AKR1C8 (aldo-keto reductase family 1 member C8) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: AKR1C8 (aldo-keto reductase family 1 member C8) Homo sapiens
Analyze
Symbol: AKR1C8
Name: aldo-keto reductase family 1 member C8
RGD ID: 1316753
HGNC Page HGNC:23469
Description: Predicted to enable aldo-keto reductase (NADPH) activity and estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Predicted to be involved in prostaglandin biosynthetic process. Predicted to be located in cytoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AKR1C8P; AKR1CL1; aldo-keto reductase family 1 member C-like protein 1; aldo-keto reductase family 1 member C8, pseudogene; aldo-keto reductase family 1, member C-like 1; aldo-keto reductase family 1, member C8, pseudogene; FLJ16347; LOC124906893; putative aldo-keto reductase family 1 member C8; uncharacterized LOC124906893
RGD Orthologs
Rat
Pig
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38105,115,813 - 5,185,150 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl105,153,920 - 5,185,187 (-)EnsemblGRCh38hg38GRCh38
GRCh37105,196,120 - 5,227,113 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,186,655 - 5,217,150 (-)NCBINCBI36Build 36hg18NCBI36
Celera105,136,630 - 5,167,354 (-)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef105,130,352 - 5,162,234 (-)NCBIHuRef
CHM1_1105,196,989 - 5,227,724 (-)NCBICHM1_1
T2T-CHM13v2.0105,115,808 - 5,186,948 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
schizophrenia  (IAGP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Schizophrenia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15164054   PMID:21873635   PMID:31391242   PMID:32814053  


Genomics

Comparative Map Data
AKR1C8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38105,115,813 - 5,185,150 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl105,153,920 - 5,185,187 (-)EnsemblGRCh38hg38GRCh38
GRCh37105,196,120 - 5,227,113 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,186,655 - 5,217,150 (-)NCBINCBI36Build 36hg18NCBI36
Celera105,136,630 - 5,167,354 (-)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef105,130,352 - 5,162,234 (-)NCBIHuRef
CHM1_1105,196,989 - 5,227,724 (-)NCBICHM1_1
T2T-CHM13v2.0105,115,808 - 5,186,948 (-)NCBIT2T-CHM13v2.0
Akr1c15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,091,398 - 71,117,985 (-)NCBIGRCr8
mRatBN7.21766,181,493 - 66,208,090 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,181,493 - 66,208,061 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1769,666,632 - 69,693,099 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,495,475 - 73,521,932 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,538,462 - 67,564,923 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,835,338 - 69,862,093 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,835,330 - 69,862,110 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01771,538,483 - 71,565,238 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,341,133 - 77,367,689 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11777,352,006 - 77,428,271 (-)NCBI
Celera1765,696,635 - 65,722,901 (-)NCBICelera
Cytogenetic Map17q12.2NCBI
AKR1C4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1065,559,508 - 65,572,895 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11065,559,508 - 65,572,892 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21072,009,208 - 72,022,624 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in AKR1C8
7 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10p15.3-14(chr10:90421-8442783)x3 copy number gain See cases [RCV000051107] Chr10:90421..8442783 [GRCh38]
Chr10:224406..8484746 [GRCh37]
Chr10:126361..8524752 [NCBI36]
Chr10:10p15.3-14		 pathogenic
GRCh38/hg38 10p15.3-15.1(chr10:69260-6209368)x1 copy number loss See cases [RCV000052493] Chr10:69260..6209368 [GRCh38]
Chr10:224406..6251331 [GRCh37]
Chr10:105200..6291337 [NCBI36]
Chr10:10p15.3-15.1		 pathogenic
GRCh38/hg38 10p15.3-12.31(chr10:54086-19336980)x1 copy number loss See cases [RCV000143703] Chr10:54086..19336980 [GRCh38]
Chr10:100026..19625909 [GRCh37]
Chr10:90026..19665915 [NCBI36]
Chr10:10p15.3-12.31		 pathogenic|likely pathogenic
GRCh38/hg38 10p15.3-13(chr10:54086-13205916)x3 copy number gain See cases [RCV000142292] Chr10:54086..13205916 [GRCh38]
Chr10:100026..13247916 [GRCh37]
Chr10:90026..13287922 [NCBI36]
Chr10:10p15.3-13		 pathogenic
GRCh38/hg38 10p15.1-q11.22(chr10:4604734-48074662)x3 copy number gain See cases [RCV000141497] Chr10:4604734..48074662 [GRCh38]
Chr10:4646926..47531169 [GRCh37]
Chr10:4636926..47125152 [NCBI36]
Chr10:10p15.1-q11.22		 benign
GRCh38/hg38 10p15.3-12.31(chr10:69261-19184047)x3 copy number gain See cases [RCV000053507] Chr10:69261..19184047 [GRCh38]
Chr10:224406..19472976 [GRCh37]
Chr10:105201..19512982 [NCBI36]
Chr10:10p15.3-12.31		 pathogenic
GRCh38/hg38 10p15.1-14(chr10:4605831-7403265)x1 copy number loss See cases [RCV000135820] Chr10:4605831..7403265 [GRCh38]
Chr10:4648023..7445227 [GRCh37]
Chr10:4638023..7485233 [NCBI36]
Chr10:10p15.1-14		 uncertain significance
GRCh38/hg38 10p15.1(chr10:4871826-5811361)x3 copy number gain See cases [RCV000137253] Chr10:4871826..5811361 [GRCh38]
Chr10:4914018..5853324 [GRCh37]
Chr10:4904018..5893330 [NCBI36]
Chr10:10p15.1		 uncertain significance
GRCh38/hg38 10p15.1(chr10:4836712-5161722)x1 copy number loss See cases [RCV000138260] Chr10:4836712..5161722 [GRCh38]
Chr10:4878904..5203685 [GRCh37]
Chr10:4868904..5193685 [NCBI36]
Chr10:10p15.1		 likely benign
GRCh38/hg38 10p15.3-12.1(chr10:90205-26339978)x3 copy number gain See cases [RCV000138428] Chr10:90205..26339978 [GRCh38]
Chr10:224406..26628907 [GRCh37]
Chr10:126145..26668913 [NCBI36]
Chr10:10p15.3-12.1		 pathogenic
GRCh38/hg38 10p15.3-13(chr10:70478-13736564)x1 copy number loss See cases [RCV000138960] Chr10:70478..13736564 [GRCh38]
Chr10:224406..13778564 [GRCh37]
Chr10:106418..13818570 [NCBI36]
Chr10:10p15.3-13		 pathogenic
GRCh38/hg38 10p15.1(chr10:5161663-5599060)x1 copy number loss See cases [RCV000140807] Chr10:5161663..5599060 [GRCh38]
Chr10:5203626..5641023 [GRCh37]
Chr10:5193626..5681029 [NCBI36]
Chr10:10p15.1		 likely benign|uncertain significance
GRCh38/hg38 10p15.3-14(chr10:1601172-9203729)x3 copy number gain See cases [RCV000142241] Chr10:1601172..9203729 [GRCh38]
Chr10:1643367..9245692 [GRCh37]
Chr10:1633367..9285698 [NCBI36]
Chr10:10p15.3-14		 likely pathogenic
GRCh38/hg38 10p15.3-14(chr10:90421-11713049)x3 copy number gain See cases [RCV000135533] Chr10:90421..11713049 [GRCh38]
Chr10:224406..11755048 [GRCh37]
Chr10:126361..11795054 [NCBI36]
Chr10:10p15.3-14		 pathogenic|uncertain significance
GRCh38/hg38 10p15.3-14(chr10:90421-6769994)x3 copy number gain See cases [RCV000051132] Chr10:90421..6769994 [GRCh38]
Chr10:224406..6811956 [GRCh37]
Chr10:126361..6851962 [NCBI36]
Chr10:10p15.3-14		 pathogenic
GRCh38/hg38 10p15.3-12.2(chr10:90221-22567425)x3 copy number gain See cases [RCV000053508] Chr10:90221..22567425 [GRCh38]
Chr10:224406..22856354 [GRCh37]
Chr10:126161..22896360 [NCBI36]
Chr10:10p15.3-12.2		 pathogenic
GRCh38/hg38 10p15.1(chr10:5161663-5196381)x1 copy number loss See cases [RCV000135263] Chr10:5161663..5196381 [GRCh38]
Chr10:5203626..5238344 [GRCh37]
Chr10:5193626..5228344 [NCBI36]
Chr10:10p15.1		 likely benign
Single allele duplication Schizophrenia [RCV000754118] Chr10:3076972..6208037 [GRCh38]
Chr10:10p15.2-15.1		 likely pathogenic
GRCh38/hg38 10p15.1(chr10:4892139-5164086)x1 copy number loss See cases [RCV000142243] Chr10:4892139..5164086 [GRCh38]
Chr10:4934331..5206049 [GRCh37]
Chr10:4924331..5196049 [NCBI36]
Chr10:10p15.1		 likely benign
GRCh38/hg38 10p15.1-13(chr10:4802753-16823491)x1 copy number loss See cases [RCV000052500] Chr10:4802753..16823491 [GRCh38]
Chr10:4844945..16865490 [GRCh37]
Chr10:4834945..16905496 [NCBI36]
Chr10:10p15.1-13		 pathogenic
GRCh38/hg38 10p15.3-13(chr10:73856-12815915)x3 copy number gain See cases [RCV000135340] Chr10:73856..12815915 [GRCh38]
Chr10:119796..12857914 [GRCh37]
Chr10:109796..12897920 [NCBI36]
Chr10:10p15.3-13		 pathogenic
GRCh38/hg38 10p15.1(chr10:5159926-5165558) copy number gain not provided [RCV003448584] Chr10:5159926..5165558 [GRCh38]
Chr10:10p15.1		 uncertain significance

QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407331894GWAS980870_HIGF-1 measurement QTL GWAS980870 (human)4e-10IGF-1 measurementblood insulin-like growth factor 1 level (CMO:0001297)1051349535134954Human
407280228GWAS929204_Hpursuit maintenance gain measurement QTL GWAS929204 (human)0.0000002pursuit maintenance gain measurement1051775765177577Human
407405247GWAS1054223_HIGF-1 measurement QTL GWAS1054223 (human)1e-14IGF-1 measurementblood insulin-like growth factor 1 level (CMO:0001297)1051415455141546Human
407400960GWAS1049936_Hsex hormone-binding globulin measurement QTL GWAS1049936 (human)8e-13sex hormone-binding globulin measurement1051415455141546Human
407163756GWAS812732_Hcolor vision disorder QTL GWAS812732 (human)0.000002color vision disorder1051596405159641Human
406969816GWAS618792_Hprotein measurement QTL GWAS618792 (human)1e-18protein measurement1051634745163475Human
406944239GWAS593215_Hbone mineral content measurement QTL GWAS593215 (human)0.000003bone mineral content measurement1051197635119764Human

Markers in Region
SHGC-106506  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37105,227,084 - 5,227,365UniSTSGRCh37
Build 36105,217,084 - 5,217,365RGDNCBI36
Celera105,167,288 - 5,167,569RGD
Cytogenetic Map10p15.1UniSTS
HuRef105,162,168 - 5,162,449UniSTS
TNG Radiation Hybrid Map102657.0UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001395972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_027916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054365731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054365732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054365733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007080927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK131335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL355303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL391427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC101204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC101205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF455191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000578467
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl105,154,460 - 5,185,187 (-)Ensembl
Ensembl Acc Id: ENST00000584929   ⟹   ENSP00000496857
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl105,154,143 - 5,185,104 (-)Ensembl
Ensembl Acc Id: ENST00000648824   ⟹   ENSP00000496804
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl105,153,920 - 5,185,150 (-)Ensembl
Ensembl Acc Id: ENST00000650030   ⟹   ENSP00000497014
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl105,161,731 - 5,185,181 (-)Ensembl
RefSeq Acc Id: NM_001395972   ⟹   NP_001382901
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38105,153,920 - 5,185,150 (-)NCBI
T2T-CHM13v2.0105,154,370 - 5,186,922 (-)NCBI
RefSeq Acc Id: NR_027916
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38105,153,920 - 5,185,150 (-)NCBI
GRCh37105,196,655 - 5,227,150 (-)RGD
Celera105,136,630 - 5,167,354 (-)RGD
HuRef105,130,352 - 5,162,234 (-)ENTREZGENE
CHM1_1105,196,989 - 5,227,724 (-)NCBI
T2T-CHM13v2.0105,154,370 - 5,186,922 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047425156   ⟹   XP_047281112
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38105,120,481 - 5,185,150 (-)NCBI
RefSeq Acc Id: XM_047425157   ⟹   XP_047281113
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38105,120,481 - 5,185,150 (-)NCBI
RefSeq Acc Id: XM_047425158   ⟹   XP_047281114
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38105,120,481 - 5,185,150 (-)NCBI
RefSeq Acc Id: XM_047425159   ⟹   XP_047281115
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38105,120,481 - 5,185,150 (-)NCBI
RefSeq Acc Id: XM_047425160   ⟹   XP_047281116
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38105,120,481 - 5,185,150 (-)NCBI
RefSeq Acc Id: XM_047425161   ⟹   XP_047281117
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38105,120,481 - 5,185,150 (-)NCBI
RefSeq Acc Id: XM_047425162   ⟹   XP_047281118
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38105,115,813 - 5,185,150 (-)NCBI
RefSeq Acc Id: XM_047425163   ⟹   XP_047281119
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38105,133,348 - 5,185,150 (-)NCBI
RefSeq Acc Id: XM_047425164   ⟹   XP_047281120
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38105,120,481 - 5,170,795 (-)NCBI
RefSeq Acc Id: XM_047425165   ⟹   XP_047281121
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38105,146,755 - 5,185,150 (-)NCBI
RefSeq Acc Id: XM_047425166   ⟹   XP_047281122
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38105,160,186 - 5,185,150 (-)NCBI
RefSeq Acc Id: XM_054365731   ⟹   XP_054221706
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0105,136,903 - 5,186,948 (-)NCBI
RefSeq Acc Id: XM_054365732   ⟹   XP_054221707
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0105,147,200 - 5,186,948 (-)NCBI
RefSeq Acc Id: XM_054365733   ⟹   XP_054221708
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0105,160,644 - 5,186,948 (-)NCBI
RefSeq Acc Id: XR_007080927
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0105,116,313 - 5,133,717 (-)NCBI
RefSeq Acc Id: XR_008488202
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0105,116,313 - 5,186,948 (-)NCBI
RefSeq Acc Id: XR_008488203
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0105,115,808 - 5,186,948 (-)NCBI
RefSeq Acc Id: XR_008488204
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0105,116,313 - 5,186,948 (-)NCBI
RefSeq Acc Id: XR_008488205
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0105,116,313 - 5,186,948 (-)NCBI
RefSeq Acc Id: XR_008488206
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0105,116,313 - 5,186,948 (-)NCBI
RefSeq Acc Id: XR_008488207
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0105,116,313 - 5,186,948 (-)NCBI
RefSeq Acc Id: XR_008488208
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0105,116,313 - 5,186,948 (-)NCBI
RefSeq Acc Id: XR_008488209
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0105,116,313 - 5,186,948 (-)NCBI
RefSeq Acc Id: XR_008488210
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0105,133,793 - 5,186,948 (-)NCBI
Ensembl Acc Id: ENSP00000496804   ⟸   ENST00000648824
Ensembl Acc Id: ENSP00000496857   ⟸   ENST00000584929
Ensembl Acc Id: ENSP00000497014   ⟸   ENST00000650030
RefSeq Acc Id: NP_001382901   ⟸   NM_001395972
- UniProtKB: A0A3B3IRI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047281118   ⟸   XM_047425162
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047281117   ⟸   XM_047425161
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047281116   ⟸   XM_047425160
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047281115   ⟸   XM_047425159
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047281114   ⟸   XM_047425158
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047281112   ⟸   XM_047425156
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047281113   ⟸   XM_047425157
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047281120   ⟸   XM_047425164
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047281119   ⟸   XM_047425163
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047281121   ⟸   XM_047425165
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047281122   ⟸   XM_047425166
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054221706   ⟸   XM_054365731
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054221707   ⟸   XM_054365732
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054221708   ⟸   XM_054365733
- Peptide Label: isoform X4
Protein Domains
NADP-dependent oxidoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5T2L2-F1-model_v2 AlphaFold Q5T2L2 1-129 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:23469 AgrOrtholog
COSMIC AKR1C8 COSMIC
Ensembl Genes ENSG00000264006 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000584929.7 UniProtKB/Swiss-Prot
  ENST00000648824 ENTREZGENE
  ENST00000648824.2 UniProtKB/TrEMBL
  ENST00000650030.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000264006 GTEx
HGNC ID HGNC:23469 ENTREZGENE
Human Proteome Map AKR1C8 Human Proteome Map
InterPro AKR1C UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/keto_reductase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 340811 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1 MEMBER C15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF AKR UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3B3IRI8 ENTREZGENE, UniProtKB/TrEMBL
  AKCL1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A6NF66 UniProtKB/Swiss-Prot
  Q6ZN81 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-03-23 AKR1C8  aldo-keto reductase family 1 member C8  LOC124906893  uncharacterized LOC124906893  Data merged from RGD:151668538 737654 PROVISIONAL
2021-09-27 AKR1C8  aldo-keto reductase family 1 member C8  AKR1C8P  aldo-keto reductase family 1 member C8, pseudogene  Symbol and/or name change 19259463 PROVISIONAL
2016-06-07 AKR1C8P  aldo-keto reductase family 1 member C8, pseudogene    aldo-keto reductase family 1, member C8, pseudogene  Symbol and/or name change 5135510 APPROVED
2014-10-07 AKR1C8P  aldo-keto reductase family 1, member C8, pseudogene  AKR1CL1  aldo-keto reductase family 1, member C-like 1  Symbol and/or name change 5135510 APPROVED