRCh38hg38GRCh38
GRCh3715101,459,562 - 101,618,462 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361599,276,983 - 99,427,840 (+)NCBINCBI36Build 36hg18NCBI36
Build 341599,380,194 - 99,427,834NCBI
Celera1577,872,799 - 78,023,725 (+)NCBICelera
Cytogenetic Map15q26.3NCBI
HuRef1577,581,355 - 77,732,446 (+)NCBIHuRef
CHM1_115101,300,443 - 101,451,610 (+)NCBICHM1_1
T2T-CHM13v2.01598,673,894 - 98,832,884 (+)NCBIT2T-CHM13v2.0
Lrrk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21119,844,360 - 119,972,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1119,845,146 - 119,979,734 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1127,837,758 - 127,964,722 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01135,009,201 - 135,136,173 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01127,819,030 - 127,946,556 (-)NCBIRnor_WKY
Rnor_6.01127,166,866 - 127,301,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1127,166,431 - 127,292,090 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01128,248,473 - 128,372,456 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41120,695,657 - 120,836,324 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11120,773,221 - 120,921,758 (-)NCBI
Celera1112,054,004 - 112,179,350 (-)NCBICelera
Cytogenetic Map1q22NCBI
Lrrk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541627,865,784 - 27,988,279 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541627,860,934 - 27,988,279 (+)NCBIChiLan1.0ChiLan1.0
LRRK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11594,208,601 - 94,360,510 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01579,642,908 - 79,793,990 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11598,936,123 - 99,081,168 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1598,931,344 - 99,081,168 (+)Ensemblpanpan1.1panPan2
LRRK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1340,003,299 - 40,122,326 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl340,004,557 - 40,122,320 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha342,692,357 - 42,816,723 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0340,394,683 - 40,519,058 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl340,377,843 - 40,513,734 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1339,927,716 - 40,048,483 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0340,164,544 - 40,288,876 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0340,366,423 - 40,490,768 (-)NCBIUU_Cfam_GSD_1.0
Lrrk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640143,409,510 - 143,562,544 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364832,771,938 - 2,924,525 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364832,771,939 - 2,922,793 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1139,494,121 - 139,624,604 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11139,494,126 - 139,624,609 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21155,637,573 - 155,853,753 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRRK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12919,385,149 - 19,532,440 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2919,386,170 - 19,533,686 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605927,010,221 - 27,156,563 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247683,712,049 - 3,848,651 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247683,701,187 - 3,848,943 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrrk1
5301 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1888
Count of miRNA genes:768
Interacting mature miRNAs:966
Transcripts:ENSMUST00000015277, ENSMUST00000130438, ENSMUST00000131239, ENSMUST00000137181, ENSMUST00000145954, ENSMUST00000154893, ENSMUST00000167705
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73239453266394681Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73405302568053223Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73431688768317043Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73729942572049748Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
1300878Skts1_mskin tumor susceptibility 1 (mouse)Not determined73789138671891582Mouse
10402488Dipa2_mdrug induced psychomotor activation 2 (mouse)Not determined73842154872421684Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74114882075148965Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
12880417V125Dq5_mvitamin D active form serum level QTL 5 (mouse)74524974879249748Mouse
25314302Vmm2_mvariable multisystem mineralization 2, heart (mouse)74714974874149748Mouse
12738423Lfibq6_mliver fibrosis QTL 6 (mouse)74769437866704862Mouse
1302141Fcsa6_mfemoral cross-sectional area 6 (mouse)Not determined74838446182384607Mouse
11532741Tbrs5_mtuberculosis resistance 5 (mouse)74915922783235415Mouse
1357752Tabw_mtally ho asscoiated body weight (mouse)Not determined74919327883193390Mouse
10053685Eae43_mexperimental allergic encephalomyelitis susceptibility 43 (mouse)Not determined75112495485125093Mouse
10054064Bwq11_mbody weight QTL 11 (mouse)Not determined75112495485125093Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
12880418V125Dq6_mvitamin D active form serum level QTL 6 (mouse)75214974886149748Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
11565101Tsve1_mvariable short tail (Tsv) enhancer 1 (mouse)75588950887142720Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
1300952Hcs1_mhepatocarcinogenesis susceptibility 1 (mouse)Not determined75732612191326352Mouse
1301465Egrm3_mearly growth rate (mouse)Not determined75732612191326352Mouse
1301663Skull9_mskull morphology 9 (mouse)Not determined75732612191326352Mouse
13432171Rosd1_mrotarod saline difference 1 (mouse)75919437869004862Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
13506761Tbthq1_mtrabecular bone thickness QTL 1 (mouse)76234974867749748Mouse
1301383Aem2_manti-erythrocyte autoantibody modifier 2 (mouse)Not determined76413542498135653Mouse
26884381Bzwq2_mbi-zygomatic width QTL 2, 5 week (mouse)76524974896949207Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
13506750Tbthq2_mtrabecular bone thickness QTL 2 (mouse)76565974877549748Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)76578898699788986Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)76578898699788986Mouse

Markers in Region
AW319595  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38766,258,857 - 66,258,949UniSTSGRCm38
MGSCv37773,403,743 - 73,403,835UniSTSGRCm37
Celera759,723,421 - 59,723,513UniSTS
Cytogenetic Map7CUniSTS
Whitehead/MRC_RH7863.11UniSTS
D7Dcr28  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38766,340,062 - 66,340,165UniSTSGRCm38
MGSCv37773,484,948 - 73,485,051UniSTSGRCm37
Celera763,792,816 - 63,792,948UniSTS
Cytogenetic Map7CUniSTS
cM Map7 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_146191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_391340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC091324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC127595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC080819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY024941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000015277   ⟹   ENSMUSP00000015277
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl765,908,493 - 66,038,098 (-)Ensembl
GRCm38.p6 Ensembl766,258,745 - 66,388,350 (-)Ensembl
RefSeq Acc Id: ENSMUST00000130438
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl765,990,428 - 65,993,013 (-)Ensembl
GRCm38.p6 Ensembl766,340,680 - 66,343,265 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131239
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl765,915,938 - 65,919,548 (-)Ensembl
GRCm38.p6 Ensembl766,266,190 - 66,269,800 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137181
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl765,908,500 - 65,915,319 (-)Ensembl
GRCm38.p6 Ensembl766,258,752 - 66,265,571 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145954   ⟹   ENSMUSP00000114938
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl765,908,932 - 65,931,965 (-)Ensembl
GRCm38.p6 Ensembl766,259,184 - 66,282,217 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154893
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl765,991,418 - 66,038,055 (-)Ensembl
GRCm38.p6 Ensembl766,341,670 - 66,388,307 (-)Ensembl
RefSeq Acc Id: ENSMUST00000167705
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl765,876,660 - 65,912,218 (-)Ensembl
GRCm38.p6 Ensembl766,226,912 - 66,262,470 (-)Ensembl
RefSeq Acc Id: NM_146191   ⟹   NP_666303
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39765,908,493 - 66,038,089 (-)NCBI
GRCm38766,258,745 - 66,388,341 (-)ENTREZGENE
MGSCv37773,403,631 - 73,533,227 (-)RGD
Celera759,723,311 - 59,724,078 (-)NCBI
Celera763,712,568 - 63,843,036 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006540838   ⟹   XP_006540901
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39765,908,493 - 65,993,022 (-)NCBI
GRCm38766,258,745 - 66,343,280 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006540839   ⟹   XP_006540902
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39765,908,923 - 66,027,399 (-)NCBI
GRCm38766,258,745 - 66,377,658 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006540840   ⟹   XP_006540903
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39765,908,923 - 65,947,499 (-)NCBI
GRCm38766,258,745 - 66,297,897 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006540841   ⟹   XP_006540904
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39765,908,493 - 66,038,055 (-)NCBI
GRCm38766,258,745 - 66,294,883 (-)NCBI
Sequence:
RefSeq Acc Id: XR_391340
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39765,912,356 - 65,993,029 (-)NCBI
GRCm38766,262,608 - 66,343,288 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_666303   ⟸   NM_146191
- UniProtKB: Q8R085 (UniProtKB/Swiss-Prot),   Q3UHC2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006540902   ⟸   XM_006540839
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006540901   ⟸   XM_006540838
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006540903   ⟸   XM_006540840
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006540904   ⟸   XM_006540841
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSMUSP00000015277   ⟸   ENSMUST00000015277
RefSeq Acc Id: ENSMUSP00000114938   ⟸   ENSMUST00000145954
Protein Domains
Protein kinase   Roc

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3UHC2-F1-model_v2 AlphaFold Q3UHC2 1-2014 view protein structure

Promoters
RGD ID:8664381
Promoter ID:EPDNEW_M10221
Type:multiple initiation site
Name:Lrrk1_1
Description:Mus musculus leucine-rich repeat kinase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38766,388,308 - 66,388,368EPDNEW
RGD ID:6841476
Promoter ID:MM_KWN:50951
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:UC009HHC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36773,409,886 - 73,410,386 (-)MPROMDB
RGD ID:6841477
Promoter ID:MM_KWN:50954
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B6
Transcripts:OTTMUST00000061380
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36773,488,061 - 73,488,561 (-)MPROMDB
RGD ID:6841473
Promoter ID:MM_KWN:50956
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000077207,   ENSMUST00000089025,   OTTMUST00000061293,   UC009HHG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36773,533,156 - 73,534,162 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2142227 AgrOrtholog
Ensembl Genes ENSMUSG00000015133 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000015277 ENTREZGENE
  ENSMUSP00000015277.8 UniProtKB/Swiss-Prot
  ENSMUSP00000114938.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000015277 ENTREZGENE
  ENSMUST00000015277.14 UniProtKB/Swiss-Prot
  ENSMUST00000145954.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot
  ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  COR UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Quino_amine_DH_bsu UniProtKB/Swiss-Prot
  ROC_dom UniProtKB/Swiss-Prot
KEGG Report mmu:233328 UniProtKB/Swiss-Prot
MGD MGI:2142227 ENTREZGENE
NCBI Gene 233328 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE UniProtKB/TrEMBL
  NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot
  PTHR48051 UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot
  COR UniProtKB/Swiss-Prot
  LRR_8 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Roc UniProtKB/Swiss-Prot
PhenoGen Lrrk1 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  LRR UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ROC UniProtKB/Swiss-Prot
SMART ANK UniProtKB/Swiss-Prot
  LRR_BAC UniProtKB/Swiss-Prot
  LRR_TYP UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
  SSF48403 UniProtKB/Swiss-Prot
  SSF50969 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F6YIW9_MOUSE UniProtKB/TrEMBL
  LRRK1_MOUSE UniProtKB/Swiss-Prot
  Q3TAH2_MOUSE UniProtKB/TrEMBL
  Q3UHC2 ENTREZGENE
  Q8R085 ENTREZGENE
UniProt Secondary Q3U476 UniProtKB/Swiss-Prot
  Q66JQ4 UniProtKB/Swiss-Prot
  Q6GQR9 UniProtKB/Swiss-Prot
  Q6NZF5 UniProtKB/Swiss-Prot
  Q6ZPI4 UniProtKB/Swiss-Prot
  Q8BKP3 UniProtKB/Swiss-Prot
  Q8BU93 UniProtKB/Swiss-Prot
  Q8BUY0 UniProtKB/Swiss-Prot
  Q8BVV2 UniProtKB/Swiss-Prot
  Q8R085 UniProtKB/Swiss-Prot