Rac2 (Rac family small GTPase 2) - Rat Genome Database

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Gene: Rac2 (Rac family small GTPase 2) Mus musculus
Analyze
Symbol: Rac2
Name: Rac family small GTPase 2
RGD ID: 1316840
MGI Page MGI
Description: Enables GTPase activity and protein kinase regulator activity. Involved in several processes, including positive regulation of lamellipodium assembly; regulation of leukocyte chemotaxis; and regulation of mast cell degranulation. Acts upstream of or within several processes, including cell projection assembly; erythrocyte enucleation; and positive regulation of mast cell proliferation. Located in cytoplasm; membrane; and nuclear envelope. Is expressed in heart; maxilla; palatal shelf; and secondary palate. Used to study immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia. Human ortholog(s) of this gene implicated in immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis; immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia; and immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia. Orthologous to human RAC2 (Rac family small GTPase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI323801; AI452260; EN-7 protein; p21-Rac2; protein EN-7; RAS-related C3 botulinum substrate 2; ras-related C3 botulinum toxin substrate 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391578,443,369 - 78,456,983 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1578,443,367 - 78,456,983 (-)EnsemblGRCm39 Ensembl
GRCm381578,559,169 - 78,572,783 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1578,559,167 - 78,572,783 (-)EnsemblGRCm38mm10GRCm38
MGSCv371578,389,599 - 78,403,213 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361578,386,424 - 78,400,038 (-)NCBIMGSCv36mm8
Celera1580,021,772 - 80,035,664 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.57NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (EXP)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-amanitin  (EXP)
alpha-pinene  (ISO)
alpha-Zearalanol  (ISO)
antirheumatic drug  (ISO)
apilimod  (EXP)
aristolochic acids  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
berberine  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
bortezomib  (ISO)
buta-1,3-diene  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (EXP)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyproconazole  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diquat  (EXP)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
gentamycin  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-acetyl-L-cysteine  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
NSC 23766  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oxycodone  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
pentanal  (ISO)
perfluorohexanesulfonic acid  (EXP)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
Soman  (ISO)
sotorasib  (ISO)
streptozocin  (ISO)
sulindac  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trametinib  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vincristine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cytotoxic T cell physiology  (IEA)
abnormal granulocyte differentiation  (IAGP)
abnormal liver morphology  (IEA)
abnormal neutrophil morphology  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal T cell activation  (IAGP)
abnormal wound healing  (IAGP)
arrested B cell differentiation  (IAGP)
decreased alpha-beta T cell number  (IAGP)
decreased angiogenesis  (IAGP)
decreased B cell number  (IAGP)
decreased B-1 B cell number  (IAGP)
decreased B-1a cell number  (IEA)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased circulating interleukin-2 level  (IAGP)
decreased follicular B cell number  (IAGP)
decreased IgE level  (IEA)
decreased IgG level  (IEA)
decreased IgM level  (IEA)
decreased leukocyte cell number  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased response to antigen  (IEA)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
decreased transitional stage B cell number  (IAGP)
decreased vascular endothelial cell proliferation  (IAGP)
delayed wound healing  (IAGP)
impaired hematopoiesis  (IEA)
impaired humoral immune response  (IEA)
impaired natural killer cell mediated cytotoxicity  (IEA)
impaired neutrophil chemotaxis  (IAGP)
increased alpha-beta T cell number  (IEA)
increased B-1 B cell number  (IEA)
increased B-1b cell number  (IEA)
increased CD8-positive, alpha-beta T cell number  (IEA)
increased central memory CD4-positive, alpha-beta T cell number  (IEA)
increased central memory CD8 positive, alpha-beta T cell number  (IEA)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased effector memory CD8-positive, alpha-beta T cell number  (IEA)
increased IgM level  (IEA)
increased leukocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
oxidative stress  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. Abe D, etal., J Periodontal Res. 2011 Jun;46(3):345-53. doi: 10.1111/j.1600-0765.2011.01349.x. Epub 2011 Mar 7.
2. Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation. Ambruso DR, etal., Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4654-9.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2189110   PMID:7888179   PMID:9438836   PMID:9507200   PMID:10072071   PMID:10098607   PMID:10349636   PMID:10843388   PMID:10864872   PMID:10922068   PMID:11042159   PMID:11076861  
PMID:11145705   PMID:11435472   PMID:11581314   PMID:11907095   PMID:12067410   PMID:12176888   PMID:12370311   PMID:12384416   PMID:12391220   PMID:12477932   PMID:12560232   PMID:12759446  
PMID:12917394   PMID:14564009   PMID:14564011   PMID:14610273   PMID:15073033   PMID:15170212   PMID:15249579   PMID:15308574   PMID:15326354   PMID:15489334   PMID:15504745   PMID:15528331  
PMID:15749928   PMID:15761153   PMID:15802529   PMID:15814684   PMID:15964829   PMID:16025125   PMID:16081809   PMID:16141072   PMID:16141073   PMID:16157315   PMID:16174757   PMID:16195235  
PMID:16275890   PMID:16546099   PMID:16772332   PMID:16809619   PMID:16863904   PMID:16882712   PMID:17056570   PMID:17177285   PMID:17483298   PMID:17575012   PMID:17922611   PMID:17954607  
PMID:17982024   PMID:17996650   PMID:18068132   PMID:18089636   PMID:18191593   PMID:18250451   PMID:18264091   PMID:18287559   PMID:18424751   PMID:18467443   PMID:18519649   PMID:18579797  
PMID:18583316   PMID:18662984   PMID:19088377   PMID:19123268   PMID:19126596   PMID:19151256   PMID:19328020   PMID:19625648   PMID:19649754   PMID:19801448   PMID:19858206   PMID:19906871  
PMID:19955208   PMID:20016102   PMID:20065081   PMID:20308364   PMID:20407032   PMID:20813901   PMID:20870900   PMID:21084708   PMID:21110188   PMID:21178006   PMID:21206905   PMID:21212270  
PMID:21267068   PMID:21444720   PMID:21474067   PMID:21511011   PMID:21606482   PMID:21698257   PMID:21712395   PMID:21873454   PMID:21873635   PMID:21940819   PMID:21976675   PMID:22043008  
PMID:22106281   PMID:22114304   PMID:22123845   PMID:22461493   PMID:22561898   PMID:22692505   PMID:22922362   PMID:23613889   PMID:23639811   PMID:23898047   PMID:24091327   PMID:24269593  
PMID:24319055   PMID:24399839   PMID:24630994   PMID:24770346   PMID:24952961   PMID:24970330   PMID:25180062   PMID:25358739   PMID:25538043   PMID:26496249   PMID:27425374   PMID:27834690  
PMID:28378742   PMID:28817691   PMID:29111324   PMID:29360039   PMID:30021868   PMID:30723080   PMID:31219639   PMID:31221776   PMID:32341385   PMID:32366477   PMID:33207246   PMID:33432150  
PMID:33689810   PMID:34711926   PMID:35354308   PMID:35778533   PMID:36462643   PMID:37017007   PMID:37172103   PMID:37196079   PMID:37982452   PMID:38355793  


Genomics

Comparative Map Data
Rac2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391578,443,369 - 78,456,983 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1578,443,367 - 78,456,983 (-)EnsemblGRCm39 Ensembl
GRCm381578,559,169 - 78,572,783 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1578,559,167 - 78,572,783 (-)EnsemblGRCm38mm10GRCm38
MGSCv371578,389,599 - 78,403,213 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361578,386,424 - 78,400,038 (-)NCBIMGSCv36mm8
Celera1580,021,772 - 80,035,664 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.57NCBI
RAC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,225,270 - 37,244,269 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2237,225,270 - 37,259,594 (-)EnsemblGRCh38hg38GRCh38
GRCh372237,621,310 - 37,640,309 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,951,256 - 35,970,251 (-)NCBINCBI36Build 36hg18NCBI36
Build 342235,945,811 - 35,964,805NCBI
Celera2221,422,402 - 21,441,189 (-)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2220,586,313 - 20,605,449 (-)NCBIHuRef
CHM1_12237,580,533 - 37,599,298 (-)NCBICHM1_1
T2T-CHM13v2.02237,685,220 - 37,704,752 (-)NCBIT2T-CHM13v2.0
Rac2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,981,825 - 112,009,201 (-)NCBIGRCr8
GRCr8 Ensembl7111,996,742 - 112,009,267 (-)EnsemblGRCr8 Ensembl
mRatBN7.27110,101,344 - 110,128,718 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7110,116,260 - 110,128,720 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7111,866,531 - 111,878,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07114,090,071 - 114,102,381 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07114,057,780 - 114,070,175 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,769,708 - 119,797,111 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,783,849 - 119,797,098 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07119,772,951 - 119,786,184 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47116,520,066 - 116,532,482 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7106,454,216 - 106,466,547 (-)NCBICelera
RGSC_v3.17116,554,295 - 116,566,712 (-)NCBI
Cytogenetic Map7q34NCBI
Rac2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541323,693,669 - 23,710,704 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541323,697,504 - 23,710,668 (-)NCBIChiLan1.0ChiLan1.0
RAC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22347,081,028 - 47,101,554 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12249,769,608 - 49,790,116 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02218,138,517 - 18,159,023 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12235,973,229 - 35,992,026 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2235,973,229 - 35,992,026 (-)Ensemblpanpan1.1panPan2
RAC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11027,295,597 - 27,311,864 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1027,295,640 - 27,311,397 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1027,250,607 - 27,266,864 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01028,087,974 - 28,104,244 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1028,088,002 - 28,104,243 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11027,809,701 - 27,825,938 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01028,118,381 - 28,134,648 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01028,296,231 - 28,312,501 (+)NCBIUU_Cfam_GSD_1.0
Rac2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494510,715,942 - 10,727,556 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364923,726,313 - 3,736,905 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364923,726,375 - 3,737,961 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl510,553,433 - 10,573,014 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1510,553,986 - 10,571,082 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.258,149,403 - 8,166,396 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11919,930,799 - 19,949,381 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1919,929,892 - 19,949,376 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045105,878,666 - 105,897,462 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rac2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475210,589,017 - 10,601,661 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475210,589,017 - 10,620,652 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rac2
398 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:923
Count of miRNA genes:546
Interacting mature miRNAs:639
Transcripts:ENSMUST00000043214
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155356339689584203Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15692948184584201Mouse
15092079Igly6_mIgG glycosylation 6, GP6 (mouse)157410054082674156Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined348969478601286Mouse
1357703Vtbt17_mvertebral trabecular bone trait 17 (mouse)Not determined154455331378553437Mouse
13504731Cath5_mcarotid atherosclerosis 5 (mouse)155478912988789129Mouse
1558786Msq1_mMAV-1 susceptibility QTL 1 (mouse)Not determined156338964681086436Mouse
15092080Igly7_mIgG glycosylation 7, GP10 (mouse)157779491982674156Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
1301006Hfib1_mhepatic fibrogenesis 1 (mouse)Not determined154730633481306479Mouse
27095936Ulnl4_mulna length 4, 5 week (mouse)155676339687684201Mouse
10755515Amzn3_manatomical modifier of Zfp423 3 (mouse)154638964680389845Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156552537699525499Mouse
1301429Pcir3_mperiosteal circumference 3 (mouse)Not determined154846536282465496Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154216339695497881Mouse
1357756Alaa4_malopecia areata 4 (mouse)Not determined154638964680389845Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
1301433Rapop5_mradiation-induced apoptosis 5 (mouse)Not determined15927302279474762Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154836339698397881Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
10412067Pain2_mpain 2 (mouse)Not determined155164533985645626Mouse
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined348969478601286Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
27226717Tibw4_mtibia width 4, proximal, 10 week (mouse)15612948178684200Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
4142198Hbtq_mhabituation QTL (mouse)Not determined155116070885160833Mouse
1357407Pfat4_mpredicted fat percentage 4 (mouse)8.6Body fat amountpredicted fat percentage155711700591117153Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined348969478601286Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15348969478601286Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
1301568Tria2_mT-cell receptor induced activation 2 (mouse)Not determined154485914178859281Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155168583285694449Mouse
1300800Ses3_msalmonella enteritidis susceptibility 3 (mouse)Not determined155711700591117153Mouse
10045637Heal27_mwound healing/regeneration 29 (mouse)Not determined155141836185418511Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155180651585806651Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156158420095584200Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
1302002Cocia2_mcocaine induced activation 2 (mouse)Not determined157237245979899178Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15348969478601286Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156533657899341028Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156481182698811946Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15612948186684201Mouse
13442492Mecth2_mmechanosensation threshold 2 (mouse)157466284979387201Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156316390397163995Mouse
1301472Pain1_mpain 1 (mouse)Not determined157532084690813185Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800024486684201Mouse
1301860Gct3_mgranulosa cell tumorigenesis 3 (mouse)Not determined154740959681409691Mouse

Markers in Region
AI323801  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381578,561,107 - 78,561,210UniSTSGRCm38
MGSCv371578,391,537 - 78,391,640UniSTSGRCm37
Celera1580,023,706 - 80,023,809UniSTS
Cytogenetic Map15E1UniSTS
Whitehead/MRC_RH15692.44UniSTS
AI452260  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381578,559,257 - 78,559,490UniSTSGRCm38
MGSCv371578,389,687 - 78,389,920UniSTSGRCm37
Celera1580,021,860 - 80,022,093UniSTS
Cytogenetic Map15E1UniSTS
Whitehead/MRC_RH15692.25UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000043214   ⟹   ENSMUSP00000036384
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1578,443,367 - 78,456,983 (-)Ensembl
GRCm38.p6 Ensembl1578,559,167 - 78,572,783 (-)Ensembl
Ensembl Acc Id: ENSMUST00000229394   ⟹   ENSMUSP00000154826
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1578,449,660 - 78,456,981 (-)Ensembl
GRCm38.p6 Ensembl1578,565,460 - 78,572,781 (-)Ensembl
Ensembl Acc Id: ENSMUST00000230952   ⟹   ENSMUSP00000155090
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1578,446,095 - 78,449,172 (-)Ensembl
GRCm38.p6 Ensembl1578,561,895 - 78,564,972 (-)Ensembl
RefSeq Acc Id: NM_009008   ⟹   NP_033034
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391578,443,369 - 78,456,983 (-)NCBI
GRCm381578,559,169 - 78,572,783 (-)ENTREZGENE
MGSCv371578,389,599 - 78,403,213 (-)RGD
Celera1580,021,772 - 80,035,664 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033034   ⟸   NM_009008
- UniProtKB: Q3TBC4 (UniProtKB/Swiss-Prot),   Q9D8X9 (UniProtKB/Swiss-Prot),   Q05144 (UniProtKB/Swiss-Prot),   Q8BPG5 (UniProtKB/TrEMBL),   Q9D859 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000155090   ⟸   ENSMUST00000230952
Ensembl Acc Id: ENSMUSP00000154826   ⟸   ENSMUST00000229394
Ensembl Acc Id: ENSMUSP00000036384   ⟸   ENSMUST00000043214

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q05144-F1-model_v2 AlphaFold Q05144 1-192 view protein structure

Promoters
RGD ID:6826395
Promoter ID:MM_KWN:18990
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver,   Lung,   Spleen
Transcripts:NM_009008
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361578,402,841 - 78,403,341 (-)MPROMDB
RGD ID:8684272
Promoter ID:EPDNEW_M20166
Type:initiation region
Name:Rac2_1
Description:Mus musculus RAS-related C3 botulinum substrate 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381578,572,720 - 78,572,780EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97846 AgrOrtholog
Ensembl Genes ENSMUSG00000033220 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000043214 ENTREZGENE
  ENSMUST00000043214.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
  Small_GTPase_Rho UniProtKB/Swiss-Prot
KEGG Report mmu:19354 UniProtKB/Swiss-Prot
MGD MGI:97846 ENTREZGENE
NCBI Gene 19354 ENTREZGENE
PANTHER PTHR24072 UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PhenoGen Rac2 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE RHO UniProtKB/Swiss-Prot
SMART RAB UniProtKB/Swiss-Prot
  RAN UniProtKB/Swiss-Prot
  RAS UniProtKB/Swiss-Prot
  RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A2R8VH29_MOUSE UniProtKB/TrEMBL
  A0A2R8VHH0_MOUSE UniProtKB/TrEMBL
  Q05144 ENTREZGENE
  Q3TBC4 ENTREZGENE
  Q8BPG5 ENTREZGENE
  Q8CEV8_MOUSE UniProtKB/TrEMBL
  Q9D859 ENTREZGENE
  Q9D8X9 ENTREZGENE
  RAC2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3TBC4 UniProtKB/Swiss-Prot
  Q9D8X9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 Rac2  Rac family small GTPase 2    RAS-related C3 botulinum substrate 2  Symbol and/or name change 5135510 APPROVED