Adipor2 (adiponectin receptor 2) - Rat Genome Database

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Gene: Adipor2 (adiponectin receptor 2) Mus musculus
Analyze
Symbol: Adipor2
Name: adiponectin receptor 2
RGD ID: 1317350
MGI Page MGI
Description: Enables adiponectin binding activity; identical protein binding activity; and signaling receptor activity. Involved in glucose homeostasis; positive regulation of cold-induced thermogenesis; and vascular wound healing. Acts upstream of or within adiponectin-activated signaling pathway. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease and type 2 diabetes mellitus. Orthologous to human ADIPOR2 (adiponectin receptor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110001I14Rik; ADCR2; adiponectin receptor protein 2; AI115388; AW554121; D6Ucla; D6Ucla1e; Paqr2; progestin and adipoQ receptor family member 2; progestin and adipoQ receptor family member II
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396119,330,111 - 119,394,489 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6119,330,111 - 119,394,665 (-)EnsemblGRCm39 Ensembl
GRCm386119,353,150 - 119,417,699 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6119,353,150 - 119,417,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv376119,303,168 - 119,367,501 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366119,318,769 - 119,383,102 (-)NCBIMGSCv36mm8
Celera6121,185,998 - 121,250,677 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map656.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-taxifolin  (ISO)
(1->4)-beta-D-glucan  (EXP)
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-methoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-aminobenzamide  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
9-cis,11-trans-octadecadienoic acid  (ISO)
acetaldehyde  (EXP)
acetamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
Aurothioglucose  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
choline  (EXP)
conjugated linoleic acid  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cysteamine  (ISO)
D-glucose  (ISO)
Deoxyschizandrin  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (ISO)
diuron  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (EXP)
finasteride  (ISO)
folic acid  (EXP)
fosinopril  (ISO)
fructose  (EXP)
genistein  (EXP)
glafenine  (ISO)
glucose  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
hexadecanoic acid  (ISO)
isoflavones  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
metformin  (ISO)
methidathion  (EXP)
methotrexate  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-acetyl-L-cysteine  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
oleic acid  (ISO)
paraquat  (ISO)
parthenolide  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
resveratrol  (EXP)
rosiglitazone  (ISO)
rotenone  (ISO)
scopoletin  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP)
Sodium oleate  (ISO)
streptozocin  (ISO)
sulindac  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (ISO)
tetrachloromethane  (EXP)
tetracycline  (EXP)
titanium dioxide  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal abdominal fat pad morphology  (IAGP)
abnormal adaptive thermogenesis  (IAGP)
abnormal brown fat cell morphology  (IAGP)
abnormal circulating glucose level  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal gluconeogenesis  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal hormone level  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal spermatogenesis  (IEA)
decreased brown adipose tissue mass  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating HDL cholesterol level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating LDL cholesterol level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased circulating VLDL cholesterol level  (IAGP)
decreased epididymis weight  (IEA)
decreased fat cell size  (IAGP)
decreased gonadal fat pad weight  (IAGP)
decreased grip strength  (IEA)
decreased lean body mass  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased lymphocyte cell number  (IEA)
decreased pancreatic beta cell number  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased renal fat pad weight  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased testis weight  (IAGP)
hyperglycemia  (IAGP)
impaired adaptive thermogenesis  (IAGP)
impaired glucose tolerance  (IAGP)
improved glucose tolerance  (IAGP)
increased brain weight  (IAGP)
increased circulating adiponectin level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased energy expenditure  (IAGP)
increased food intake  (IAGP)
increased liver triglyceride level  (IAGP)
increased locomotor activity  (IAGP)
increased neutrophil cell number  (IEA)
insulin resistance  (IAGP)
limb grasping  (IEA)
male infertility  (IEA)
multinucleated giant male germ cells  (IEA)
oligozoospermia  (IEA)
seminiferous tubule degeneration  (IEA)
small testis  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Resveratrol alleviates alcoholic fatty liver in mice. Ajmo JM, etal., Am J Physiol Gastrointest Liver Physiol. 2008 Oct;295(4):G833-42. doi: 10.1152/ajpgi.90358.2008. Epub 2008 Aug 28.
2. The role of AdipoR1 and AdipoR2 in liver fibrosis. Alzahrani B, etal., Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):700-708. doi: 10.1016/j.bbadis.2017.12.012. Epub 2017 Dec 10.
3. Maternal docosahexaenoic acid increases adiponectin and normalizes IUGR-induced changes in rat adipose deposition. Bagley HN, etal., J Obes. 2013;2013:312153. doi: 10.1155/2013/312153. Epub 2013 Mar 6.
4. Expression of the adiponectin receptors AdipoR1 and AdipoR2 in lean rats and in obese Zucker rats. Beylot M, etal., Metabolism. 2006 Mar;55(3):396-401.
5. Changes in adiponectin, its receptors and AMPK activity in tissues of diet-induced diabetic mice. Bonnard C, etal., Diabetes Metab. 2008 Feb;34(1):52-61. Epub 2008 Jan 25.
6. Antilipogenic and anti-inflammatory activities of Codonopsis lanceolata in mice hepatic tissues after chronic ethanol feeding. Cha A, etal., J Biomed Biotechnol. 2012;2012:141395. doi: 10.1155/2012/141395. Epub 2011 Oct 12.
7. Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of hepatic steatosis in obese rats consuming a high fat diet. de Sousa AR, etal., Food Res Int. 2018 Oct;112:48-55. doi: 10.1016/j.foodres.2018.06.004. Epub 2018 Jun 4.
8. Hyperglycemia- and hyperinsulinemia-induced alteration of adiponectin receptor expression and adiponectin effects in L6 myoblasts. Fang X, etal., J Mol Endocrinol. 2005 Dec;35(3):465-76.
9. Role of adiponectin receptors in endothelin-induced cellular hypertrophy in cultured cardiomyocytes and their expression in infarcted heart. Fujioka D, etal., Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2409-16. Epub 2006 Jan 13.
10. Cardiac expression of adiponectin and its receptors in streptozotocin-induced diabetic rats. Guo Z, etal., Metabolism. 2007 Oct;56(10):1363-71.
11. Adiponectin, skeletal muscle adiponectin receptor expression and insulin resistance following dexamethasone. Jang C, etal., Clin Endocrinol (Oxf). 2008 Nov;69(5):745-50. Epub 2008 Mar 15.
12. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. Kadowaki T, etal., J Clin Invest. 2006 Jul;116(7):1784-92.
13. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
14. Coordinated regulation of scopoletin at adipose tissue-liver axis improved alcohol-induced lipid dysmetabolism and inflammation in rats. Lee HI and Lee MK, Toxicol Lett. 2015 Sep 17;237(3):210-8. doi: 10.1016/j.toxlet.2015.06.016. Epub 2015 Jun 23.
15. Down-regulation of microRNA-375 regulates adipokines and inhibits inflammatory cytokines by targeting AdipoR2 in non-alcoholic fatty liver disease. Lei L, etal., Clin Exp Pharmacol Physiol. 2018 Aug;45(8):819-831. doi: 10.1111/1440-1681.12940. Epub 2018 Apr 30.
16. Serum adipokine levels predictive of liver injury in non-alcoholic fatty liver disease. Lemoine M, etal., Liver Int. 2009 Oct;29(9):1431-8. doi: 10.1111/j.1478-3231.2009.02022.x. Epub 2009 Apr 24.
17. Rosiglitazone Elicits an Adiponectin-Mediated Insulin-Sensitizing Action at the Adipose Tissue-Liver Axis in Otsuka Long-Evans Tokushima Fatty Rats. Li J, etal., J Diabetes Res. 2018 Aug 27;2018:4627842. doi: 10.1155/2018/4627842. eCollection 2018.
18. Hawthorn leaf flavonoids alleviate nonalcoholic fatty liver disease by enhancing the adiponectin/AMPK pathway. Li Z, etal., Int J Clin Exp Med. 2015 Oct 15;8(10):17295-307. eCollection 2015.
19. Role of SIRT1-FoxO1 signaling in dietary saturated fat-dependent upregulation of liver adiponectin receptor 2 in ethanol-administered mice. Liang X, etal., Antioxid Redox Signal. 2011 Jul 15;15(2):425-35. doi: 10.1089/ars.2010.3780. Epub 2011 May 4.
20. Association of the +33371 A/G polymorphism in adiponectin receptor 2 gene with Type 2 diabetes in the Chinese population. Liao YF, etal., J Endocrinol Invest. 2007 Nov;30(10):860-4.
21. The ameliorating effect of rosiglitazone on experimental nonalcoholic steatohepatitis is associated with regulating adiponectin receptor expression in rats. Liu S, etal., Eur J Pharmacol. 2011 Jan 10;650(1):384-9. doi: 10.1016/j.ejphar.2010.09.082. Epub 2010 Oct 20.
22. Effects of a low-fat diet on the hepatic expression of adiponectin and its receptors in rats with NAFLD. Ma H, etal., Ann Hepatol. 2015 Jan-Feb;14(1):108-17.
23. Regulation of oxidative stress and inflammation by hepatic adiponectin receptor 2 in an animal model of nonalcoholic steatohepatitis. Matsunami T, etal., Int J Clin Exp Pathol. 2010 May 22;3(5):472-81.
24. MGDs mouse GO annotations MGD data from the GO Consortium
25. MGD IEA MGD IEA
26. Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis. Neumeier M, etal., World J Gastroenterol. 2006 Sep 14;12(34):5490-4.
27. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
28. Downregulation of adiponectin/AdipoR2 is associated with steatohepatitis in obese mice. Peng Y, etal., J Gastrointest Surg. 2009 Nov;13(11):2043-9. doi: 10.1007/s11605-009-1032-2. Epub 2009 Sep 18.
29. Adiponectin and adiponectin receptor gene variants in relation to type 2 diabetes and insulin resistance-related phenotypes. Potapov VA, etal., Rev Diabet Stud. 2008 Spring;5(1):28-37. Epub 2008 May 10.
30. Mouse MP Annotation Import Pipeline RGD automated import pipeline
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Mild obesity reduces survival and adiponectin sensitivity in endotoxemic rats. Sakai S, etal., J Surg Res. 2013 Nov;185(1):353-63. doi: 10.1016/j.jss.2013.06.002. Epub 2013 Jun 25.
33. No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk. Teras LR, etal., Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2553-7. doi: 10.1158/1055-9965.EPI-09-0542. Epub 2009 Sep 1.
34. Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice. Tomita K, etal., Hepatology. 2008 Aug;48(2):458-73. doi: 10.1002/hep.22365.
35. Dietary α-linolenic acid-rich flaxseed oil prevents against alcoholic hepatic steatosis via ameliorating lipid homeostasis at adipose tissue-liver axis in mice. Wang M, etal., Sci Rep. 2016 May 25;6:26826. doi: 10.1038/srep26826.
36. Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese. Wang Y, etal., J Genet Genomics. 2009 Jul;36(7):417-23.
37. Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Warden CH, etal., Genomics 1993 Nov;18(2):295-307.
38. Tissue-specific effect of dietary cysteamine on expression of adiponectin receptors in rats. Xu J, etal., J Agric Food Chem. 2007 Sep 19;55(19):7968-73. doi: 10.1021/jf0718695. Epub 2007 Aug 16.
39. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Yamauchi T, etal., Nature 2003 Jun 12;423(6941):762-9.
40. Changes of adiponectin and its receptors in rats following chronic renal failure. Yu Y, etal., Ren Fail. 2014 Feb;36(1):92-7. doi: 10.3109/0886022X.2013.830975. Epub 2013 Sep 13.
41. [Correlation of polymorphisms of adiponectin receptor 2 gene +33371Gln/Arg, cytochrome P4502E1 gene Rsa I and smoking with nonalcoholic fatty liver disease]. Zhang C and Guo L, Nan Fang Yi Ke Da Xue Xue Bao. 2014 Oct;34(10):1481-7.
42. ANGIOTENSIN CONVERTING ENZYME INHIBITORS IMPROVE HEPATIC STEATOSIS BY MODULATING EXPRESSION OF TUMOR NECROSIS FACTOR-Alpha, INTERLEUKIN-6 AND ADIPONECTIN RECEPTOR-2 IN RATS WITH TYPE 2 DIABETES. Zhang X, etal., Clin Exp Pharmacol Physiol. 2008 Nov 28.
43. Effects of probucol on hepatic tumor necrosis factor-alpha, interleukin-6 and adiponectin receptor-2 expression in diabetic rats. Zhang X, etal., J Gastroenterol Hepatol. 2009 Jun;24(6):1058-63. Epub 2009 Feb 9.
44. Probiotic Lactobacillus casei Zhang ameliorates high-fructose-induced impaired glucose tolerance in hyperinsulinemia rats. Zhang Y, etal., Eur J Nutr. 2014 Feb;53(1):221-32. doi: 10.1007/s00394-013-0519-5.
45. Involvement of insulin resistance in the protective effect of metformin against alcoholic liver injury. Zhu Z, etal., Alcohol Clin Exp Res. 2014 Jun;38(6):1510-9. doi: 10.1111/acer.12418. Epub 2014 May 5.
Additional References at PubMed
PMID:8661743   PMID:8827514   PMID:8889548   PMID:10349636   PMID:10512203   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273  
PMID:14759511   PMID:15123605   PMID:15226823   PMID:15358228   PMID:15454091   PMID:15613685   PMID:15752770   PMID:15840001   PMID:15939384   PMID:16141072   PMID:16141073   PMID:16150499  
PMID:16306350   PMID:16624897   PMID:17068142   PMID:17164441   PMID:17268472   PMID:17327425   PMID:17647137   PMID:17878241   PMID:17967808   PMID:17975745   PMID:18245842   PMID:18287559  
PMID:18330590   PMID:18795895   PMID:18799693   PMID:18971219   PMID:19062045   PMID:19336949   PMID:19500219   PMID:19661063   PMID:19878661   PMID:20028965   PMID:20380822   PMID:20470935  
PMID:20663797   PMID:21106494   PMID:21186369   PMID:21267068   PMID:21459325   PMID:21873635   PMID:21889885   PMID:22000082   PMID:22323595   PMID:22872236   PMID:22904306   PMID:23043361  
PMID:23046739   PMID:23425917   PMID:23684624   PMID:23824191   PMID:23922494   PMID:24172895   PMID:24194600   PMID:24324556   PMID:24531262   PMID:24564393   PMID:24742672   PMID:25392268  
PMID:27023866   PMID:28145500   PMID:28825851   PMID:29184485   PMID:29688375   PMID:32325033   PMID:32554809   PMID:33420419   PMID:34925309   PMID:35863637  


Genomics

Comparative Map Data
Adipor2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396119,330,111 - 119,394,489 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6119,330,111 - 119,394,665 (-)EnsemblGRCm39 Ensembl
GRCm386119,353,150 - 119,417,699 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6119,353,150 - 119,417,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv376119,303,168 - 119,367,501 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366119,318,769 - 119,383,102 (-)NCBIMGSCv36mm8
Celera6121,185,998 - 121,250,677 (-)NCBICelera
Cytogenetic Map6F1NCBI
cM Map656.78NCBI
ADIPOR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38121,691,070 - 1,788,674 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl121,688,574 - 1,788,674 (+)EnsemblGRCh38hg38GRCh38
GRCh37121,800,236 - 1,897,840 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36121,670,508 - 1,768,106 (+)NCBINCBI36Build 36hg18NCBI36
Build 34121,670,507 - 1,768,105NCBI
Celera123,408,168 - 3,505,568 (+)NCBICelera
Cytogenetic Map12p13.33NCBI
HuRef121,655,190 - 1,752,562 (+)NCBIHuRef
CHM1_1121,799,110 - 1,896,969 (+)NCBICHM1_1
T2T-CHM13v2.0121,687,685 - 1,784,807 (+)NCBIT2T-CHM13v2.0
Adipor2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24152,524,604 - 152,588,848 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4152,524,623 - 152,559,355 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4158,792,285 - 158,806,087 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04154,575,983 - 154,589,788 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04153,199,317 - 153,213,123 (-)NCBIRnor_WKY
Rnor_6.04151,412,135 - 151,480,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4151,414,684 - 151,428,894 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04217,327,044 - 217,392,865 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44155,664,035 - 155,677,627 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14155,907,605 - 155,942,117 (-)NCBI
Celera4141,389,717 - 141,403,635 (-)NCBICelera
Cytogenetic Map4q42NCBI
Adipor2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554544,243,898 - 4,327,308 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554544,243,898 - 4,327,255 (+)NCBIChiLan1.0ChiLan1.0
ADIPOR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1127,197,038 - 7,326,716 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0121,772,426 - 1,902,070 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1121,750,756 - 1,852,251 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl121,817,620 - 1,852,251 (+)Ensemblpanpan1.1panPan2
ADIPOR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12743,739,269 - 43,840,116 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2743,741,679 - 43,878,467 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,844,989 - 2,990,473 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02744,061,828 - 44,210,393 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2744,061,877 - 44,207,857 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12743,993,124 - 44,138,443 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02743,965,465 - 44,111,111 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,202,709 - 2,348,377 (-)NCBIUU_Cfam_GSD_1.0
Adipor2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945107,176,992 - 107,255,585 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366061,948,743 - 2,007,163 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366061,911,104 - 2,007,109 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADIPOR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl568,755,811 - 68,807,235 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1568,755,789 - 68,807,247 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2570,997,251 - 71,062,632 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADIPOR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1111,802,694 - 1,836,703 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl111,738,026 - 1,837,060 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660636,490,807 - 6,589,764 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adipor2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473511,103,076 - 11,174,337 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473511,103,082 - 11,174,277 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adipor2
1850 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir375mmu-miR-375-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Functional MTI15806104
Mir375mmu-miR-375-3pTarbaseexternal_infoReporter GenePOSITIVE
Mir124a-2mmu-miR-124-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Non-Functional MTI15806104
Mir124a-2mmu-miR-124-3pTarbaseexternal_infoReporter GeneNEGATIVE

Predicted Target Of
Summary Value
Count of predictions:1438
Count of miRNA genes:523
Interacting mature miRNAs:616
Transcripts:ENSMUST00000032272, ENSMUST00000169744
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678606487121092347Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687480321121480516Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined688982366122982564Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690772571124772807Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined694981612128981699Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104480321127019938Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
4141699Ibdq2_minflammatory bowel disease QTL 2 (mouse)Not determined105982366120894102Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
10043891Tilss4_mTNF-induced lethal shock susceptibility 3 (mouse)Not determined6112246918125333748Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
8552704Cia43_mcollagen induced arthritis QTL 43 (mouse)Not determined6114159241119737532Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
1301083Bhr5_mbronchial hyperresponsiveness 5 (mouse)Not determined6115694477132578150Mouse
4141064Ath37_matherosclerosis 37 (mouse)Not determined6116641858128495988Mouse
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse

Markers in Region
Adipor2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386119,358,934 - 119,359,528UniSTSGRCm38
MGSCv376119,308,952 - 119,309,546UniSTSGRCm37
Celera6121,191,779 - 121,192,373UniSTS
Cytogenetic Map6F1UniSTS
cM Map660.7UniSTS
AW554121  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386119,353,501 - 119,353,614UniSTSGRCm38
MGSCv376119,303,519 - 119,303,632UniSTSGRCm37
Celera6121,186,349 - 121,186,462UniSTS
Cytogenetic Map6F1UniSTS
cM Map660.7UniSTS
Whitehead/MRC_RH61222.14UniSTS
Adipor2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001355692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_197985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030255574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030255576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004933620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC126607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK039667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY424291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000032272   ⟹   ENSMUSP00000032272
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6119,330,111 - 119,394,665 (-)Ensembl
GRCm38.p6 Ensembl6119,353,150 - 119,417,704 (-)Ensembl
RefSeq Acc Id: ENSMUST00000169744   ⟹   ENSMUSP00000126138
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6119,330,726 - 119,365,647 (-)Ensembl
GRCm38.p6 Ensembl6119,353,765 - 119,388,686 (-)Ensembl
RefSeq Acc Id: ENSMUST00000187699   ⟹   ENSMUSP00000139703
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6119,332,427 - 119,367,209 (-)Ensembl
GRCm38.p6 Ensembl6119,355,466 - 119,390,248 (-)Ensembl
RefSeq Acc Id: ENSMUST00000188851
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6119,334,647 - 119,394,651 (-)Ensembl
GRCm38.p6 Ensembl6119,357,686 - 119,417,690 (-)Ensembl
RefSeq Acc Id: ENSMUST00000189710   ⟹   ENSMUSP00000139895
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6119,347,112 - 119,394,436 (-)Ensembl
GRCm38.p6 Ensembl6119,370,151 - 119,417,475 (-)Ensembl
RefSeq Acc Id: NM_001355692   ⟹   NP_001342621
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396119,330,111 - 119,365,695 (-)NCBI
GRCm386119,353,150 - 119,388,734 (-)NCBI
Sequence:
RefSeq Acc Id: NM_197985   ⟹   NP_932102
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396119,330,111 - 119,394,489 (-)NCBI
GRCm386119,353,150 - 119,417,528 (-)NCBI
MGSCv376119,303,168 - 119,367,501 (-)RGD
Celera6121,185,998 - 121,250,677 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030255574   ⟹   XP_030111434
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396119,330,625 - 119,365,641 (-)NCBI
GRCm386119,353,664 - 119,388,680 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030255576   ⟹   XP_030111436
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396119,330,111 - 119,365,685 (-)NCBI
GRCm386119,353,150 - 119,388,714 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004933620
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396119,331,379 - 119,365,698 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_932102   ⟸   NM_197985
- UniProtKB: Q8CID6 (UniProtKB/Swiss-Prot),   Q8BQS5 (UniProtKB/Swiss-Prot),   Q53YY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001342621   ⟸   NM_001355692
- UniProtKB: Q8CID6 (UniProtKB/Swiss-Prot),   Q53YY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030111436   ⟸   XM_030255576
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030111434   ⟸   XM_030255574
- Peptide Label: isoform X1
- UniProtKB: Q8CID6 (UniProtKB/Swiss-Prot),   Q53YY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000032272   ⟸   ENSMUST00000032272
RefSeq Acc Id: ENSMUSP00000139703   ⟸   ENSMUST00000187699
RefSeq Acc Id: ENSMUSP00000126138   ⟸   ENSMUST00000169744
RefSeq Acc Id: ENSMUSP00000139895   ⟸   ENSMUST00000189710

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BQS5-F1-model_v2 AlphaFold Q8BQS5 1-386 view protein structure

Promoters
RGD ID:6838836
Promoter ID:MM_KWN:47367
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:UC009DMD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366119,338,421 - 119,339,027 (-)MPROMDB
RGD ID:6838835
Promoter ID:MM_KWN:47368
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   Brain,   ES_Cell,   Liver,   Lung
Transcripts:NM_197985,   UC009DMF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366119,367,224 - 119,367,724 (-)MPROMDB
RGD ID:6890822
Promoter ID:EPDNEW_M8862
Type:initiation region
Name:Adipor2_1
Description:Mus musculus adiponectin receptor 2 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386119,388,686 - 119,388,746EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:93830 AgrOrtholog
Ensembl Genes ENSMUSG00000030168 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000032272 ENTREZGENE
  ENSMUSP00000032272.7 UniProtKB/Swiss-Prot
  ENSMUSP00000126138 ENTREZGENE
  ENSMUSP00000126138.2 UniProtKB/Swiss-Prot
  ENSMUSP00000139703.2 UniProtKB/TrEMBL
  ENSMUSP00000139895.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000032272 ENTREZGENE
  ENSMUST00000032272.13 UniProtKB/Swiss-Prot
  ENSMUST00000169744 ENTREZGENE
  ENSMUST00000169744.8 UniProtKB/Swiss-Prot
  ENSMUST00000187699.7 UniProtKB/TrEMBL
  ENSMUST00000189710.2 UniProtKB/TrEMBL
InterPro AdipoR/HlyIII-related UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:68465 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:93830 ENTREZGENE
NCBI Gene 68465 ENTREZGENE
PANTHER ADIPONECTIN RECEPTOR PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR20855 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HlyIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adipor2 PhenoGen
UniProt A0A087WPB1_MOUSE UniProtKB/TrEMBL
  A0A087WPS4_MOUSE UniProtKB/TrEMBL
  PAQR2_MOUSE UniProtKB/Swiss-Prot
  Q53YY3 ENTREZGENE, UniProtKB/TrEMBL
  Q8BQS5 ENTREZGENE
  Q8CID6 ENTREZGENE
UniProt Secondary Q8CA45 UniProtKB/Swiss-Prot
  Q8CID6 UniProtKB/Swiss-Prot