Il21 (interleukin 21) - Rat Genome Database

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Gene: Il21 (interleukin 21) Mus musculus
Analyze
Symbol: Il21
Name: interleukin 21
RGD ID: 1316554
MGI Page MGI
Description: Enables cytokine receptor binding activity. Involved in cellular response to virus; lymphocyte activation involved in immune response; and positive regulation of immunoglobulin production. Acts upstream of or within positive regulation of cytokine production; positive regulation of natural killer cell differentiation; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in extracellular space. Is expressed in ductus deferens; epididymis; liver; and testis. Human ortholog(s) of this gene implicated in asthma; common variable immunodeficiency 11; hepatocellular carcinoma; and systemic lupus erythematosus. Orthologous to human IL21 (interleukin 21).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IL-21; interleukin-21
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39337,276,908 - 37,286,785 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl337,276,908 - 37,286,785 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38337,222,759 - 37,232,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,222,759 - 37,232,636 (-)Ensemblmm10GRCm38
MGSCv37337,121,681 - 37,131,540 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36337,107,141 - 37,117,000 (-)NCBIMGSCv36mm8
MGSCv36337,414,308 - 37,424,167 (-)NCBIMGSCv36mm8
Celera337,106,874 - 37,116,609 (-)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interleukin-21 plays a critical role in the pathogenesis and severity of type I autoimmune hepatitis. Abe K, etal., Springerplus. 2016 Jun 18;5(1):777. doi: 10.1186/s40064-016-2512-y. eCollection 2016.
2. Possible role of interleukin 21 and interleukin 33 in patients with genital warts. Abu El-Hamd M, etal., Dermatol Ther. 2019 Sep;32(5):e13063. doi: 10.1111/dth.13063. Epub 2019 Aug 29.
3. Impaired autoimmune T helper 17 cell responses following DNA vaccination against rat experimental autoimmune encephalomyelitis. Andersson A, etal., PLoS One. 2008;3(11):e3682. Epub 2008 Nov 10.
4. Interleukin-21-dependent modulation of T cell antigen receptor reactivity towards low affinity peptide ligands in autoreactive CD8(+) T lymphocytes. Bobbala D, etal., Cytokine. 2016 Sep;85:83-91. doi: 10.1016/j.cyto.2016.06.011. Epub 2016 Jun 11.
5. IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis. Caruso R, etal., J Immunol. 2007 May 1;178(9):5957-65. doi: 10.4049/jimmunol.178.9.5957.
6. A common exonic variant of interleukin21 confers susceptibility to atopic asthma. Chatterjee R, etal., Int Arch Allergy Immunol. 2009;148(2):137-46. Epub 2008 Sep 19.
7. Genome-wide analysis of extended pedigrees confirms IL2-IL21 linkage and shows additional regions of interest potentially influencing coeliac disease risk. Einarsdottir E, etal., Tissue Antigens. 2011 Dec;78(6):428-37. doi: 10.1111/j.1399-0039.2011.01791.x.
8. IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. Eto D, etal., PLoS One. 2011 Mar 14;6(3):e17739. doi: 10.1371/journal.pone.0017739.
9. HCV-specific interleukin-21+CD4+ T cells responses associated with viral control through the modulation of HCV-specific CD8+ T cells function in chronic hepatitis C patients. Feng G, etal., Mol Cells. 2013 Oct;36(4):362-7. doi: 10.1007/s10059-013-0181-z. Epub 2013 Oct 22.
10. Promotion of a functional B cell germinal center response after Leishmania species co-infection is associated with lesion resolution. Gibson-Corley KN, etal., Am J Pathol. 2012 May;180(5):2009-17. doi: 10.1016/j.ajpath.2012.01.012. Epub 2012 Mar 17.
11. Combinatory gene therapy with electrotransfer of midkine promoter-HSV-TK and interleukin-21. Hanari N, etal., Anticancer Res. 2007 Jul-Aug;27(4B):2305-10.
12. Antitumor efficacy of viable tumor vaccine modified by heterogenetic ESAT-6 antigen and cytokine IL-21 in melanomatous mouse. He X, etal., Immunol Res. 2012 Jun;52(3):240-9. doi: 10.1007/s12026-012-8332-4.
13. Association of IL-17, IL-21, and IL-23R gene polymorphisms with HBV infection in kidney transplant patients. Hejr S, etal., Viral Immunol. 2013 Jun;26(3):201-6. doi: 10.1089/vim.2013.0007. Epub 2013 May 8.
14. IL-21 administration into the nostril alleviates murine allergic rhinitis. Hiromura Y, etal., J Immunol. 2007 Nov 15;179(10):7157-65.
15. Interleukin-21 mRNA expression during virus infections. Holm C, etal., Cytokine. 2006 Jan 7;33(1):41-5. doi: 10.1016/j.cyto.2005.11.014. Epub 2006 Jan 5.
16. Immunization with DNA vaccine expressing herpes simplex virus type 1 gD and IL-21 protects against mouse herpes keratitis. Hu K, etal., Immunol Invest. 2011;40(3):265-78. doi: 10.3109/08820139.2010.534219. Epub 2011 Jan 4.
17. Interleukin-21 is upregulated in hepatitis B-related acute-on-chronic liver failure and associated with severity of liver disease. Hu X, etal., J Viral Hepat. 2011 Jul;18(7):458-67. doi: 10.1111/j.1365-2893.2011.01475.x. Epub 2011 Jun 1.
18. Interleukin-21 receptor signalling is important for innate immune protection against HSV-2 infections. Kratholm SK, etal., PLoS One. 2013 Dec 16;8(12):e81790. doi: 10.1371/journal.pone.0081790. eCollection 2013.
19. Gene-gene and gene-sex epistatic interactions of MiR146a, IRF5, IKZF1, ETS1 and IL21 in systemic lupus erythematosus. Leng RX, etal., PLoS One. 2012;7(12):e51090. doi: 10.1371/journal.pone.0051090. Epub 2012 Dec 7.
20. Interleukin-21 responses in patients with chronic hepatitis B. Li J, etal., J Interferon Cytokine Res. 2015 Feb;35(2):134-42. doi: 10.1089/jir.2013.0119. Epub 2014 Sep 22.
21. IL21 and IL21R polymorphisms and their interactive effects on serum IL-21 and IgE levels in patients with chronic hepatitis B virus infection. Li N, etal., Hum Immunol. 2013 May;74(5):567-73. doi: 10.1016/j.humimm.2013.01.005. Epub 2013 Jan 24.
22. Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease. Li Y, etal., Mol Oral Microbiol. 2010 Aug;25(4):275-92.
23. Interleukin-21 Is Associated with Early Antiviral Response in Patients with Hepatitis B e Antigen-Positive Chronic Hepatitis B and Nonalcoholic Fatty Liver Disease. Liu X, etal., J Interferon Cytokine Res. 2016 Jun;36(6):367-73. doi: 10.1089/jir.2015.0129. Epub 2016 Feb 3.
24. MGDs mouse GO annotations MGD data from the GO Consortium
25. MGD IEA MGD IEA
26. IL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular Infection. Moretto MM and Khan IA, J Immunol. 2016 Jan 1;196(1):375-84. doi: 10.4049/jimmunol.1501258. Epub 2015 Nov 23.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Increased levels of IL-21 responses are associated with the severity of liver injury in patients with chronic active hepatitis B. Pan Q, etal., J Viral Hepat. 2014;21(9):e78-88. doi: 10.1111/jvh.12242. Epub 2014 Mar 10.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. Disruption of IL-21 signaling affects T cell-B cell interactions and abrogates protective humoral immunity to malaria. Pérez-Mazliah D, etal., PLoS Pathog. 2015 Mar 12;11(3):e1004715. doi: 10.1371/journal.ppat.1004715. eCollection 2015 Mar.
31. Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Rajaei T, etal., Med Microbiol Immunol. 2017 Jun;206(3):195-201. doi: 10.1007/s00430-017-0492-3. Epub 2017 Apr 4.
32. Interleukin 21 augments the hepatitis B virus-specific CD8+ T-cell response in vitro in patients coinfected with HIV-1. Ren G, etal., AIDS. 2012 Nov 13;26(17):2145-53. doi: 10.1097/QAD.0b013e328359b7ae.
33. Mouse MP Annotation Import Pipeline RGD automated import pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. IL-21 and IL-15 cytokine DNA augments HSV specific effector and memory CD8+ T cell response. Rodrigues L, etal., Mol Immunol. 2009 Apr;46(7):1494-504. doi: 10.1016/j.molimm.2008.12.033. Epub 2009 Feb 23.
37. Anti-IL-21 monoclonal antibody combined with liraglutide effectively reverses established hyperglycemia in mouse models of type 1 diabetes. Rydén AK, etal., J Autoimmun. 2017 Nov;84:65-74. doi: 10.1016/j.jaut.2017.07.006. Epub 2017 Jul 12.
38. IL-21-based therapies induce clearance of hepatitis B virus persistence in mouse models. Shen Z, etal., Theranostics. 2019 May 31;9(13):3798-3811. doi: 10.7150/thno.35331. eCollection 2019.
39. Characterization of IL-21-expressing recombinant hepatitis B virus (HBV) as a therapeutic agent targeting persisting HBV infection. Shen Z, etal., Theranostics. 2020 Apr 25;10(12):5600-5612. doi: 10.7150/thno.44715. eCollection 2020.
40. IL-21 promotes the pathologic immune response to pneumovirus infection. Spolski R, etal., J Immunol. 2012 Feb 15;188(4):1924-32. Epub 2012 Jan 11.
41. IL-21 is required for optimal antibody production and T cell responses during chronic Toxoplasma gondii infection. Stumhofer JS, etal., PLoS One. 2013 May 7;8(5):e62889. doi: 10.1371/journal.pone.0062889. Print 2013.
42. Bupi Hewei decoction ameliorates 5-fluorouracil-induced intestinal dysbiosis in rats through T helper 17/T regulatory cell signaling pathway. Sun Z, etal., J Tradit Chin Med. 2020 Feb;40(1):38-48.
43. Interleukin 21 Reinvigorates the Antiviral Activity of Hepatitis B Virus (HBV)-Specific CD8+ T Cells in Chronic HBV Infection. Tang L, etal., J Infect Dis. 2019 Feb 15;219(5):750-759. doi: 10.1093/infdis/jiy576.
44. Immunization with dendritic cell-based DNA vaccine pRSC-NLDC145.gD-IL21 protects mice against herpes simplex virus keratitis. Tang R, etal., Immunotherapy. 2018 Mar;10(3):189-200. doi: 10.2217/imt-2017-0060.
45. Dynamics of interleukin-21 production during the clinical course of primary and secondary dengue virus infections. Vivanco-Cid H, etal., Immunol Lett. 2014 Sep;161(1):89-95. doi: 10.1016/j.imlet.2014.05.006. Epub 2014 May 22.
46. Immune correlates of hepatitis B surface antigen spontaneous seroconversion in hepatitis B e antigen negative chronic hepatitis B patients. Vyas AK, etal., Liver Int. 2018 Jan;38(1):38-49. doi: 10.1111/liv.13475. Epub 2017 Jun 1.
47. Dysregulated Response of Follicular Helper T Cells to Hepatitis B Surface Antigen Promotes HBV Persistence in Mice and Associates With Outcomes of Patients. Wang X, etal., Gastroenterology. 2018 Jun;154(8):2222-2236. doi: 10.1053/j.gastro.2018.03.021. Epub 2018 Mar 12.
48. Role of interleukin-21 and interleukin-21 receptor polymorphisms in the treatment of HBeAg-positive chronic hepatitis B patients with peginterferon. Wang X, etal., Medicine (Baltimore). 2018 Jun;97(23):e10891. doi: 10.1097/MD.0000000000010891.
49. Cerebrospinal fluid IL-21 levels in Neuromyelitis Optica and multiple sclerosis. Wu A, etal., Can J Neurol Sci. 2012 Nov;39(6):813-20. doi: 10.1017/s0317167100015663.
50. Increased frequency of follicular helper T cells in mice viral myocarditis is relevant with anti-ANT antoantibody. Yang F, etal., Virol J. 2015 Feb 11;12:20. doi: 10.1186/s12985-015-0257-9.
51. Interleukin-21 gene polymorphisms and chronic hepatitis B infection in a Chinese population. Yao JY, etal., World J Gastroenterol. 2015 Apr 14;21(14):4232-9. doi: 10.3748/wjg.v21.i14.4232.
52. Interleukin-21 (IL-21) Downregulates Dendritic Cell Cytokine Responses to Helicobacter pylori and Modulates T Lymphocyte IL-17A Expression in Peyer's Patches during Infection. Yasmin S, etal., Infect Immun. 2019 Oct 18;87(11). pii: IAI.00237-19. doi: 10.1128/IAI.00237-19. Print 2019 Nov.
53. Fusobacterium Nucleatum Subspecies Animalis Influences Proinflammatory Cytokine Expression and Monocyte Activation in Human Colorectal Tumors. Ye X, etal., Cancer Prev Res (Phila). 2017 Jul;10(7):398-409. doi: 10.1158/1940-6207.CAPR-16-0178. Epub 2017 May 8.
54. IL-21 promotes late activator APC-mediated T follicular helper cell differentiation in experimental pulmonary virus infection. Yoo JK and Braciale TJ, PLoS One. 2014 Sep 24;9(9):e105872. doi: 10.1371/journal.pone.0105872. eCollection 2014.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11081504   PMID:11217851   PMID:11970879   PMID:12370258   PMID:12393685   PMID:12446913   PMID:12466851   PMID:12477932   PMID:12682241  
PMID:12847225   PMID:12893770   PMID:14502230   PMID:14675186   PMID:14679059   PMID:14734732   PMID:14764669   PMID:15100251   PMID:15240677   PMID:15494482   PMID:15585879   PMID:15684054  
PMID:15728477   PMID:15879595   PMID:16141072   PMID:16141073   PMID:16600195   PMID:16778988   PMID:16785504   PMID:16785506   PMID:16943384   PMID:16951332   PMID:16979605   PMID:17178921  
PMID:17312126   PMID:17339481   PMID:17509926   PMID:17532053   PMID:17548600   PMID:17554014   PMID:17581588   PMID:17581589   PMID:17673207   PMID:17884812   PMID:17918200   PMID:17918202  
PMID:17938255   PMID:18052963   PMID:18056403   PMID:18276844   PMID:18390721   PMID:18395085   PMID:18413772   PMID:18474630   PMID:18490706   PMID:18515660   PMID:18546146   PMID:18585065  
PMID:18599325   PMID:18602282   PMID:18656702   PMID:18773086   PMID:18981236   PMID:19020307   PMID:19050256   PMID:19062315   PMID:19073938   PMID:19088203   PMID:19098919   PMID:19139170  
PMID:19168593   PMID:19208913   PMID:19221396   PMID:19234181   PMID:19265120   PMID:19342640   PMID:19443735   PMID:19570826   PMID:19592651   PMID:19628815   PMID:19718060   PMID:19797314  
PMID:19841075   PMID:19843883   PMID:19880748   PMID:19915059   PMID:20042469   PMID:20057909   PMID:20061408   PMID:20064451   PMID:20101507   PMID:20131264   PMID:20142429   PMID:20142430  
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PMID:21098093   PMID:21257966   PMID:21258423   PMID:21267068   PMID:21270405   PMID:21357471   PMID:21393863   PMID:21430227   PMID:21441456   PMID:21505191   PMID:21511186   PMID:21593413  
PMID:21873635   PMID:21911600   PMID:21949017   PMID:21987656   PMID:22013017   PMID:22019586   PMID:22118527   PMID:22120117   PMID:22120118   PMID:22205023   PMID:22231702   PMID:22365664  
PMID:22370718   PMID:22442347   PMID:22466669   PMID:22552227   PMID:22643047   PMID:22665806   PMID:22723520   PMID:22781775   PMID:22829452   PMID:23045607   PMID:23064231   PMID:23098768  
PMID:23168836   PMID:23169140   PMID:23200827   PMID:23281399   PMID:23312859   PMID:23437182   PMID:23447690   PMID:23453633   PMID:23516660   PMID:23557800   PMID:23607664   PMID:23637417  
PMID:23696736   PMID:23825648   PMID:23858031   PMID:23960240   PMID:23992866   PMID:24078696   PMID:24194600   PMID:24350772   PMID:24357415   PMID:24416451   PMID:24430438   PMID:24446516  
PMID:24470500   PMID:24508410   PMID:24550509   PMID:24572790   PMID:24616379   PMID:24820310   PMID:24973819   PMID:25053783   PMID:25073789   PMID:25092334   PMID:25170154   PMID:25246268  
PMID:25339665   PMID:25351608   PMID:25545680   PMID:25586558   PMID:26170288   PMID:26194763   PMID:26287681   PMID:26363366   PMID:26410627   PMID:26413871   PMID:26491200   PMID:26499265  
PMID:26519529   PMID:26527008   PMID:26792801   PMID:26826252   PMID:27062692   PMID:27067007   PMID:27118610   PMID:27487330   PMID:27554052   PMID:27571893   PMID:27573866   PMID:27670591  
PMID:27798619   PMID:27819295   PMID:27924822   PMID:28057742   PMID:28197386   PMID:28294304   PMID:28303891   PMID:28351982   PMID:28358362   PMID:28405614   PMID:28583714   PMID:28798332  
PMID:28875978   PMID:28978474   PMID:29192177   PMID:29220875   PMID:29242561   PMID:29483597   PMID:29549115   PMID:29563177   PMID:29844233   PMID:29925696   PMID:30144035   PMID:30446568  
PMID:30478091   PMID:30654048   PMID:31019062   PMID:31132747   PMID:31276232   PMID:31356165   PMID:31356706   PMID:31412245   PMID:31467912   PMID:31491724   PMID:31756235   PMID:31940277  
PMID:32122993   PMID:32130409   PMID:32271164   PMID:32493841   PMID:32680956   PMID:32855360   PMID:32859726   PMID:32948671   PMID:33879579   PMID:33916486   PMID:34158852   PMID:34852236  
PMID:34887406   PMID:35129769   PMID:35216666   PMID:35300072   PMID:35503415   PMID:35801309   PMID:35896116   PMID:36587888   PMID:36762954   PMID:37133336   PMID:37466652   PMID:37628716  
PMID:37628738   PMID:37686246   PMID:37708033   PMID:37708215   PMID:37815034   PMID:38477614   PMID:38761804   PMID:39087473   PMID:39096910   PMID:39891019  


Genomics

Comparative Map Data
Il21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39337,276,908 - 37,286,785 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl337,276,908 - 37,286,785 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38337,222,759 - 37,232,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,222,759 - 37,232,636 (-)Ensemblmm10GRCm38
MGSCv37337,121,681 - 37,131,540 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36337,107,141 - 37,117,000 (-)NCBIMGSCv36mm8
MGSCv36337,414,308 - 37,424,167 (-)NCBIMGSCv36mm8
Celera337,106,874 - 37,116,609 (-)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.36NCBI
IL21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384122,610,108 - 122,621,066 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4122,610,108 - 122,621,066 (-)Ensemblhg38GRCh38
GRCh374123,531,263 - 123,542,221 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,739,272 - 123,761,662 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344123,891,388 - 123,899,817NCBI
Celera4120,916,832 - 120,925,261 (-)NCBICelera
Cytogenetic Map4q27NCBI
HuRef4119,260,228 - 119,268,550 (-)NCBIHuRef
CHM1_14123,510,250 - 123,518,679 (-)NCBICHM1_1
T2T-CHM13v2.04125,914,209 - 125,925,168 (-)NCBIT2T-CHM13v2.0
Il21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82122,045,240 - 122,055,142 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2122,045,240 - 122,055,142 (-)EnsemblGRCr8
mRatBN7.22120,117,105 - 120,127,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,119,444 - 120,126,996 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2126,682,458 - 126,689,816 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,794,962 - 124,802,318 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,423,940 - 119,431,294 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02123,965,021 - 123,972,356 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2123,965,021 - 123,972,356 (-)Ensemblrn6Rnor6.0
Rnor_5.02143,573,215 - 143,580,530 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42123,774,331 - 123,781,697 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2115,067,969 - 115,075,326 (-)NCBICelera
RGSC_v3.12123,697,822 - 123,750,231 (-)NCBI
Cytogenetic Map2q25NCBI
Il21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542818,057,096 - 18,065,492 (+)Ensembl
ChiLan1.0NW_00495542818,057,096 - 18,065,492 (+)NCBIChiLan1.0ChiLan1.0
IL21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23120,394,845 - 120,405,796 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14120,660,750 - 120,671,701 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04114,795,979 - 114,806,936 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14125,940,979 - 125,951,915 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4125,943,495 - 125,951,915 (-)EnsemblpanPan2panpan1.1
IL21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11917,641,833 - 17,651,275 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1917,641,833 - 17,651,266 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1917,860,011 - 17,869,452 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01917,760,158 - 17,769,609 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1917,760,158 - 17,769,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11917,712,780 - 17,722,226 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01917,993,018 - 18,002,469 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01918,463,313 - 18,472,753 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530165,422,896 - 65,429,900 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366621,689,879 - 1,696,883 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366621,689,879 - 1,696,883 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8101,532,531 - 101,541,713 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18101,532,742 - 101,540,712 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,688,772 - 108,696,742 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1769,859,793 - 69,872,237 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl769,863,535 - 69,872,025 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603748,822,863 - 48,834,392 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247773,054,368 - 3,061,304 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247773,054,368 - 3,061,304 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Il21
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13116,779,438 - 116,787,031 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Il21
492 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:868
Count of miRNA genes:529
Interacting mature miRNAs:628
Transcripts:ENSMUST00000029273, ENSMUST00000161015
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
14746977Manh53_mmandible shape 53 (mouse)33592528069925280Mouse
15039332Nmrs6_mNAFLD-associated magnetic resonance shift 6 (mouse)33417074168170741Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
15039336Nmrs2_mNAFLD-associated magnetic resonance shift 2 (mouse)33457610368576103Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3758617468716946Mouse
9587784Afw13_mabdominal fat weight QTL 13 (mouse)Not determined33375204567752228Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
1300559Thypr3_mthymocyte proliferative response 3 (mouse)Not determined3452541938525519Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1301114Ssial2_msusceptibility to sialadenitis 2 (mouse)Not determined32017486254180103Mouse
1357689Mdmsc1_mmodifier of muscularity 1 (mouse)Not determined33332720145916479Mouse
18337272Bmd46_mbone mineral density 46, males (mouse)33540742169407421Mouse
1300961Bh4p_mbar holding four paws (mouse)Not determined33183785465837997Mouse
4142092Tgq13_mtriglyceride QTL 13 (mouse)Not determined1828816852288168Mouse
10043882Bwtq13_mbody weight QTL 13 (mouse)Not determined33375204567752228Mouse
10412073Ssen2_msuseptibility to Sendai virus 2 (mouse)Not determined33353546567535615Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
12910781Pwgrq12_mpost-weaning growth rate QTL 12 (mouse)33263576058017363Mouse
1300587Aod2_mautoimmune ovarian dysgenesis 2 (mouse)Not determined33717974268716946Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301358Eae20_mexperimental allergic encephalomyelitis 20 (mouse)Not determined31163045345630591Mouse
12910778Pwgrq13_mpost-weaning growth rate QTL 13 (mouse)33263576058017363Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000029273   ⟹   ENSMUSP00000029273
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl337,276,908 - 37,286,767 (-)Ensembl
GRCm38.p6 Ensembl337,222,759 - 37,232,618 (-)Ensembl
Ensembl Acc Id: ENSMUST00000161015   ⟹   ENSMUSP00000124668
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl337,279,486 - 37,286,714 (-)Ensembl
GRCm38.p6 Ensembl337,225,337 - 37,232,565 (-)Ensembl
Ensembl Acc Id: ENSMUST00000196943
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl337,284,451 - 37,286,785 (-)Ensembl
GRCm38.p6 Ensembl337,230,302 - 37,232,636 (-)Ensembl
RefSeq Acc Id: NM_001291041   ⟹   NP_001277970
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39337,276,908 - 37,286,785 (-)NCBI
GRCm38337,222,759 - 37,232,636 (-)NCBI
Celera337,106,874 - 37,116,627 (-)NCBI
Sequence:
RefSeq Acc Id: NM_021782   ⟹   NP_068554
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39337,276,908 - 37,286,785 (-)NCBI
GRCm38337,222,759 - 37,232,636 (-)NCBI
MGSCv37337,121,681 - 37,131,540 (-)RGD
Celera337,106,874 - 37,116,627 (-)NCBI
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_068554   ⟸   NM_021782
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9ES17 (UniProtKB/Swiss-Prot),   Q5SUE2 (UniProtKB/TrEMBL),   A5J0L5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001277970   ⟸   NM_001291041
- Peptide Label: isoform 1 precursor
- UniProtKB: E9PX58 (UniProtKB/TrEMBL),   A5J0L5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000029273   ⟸   ENSMUST00000029273
Ensembl Acc Id: ENSMUSP00000124668   ⟸   ENSMUST00000161015

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ES17-F1-model_v2 AlphaFold Q9ES17 1-146 view protein structure

Promoters
RGD ID:6880512
Promoter ID:EPDNEW_M3707
Type:single initiation site
Name:Il21_1
Description:Mus musculus interleukin 21 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38337,232,636 - 37,232,696EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1890474 AgrOrtholog
Ensembl Genes ENSMUSG00000027718 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000029273 ENTREZGENE
  ENSMUST00000029273.8 UniProtKB/Swiss-Prot
  ENSMUST00000161015 ENTREZGENE
Gene3D-CATH 1.20.1250.70 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-15/IL-21_fam UniProtKB/Swiss-Prot
KEGG Report mmu:60505 UniProtKB/Swiss-Prot
MGD MGI:1890474 ENTREZGENE
NCBI Gene 60505 ENTREZGENE
PANTHER INTERLEUKIN-21 UniProtKB/Swiss-Prot
  PTHR14356 UniProtKB/Swiss-Prot
PhenoGen Il21 PhenoGen
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt A5J0L5 ENTREZGENE, UniProtKB/TrEMBL
  E9PX58 ENTREZGENE, UniProtKB/TrEMBL
  IL21_MOUSE UniProtKB/Swiss-Prot
  Q5SUE2 ENTREZGENE, UniProtKB/TrEMBL
  Q9ES17 ENTREZGENE