Kdm6b (KDM1 lysine (K)-specific demethylase 6B) - Rat Genome Database

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Gene: Kdm6b (KDM1 lysine (K)-specific demethylase 6B) Mus musculus
Analyze
Symbol: Kdm6b
Name: KDM1 lysine (K)-specific demethylase 6B
RGD ID: 1316935
MGI Page MGI
Description: Enables beta-catenin binding activity; histone H3K27me2/H3K27me3 demethylase activity; and sequence-specific DNA binding activity. Involved in several processes, including cardiac muscle cell differentiation; mesodermal cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within cell fate commitment; cellular response to hydrogen peroxide; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including 1st branchial arch ectoderm; brain; genitourinary system; olfactory epithelium; and palatal shelf. Orthologous to human KDM6B (lysine demethylase 6B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700064E03Rik; [histone H3]-trimethyl-L-lysine(27) demethylase 6B; BC038313; jmjC domain-containing protein 3; Jmjd3; jumonji domain containing 3; jumonji domain-containing protein 3; KIAA0346; lysine-specific demethylase 6B; mKIAA0346; RP23-5O23.5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,289,334 - 69,311,188 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,289,334 - 69,304,501 (-)EnsemblGRCm39 Ensembl
GRCm381169,398,508 - 69,420,367 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,398,508 - 69,413,675 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,212,010 - 69,227,177 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,214,703 - 69,229,870 (-)NCBIMGSCv36mm8
Celera1176,352,998 - 76,368,171 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.6NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
aristolochic acid A  (ISO)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
fenthion  (EXP)
folic acid  (EXP)
FR900359  (ISO)
gentamycin  (ISO)
glycidol  (ISO)
hydrogen peroxide  (ISO)
isoprenaline  (EXP)
L-methionine  (EXP)
leflunomide  (EXP,ISO)
lipopolysaccharide  (ISO)
mercury dichloride  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methimazole  (ISO)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
propiconazole  (EXP,ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal appendicular skeleton morphology  (IAGP)
abnormal axial skeleton morphology  (IAGP)
abnormal cartilage development  (IAGP)
abnormal cell physiology  (IAGP)
abnormal lung development  (IAGP)
abnormal lung morphology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal osteoblast differentiation  (IAGP)
abnormal palatal mesenchymal cell differentiation  (IAGP)
abnormal palatal mesenchymal cell proliferation  (IAGP)
abnormal palate development  (IAGP)
abnormal pre-Botzinger complex morphology  (IAGP)
abnormal pre-Botzinger complex physiology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal response to infection  (IAGP)
abnormal skeleton development  (IAGP)
abnormal soft palate morphology  (IAGP)
abnormal soft palate muscle morphology  (IAGP)
abnormal spermatogonia morphology  (IAGP)
cleft palate  (IAGP)
complete cleft palate  (IAGP)
cyanosis  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone ossification  (IAGP)
decreased chondrocyte proliferation  (IAGP)
decreased fetal size  (IAGP)
decreased fetal weight  (IAGP)
decreased length of long bones  (IAGP)
decreased width of hypertrophic chondrocyte zone  (IAGP)
delayed chondrocyte differentiation  (IAGP)
delayed endochondral bone ossification  (IAGP)
delayed reproductive senescence  (IAGP)
enhanced male fertility  (IAGP)
enlarged testis  (IAGP)
flat head  (IAGP)
impaired eosinophil recruitment  (IAGP)
increased cell proliferation  (IAGP)
kyphosis  (IAGP)
maxillary shelf hypoplasia  (IAGP)
neonatal lethality  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
palatal shelf hypoplasia  (IAGP)
palatine bone horizontal plate hypoplasia  (IAGP)
perinatal lethality  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
short humerus  (IAGP)
short limbs  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
2. Epigenetic induction of the Ink4a/Arf locus prevents Schwann cell overproliferation during nerve regeneration and after tumorigenic challenge. Gomez-Sanchez JA, etal., Brain. 2013 Jul;136(Pt 7):2262-78. doi: 10.1093/brain/awt130. Epub 2013 Jun 6.
3. Molecular mechanism of Jmjd3-mediated interleukin-6 gene regulation in endothelial cells underlying spinal cord injury. Lee K, etal., J Neurochem. 2012 Jul;122(2):272-82. doi: 10.1111/j.1471-4159.2012.07786.x. Epub 2012 Jun 6.
4. Histone demethylase KDM6B promotes epithelial-mesenchymal transition. Ramadoss S, etal., J Biol Chem. 2012 Dec 28;287(53):44508-17. doi: 10.1074/jbc.M112.424903. Epub 2012 Nov 14.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Expression and significance of histone H3K27 demethylases in renal cell carcinoma. Shen Y, etal., BMC Cancer. 2012 Oct 12;12:470. doi: 10.1186/1471-2407-12-470.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:14621295   PMID:16141072   PMID:16141073  
PMID:17825402   PMID:17928865   PMID:18003914   PMID:18022353   PMID:18554416   PMID:18716661   PMID:18799693   PMID:19451217   PMID:19451218   PMID:19575012   PMID:19779457   PMID:19926752  
PMID:20360974   PMID:20506217   PMID:20729857   PMID:20808772   PMID:21095589   PMID:21267068   PMID:21378168   PMID:21483786   PMID:21677750   PMID:21735477   PMID:21873635   PMID:22782721  
PMID:22915621   PMID:22949634   PMID:22955275   PMID:23103168   PMID:23243002   PMID:23251711   PMID:23332759   PMID:23452852   PMID:23515163   PMID:23584530   PMID:23671187   PMID:23856522  
PMID:23967333   PMID:24097101   PMID:24106268   PMID:24183668   PMID:24212761   PMID:24289921   PMID:24552709   PMID:24572572   PMID:24703936   PMID:24983519   PMID:25079229   PMID:25101834  
PMID:25132549   PMID:25176653   PMID:25370275   PMID:25531312   PMID:25552720   PMID:25587042   PMID:25840993   PMID:26193001   PMID:26215835   PMID:26302868   PMID:26328764   PMID:26399931  
PMID:26625958   PMID:26655900   PMID:26699812   PMID:26759175   PMID:26802933   PMID:27017927   PMID:27105846   PMID:27133168   PMID:27384759   PMID:27528513   PMID:27532872   PMID:27600842  
PMID:27626377   PMID:28002407   PMID:28188179   PMID:28314754   PMID:28322580   PMID:28323958   PMID:28328977   PMID:28587848   PMID:29254825   PMID:29377540   PMID:29445148   PMID:29481307  
PMID:29530603   PMID:29559448   PMID:29688375   PMID:29908485   PMID:29911994   PMID:29982434   PMID:30028997   PMID:30135572   PMID:30186101   PMID:30254164   PMID:30275007   PMID:30389724  
PMID:30556290   PMID:30626691   PMID:30936419   PMID:31092054   PMID:31334687   PMID:31393857   PMID:31971317   PMID:32042044   PMID:32215989   PMID:32325033   PMID:32346138   PMID:32405722  
PMID:32541010   PMID:32553152   PMID:32662520   PMID:32986815   PMID:32992420   PMID:33033262   PMID:33253789   PMID:33340793   PMID:33349663   PMID:33391480   PMID:33434305   PMID:33730567  
PMID:33779682   PMID:33784295   PMID:33863789   PMID:33895173   PMID:34090875   PMID:34173271   PMID:34216539   PMID:34321999   PMID:34368113   PMID:34464689   PMID:34494552   PMID:34533398  
PMID:34542160   PMID:34696686   PMID:34880105   PMID:34999729   PMID:35078993   PMID:35084365   PMID:35100965   PMID:35174906   PMID:35177643   PMID:35181970   PMID:35212626   PMID:35278430  
PMID:35346967   PMID:35396990   PMID:35697791   PMID:35777266   PMID:35926054   PMID:36028572   PMID:36127466   PMID:36159833   PMID:36458991   PMID:36537648   PMID:36797416   PMID:36948185  
PMID:37068788   PMID:37092728   PMID:37275887   PMID:37602956   PMID:37653141   PMID:37917239   PMID:38019914   PMID:38245781   PMID:38851307  


Genomics

Comparative Map Data
Kdm6b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,289,334 - 69,311,188 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,289,334 - 69,304,501 (-)EnsemblGRCm39 Ensembl
GRCm381169,398,508 - 69,420,367 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,398,508 - 69,413,675 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,212,010 - 69,227,177 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,214,703 - 69,229,870 (-)NCBIMGSCv36mm8
Celera1176,352,998 - 76,368,171 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.6NCBI
KDM6B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,834,217 - 7,854,796 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,834,217 - 7,854,796 (+)EnsemblGRCh38hg38GRCh38
GRCh37177,737,535 - 7,758,114 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,683,960 - 7,698,843 (+)NCBINCBI36Build 36hg18NCBI36
Celera177,771,102 - 7,785,939 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,637,994 - 7,652,831 (+)NCBIHuRef
CHM1_1177,752,263 - 7,767,093 (+)NCBICHM1_1
T2T-CHM13v2.0177,738,322 - 7,760,122 (+)NCBIT2T-CHM13v2.0
Kdm6b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,619,520 - 54,641,014 (-)NCBIGRCr8
mRatBN7.21054,120,716 - 54,142,212 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,121,848 - 54,130,794 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,782,470 - 58,803,961 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,271,086 - 58,292,578 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,779,180 - 53,800,683 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,000,494 - 56,009,582 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,001,799 - 56,008,885 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,743,701 - 55,751,368 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,194,131 - 56,202,139 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,207,737 - 56,221,527 (-)NCBI
Celera1053,278,345 - 53,286,159 (-)NCBICelera
Cytogenetic Map10q24NCBI
Kdm6b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,086,204 - 9,094,404 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,085,239 - 9,106,658 (-)NCBIChiLan1.0ChiLan1.0
KDM6B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,431,013 - 15,452,821 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11717,397,061 - 17,418,850 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,878,783 - 7,889,372 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,858,734 - 7,876,220 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,866,973 - 7,874,937 (+)Ensemblpanpan1.1panPan2
KDM6B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,689,000 - 32,711,026 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,696,211 - 32,710,666 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,827,236 - 32,848,755 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,792,977 - 32,814,492 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,792,975 - 32,814,114 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,760,822 - 32,782,338 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,716,996 - 32,738,518 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,895,969 - 32,917,506 (+)NCBIUU_Cfam_GSD_1.0
Kdm6b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,603,112 - 47,624,715 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365951,089,544 - 1,097,595 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365951,077,318 - 1,099,082 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KDM6B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1253,098,964 - 53,108,214 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11253,087,072 - 53,108,949 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,452,697 - 55,475,051 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KDM6B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,221,769 - 7,241,230 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,232,426 - 7,241,040 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,166,684 - 14,188,438 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kdm6b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,425,816 - 10,433,806 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478610,413,670 - 10,435,118 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kdm6b
869 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:627
Count of miRNA genes:411
Interacting mature miRNAs:449
Transcripts:ENSMUST00000094077, ENSMUST00000156562
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116899082672490826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115925661769482699Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116899082672490826Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116899082672490826Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116899082672490826Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116899082672490826Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116899082672490826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116899082672490826Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116899082672490826Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116899082672490826Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116899082672490826Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001017426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK129121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC075632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA945559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000094077   ⟹   ENSMUSP00000091620
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,289,334 - 69,304,501 (-)Ensembl
GRCm38.p6 Ensembl1169,398,508 - 69,413,675 (-)Ensembl
Ensembl Acc Id: ENSMUST00000156562
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,294,104 - 69,295,041 (-)Ensembl
GRCm38.p6 Ensembl1169,403,278 - 69,404,215 (-)Ensembl
RefSeq Acc Id: NM_001017426   ⟹   NP_001017426
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,289,334 - 69,307,020 (-)NCBI
GRCm381169,398,508 - 69,416,194 (-)NCBI
MGSCv371169,212,010 - 69,227,177 (-)RGD
Celera1176,352,998 - 76,368,171 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030245816   ⟹   XP_030101676
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,290,338 - 69,307,175 (-)NCBI
GRCm381169,398,542 - 69,416,349 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245817   ⟹   XP_030101677
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,290,338 - 69,311,188 (-)NCBI
GRCm381169,398,542 - 69,420,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245818   ⟹   XP_030101678
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,290,338 - 69,308,962 (-)NCBI
GRCm381169,398,542 - 69,418,140 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245819   ⟹   XP_030101679
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,290,338 - 69,305,185 (-)NCBI
GRCm381169,398,542 - 69,414,359 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245820   ⟹   XP_030101680
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,290,338 - 69,302,049 (-)NCBI
GRCm381169,398,861 - 69,411,230 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245821   ⟹   XP_030101681
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,290,338 - 69,300,400 (-)NCBI
GRCm381169,398,861 - 69,409,629 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245822   ⟹   XP_030101682
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,290,338 - 69,301,722 (-)NCBI
GRCm381169,398,861 - 69,410,897 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245823   ⟹   XP_030101683
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,290,338 - 69,304,189 (-)NCBI
GRCm381169,398,861 - 69,412,434 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245824   ⟹   XP_030101684
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,290,338 - 69,302,049 (-)NCBI
GRCm381169,398,861 - 69,411,230 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245825   ⟹   XP_030101685
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,290,338 - 69,301,722 (-)NCBI
GRCm381169,398,861 - 69,410,897 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245826   ⟹   XP_030101686
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,290,338 - 69,304,470 (-)NCBI
GRCm381169,398,861 - 69,413,621 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036156570   ⟹   XP_036012463
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,290,338 - 69,306,165 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036156571   ⟹   XP_036012464
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,290,338 - 69,302,065 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001017426   ⟸   NM_001017426
- UniProtKB: Q4VC26 (UniProtKB/Swiss-Prot),   Q3UWY9 (UniProtKB/Swiss-Prot),   Q6ZQD3 (UniProtKB/Swiss-Prot),   Q5NCY0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030101677   ⟸   XM_030245817
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030101678   ⟸   XM_030245818
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030101676   ⟸   XM_030245816
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030101679   ⟸   XM_030245819
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030101686   ⟸   XM_030245826
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030101683   ⟸   XM_030245823
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030101684   ⟸   XM_030245824
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030101680   ⟸   XM_030245820
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030101685   ⟸   XM_030245825
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030101682   ⟸   XM_030245822
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030101681   ⟸   XM_030245821
- Peptide Label: isoform X1
Ensembl Acc Id: ENSMUSP00000091620   ⟸   ENSMUST00000094077
RefSeq Acc Id: XP_036012463   ⟸   XM_036156570
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036012464   ⟸   XM_036156571
- Peptide Label: isoform X1
Protein Domains
JmjC   Lysine-specific demethylase 6A/B-like C-terminal   Lysine-specific demethylase 6A/B-like GATA-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5NCY0-F1-model_v2 AlphaFold Q5NCY0 1-1641 view protein structure

Promoters
RGD ID:6821136
Promoter ID:MM_KWN:8068
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Brain,   Kidney,   Liver,   Lung
Transcripts:UC007JQD.1,   UC007JQF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,217,596 - 69,219,852 (-)MPROMDB
RGD ID:6846870
Promoter ID:MM_ACW:7819
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:JMJD3.ISEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,222,071 - 69,223,272 (-)MPROMDB
RGD ID:6846866
Promoter ID:MM_ACW:7820
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:JMJD3.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,224,181 - 69,225,607 (-)MPROMDB
RGD ID:6821138
Promoter ID:MM_KWN:8069
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   Brain,   Kidney,   Lung,   MEF_B6
Transcripts:OTTMUST00000013375
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,226,696 - 69,228,127 (-)MPROMDB
RGD ID:6846865
Promoter ID:MM_ACW:7821
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   MEF_B4,   MEF_B6
Transcripts:JMJD3.ASEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,229,231 - 69,230,057 (-)MPROMDB
RGD ID:8675178
Promoter ID:EPDNEW_M15620
Type:initiation region
Name:Kdm6b_1
Description:Mus musculus KDM1 lysine -specific demethylase 6B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381169,409,438 - 69,409,498EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2448492 AgrOrtholog
Ensembl Genes ENSMUSG00000018476 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000094077 ENTREZGENE
  ENSMUST00000094077.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.1370 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.10.110.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cupin UniProtKB/Swiss-Prot
InterPro Corepressor-Demethylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  JmjC_dom UniProtKB/Swiss-Prot
  KDM6_GATAL_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KDM6A_B-like_C-hel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KDM6A_B-like_GATAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:216850 UniProtKB/Swiss-Prot
MGD MGI:2448492 ENTREZGENE
NCBI Gene 216850 ENTREZGENE
PANTHER LYSINE-SPECIFIC DEMETHYLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14017:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam JmjC UniProtKB/Swiss-Prot
  KDM6_C-hel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KDM6_GATAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kdm6b PhenoGen
PROSITE JMJC UniProtKB/Swiss-Prot
SMART JmjC UniProtKB/Swiss-Prot
Superfamily-SCOP Clavaminate synthase-like UniProtKB/Swiss-Prot
UniProt KDM6B_MOUSE UniProtKB/Swiss-Prot
  Q3UQG0_MOUSE UniProtKB/TrEMBL
  Q3UWY9 ENTREZGENE
  Q4VC26 ENTREZGENE
  Q5NCY0 ENTREZGENE
  Q6ZQD3 ENTREZGENE
  Q8K0Z1_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3UWY9 UniProtKB/Swiss-Prot
  Q4VC26 UniProtKB/Swiss-Prot
  Q6ZQD3 UniProtKB/Swiss-Prot