Opalin (oligodendrocytic myelin paranodal and inner loop protein) - Rat Genome Database

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Gene: Opalin (oligodendrocytic myelin paranodal and inner loop protein) Mus musculus
Analyze
Symbol: Opalin
Name: oligodendrocytic myelin paranodal and inner loop protein
RGD ID: 1317164
MGI Page MGI
Description: Involved in regulation of oligodendrocyte differentiation. Located in cell-cell contact zone and plasma membrane. Is expressed in brain; spinal cord; and visual system. Orthologous to human OPALIN (oligodendrocytic myelin paranodal and inner loop protein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Tmem10; Tmp1; Tmp10; transmembrane protein 10; transmembrane protein TMP10
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391941,050,398 - 41,065,552 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1941,050,149 - 41,065,552 (-)EnsemblGRCm39 Ensembl
GRCm381941,061,959 - 41,077,113 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1941,061,710 - 41,077,113 (-)EnsemblGRCm38mm10GRCm38
MGSCv371941,137,910 - 41,151,603 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361941,116,731 - 41,130,424 (-)NCBIMGSCv36mm8
Celera1941,867,158 - 41,880,743 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1934.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11814680   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17309606   PMID:17442045  
PMID:18439243   PMID:18490449   PMID:18571792   PMID:18603407   PMID:21873635   PMID:24391449   PMID:24427314   PMID:25411504   PMID:27149841   PMID:27163549   PMID:27855200   PMID:30837646  
PMID:33215680   PMID:35022234  


Genomics

Comparative Map Data
Opalin
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391941,050,398 - 41,065,552 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1941,050,149 - 41,065,552 (-)EnsemblGRCm39 Ensembl
GRCm381941,061,959 - 41,077,113 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1941,061,710 - 41,077,113 (-)EnsemblGRCm38mm10GRCm38
MGSCv371941,137,910 - 41,151,603 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361941,116,731 - 41,130,424 (-)NCBIMGSCv36mm8
Celera1941,867,158 - 41,880,743 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1934.36NCBI
OPALIN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381096,343,221 - 96,359,002 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1096,343,221 - 96,359,365 (-)EnsemblGRCh38hg38GRCh38
GRCh371098,102,978 - 98,118,759 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361098,092,963 - 98,109,082 (-)NCBINCBI36Build 36hg18NCBI36
Build 341098,092,968 - 98,109,049NCBI
Celera1091,844,157 - 91,860,285 (-)NCBICelera
Cytogenetic Map10q24.1NCBI
HuRef1091,730,870 - 91,746,991 (-)NCBIHuRef
CHM1_11098,384,860 - 98,400,982 (-)NCBICHM1_1
T2T-CHM13v2.01097,222,521 - 97,238,300 (-)NCBIT2T-CHM13v2.0
Opalin
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81249,840,539 - 249,858,423 (-)NCBIGRCr8
mRatBN7.21239,891,137 - 239,909,388 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1239,891,142 - 239,908,788 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1248,034,137 - 248,051,685 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01254,731,240 - 254,748,788 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01247,384,261 - 247,401,806 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01260,324,028 - 260,341,677 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1260,324,028 - 260,341,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01267,766,690 - 267,784,339 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41246,234,646 - 246,252,295 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11246,349,120 - 246,366,770 (-)NCBI
Celera1235,733,242 - 235,750,891 (-)NCBICelera
Cytogenetic Map1q54NCBI
Opalin
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555072,570,294 - 2,586,656 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555072,570,079 - 2,586,633 (-)NCBIChiLan1.0ChiLan1.0
OPALIN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28108,252,002 - 108,265,986 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110108,257,321 - 108,271,287 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01092,956,966 - 92,973,093 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11096,462,399 - 96,478,157 (-)NCBIpanpan1.1PanPan1.1panPan2
OPALIN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1289,760,419 - 9,772,123 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl289,760,612 - 9,771,737 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha289,944,885 - 9,956,629 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02810,031,970 - 10,043,760 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2810,032,158 - 10,043,604 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1289,746,951 - 9,758,656 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0289,805,983 - 9,817,957 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0289,943,642 - 9,955,414 (-)NCBIUU_Cfam_GSD_1.0
Opalin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721337,092,052 - 37,106,025 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366363,131,299 - 3,142,431 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366363,131,096 - 3,145,130 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPALIN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14107,793,682 - 107,809,518 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114107,793,678 - 107,809,814 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214117,428,249 - 117,444,403 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OPALIN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1989,500,932 - 89,515,833 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl989,498,362 - 89,515,699 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604850,386,010 - 50,402,141 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Opalin
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247377,779,325 - 7,799,909 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247377,782,166 - 7,799,835 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Opalin
652 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:472
Count of miRNA genes:343
Interacting mature miRNAs:383
Transcripts:ENSMUST00000087176
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193918406461420004Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
10043896Bw21_mbody weight QTL 21 (mouse)Not determined193959606661420004Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
13504736Ifvrq6_minfluenza virus resistance QTL 6 (mouse)193690291044913949Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1301479Sluc1_msusceptibility to lung cancer 1 (mouse)Not determined193601694446761521Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192513600242388916Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse

Markers in Region
09.MMHAP34FRC9.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381941,070,668 - 41,070,844UniSTSGRCm38
MGSCv371941,145,158 - 41,145,334UniSTSGRCm37
Celera1941,874,292 - 41,874,468UniSTS
Cytogenetic Map19C3UniSTS
Whitehead_YAC14 UniSTS
Opalin  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C3UniSTS
cM Map1934.36UniSTS
Opalin  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381941,063,770 - 41,063,970UniSTSGRCm38
Celera1941,867,508 - 41,867,708UniSTS
Cytogenetic Map19C3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000087176   ⟹   ENSMUSP00000084422
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1941,050,912 - 41,065,552 (-)Ensembl
GRCm38.p6 Ensembl1941,062,473 - 41,077,113 (-)Ensembl
Ensembl Acc Id: ENSMUST00000236184
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1941,050,149 - 41,056,562 (-)Ensembl
GRCm38.p6 Ensembl1941,061,710 - 41,068,123 (-)Ensembl
RefSeq Acc Id: NM_153520   ⟹   NP_705740
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391941,050,398 - 41,065,552 (-)NCBI
GRCm381941,061,959 - 41,077,113 (-)NCBI
MGSCv371941,137,910 - 41,151,603 (-)RGD
Celera1941,867,158 - 41,880,743 (-)RGD
cM Map19 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_705740 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH60980 (Get FASTA)   NCBI Sequence Viewer  
  BAE24217 (Get FASTA)   NCBI Sequence Viewer  
  DAA00020 (Get FASTA)   NCBI Sequence Viewer  
  EDL41850 (Get FASTA)   NCBI Sequence Viewer  
  EDL41851 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000084422
  ENSMUSP00000084422.7
GenBank Protein Q7M750 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_705740   ⟸   NM_153520
- UniProtKB: Q6P903 (UniProtKB/Swiss-Prot),   Q7M750 (UniProtKB/Swiss-Prot),   Q3USW3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000084422   ⟸   ENSMUST00000087176

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7M750-F1-model_v2 AlphaFold Q7M750 1-143 view protein structure

Promoters
RGD ID:13679468
Promoter ID:EPDNEW_M23883
Type:initiation region
Name:Opalin_1
Description:Mus musculus oligodendrocytic myelin paranodal and inner loopprotein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381941,077,072 - 41,077,132EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2657025 AgrOrtholog
Ensembl Genes ENSMUSG00000050121 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000087176 ENTREZGENE
  ENSMUST00000087176.8 UniProtKB/Swiss-Prot
InterPro Opalin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:226115 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2657025 ENTREZGENE
NCBI Gene 226115 ENTREZGENE
PANTHER OPALIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR21102 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Opalin PhenoGen
UniProt OPALI_MOUSE UniProtKB/Swiss-Prot
  Q3USW3 ENTREZGENE, UniProtKB/TrEMBL
  Q6P903 ENTREZGENE
  Q7M750 ENTREZGENE
UniProt Secondary Q6P903 UniProtKB/Swiss-Prot