Adam12 (ADAM metallopeptidase domain 12) - Rat Genome Database

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Gene: Adam12 (ADAM metallopeptidase domain 12) Mus musculus
Analyze
Symbol: Adam12
Name: ADAM metallopeptidase domain 12
RGD ID: 1317266
MGI Page MGI
Description: Predicted to enable SH3 domain binding activity and metalloendopeptidase activity. Predicted to be involved in positive regulation of angiogenesis and proteolysis. Predicted to be located in nucleoplasm and plasma membrane. Is expressed in several structures, including bone; embryo mesenchyme; genitourinary system; gut; and meninges. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human ADAM12 (ADAM metallopeptidase domain 12).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metallopeptidase domain 12 (meltrin alpha); a disintegrin and metalloprotease domain 12; a disintegrin and metalloproteinase domain 12 (meltrin alpha); ADAM; ADAM 12; disintegrin and metalloproteinase domain-containing protein 12; KIAA4001; meltrin alpha; meltrin-alpha; mKIAA4001; Ml; Mltna
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397133,484,928 - 133,826,859 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7133,484,928 - 133,833,875 (-)EnsemblGRCm39 Ensembl
GRCm387133,883,199 - 134,225,097 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7133,883,199 - 134,232,146 (-)EnsemblGRCm38mm10GRCm38
MGSCv377141,074,882 - 141,416,780 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367133,722,315 - 134,063,440 (-)NCBIMGSCv36mm8
Celera7133,687,776 - 134,032,137 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map777.61NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP,ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
azoxystrobin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
CGP 52608  (ISO)
choline  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
cortisol  (ISO)
deguelin  (ISO)
dexamethasone  (EXP)
dichloroacetic acid  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
diquat  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP)
folic acid  (EXP,ISO)
gentamycin  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (ISO)
methoxychlor  (ISO)
N,N-diethyl-m-toluamide  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
ozone  (EXP)
panobinostat  (ISO)
PCB138  (EXP)
perfluorohexanesulfonic acid  (EXP)
permethrin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
potassium chromate  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
tetrachloromethane  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
nucleoplasm  (ISO)
plasma membrane  (ISO,TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ADAMs: key components in EGFR signalling and development. Blobel CP Nat Rev Mol Cell Biol. 2005 Jan;6(1):32-43.
2. Phenotypic analysis of Meltrin alpha (ADAM12)-deficient mice: involvement of Meltrin alpha in adipogenesis and myogenesis. Kurisaki T, etal., Mol Cell Biol. 2003 Jan;23(1):55-61.
3. The genetic epidemiology of human primary osteoarthritis: current status. Loughlin J Expert Rev Mol Med. 2005 May 24;7(9):1-12.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. Canonical transforming growth factor-ß signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29. Ramdas V, etal., Am J Pathol. 2013 Dec;183(6):1885-1896. doi: 10.1016/j.ajpath.2013.08.027. Epub 2013 Oct 6.
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Association study of candidate genes for the prevalence and progression of knee osteoarthritis. Valdes AM, etal., Arthritis Rheum. 2004 Aug;50(8):2497-507.
Additional References at PubMed
PMID:7566181   PMID:9461614   PMID:9622634   PMID:10349636   PMID:10527948   PMID:10788519   PMID:11042159   PMID:11076861   PMID:11127814   PMID:11217851   PMID:12000741   PMID:12000744  
PMID:12414501   PMID:12615925   PMID:12915458   PMID:12915587   PMID:12972593   PMID:14691998   PMID:14993236   PMID:15063736   PMID:15637293   PMID:15849365   PMID:15907280   PMID:15930294  
PMID:15936750   PMID:16054021   PMID:16079176   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16607276   PMID:16869727   PMID:16916601   PMID:17072319   PMID:17107962   PMID:17344430  
PMID:17620406   PMID:17653278   PMID:17982130   PMID:18241035   PMID:18287559   PMID:19398663   PMID:19581512   PMID:19841944   PMID:20457602   PMID:20660068   PMID:21062905   PMID:21267068  
PMID:21491542   PMID:21873635   PMID:21875931   PMID:23458101   PMID:23686306   PMID:24006456   PMID:24336287   PMID:24798404   PMID:25892053   PMID:26163448   PMID:26242473   PMID:26975138  
PMID:27487498   PMID:28637396   PMID:29846135   PMID:30042416   PMID:30389854   PMID:30753595   PMID:30993375   PMID:31774689   PMID:32325033   PMID:32913205   PMID:33952697   PMID:34321999  
PMID:34731528   PMID:35008854   PMID:35610640   PMID:35946473   PMID:36545255   PMID:36866761   PMID:37495855  


Genomics

Comparative Map Data
Adam12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397133,484,928 - 133,826,859 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7133,484,928 - 133,833,875 (-)EnsemblGRCm39 Ensembl
GRCm387133,883,199 - 134,225,097 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7133,883,199 - 134,232,146 (-)EnsemblGRCm38mm10GRCm38
MGSCv377141,074,882 - 141,416,780 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367133,722,315 - 134,063,440 (-)NCBIMGSCv36mm8
Celera7133,687,776 - 134,032,137 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map777.61NCBI
ADAM12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810126,012,391 - 126,388,477 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10126,012,381 - 126,388,477 (-)EnsemblGRCh38hg38GRCh38
GRCh3710127,700,960 - 128,077,046 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610127,693,415 - 128,067,055 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410127,719,903 - 128,067,014NCBI
Celera10121,478,343 - 121,851,743 (-)NCBICelera
Cytogenetic Map10q26.2NCBI
HuRef10121,392,073 - 121,764,737 (-)NCBIHuRef
CHM1_110127,984,707 - 128,358,883 (-)NCBICHM1_1
T2T-CHM13v2.010126,894,888 - 127,270,982 (-)NCBIT2T-CHM13v2.0
Adam12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,116,968 - 198,443,680 (-)NCBIGRCr8
mRatBN7.21188,686,984 - 189,014,206 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1188,686,989 - 189,020,667 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01205,951,840 - 206,286,294 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1205,956,342 - 206,282,575 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01212,899,587 - 213,227,846 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41193,384,457 - 193,650,892 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11193,533,921 - 193,999,142 (-)NCBI
Celera1186,424,760 - 186,758,584 (-)NCBICelera
Cytogenetic Map1q41NCBI
Adam12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554773,922,644 - 4,263,296 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554773,917,637 - 4,263,529 (-)NCBIChiLan1.0ChiLan1.0
ADAM12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28137,873,308 - 138,248,641 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110137,878,657 - 138,253,774 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010122,583,989 - 122,958,895 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110126,847,555 - 127,165,887 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10126,852,441 - 127,165,048 (-)Ensemblpanpan1.1panPan2
ADAM12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12835,154,899 - 35,484,852 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2835,158,126 - 35,485,573 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2835,213,245 - 35,542,024 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02835,712,857 - 36,042,749 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2835,717,643 - 36,042,829 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12835,266,353 - 35,595,299 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02835,256,524 - 35,591,575 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02835,517,721 - 35,847,105 (-)NCBIUU_Cfam_GSD_1.0
Adam12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721311,501,260 - 11,602,871 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648613,963,091 - 14,279,796 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648613,963,000 - 14,189,948 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14135,302,813 - 135,682,159 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114135,302,188 - 135,682,144 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214146,932,579 - 147,045,417 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19118,641,551 - 119,014,280 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9118,646,539 - 118,749,351 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604880,005,529 - 80,378,803 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473720,650,427 - 21,065,944 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473720,650,365 - 21,107,171 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adam12
11224 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3028
Count of miRNA genes:844
Interacting mature miRNAs:1172
Transcripts:ENSMUST00000067680, ENSMUST00000127524, ENSMUST00000134504, ENSMUST00000138363, ENSMUST00000154144
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301903Tlsm1_mthymic lymphoma susceptible 1 (mouse)Not determined7122250663135170901Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117199227134101729Mouse

Markers in Region
D7Mit332  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387134,032,360 - 134,032,474UniSTSGRCm38
MGSCv377141,224,043 - 141,224,157UniSTSGRCm37
Celera7133,837,638 - 133,837,752UniSTS
Cytogenetic Map7F4UniSTS
cM Map765.6UniSTS
Whitehead Genetic755.7UniSTS
PMC140658P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387134,224,866 - 134,224,981UniSTSGRCm38
MGSCv377141,416,549 - 141,416,664UniSTSGRCm37
Cytogenetic Map7F4UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000067680   ⟹   ENSMUSP00000065213
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7133,484,928 - 133,826,826 (-)Ensembl
GRCm38.p6 Ensembl7133,883,199 - 134,225,097 (-)Ensembl
Ensembl Acc Id: ENSMUST00000127524   ⟹   ENSMUSP00000120094
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7133,583,141 - 133,833,875 (-)Ensembl
GRCm38.p6 Ensembl7133,981,412 - 134,232,146 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134504   ⟹   ENSMUSP00000123161
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7133,577,204 - 133,833,734 (-)Ensembl
GRCm38.p6 Ensembl7133,975,475 - 134,232,005 (-)Ensembl
Ensembl Acc Id: ENSMUST00000138363   ⟹   ENSMUSP00000114874
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7133,487,925 - 133,562,994 (-)Ensembl
GRCm38.p6 Ensembl7133,886,196 - 133,961,265 (-)Ensembl
Ensembl Acc Id: ENSMUST00000154144
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7133,793,001 - 133,827,101 (-)Ensembl
GRCm38.p6 Ensembl7134,191,272 - 134,225,372 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206313
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7133,773,631 - 133,774,673 (-)Ensembl
GRCm38.p6 Ensembl7134,171,902 - 134,172,944 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206426
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7133,786,625 - 133,833,860 (-)Ensembl
GRCm38.p6 Ensembl7134,184,896 - 134,232,131 (-)Ensembl
RefSeq Acc Id: NM_007400   ⟹   NP_031426
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397133,484,928 - 133,826,859 (-)NCBI
GRCm387133,883,199 - 134,225,097 (-)NCBI
MGSCv377141,074,882 - 141,416,780 (-)RGD
Celera7133,687,776 - 134,032,137 (-)NCBI
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_031426   ⟸   NM_007400
- Peptide Label: preproprotein
- UniProtKB: F8VQN4 (UniProtKB/Swiss-Prot),   Q61824 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000114874   ⟸   ENSMUST00000138363
Ensembl Acc Id: ENSMUSP00000120094   ⟸   ENSMUST00000127524
Ensembl Acc Id: ENSMUSP00000065213   ⟸   ENSMUST00000067680
Ensembl Acc Id: ENSMUSP00000123161   ⟸   ENSMUST00000134504
Protein Domains
Disintegrin   EGF-like   Peptidase M12B   Peptidase M12B propeptide

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61824-F1-model_v2 AlphaFold Q61824 1-903 view protein structure

Promoters
RGD ID:8665891
Promoter ID:EPDNEW_M10976
Type:initiation region
Name:Adam12_1
Description:Mus musculus a disintegrin and metallopeptidase domain 12 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387134,225,097 - 134,225,157EPDNEW
RGD ID:6840495
Promoter ID:MM_KWN:53038
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000067680,   OTTMUST00000050388
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367141,416,651 - 141,417,822 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105378 AgrOrtholog
Ensembl Genes ENSMUSG00000054555 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000067680 ENTREZGENE
  ENSMUST00000067680.11 UniProtKB/Swiss-Prot
  ENSMUST00000127524.2 UniProtKB/TrEMBL
  ENSMUST00000134504.8 UniProtKB/TrEMBL
  ENSMUST00000138363.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/Swiss-Prot
KEGG Report mmu:11489 UniProtKB/Swiss-Prot
MGD MGI:105378 ENTREZGENE
NCBI Gene 11489 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adam12 PhenoGen
PRINTS DISINTEGRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART ACR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57552 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ADA12_MOUSE UniProtKB/Swiss-Prot
  D3YUK3_MOUSE UniProtKB/TrEMBL
  D3Z117_MOUSE UniProtKB/TrEMBL
  F6YWH6_MOUSE UniProtKB/TrEMBL
  F8VQN4 ENTREZGENE
  Q571B5_MOUSE UniProtKB/TrEMBL
  Q61824 ENTREZGENE
UniProt Secondary F8VQN4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-04 Adam12  ADAM metallopeptidase domain 12  Adam12  a disintegrin and metallopeptidase domain 12 (meltrin alpha)  Symbol and/or name change 5135510 APPROVED