PTPN22 (protein tyrosine phosphatase non-receptor type 22) - Rat Genome Database

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Gene: PTPN22 (protein tyrosine phosphatase non-receptor type 22) Homo sapiens
Analyze
Symbol: PTPN22
Name: protein tyrosine phosphatase non-receptor type 22
RGD ID: 1317504
HGNC Page HGNC:9652
Description: Enables protein tyrosine phosphatase activity and ubiquitin protein ligase binding activity. Involved in several processes, including regulation of cytokine production; regulation of lymphocyte activation; and regulation of signal transduction. Located in cytoplasmic side of plasma membrane; nucleus; and perinuclear region of cytoplasm. Implicated in several diseases, including Addison's disease; Meniere's disease; autoimmune disease (multiple); pulmonary tuberculosis; and systemic scleroderma. Biomarker of chronic lymphocytic leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; lymphoid phosphatase; lymphoid-specific protein tyrosine phosphatase; LYP; LYP1; LYP2; PEP; PEST-domain phosphatase; protein tyrosine phosphatase, non-receptor type 8; PTPN22.5; PTPN22.6; PTPN8; tyrosine-protein phosphatase non-receptor type 22
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381113,813,811 - 113,871,759 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1113,813,811 - 113,871,753 (-)EnsemblGRCh38hg38GRCh38
GRCh371114,356,433 - 114,414,381 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361114,157,960 - 114,215,857 (-)NCBINCBI36Build 36hg18NCBI36
Build 341114,068,480 - 114,126,376NCBI
Celera1112,585,654 - 112,643,598 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1112,214,556 - 112,272,493 (-)NCBIHuRef
CHM1_11114,471,278 - 114,529,225 (-)NCBICHM1_1
T2T-CHM13v2.01113,825,481 - 113,883,420 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy  (IEA)
cellular response to muramyl dipeptide  (IDA,IEA)
dephosphorylation  (IEA)
immune system process  (IEA)
lipid metabolic process  (IEA)
lipid metabolic process  (IEA)
lipopolysaccharide-mediated signaling pathway  (IMP)
negative regulation of autophagy  (IMP)
negative regulation of gene expression  (IEA,IMP)
negative regulation of interleukin-6 production  (IEA,IMP)
negative regulation of interleukin-8 production  (IEA,IMP)
negative regulation of JUN kinase activity  (IMP)
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (IBA,IEA,IMP)
negative regulation of p38MAPK cascade  (IBA,IEA,IMP)
negative regulation of T cell activation  (IBA,IEA,IMP)
negative regulation of T cell receptor signaling pathway  (IDA)
negative regulation of tumor necrosis factor production  (IBA,IEA,IMP)
peptidyl-tyrosine dephosphorylation  (IBA,IEA)
phosphoanandamide dephosphorylation  (IEA,ISS)
positive regulation of CD8-positive, alpha-beta T cell proliferation  (IBA,IEA)
positive regulation of defense response to virus by host  (IBA,IEA)
positive regulation of ERK1 and ERK2 cascade  (IBA,IEA,IMP)
positive regulation of gene expression  (IEA,IMP)
positive regulation of granzyme B production  (IBA,IEA)
positive regulation of interferon-alpha production  (IEA)
positive regulation of interferon-beta production  (IEA)
positive regulation of NLRP3 inflammasome complex assembly  (IDA,IEA)
positive regulation of protein import into nucleus  (IEA)
positive regulation of protein K63-linked ubiquitination  (IBA,IEA,IMP)
positive regulation of toll-like receptor 3 signaling pathway  (IBA,IEA,IMP)
positive regulation of toll-like receptor 4 signaling pathway  (IBA,IEA,IMP)
positive regulation of toll-like receptor 7 signaling pathway  (IBA,IEA)
positive regulation of toll-like receptor 9 signaling pathway  (IBA,IEA)
positive regulation of type I interferon production  (IMP)
positive regulation of type II interferon production  (IMP)
protein dephosphorylation  (IDA,IEA,ISO,TAS)
regulation of antigen processing and presentation  (ISO)
regulation of B cell receptor signaling pathway  (NAS)
regulation of calcium ion transmembrane transport  (IEA,ISO)
regulation of innate immune response  (IC)
regulation of leukocyte migration  (IEA)
regulation of natural killer cell proliferation  (IDA)
regulation of NIK/NF-kappaB signaling  (IBA,IEA,IMP)
regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
regulation of T cell receptor signaling pathway  (IEA)
response to lipopolysaccharide  (IMP)
T cell differentiation  (IBA,IEA,ISO,ISS)
T cell receptor signaling pathway  (IBA,IEA,ISO,TAS)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abdominal aortic aneurysm  (IAGP)
Abdominal pain  (IAGP)
Abnormal B cell morphology  (IAGP)
Abnormal circulating interleukin concentration  (IAGP)
Abnormal eyebrow morphology  (IAGP)
Abnormal eyelash morphology  (IAGP)
Abnormal hair quantity  (IAGP)
Abnormal hip joint morphology  (IAGP)
Abnormal metacarpophalangeal joint morphology  (IAGP)
Abnormal metatarsal morphology  (IAGP)
Abnormal oral cavity morphology  (IAGP)
Abnormal pleura morphology  (IAGP)
Abnormal shoulder morphology  (IAGP)
Abnormality of the ankles  (IAGP)
Abnormality of the cervical spine  (IAGP)
Abnormality of the hypothalamus-pituitary axis  (IAGP)
Abnormality of the immune system  (IAGP)
Abnormality of the kidney  (IAGP)
Abnormality of the temporomandibular joint  (IAGP)
Abnormality of the wrist  (IAGP)
Abnormality of thrombocytes  (IAGP)
Adrenocorticotropic hormone excess  (IAGP)
Alopecia  (IAGP)
Amaurosis fugax  (IAGP)
Anemia  (IAGP)
Angina pectoris  (IAGP)
Ankle swelling  (IAGP)
Anorexia  (IAGP)
Anterior chamber synechiae  (IAGP)
Anti-citrullinated protein antibody positivity  (IAGP)
Antinuclear antibody positivity  (IAGP)
Antiphospholipid antibody positivity  (IAGP)
Aortic dissection  (IAGP)
Arrhythmia  (IAGP)
Arterial thrombosis  (IAGP)
Arthralgia  (IAGP)
Arthritis  (IAGP)
Ataxia  (IAGP)
Autoimmunity  (IAGP)
Autosomal dominant inheritance  (IAGP)
Band keratopathy  (IAGP)
Cataract  (IAGP)
Cerebral ischemia  (IAGP)
Chest pain  (IAGP)
Chronic otitis media  (IAGP)
Chronic pulmonary obstruction  (IAGP)
Cognitive impairment  (IAGP)
Conductive hearing impairment  (IAGP)
Cough  (IAGP)
Cranial nerve paralysis  (IAGP)
Cutaneous photosensitivity  (IAGP)
Decreased circulating cortisol level  (IAGP)
Decreased level of 1,5 anhydroglucitol in serum  (IAGP)
Depression  (IAGP)
Diabetes insipidus  (IAGP)
Diabetes mellitus  (IAGP)
Digital flexor tenosynovitis  (IAGP)
Diplopia  (IAGP)
Double outlet right ventricle with subpulmonary ventricular septal defect without pulmonary stenosis  (IAGP)
Elevated circulating C-reactive protein concentration  (IAGP)
Elevated erythrocyte sedimentation rate  (IAGP)
Enthesitis  (IAGP)
Epistaxis  (IAGP)
Failure to thrive  (IAGP)
Fatigue  (IAGP)
Fever  (IAGP)
Flexion contracture  (IAGP)
Gangrene  (IAGP)
Gastrointestinal hemorrhage  (IAGP)
Gastrointestinal infarctions  (IAGP)
Glaucoma  (IAGP)
Glomerulopathy  (IAGP)
Glossitis  (IAGP)
Granulomatosis  (IAGP)
Headache  (IAGP)
Hematuria  (IAGP)
Hemiplegia  (IAGP)
Hemolytic anemia  (IAGP)
Hemoptysis  (IAGP)
Hepatic failure  (IAGP)
Hepatosplenomegaly  (IAGP)
Hip osteoarthritis  (IAGP)
Hydronephrosis  (IAGP)
Hyperglycemia  (IAGP)
Hyperhidrosis  (IAGP)
Hypertension  (IAGP)
Hypopigmented skin patches  (IAGP)
Impaired mastication  (IAGP)
Increased circulating interferon-gamma concentration  (IAGP)
Inflammatory abnormality of the eye  (IAGP)
Interphalangeal joint erosions  (IAGP)
Intestinal obstruction  (IAGP)
Iridocyclitis  (IAGP)
Joint hypermobility  (IAGP)
Joint stiffness  (IAGP)
Joint swelling  (IAGP)
Ketoacidosis  (IAGP)
Knee osteoarthritis  (IAGP)
Leukopenia  (IAGP)
Low-grade fever  (IAGP)
Lupus nephritis  (IAGP)
Lymphadenopathy  (IAGP)
Malar rash  (IAGP)
Mediastinal lymphadenopathy  (IAGP)
Meningitis  (IAGP)
Mild postnatal growth retardation  (IAGP)
Muscle weakness  (IAGP)
Myalgia  (IAGP)
Nausea and vomiting  (IAGP)
Nephritis  (IAGP)
Nystagmus  (IAGP)
Oligoarthritis  (IAGP)
Ophthalmoparesis  (IAGP)
Optic atrophy  (IAGP)
Pancreatitis  (IAGP)
Papule  (IAGP)
Paresthesia  (IAGP)
Pericarditis  (IAGP)
Periorbital edema  (IAGP)
Peripheral neuropathy  (IAGP)
Pleuritis  (IAGP)
Poliosis  (IAGP)
Polyarticular arthritis  (IAGP)
Polydipsia  (IAGP)
Polyphagia  (IAGP)
Polyuria  (IAGP)
Premature graying of hair  (IAGP)
Proptosis  (IAGP)
Prostatitis  (IAGP)
Proteinuria  (IAGP)
Psoriasiform dermatitis  (IAGP)
Psychosis  (IAGP)
Ptosis  (IAGP)
Pulmonary fibrosis  (IAGP)
Pulmonary infiltrates  (IAGP)
Purpura  (IAGP)
Recurrent intrapulmonary hemorrhage  (IAGP)
Recurrent pharyngitis  (IAGP)
Recurrent respiratory infections  (IAGP)
Reduced visual acuity  (IAGP)
Renal insufficiency  (IAGP)
Respiratory insufficiency  (IAGP)
Restrictive ventilatory defect  (IAGP)
Retinal detachment  (IAGP)
Retinopathy  (IAGP)
Rheumatoid arthritis  (IAGP)
Rheumatoid factor positive  (IAGP)
Scleroderma  (IAGP)
Seizure  (IAGP)
Sensorineural hearing impairment  (IAGP)
Sensory neuropathy  (IAGP)
Severe postnatal growth retardation  (IAGP)
Short stature  (IAGP)
Sinusitis  (IAGP)
Skin rash  (IAGP)
Skin ulcer  (IAGP)
Sparse scalp hair  (IAGP)
Sudden cardiac death  (IAGP)
Swan neck-like deformities of the fingers  (IAGP)
Synovial hypertrophy  (IAGP)
Synovitis  (IAGP)
Systemic lupus erythematosus  (IAGP)
Thrombocytopenia  (IAGP)
Ureteral stenosis  (IAGP)
Uveitis  (IAGP)
Vasculitis  (IAGP)
Venous thrombosis  (IAGP)
Vertigo  (IAGP)
Visual field defect  (IAGP)
Visual impairment  (IAGP)
Visual loss  (IAGP)
Vitiligo  (IAGP)
Weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. The role of PTPN22 gene polymorphism in childhood immune thrombocytopenic purpura. Anis SK, etal., Blood Coagul Fibrinolysis. 2011 Sep;22(6):521-5.
2. Multiplex family-based study in systemic lupus erythematosus: association between the R620W polymorphism of PTPN22 and the FcgammaRIIa (CD32A) R131 allele. Balada E, etal., Tissue Antigens. 2006 Nov;68(5):432-8.
3. The association of the PTPN22 620W polymorphism with Behcet's disease. Baranathan V, etal., Ann Rheum Dis. 2007 Nov;66(11):1531-3. Epub 2007 Jul 27.
4. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Barrett JC, etal., Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
5. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Begovich AB, etal., Am J Hum Genet. 2004 Aug;75(2):330-7. Epub 2004 Jun 18.
6. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Bottini N, etal., Nat Genet. 2004 Apr;36(4):337-8. Epub 2004 Mar 7.
7. PTPN22 polymorphism presumably plays a role in the genetic background of chronic spontaneous autoreactive urticaria. Brzoza Z, etal., Dermatology. 2012;224(4):340-5. doi: 10.1159/000339332. Epub 2012 Jun 19.
8. A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo. Canton I, etal., Genes Immun. 2005 Oct;6(7):584-7.
9. High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis. Cao Y, etal., PLoS One. 2012;7(8):e42783. doi: 10.1371/journal.pone.0042783. Epub 2012 Aug 3.
10. The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients. Chinoy H, etal., Arthritis Rheum. 2008 Oct;58(10):3247-54. doi: 10.1002/art.23900.
11. The PTPN22gain-of-function+1858T(+) genotypes correlate with low IL-2 expression in thymomas and predispose to myasthenia gravis. Chuang WY, etal., Genes Immun. 2009 Dec;10(8):667-72. Epub 2009 Aug 20.
12. Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. Criswell LA, etal., Am J Hum Genet. 2005 Apr;76(4):561-71. Epub 2005 Feb 17.
13. A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. Dai X, etal., J Clin Invest. 2013 May 1;123(5):2024-36. doi: 10.1172/JCI66963. Epub 2013 Apr 24.
14. Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis. Diaz-Gallo LM, etal., Ann Rheum Dis. 2011 Mar;70(3):454-62. Epub 2010 Dec 3.
15. Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population. Douroudis K, etal., Tissue Antigens. 2008 Nov;72(5):425-30. Epub 2008 Aug 26.
16. Novel associations for hypothyroidism include known autoimmune risk loci. Eriksson N, etal., PLoS One. 2012;7(4):e34442. Epub 2012 Apr 6.
17. Recipient PTPN22 -1123 C/C genotype predicts acute graft-versus-host disease after HLA fully matched unrelated bone marrow transplantation for hematologic malignancies. Espinoza JL, etal., Biol Blood Marrow Transplant. 2013 Feb;19(2):240-6. doi: 10.1016/j.bbmt.2012.09.014. Epub 2012 Sep 28.
18. PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner. Fousteri G, etal., Clin Immunol. 2015 Feb;156(2):98-108. doi: 10.1016/j.clim.2014.12.002. Epub 2014 Dec 13.
19. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
20. PTPN22 C1858T polymorphism in women with endometriosis. Gomes FM, etal., Am J Reprod Immunol. 2010 Mar 1;63(3):227-32. Epub 2010 Jan 12.
21. PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases. Gomez LM, etal., Genes Immun. 2005 Oct;6(7):628-31.
22. Lack of association of a functional single nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with susceptibility to biopsy-proven giant cell arteritis. Gonzalez-Gay MA, etal., J Rheumatol. 2005 Aug;32(8):1510-2.
23. Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia. Hebbring SJ, etal., Blood. 2013 Jan 3;121(1):237-8. doi: 10.1182/blood-2012-08-450221.
24. Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene. Hinks A, etal., Arthritis Rheum. 2005 Jun;52(6):1694-9.
25. Genetic analysis of adult-onset autoimmune diabetes. Howson JM, etal., Diabetes. 2011 Oct;60(10):2645-53. Epub 2011 Aug 26.
26. No evidence for association between 1858 C/T single-nucleotide polymorphism of PTPN22 gene and primary Sjogren's syndrome. Ittah M, etal., Genes Immun. 2005 Aug;6(5):457-8.
27. Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis. Juneblad K, etal., Arthritis Res Ther. 2011 Mar 16;13(2):R45.
28. The non-synonymous C1858T substitution in the PTPN22 gene is associated with susceptibility to the severe forms of alopecia areata. Kemp EH, etal., Hum Immunol. 2006 Jul;67(7):535-9. Epub 2006 May 4.
29. The PTPN22-1858C>T (R620W) functional polymorphism is associated with generalized vitiligo in the Romanian population. Laberge GS, etal., Pigment Cell Melanoma Res. 2008 Apr;21(2):206-8. doi: 10.1111/j.1755-148X.2008.00443.x.
30. Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population. Lamsyah H, etal., Tissue Antigens. 2009 Sep;74(3):228-32. Epub 2009 Jun 25.
31. Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22. Li Y, etal., J Invest Dermatol. 2009 Mar;129(3):629-34. doi: 10.1038/jid.2008.297. Epub 2008 Oct 16.
32. No impact of PTPN22, PTPRJ and ACP1 genes polymorphisms on the risk of immune thrombocytopenia in French adult patients. Lioger B, etal., Thromb Res. 2016 Aug;144:76-8. doi: 10.1016/j.thromres.2016.04.013. Epub 2016 Apr 25.
33. Association of a functional polymorphism of PTPN22 encoding a lymphoid protein phosphatase in bilateral Meniere's disease. Lopez-Escamez JA, etal., Laryngoscope. 2010 Jan;120(1):103-7. doi: 10.1002/lary.20650.
34. Association of Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) C1858T gene polymorphism with susceptibility to autoimmune thyroid diseases: a meta-analysis. Luo L, etal., Endocr J. 2012 Feb 25.
35. PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes. Namjou B, etal., PLoS One. 2013 Aug 7;8(8):e69404. doi: 10.1371/journal.pone.0069404. eCollection 2013.
36. Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT. Negro R, etal., Blood. 2012 Jun 28;119(26):6278-87. doi: 10.1182/blood-2012-01-403162. Epub 2012 May 8.
37. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
38. A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Orru V, etal., Hum Mol Genet. 2009 Feb 1;18(3):569-79. doi: 10.1093/hmg/ddn363. Epub 2008 Nov 3.
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
42. The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples. Rodriguez-Rodriguez L, etal., Arthritis Rheum. 2011 Feb;63(2):365-72. doi: 10.1002/art.30145.
43. Atherosclerosis and PTPN22: a study in coronary artery disease. Saccucci P, etal., Cardiology. 2011;119(1):54-6. Epub 2011 Aug 12.
44. A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat. Sarmiento J, etal., J Immunol. 2015 Jan 15;194(2):615-29. doi: 10.4049/jimmunol.1302689. Epub 2014 Dec 12.
45. Identification of the PTPN22 functional variant R620W as susceptibility genetic factor for giant cell arteritis. Serrano A, etal., Ann Rheum Dis. 2013 Nov 1;72(11):1882-6. doi: 10.1136/annrheumdis-2013-203641. Epub 2013 Aug 14.
46. Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease. Skinningsrud B, etal., Eur J Hum Genet. 2008 Aug;16(8):977-82. Epub 2008 Feb 27.
47. Polymorphisms in the PTPN22 region are associated with psoriasis of early onset. Smith RL, etal., Br J Dermatol. 2008 May;158(5):962-8. doi: 10.1111/j.1365-2133.2008.08482.x. Epub 2008 Mar 13.
48. Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Smyth D, etal., Diabetes. 2004 Nov;53(11):3020-3.
49. Preliminary evidence for interaction of PTPN12 polymorphism with TSHR genotype and association with Graves' ophthalmopathy. Syed AA, etal., Clin Endocrinol (Oxf). 2007 Nov;67(5):663-7. Epub 2007 Jul 3.
50. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Wang K, etal., Hum Mol Genet. 2010 May 15;19(10):2059-67. doi: 10.1093/hmg/ddq078. Epub 2010 Feb 22.
51. Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population. Wipff J, etal., Ann Rheum Dis. 2006 Sep;65(9):1230-2. Epub 2006 Feb 7.
52. Expression of peptidylarginine deiminase 4 and protein tyrosine phosphatase nonreceptor type 22 in the synovium of collagen-induced arthritis rats. Xu YB, etal., Chin Med Sci J. 2014 Jun;29(2):85-90.
53. [Association of polymorphism of protein tyrosine phosphatase nonreceptor-22 gene with AITD]. Yu ZY, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 Aug;24(8):804-7.
54. The protein tyrosine phosphatase, non-receptor type 22 R620W polymorphism does not confer susceptibility to psoriasis in the genetic homogeneous population of Crete. Zervou MI, etal., Genet Test Mol Biomarkers. 2010 Feb;14(1):107-11. doi: 10.1089/gtmb.2009.0130.
55. No association of PTPN22 polymorphisms with susceptibility to ocular Behcet's disease in two Chinese Han populations. Zhang Q, etal., PLoS One. 2012;7(3):e31230. doi: 10.1371/journal.pone.0031230. Epub 2012 Mar 2.
56. Association of PTPN22 1858T/T genotype with type 1 diabetes, Graves' disease but not with rheumatoid arthritis in Russian population. Zhebrun D, etal., Aging (Albany NY). 2011 Apr;3(4):368-73.
57. Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue. Zheng J, etal., Genes Immun. 2012 Dec;13(8):641-52. doi: 10.1038/gene.2012.46. Epub 2012 Oct 18.
Additional References at PubMed
PMID:1373816   PMID:10068674   PMID:10940933   PMID:11882361   PMID:12477932   PMID:12764153   PMID:15273934   PMID:15531553   PMID:15620463   PMID:15641066   PMID:15641088   PMID:15674368  
PMID:15734872   PMID:15759012   PMID:15790351   PMID:15875058   PMID:15883854   PMID:15943829   PMID:15986374   PMID:16052172   PMID:16052563   PMID:16098055   PMID:16107870   PMID:16112033  
PMID:16164701   PMID:16175503   PMID:16185327   PMID:16185328   PMID:16229750   PMID:16273109   PMID:16277672   PMID:16279843   PMID:16279844   PMID:16320352   PMID:16322396   PMID:16339849  
PMID:16344560   PMID:16380915   PMID:16385499   PMID:16391555   PMID:16437561   PMID:16456530   PMID:16461343   PMID:16470599   PMID:16490755   PMID:16507117   PMID:16507123   PMID:16539704  
PMID:16614815   PMID:16635271   PMID:16671953   PMID:16671954   PMID:16690411   PMID:16690758   PMID:16697661   PMID:16750991   PMID:16760194   PMID:16764945   PMID:16868974   PMID:16870103  
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PMID:36741403  


Genomics

Comparative Map Data
PTPN22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381113,813,811 - 113,871,759 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1113,813,811 - 113,871,753 (-)EnsemblGRCh38hg38GRCh38
GRCh371114,356,433 - 114,414,381 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361114,157,960 - 114,215,857 (-)NCBINCBI36Build 36hg18NCBI36
Build 341114,068,480 - 114,126,376NCBI
Celera1112,585,654 - 112,643,598 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1112,214,556 - 112,272,493 (-)NCBIHuRef
CHM1_11114,471,278 - 114,529,225 (-)NCBICHM1_1
T2T-CHM13v2.01113,825,481 - 113,883,420 (-)NCBIT2T-CHM13v2.0
Ptpn22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393103,763,891 - 103,819,568 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3103,767,111 - 103,819,563 (+)EnsemblGRCm39 Ensembl
GRCm383103,856,575 - 103,912,252 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3103,859,795 - 103,912,247 (+)EnsemblGRCm38mm10GRCm38
MGSCv373103,664,215 - 103,716,170 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363103,989,353 - 104,041,308 (+)NCBIMGSCv36mm8
Celera3106,063,559 - 106,114,657 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
Ptpn22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22191,366,761 - 191,414,782 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2191,366,808 - 191,414,779 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2198,963,704 - 199,011,553 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02196,836,441 - 196,884,289 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02191,653,405 - 191,701,246 (+)NCBIRnor_WKY
Rnor_6.02206,342,066 - 206,390,348 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2206,342,066 - 206,390,348 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02225,765,744 - 225,814,130 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42199,083,186 - 199,144,309 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12199,045,987 - 199,095,515 (+)NCBI
Celera2183,836,919 - 183,884,957 (+)NCBICelera
Cytogenetic Map2q34NCBI
Ptpn22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543517,082,762 - 17,139,067 (-)NCBIChiLan1.0ChiLan1.0
PTPN22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11123,734,511 - 123,790,830 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1123,734,511 - 123,790,830 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0188,685,736 - 88,743,164 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PTPN22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11751,623,628 - 51,683,039 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1751,623,623 - 51,682,858 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1751,274,140 - 51,334,343 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01752,501,113 - 52,561,235 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1752,501,116 - 52,561,182 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11751,508,535 - 51,568,572 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01751,576,143 - 51,636,627 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01752,148,984 - 52,209,317 (-)NCBIUU_Cfam_GSD_1.0
Ptpn22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505815,244,798 - 15,296,846 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366902,181,047 - 2,232,958 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366902,180,804 - 2,232,869 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4106,686,604 - 106,758,099 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14106,692,102 - 106,758,101 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24116,897,216 - 116,927,483 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12019,792,807 - 19,855,784 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2019,793,083 - 19,855,827 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603822,562,918 - 22,626,522 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247729,472,913 - 9,550,990 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247729,472,869 - 9,552,751 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTPN22
39 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_015967.8(PTPN22):c.1858= (p.Trp620=) single nucleotide variant Addison disease, susceptibility to [RCV000009464]|Diabetes mellitus, insulin-dependent, susceptibility to [RCV000009460]|Hashimoto thyroiditis, susceptibility to [RCV000009463]|Rheumatoid arthritis [RCV000009461]|Systemic lupus erythematosus, susceptibility to [RCV000009462]|chronic fatigue syndrome with infection-triggered onset [RCV001254797]|not provided [RCV000954217] Chr1:113834946 [GRCh38]
Chr1:114377568 [GRCh37]
Chr1:1p13.2		 risk factor|benign
NM_015967.6(PTPN22):c.-1123C>G single nucleotide variant Diabetes mellitus, insulin-dependent, susceptibility to [RCV000009465] Chr1:113872746 [GRCh38]
Chr1:114415368 [GRCh37]
Chr1:1p13.2		 risk factor
GRCh38/hg38 1p13.3-12(chr1:109756630-118650204)x3 copy number gain See cases [RCV000051827] Chr1:109756630..118650204 [GRCh38]
Chr1:110299252..119192827 [GRCh37]
Chr1:110100775..118994350 [NCBI36]
Chr1:1p13.3-12		 pathogenic
NM_001193431.2(PTPN22):c.1337G>A (p.Arg446Gln) single nucleotide variant Malignant melanoma [RCV000064022] Chr1:113838063 [GRCh38]
Chr1:114380685 [GRCh37]
Chr1:114182208 [NCBI36]
Chr1:1p13.2		 not provided
NM_015967.8(PTPN22):c.2250G>C (p.Lys750Asn) single nucleotide variant not specified [RCV000203173] Chr1:113829592 [GRCh38]
Chr1:114372214 [GRCh37]
Chr1:1p13.2		 likely pathogenic|uncertain significance
GRCh38/hg38 1p21.1-12(chr1:104325484-119977655)x3 copy number gain See cases [RCV000142953] Chr1:104325484..119977655 [GRCh38]
Chr1:104868106..120471049 [GRCh37]
Chr1:104669629..120321801 [NCBI36]
Chr1:1p21.1-12		 pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12		 likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p22.1-11.2(chr1:93837992-121343783)x3 copy number gain See cases [RCV000512354] Chr1:93837992..121343783 [GRCh37]
Chr1:1p22.1-11.2		 pathogenic
GRCh37/hg19 1p13.2(chr1:114011163-114803749)x3 copy number gain See cases [RCV000512362] Chr1:114011163..114803749 [GRCh37]
Chr1:1p13.2		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p13.2(chr1:114209101-114831532)x3 copy number gain not provided [RCV000749141] Chr1:114209101..114831532 [GRCh37]
Chr1:1p13.2		 likely benign
NM_015967.8(PTPN22):c.1701G>A (p.Leu567=) single nucleotide variant not provided [RCV001703407] Chr1:113837699 [GRCh38]
Chr1:114380321 [GRCh37]
Chr1:1p13.2		 likely benign
NM_015967.8(PTPN22):c.1971T>A (p.Gly657=) single nucleotide variant not provided [RCV000894528] Chr1:113834363 [GRCh38]
Chr1:114376985 [GRCh37]
Chr1:1p13.2		 benign
NM_015967.8(PTPN22):c.1514C>G (p.Ser505Cys) single nucleotide variant not provided [RCV000927358] Chr1:113837886 [GRCh38]
Chr1:114380508 [GRCh37]
Chr1:1p13.2		 benign
NM_015967.8(PTPN22):c.1548G>A (p.Lys516=) single nucleotide variant not provided [RCV000914567] Chr1:113837852 [GRCh38]
Chr1:114380474 [GRCh37]
Chr1:1p13.2		 likely benign
NM_015967.8(PTPN22):c.2135-4del deletion not provided [RCV000948222] Chr1:113829711 [GRCh38]
Chr1:114372333 [GRCh37]
Chr1:1p13.2		 benign
NM_015967.8(PTPN22):c.1108C>A (p.His370Asn) single nucleotide variant not provided [RCV000948223] Chr1:113838292 [GRCh38]
Chr1:114380914 [GRCh37]
Chr1:1p13.2		 likely benign
GRCh37/hg19 1p13.2-13.1(chr1:114024461-116189135)x1 copy number loss not provided [RCV001005130] Chr1:114024461..116189135 [GRCh37]
Chr1:1p13.2-13.1		 likely pathogenic
NM_015967.8(PTPN22):c.1627A>G (p.Ser543Gly) single nucleotide variant not provided [RCV000974857] Chr1:113837773 [GRCh38]
Chr1:114380395 [GRCh37]
Chr1:1p13.2		 likely benign
NM_015967.8(PTPN22):c.197-4A>G single nucleotide variant not provided [RCV000910388] Chr1:113859082 [GRCh38]
Chr1:114401704 [GRCh37]
Chr1:1p13.2		 benign
NM_015967.8(PTPN22):c.1407T>C (p.Phe469=) single nucleotide variant not provided [RCV000894983] Chr1:113837993 [GRCh38]
Chr1:114380615 [GRCh37]
Chr1:1p13.2		 likely benign
NM_015967.8(PTPN22):c.1366C>G (p.Gln456Glu) single nucleotide variant not provided [RCV000953155] Chr1:113838034 [GRCh38]
Chr1:114380656 [GRCh37]
Chr1:1p13.2		 likely benign
NM_015967.8(PTPN22):c.1431T>C (p.His477=) single nucleotide variant not provided [RCV000909121] Chr1:113837969 [GRCh38]
Chr1:114380591 [GRCh37]
Chr1:1p13.2		 likely benign
NC_000001.10:g.(?_113456513)_(116311162_?)dup duplication RASopathy [RCV003107709] Chr1:113456513..116311162 [GRCh37]
Chr1:1p13.2-13.1		 uncertain significance
NM_015967.8(PTPN22):c.2075C>G (p.Ser692Cys) single nucleotide variant not provided [RCV000952810] Chr1:113830008 [GRCh38]
Chr1:114372630 [GRCh37]
Chr1:1p13.2		 benign
NM_015967.8(PTPN22):c.2135-5_2135-4del deletion not provided [RCV000955243] Chr1:113829711..113829712 [GRCh38]
Chr1:114372333..114372334 [GRCh37]
Chr1:1p13.2		 benign
NM_015967.8(PTPN22):c.147T>C (p.Ala49=) single nucleotide variant not provided [RCV000971099] Chr1:113859401 [GRCh38]
Chr1:114402023 [GRCh37]
Chr1:1p13.2		 benign
NM_015967.8(PTPN22):c.222C>T (p.Ser74=) single nucleotide variant not provided [RCV000938673] Chr1:113859053 [GRCh38]
Chr1:114401675 [GRCh37]
Chr1:1p13.2		 likely benign
NM_015967.8(PTPN22):c.828+4T>G single nucleotide variant not provided [RCV001528606] Chr1:113852023 [GRCh38]
Chr1:114394645 [GRCh37]
Chr1:1p13.2		 likely benign
GRCh37/hg19 1p21.2-12(chr1:102021465-119737478) copy number loss Seizure [RCV001352640] Chr1:102021465..119737478 [GRCh37]
Chr1:1p21.2-12		 pathogenic
GRCh37/hg19 1p21.3-13.2(chr1:95046805-114714931) copy number loss not specified [RCV002053503] Chr1:95046805..114714931 [GRCh37]
Chr1:1p21.3-13.2		 pathogenic
GRCh37/hg19 1p13.3-11.2(chr1:111647582-121343783) copy number gain not specified [RCV002053602] Chr1:111647582..121343783 [GRCh37]
Chr1:1p13.3-11.2		 pathogenic
NM_015967.8(PTPN22):c.2171G>C (p.Ser724Thr) single nucleotide variant not provided [RCV002224158] Chr1:113829671 [GRCh38]
Chr1:114372293 [GRCh37]
Chr1:1p13.2		 uncertain significance
NC_000001.10:g.(?_112318699)_(115576848_?)del deletion Hereditary spastic paraplegia 47 [RCV003109541] Chr1:112318699..115576848 [GRCh37]
Chr1:1p13.2		 pathogenic
NC_000001.10:g.(?_111145905)_(114454813_?)del deletion not provided [RCV003113195] Chr1:111145905..114454813 [GRCh37]
Chr1:1p13.3-13.2		 pathogenic
NM_015967.8(PTPN22):c.1130C>T (p.Ser377Phe) single nucleotide variant Inborn genetic diseases [RCV002818153] Chr1:113838270 [GRCh38]
Chr1:114380892 [GRCh37]
Chr1:1p13.2		 uncertain significance
NM_015967.8(PTPN22):c.2081C>G (p.Pro694Arg) single nucleotide variant Inborn genetic diseases [RCV002821520] Chr1:113830002 [GRCh38]
Chr1:114372624 [GRCh37]
Chr1:1p13.2		 uncertain significance
NM_015967.8(PTPN22):c.1078G>A (p.Glu360Lys) single nucleotide variant Inborn genetic diseases [RCV002757336] Chr1:113838322 [GRCh38]
Chr1:114380944 [GRCh37]
Chr1:1p13.2		 uncertain significance
NM_015967.8(PTPN22):c.2267G>A (p.Arg756Gln) single nucleotide variant Inborn genetic diseases [RCV002739869] Chr1:113825156 [GRCh38]
Chr1:114367778 [GRCh37]
Chr1:1p13.2		 uncertain significance
NM_015967.8(PTPN22):c.208C>T (p.Arg70Trp) single nucleotide variant Inborn genetic diseases [RCV002976773] Chr1:113859067 [GRCh38]
Chr1:114401689 [GRCh37]
Chr1:1p13.2		 uncertain significance
NM_015967.8(PTPN22):c.2081C>A (p.Pro694Gln) single nucleotide variant Inborn genetic diseases [RCV002850831] Chr1:113830002 [GRCh38]
Chr1:114372624 [GRCh37]
Chr1:1p13.2		 uncertain significance
NM_015967.8(PTPN22):c.1233G>T (p.Lys411Asn) single nucleotide variant Inborn genetic diseases [RCV002697856] Chr1:113838167 [GRCh38]
Chr1:114380789 [GRCh37]
Chr1:1p13.2		 uncertain significance
NM_015967.8(PTPN22):c.621G>C (p.Glu207Asp) single nucleotide variant Inborn genetic diseases [RCV002916033] Chr1:113854969 [GRCh38]
Chr1:114397591 [GRCh37]
Chr1:1p13.2		 uncertain significance
NM_015967.8(PTPN22):c.422G>A (p.Arg141His) single nucleotide variant Inborn genetic diseases [RCV002897621] Chr1:113856606 [GRCh38]
Chr1:114399228 [GRCh37]
Chr1:1p13.2		 uncertain significance
NM_015967.8(PTPN22):c.1529G>A (p.Arg510His) single nucleotide variant Inborn genetic diseases [RCV002714466] Chr1:113837871 [GRCh38]
Chr1:114380493 [GRCh37]
Chr1:1p13.2		 uncertain significance
NM_015967.8(PTPN22):c.91C>A (p.Leu31Met) single nucleotide variant Inborn genetic diseases [RCV002668360] Chr1:113859457 [GRCh38]
Chr1:114402079 [GRCh37]
Chr1:1p13.2		 uncertain significance
NM_015967.8(PTPN22):c.860T>C (p.Leu287Ser) single nucleotide variant Inborn genetic diseases [RCV002678342] Chr1:113848595 [GRCh38]
Chr1:114391217 [GRCh37]
Chr1:1p13.2		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2580
Count of miRNA genes:836
Interacting mature miRNAs:951
Transcripts:ENST00000359785, ENST00000420377, ENST00000460620, ENST00000469077, ENST00000484147, ENST00000525799, ENST00000528414, ENST00000529045, ENST00000532224, ENST00000534519, ENST00000538253
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-75350  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371114,357,482 - 114,357,577UniSTSGRCh37
Build 361114,159,005 - 114,159,100RGDNCBI36
Celera1112,586,703 - 112,586,798RGD
Cytogenetic Map1p13.2UniSTS
HuRef1112,215,605 - 112,215,700UniSTS
TNG Radiation Hybrid Map162203.0UniSTS
GeneMap99-GB4 RH Map1370.86UniSTS
NCBI RH Map1788.3UniSTS
RH117  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371114,356,506 - 114,356,656UniSTSGRCh37
Build 361114,158,029 - 114,158,179RGDNCBI36
Celera1112,585,727 - 112,585,877RGD
Cytogenetic Map1p13.2UniSTS
HuRef1112,214,629 - 112,214,779UniSTS
AL034193  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371114,365,965 - 114,366,044UniSTSGRCh37
Build 361114,167,488 - 114,167,567RGDNCBI36
Celera1112,595,186 - 112,595,265RGD
Cytogenetic Map1p13.2UniSTS
HuRef1112,224,090 - 112,224,169UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 96 455 21 3 1393 4 12 13 7 4 29 231 11 6
Low 1919 1799 1304 449 539 308 2912 746 1375 241 1178 1147 147 1167 1727 2 2
Below cutoff 404 734 383 157 11 138 1281 1422 2314 160 220 177 27 1 26 1047 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001193431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001308297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_015967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011541221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011541222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011541223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011541225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017001004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017001005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017001006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA836401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF001846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF077031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF150732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL137856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC071670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK008060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK008061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD692658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB145424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN997966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF064714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU479452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN084012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY471636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OP794507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U69700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000359785   ⟹   ENSP00000352833
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1113,813,811 - 113,871,712 (-)Ensembl
RefSeq Acc Id: ENST00000420377   ⟹   ENSP00000388229
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1113,819,299 - 113,871,712 (-)Ensembl
RefSeq Acc Id: ENST00000460620   ⟹   ENSP00000433141
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1113,813,811 - 113,871,712 (-)Ensembl
RefSeq Acc Id: ENST00000469077
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1113,814,664 - 113,819,832 (-)Ensembl
RefSeq Acc Id: ENST00000484147
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1113,832,947 - 113,871,664 (-)Ensembl
RefSeq Acc Id: ENST00000525799   ⟹   ENSP00000432674
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1113,819,526 - 113,871,712 (-)Ensembl
RefSeq Acc Id: ENST00000528414   ⟹   ENSP00000435176
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1113,813,815 - 113,871,698 (-)Ensembl
RefSeq Acc Id: ENST00000529045   ⟹   ENSP00000434932
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1113,859,063 - 113,871,753 (-)Ensembl
RefSeq Acc Id: ENST00000532224   ⟹   ENSP00000431249
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1113,814,679 - 113,871,708 (-)Ensembl
RefSeq Acc Id: ENST00000534519
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1113,856,783 - 113,871,736 (-)Ensembl
RefSeq Acc Id: ENST00000538253   ⟹   ENSP00000439372
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1113,813,812 - 113,871,753 (-)Ensembl
RefSeq Acc Id: NM_001193431   ⟹   NP_001180360
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381113,813,811 - 113,871,759 (-)NCBI
GRCh371114,356,433 - 114,414,375 (-)ENTREZGENE
HuRef1112,214,556 - 112,272,493 (-)ENTREZGENE
CHM1_11114,471,278 - 114,529,231 (-)NCBI
T2T-CHM13v2.01113,825,481 - 113,883,420 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001308297   ⟹   NP_001295226
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381113,813,811 - 113,871,759 (-)NCBI
CHM1_11114,471,278 - 114,529,231 (-)NCBI
T2T-CHM13v2.01113,825,481 - 113,883,420 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012411   ⟹   NP_036543
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381113,813,811 - 113,871,759 (-)NCBI
GRCh371114,356,433 - 114,414,375 (-)ENTREZGENE
Build 361114,177,092 - 114,215,840 (-)NCBI Archive
HuRef1112,214,556 - 112,272,493 (-)ENTREZGENE
CHM1_11114,471,278 - 114,529,231 (-)NCBI
T2T-CHM13v2.01113,825,481 - 113,883,420 (-)NCBI
Sequence:
RefSeq Acc Id: NM_015967   ⟹   NP_057051
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381113,813,811 - 113,871,712 (-)NCBI
GRCh371114,356,433 - 114,414,375 (-)ENTREZGENE
Build 361114,157,960 - 114,215,857 (-)NCBI Archive
HuRef1112,214,556 - 112,272,493 (-)ENTREZGENE
CHM1_11114,471,278 - 114,529,231 (-)NCBI
T2T-CHM13v2.01113,825,481 - 113,883,373 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011541221   ⟹   XP_011539523
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381113,813,811 - 113,871,759 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011541222   ⟹   XP_011539524
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381113,813,811 - 113,871,759 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011541223   ⟹   XP_011539525
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381113,830,054 - 113,871,759 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011541225   ⟹   XP_011539527
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381113,813,811 - 113,871,759 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017001005   ⟹   XP_016856494
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381113,813,811 - 113,864,277 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017001006   ⟹   XP_016856495
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381113,838,608 - 113,871,759 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047417630   ⟹   XP_047273586
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381113,813,811 - 113,871,759 (-)NCBI
RefSeq Acc Id: XM_047417631   ⟹   XP_047273587
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381113,813,811 - 113,871,759 (-)NCBI
RefSeq Acc Id: XM_047417632   ⟹   XP_047273588
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381113,813,811 - 113,871,759 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001180360 (Get FASTA)   NCBI Sequence Viewer  
  NP_001295226 (Get FASTA)   NCBI Sequence Viewer  
  NP_036543 (Get FASTA)   NCBI Sequence Viewer  
  NP_057051 (Get FASTA)   NCBI Sequence Viewer  
  XP_011539523 (Get FASTA)   NCBI Sequence Viewer  
  XP_011539524 (Get FASTA)   NCBI Sequence Viewer  
  XP_011539525 (Get FASTA)   NCBI Sequence Viewer  
  XP_011539527 (Get FASTA)   NCBI Sequence Viewer  
  XP_016856494 (Get FASTA)   NCBI Sequence Viewer  
  XP_016856495 (Get FASTA)   NCBI Sequence Viewer  
  XP_047273586 (Get FASTA)   NCBI Sequence Viewer  
  XP_047273587 (Get FASTA)   NCBI Sequence Viewer  
  XP_047273588 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB09079 (Get FASTA)   NCBI Sequence Viewer  
  AAD00904 (Get FASTA)   NCBI Sequence Viewer  
  AAD27764 (Get FASTA)   NCBI Sequence Viewer  
  AAF67472 (Get FASTA)   NCBI Sequence Viewer  
  AAH17785 (Get FASTA)   NCBI Sequence Viewer  
  AAH71670 (Get FASTA)   NCBI Sequence Viewer  
  ABK41897 (Get FASTA)   NCBI Sequence Viewer  
  ADD59979 (Get FASTA)   NCBI Sequence Viewer  
  AEL79472 (Get FASTA)   NCBI Sequence Viewer  
  AQT03316 (Get FASTA)   NCBI Sequence Viewer  
  BAG64230 (Get FASTA)   NCBI Sequence Viewer  
  DAA79957 (Get FASTA)   NCBI Sequence Viewer  
  DAA79958 (Get FASTA)   NCBI Sequence Viewer  
  EAW56573 (Get FASTA)   NCBI Sequence Viewer  
  EAW56574 (Get FASTA)   NCBI Sequence Viewer  
  EAW56575 (Get FASTA)   NCBI Sequence Viewer  
  EAW56576 (Get FASTA)   NCBI Sequence Viewer  
  Q9Y2R2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036543   ⟸   NM_012411
- Peptide Label: isoform 2
- UniProtKB: Q9Y2R2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001180360   ⟸   NM_001193431
- Peptide Label: isoform 3
- UniProtKB: Q9Y2R2 (UniProtKB/Swiss-Prot),   B4DZW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_057051   ⟸   NM_015967
- Peptide Label: isoform 1
- UniProtKB: A0A0B4J1S7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011539527   ⟸   XM_011541225
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_011539523   ⟸   XM_011541221
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011539524   ⟸   XM_011541222
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011539525   ⟸   XM_011541223
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: NP_001295226   ⟸   NM_001308297
- Peptide Label: isoform 4
- UniProtKB: Q9Y2R2 (UniProtKB/Swiss-Prot),   G3K0T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016856494   ⟸   XM_017001005
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_016856495   ⟸   XM_017001006
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: ENSP00000352833   ⟸   ENST00000359785
RefSeq Acc Id: ENSP00000431249   ⟸   ENST00000532224
RefSeq Acc Id: ENSP00000439372   ⟸   ENST00000538253
RefSeq Acc Id: ENSP00000432674   ⟸   ENST00000525799
RefSeq Acc Id: ENSP00000388229   ⟸   ENST00000420377
RefSeq Acc Id: ENSP00000435176   ⟸   ENST00000528414
RefSeq Acc Id: ENSP00000433141   ⟸   ENST00000460620
RefSeq Acc Id: ENSP00000434932   ⟸   ENST00000529045
RefSeq Acc Id: XP_047273586   ⟸   XM_047417630
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047273587   ⟸   XM_047417631
- Peptide Label: isoform X4
RefSeq Acc Id: XP_047273588   ⟸   XM_047417632
- Peptide Label: isoform X5
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Y2R2-F1-model_v2 AlphaFold Q9Y2R2 1-807 view protein structure

Promoters
RGD ID:6856688
Promoter ID:EPDNEW_H1508
Type:initiation region
Name:PTPN22_1
Description:protein tyrosine phosphatase, non-receptor type 22
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381113,871,712 - 113,871,772EPDNEW
RGD ID:6786347
Promoter ID:HG_KWN:4209
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_012411,   OTTHUMT00000033015,   OTTHUMT00000033016,   OTTHUMT00000033018,   UC009WGQ.1,   UC009WGR.1,   UC009WGS.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361114,215,831 - 114,216,627 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9652 AgrOrtholog
COSMIC PTPN22 COSMIC
Ensembl Genes ENSG00000134242 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000352833 ENTREZGENE
  ENSP00000352833.5 UniProtKB/TrEMBL
  ENSP00000388229.2 UniProtKB/TrEMBL
  ENSP00000431249.1 UniProtKB/TrEMBL
  ENSP00000432674.1 UniProtKB/TrEMBL
  ENSP00000433141.1 UniProtKB/Swiss-Prot
  ENSP00000434932.1 UniProtKB/TrEMBL
  ENSP00000435176 ENTREZGENE
  ENSP00000435176.1 UniProtKB/TrEMBL
  ENSP00000439372 ENTREZGENE
  ENSP00000439372.2 UniProtKB/TrEMBL
Ensembl Transcript ENST00000359785 ENTREZGENE
  ENST00000359785.10 UniProtKB/TrEMBL
  ENST00000420377.6 UniProtKB/TrEMBL
  ENST00000460620.5 UniProtKB/Swiss-Prot
  ENST00000525799.1 UniProtKB/TrEMBL
  ENST00000528414 ENTREZGENE
  ENST00000528414.5 UniProtKB/TrEMBL
  ENST00000529045.1 UniProtKB/TrEMBL
  ENST00000532224.5 UniProtKB/TrEMBL
  ENST00000538253 ENTREZGENE
  ENST00000538253.5 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000134242 GTEx
HGNC ID HGNC:9652 ENTREZGENE
Human Proteome Map PTPN22 Human Proteome Map
InterPro Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPase_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPN22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:26191 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 26191 ENTREZGENE
OMIM 152700 OMIM
  180300 OMIM
  222100 OMIM
  600716 OMIM
PANTHER PRIMATE-EXPANDED PROTEIN FAMILY UniProtKB/TrEMBL
  PTHR12138:SF132 UniProtKB/TrEMBL
  TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Y_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33995 PharmGKB
PIRSF PTPN8_PTPN22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS F138DOMAIN UniProtKB/TrEMBL
  PRTYPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PTPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MTD9_HUMAN UniProtKB/TrEMBL
  A0A0A0MTE6_HUMAN UniProtKB/TrEMBL
  A0A0B4J1S7 ENTREZGENE, UniProtKB/TrEMBL
  A0A1Q2XD95_HUMAN UniProtKB/TrEMBL
  A0A1Q2XDC9_HUMAN UniProtKB/TrEMBL
  A0A1S6KJG4_HUMAN UniProtKB/TrEMBL
  B4DZW8 ENTREZGENE, UniProtKB/TrEMBL
  E9PM87_HUMAN UniProtKB/TrEMBL
  E9PMK2_HUMAN UniProtKB/TrEMBL
  E9PMT0_HUMAN UniProtKB/TrEMBL
  F5H2S8_HUMAN UniProtKB/TrEMBL
  G3K0T4 ENTREZGENE, UniProtKB/TrEMBL
  PTN22_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0N0K6 UniProtKB/Swiss-Prot
  B1ALC8 UniProtKB/Swiss-Prot
  D4NZ71 UniProtKB/Swiss-Prot
  E9PLD8 UniProtKB/Swiss-Prot
  E9PPI1 UniProtKB/Swiss-Prot
  O95063 UniProtKB/Swiss-Prot
  O95064 UniProtKB/Swiss-Prot
  Q6IPX8 UniProtKB/Swiss-Prot
  Q8WVM1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 PTPN22  protein tyrosine phosphatase non-receptor type 22    protein tyrosine phosphatase, non-receptor type 22  Symbol and/or name change 5135510 APPROVED
2016-01-19 PTPN22  protein tyrosine phosphatase, non-receptor type 22    protein tyrosine phosphatase, non-receptor type 22 (lymphoid)  Symbol and/or name change 5135510 APPROVED
2011-08-16 PTPN22  protein tyrosine phosphatase, non-receptor type 22 (lymphoid)  PTPN22  protein tyrosine phosphatase, non-receptor type 22 (lymphoid)  Symbol and/or name change 5135510 APPROVED