LGALS12 (galectin 12) - Rat Genome Database

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Gene: LGALS12 (galectin 12) Homo sapiens
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Symbol: LGALS12
Name: galectin 12
RGD ID: 1315798
HGNC Page HGNC:15788
Description: Enables lactose binding activity. Acts upstream of or within intrinsic apoptotic signaling pathway. Predicted to be located in mitochondrion and nucleus. Predicted to be active in cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: GAL12; galectin-12; galectin-related inhibitor of proliferation; GRIP1; lectin, galactoside binding soluble 12; lectin, galactoside-binding, soluble, 12; testicular secretory protein Li 26
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381163,506,084 - 63,516,772 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1163,506,052 - 63,516,774 (+)EnsemblGRCh38hg38GRCh38
GRCh371163,273,556 - 63,284,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,030,132 - 63,040,815 (+)NCBINCBI36Build 36hg18NCBI36
Build 341163,030,131 - 63,040,815NCBI
Celera1160,597,611 - 60,608,333 (+)NCBICelera
Cytogenetic Map11q12.3NCBI
HuRef1159,602,375 - 59,613,101 (+)NCBIHuRef
CHM1_11163,156,531 - 63,167,253 (+)NCBICHM1_1
T2T-CHM13v2.01163,495,347 - 63,506,035 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
mitochondrion  (IEA)
nucleus  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11283015   PMID:11435439   PMID:12477932   PMID:15131127   PMID:15489334   PMID:21873635   PMID:25953264   PMID:26186194   PMID:27256573   PMID:28514442   PMID:29098769   PMID:30935948  
PMID:32752134   PMID:33961781   PMID:34860822   PMID:38492532   PMID:38685860  


Genomics

Comparative Map Data
LGALS12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381163,506,084 - 63,516,772 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1163,506,052 - 63,516,774 (+)EnsemblGRCh38hg38GRCh38
GRCh371163,273,556 - 63,284,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,030,132 - 63,040,815 (+)NCBINCBI36Build 36hg18NCBI36
Build 341163,030,131 - 63,040,815NCBI
Celera1160,597,611 - 60,608,333 (+)NCBICelera
Cytogenetic Map11q12.3NCBI
HuRef1159,602,375 - 59,613,101 (+)NCBIHuRef
CHM1_11163,156,531 - 63,167,253 (+)NCBICHM1_1
T2T-CHM13v2.01163,495,347 - 63,506,035 (+)NCBIT2T-CHM13v2.0
Lgals12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39197,574,021 - 7,584,601 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl197,574,025 - 7,584,558 (-)EnsemblGRCm39 Ensembl
GRCm38197,596,656 - 7,607,233 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl197,596,660 - 7,607,193 (-)EnsemblGRCm38mm10GRCm38
MGSCv37197,671,151 - 7,681,666 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36197,663,705 - 7,674,217 (-)NCBIMGSCv36mm8
Celera197,368,607 - 7,379,120 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.33NCBI
Lgals12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,261,216 - 214,272,825 (-)NCBIGRCr8
mRatBN7.21204,832,065 - 204,842,759 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1204,832,065 - 204,842,759 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1213,183,073 - 213,193,735 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01220,276,890 - 220,287,586 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,968,309 - 212,979,005 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,891,626 - 222,903,728 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,891,626 - 222,902,320 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01229,878,714 - 229,889,591 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41210,330,945 - 210,341,639 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11210,490,756 - 210,499,625 (-)NCBI
Celera1202,358,820 - 202,369,515 (-)NCBICelera
Cytogenetic Map1q43NCBI
Lgals12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955599249,317 - 257,567 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955599248,058 - 261,697 (+)NCBIChiLan1.0ChiLan1.0
LGALS12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2964,728,127 - 64,739,587 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11165,773,324 - 65,784,800 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01158,859,004 - 58,869,957 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11162,210,487 - 62,221,116 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1162,210,487 - 62,221,110 (+)Ensemblpanpan1.1panPan2
LGALS12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11853,428,894 - 53,446,767 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1853,437,562 - 53,447,013 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1852,045,428 - 52,053,730 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01854,474,201 - 54,492,040 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1854,481,445 - 54,491,949 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11853,586,266 - 53,594,568 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01853,160,689 - 53,168,988 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01853,947,729 - 53,956,035 (-)NCBIUU_Cfam_GSD_1.0
LGALS12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl28,463,402 - 8,475,162 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.128,454,362 - 8,475,360 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.227,840,530 - 7,852,683 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LGALS12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1110,741,778 - 10,762,043 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl110,745,373 - 10,761,684 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038108,090,684 - 108,101,569 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lgals12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249261,418,930 - 1,426,078 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249261,416,674 - 1,427,162 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LGALS12
34 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
GRCh38/hg38 11q12.3-13.1(chr11:62893226-64335043)x1 copy number loss See cases [RCV000140879] Chr11:62893226..64335043 [GRCh38]
Chr11:62660698..64102515 [GRCh37]
Chr11:62417274..63859091 [NCBI36]
Chr11:11q12.3-13.1		 likely pathogenic
GRCh37/hg19 11q12.3(chr11:63230830-63342467)x3 copy number gain See cases [RCV000239977] Chr11:63230830..63342467 [GRCh37]
Chr11:11q12.3		 uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_033101.4(LGALS12):c.-30A>G single nucleotide variant not specified [RCV004311939] Chr11:63506429 [GRCh38]
Chr11:63273901 [GRCh37]
Chr11:11q12.3		 uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q12.3(chr11:63064163-63343322)x1 copy number loss not provided [RCV000750073] Chr11:63064163..63343322 [GRCh37]
Chr11:11q12.3		 benign
NM_033101.4(LGALS12):c.842A>G (p.Asn281Ser) single nucleotide variant not specified [RCV004324704] Chr11:63516290 [GRCh38]
Chr11:63283762 [GRCh37]
Chr11:11q12.3		 uncertain significance
GRCh37/hg19 11q12.3(chr11:62714816-63383226)x3 copy number gain not provided [RCV001260131] Chr11:62714816..63383226 [GRCh37]
Chr11:11q12.3		 uncertain significance
NC_000011.9:g.(?_59596957)_(68707199_?)dup duplication Familial temporal lobe epilepsy 8 [RCV001372442] Chr11:59596957..68707199 [GRCh37]
Chr11:11q12.1-13.3		 uncertain significance
NC_000011.9:g.(?_58916346)_(64972349_?)dup duplication Leukocyte adhesion deficiency 3 [RCV003113394]|not provided [RCV003113393] Chr11:58916346..64972349 [GRCh37]
Chr11:11q12.1-13.1		 uncertain significance|no classifications from unflagged records
NM_033101.4(LGALS12):c.355G>A (p.Gly119Arg) single nucleotide variant not specified [RCV004307458] Chr11:63508974 [GRCh38]
Chr11:63276446 [GRCh37]
Chr11:11q12.3		 uncertain significance
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
NM_033101.4(LGALS12):c.833T>C (p.Leu278Pro) single nucleotide variant not specified [RCV004139956] Chr11:63516281 [GRCh38]
Chr11:63283753 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.893T>C (p.Leu298Pro) single nucleotide variant not specified [RCV004245743] Chr11:63516341 [GRCh38]
Chr11:63283813 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.280C>T (p.Arg94Cys) single nucleotide variant not specified [RCV004086699] Chr11:63508899 [GRCh38]
Chr11:63276371 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.232T>C (p.Phe78Leu) single nucleotide variant not specified [RCV004082760] Chr11:63508851 [GRCh38]
Chr11:63276323 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.34G>A (p.Asp12Asn) single nucleotide variant not specified [RCV004110212] Chr11:63506492 [GRCh38]
Chr11:63273964 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.-51G>T single nucleotide variant not specified [RCV004162073] Chr11:63506408 [GRCh38]
Chr11:63273880 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.247C>T (p.Pro83Ser) single nucleotide variant not specified [RCV004201982] Chr11:63508866 [GRCh38]
Chr11:63276338 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.682G>A (p.Ala228Thr) single nucleotide variant not specified [RCV004206929] Chr11:63515597 [GRCh38]
Chr11:63283069 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.83T>C (p.Val28Ala) single nucleotide variant not specified [RCV004077573] Chr11:63508566 [GRCh38]
Chr11:63276038 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.763G>A (p.Ala255Thr) single nucleotide variant not specified [RCV004282940] Chr11:63515678 [GRCh38]
Chr11:63283150 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.292G>A (p.Glu98Lys) single nucleotide variant not specified [RCV004285114] Chr11:63508911 [GRCh38]
Chr11:63276383 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.683C>T (p.Ala228Val) single nucleotide variant not specified [RCV004328677] Chr11:63515598 [GRCh38]
Chr11:63283070 [GRCh37]
Chr11:11q12.3		 likely benign
NM_033101.4(LGALS12):c.562G>A (p.Val188Met) single nucleotide variant not specified [RCV004358549] Chr11:63511755 [GRCh38]
Chr11:63279227 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.529C>T (p.His177Tyr) single nucleotide variant not specified [RCV004363352] Chr11:63510499 [GRCh38]
Chr11:63277971 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.407G>A (p.Arg136His) single nucleotide variant not specified [RCV004341990] Chr11:63509812 [GRCh38]
Chr11:63277284 [GRCh37]
Chr11:11q12.3		 uncertain significance
GRCh37/hg19 11q12.2-13.5(chr11:59923608-76272324)x3 copy number gain not provided [RCV003484842] Chr11:59923608..76272324 [GRCh37]
Chr11:11q12.2-13.5		 pathogenic
GRCh37/hg19 11p11.12-q13.1(chr11:50398499-63924462)x3 copy number gain not specified [RCV003986918] Chr11:50398499..63924462 [GRCh37]
Chr11:11p11.12-q13.1		 likely pathogenic
GRCh37/hg19 11q12.1-13.3(chr11:56895955-69295402)x3 copy number gain not specified [RCV003986944] Chr11:56895955..69295402 [GRCh37]
Chr11:11q12.1-13.3		 likely pathogenic
NM_033101.4(LGALS12):c.68C>T (p.Pro23Leu) single nucleotide variant not specified [RCV004412815] Chr11:63506526 [GRCh38]
Chr11:63273998 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.230G>A (p.Arg77His) single nucleotide variant not specified [RCV004412816] Chr11:63508849 [GRCh38]
Chr11:63276321 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.304C>G (p.Pro102Ala) single nucleotide variant not specified [RCV004412817] Chr11:63508923 [GRCh38]
Chr11:63276395 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.505G>C (p.Gly169Arg) single nucleotide variant not specified [RCV004412819] Chr11:63510475 [GRCh38]
Chr11:63277947 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.571T>C (p.Ser191Pro) single nucleotide variant not specified [RCV004412820] Chr11:63511764 [GRCh38]
Chr11:63279236 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.646C>G (p.His216Asp) single nucleotide variant not specified [RCV004412821] Chr11:63511839 [GRCh38]
Chr11:63279311 [GRCh37]
Chr11:11q12.3		 likely benign
NM_033101.4(LGALS12):c.736C>T (p.Arg246Cys) single nucleotide variant not specified [RCV004412822] Chr11:63515651 [GRCh38]
Chr11:63283123 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.458T>C (p.Ile153Thr) single nucleotide variant not specified [RCV004412818] Chr11:63509863 [GRCh38]
Chr11:63277335 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.130C>A (p.Gln44Lys) single nucleotide variant not specified [RCV004642374] Chr11:63508613 [GRCh38]
Chr11:63276085 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.49C>G (p.Gln17Glu) single nucleotide variant not specified [RCV004633944] Chr11:63506507 [GRCh38]
Chr11:63273979 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.178T>C (p.Cys60Arg) single nucleotide variant not specified [RCV004642373] Chr11:63508797 [GRCh38]
Chr11:63276269 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.638A>G (p.Glu213Gly) single nucleotide variant not specified [RCV004941654] Chr11:63511831 [GRCh38]
Chr11:63279303 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.524C>T (p.Ala175Val) single nucleotide variant not specified [RCV004941655] Chr11:63510494 [GRCh38]
Chr11:63277966 [GRCh37]
Chr11:11q12.3		 likely benign
NM_033101.4(LGALS12):c.400C>T (p.His134Tyr) single nucleotide variant not specified [RCV004941653] Chr11:63509805 [GRCh38]
Chr11:63277277 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.896G>A (p.Arg299Gln) single nucleotide variant not specified [RCV004934942] Chr11:63516344 [GRCh38]
Chr11:63283816 [GRCh37]
Chr11:11q12.3		 uncertain significance
NM_033101.4(LGALS12):c.326G>A (p.Gly109Asp) single nucleotide variant not specified [RCV004934943] Chr11:63508945 [GRCh38]
Chr11:63276417 [GRCh37]
Chr11:11q12.3		 uncertain significance
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1134
Count of miRNA genes:224
Interacting mature miRNAs:234
Transcripts:ENST00000255684, ENST00000340246, ENST00000394618, ENST00000415491, ENST00000425950
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357380BW64_HBody weight QTL 64 (human)2.2Body weightpercent fat after exercise training116097893786978937Human


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2204 2697 2140 4314 1463 1965 4 485 1477 326 2152 6345 5823 19 3194 761 1505 1381 163

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001142535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001142536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001142537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001142538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_033101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047427779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054370308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054370309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007062516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_950085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_950086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_950087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF222694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF222695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF244974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF244975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF244976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF244977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF310686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF310687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP001591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000255684   ⟹   ENSP00000255684
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1163,506,084 - 63,516,767 (+)Ensembl
Ensembl Acc Id: ENST00000340246   ⟹   ENSP00000339374
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1163,506,363 - 63,516,774 (+)Ensembl
Ensembl Acc Id: ENST00000394618   ⟹   ENSP00000378116
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1163,506,084 - 63,516,772 (+)Ensembl
Ensembl Acc Id: ENST00000415491   ⟹   ENSP00000394659
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1163,507,987 - 63,516,767 (+)Ensembl
Ensembl Acc Id: ENST00000425950   ⟹   ENSP00000399093
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1163,507,987 - 63,516,767 (+)Ensembl
Ensembl Acc Id: ENST00000674247   ⟹   ENSP00000501500
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1163,506,052 - 63,516,774 (+)Ensembl
RefSeq Acc Id: NM_001142535   ⟹   NP_001136007
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,506,084 - 63,516,772 (+)NCBI
GRCh371163,273,524 - 63,284,246 (+)RGD
Celera1160,597,611 - 60,608,333 (+)RGD
HuRef1159,602,375 - 59,613,101 (+)RGD
CHM1_11163,156,531 - 63,167,253 (+)NCBI
T2T-CHM13v2.01163,495,347 - 63,506,035 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001142536   ⟹   NP_001136008
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,506,084 - 63,516,772 (+)NCBI
GRCh371163,273,524 - 63,284,246 (+)RGD
Celera1160,597,611 - 60,608,333 (+)RGD
HuRef1159,602,375 - 59,613,101 (+)RGD
CHM1_11163,156,531 - 63,167,253 (+)NCBI
T2T-CHM13v2.01163,495,347 - 63,506,035 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001142537   ⟹   NP_001136009
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,507,987 - 63,516,772 (+)NCBI
GRCh371163,273,524 - 63,284,246 (+)RGD
Celera1160,597,611 - 60,608,333 (+)RGD
HuRef1159,602,375 - 59,613,101 (+)RGD
CHM1_11163,158,466 - 63,167,253 (+)NCBI
T2T-CHM13v2.01163,497,250 - 63,506,035 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001142538   ⟹   NP_001136010
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,507,987 - 63,516,772 (+)NCBI
GRCh371163,273,524 - 63,284,246 (+)RGD
Celera1160,597,611 - 60,608,333 (+)RGD
HuRef1159,602,375 - 59,613,101 (+)RGD
CHM1_11163,158,466 - 63,167,253 (+)NCBI
T2T-CHM13v2.01163,497,250 - 63,506,035 (+)NCBI
Sequence:
RefSeq Acc Id: NM_033101   ⟹   NP_149092
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,506,084 - 63,516,772 (+)NCBI
GRCh371163,273,524 - 63,284,246 (+)RGD
Build 361163,030,132 - 63,040,815 (+)NCBI Archive
Celera1160,597,611 - 60,608,333 (+)RGD
HuRef1159,602,375 - 59,613,101 (+)RGD
CHM1_11163,156,531 - 63,167,253 (+)NCBI
T2T-CHM13v2.01163,495,347 - 63,506,035 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017018458   ⟹   XP_016873947
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,506,084 - 63,516,772 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047427779   ⟹   XP_047283735
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,506,084 - 63,514,325 (+)NCBI
RefSeq Acc Id: XM_054370308   ⟹   XP_054226283
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01163,495,347 - 63,506,035 (+)NCBI
RefSeq Acc Id: XM_054370309   ⟹   XP_054226284
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01163,495,347 - 63,503,588 (+)NCBI
RefSeq Acc Id: XR_007062516
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,506,084 - 63,515,647 (+)NCBI
RefSeq Acc Id: XR_008488474
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01163,495,347 - 63,504,910 (+)NCBI
RefSeq Acc Id: XR_008488475
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01163,495,347 - 63,504,907 (+)NCBI
RefSeq Acc Id: XR_008488476
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01163,495,347 - 63,504,910 (+)NCBI
RefSeq Acc Id: XR_008488477
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01163,495,347 - 63,504,910 (+)NCBI
RefSeq Acc Id: XR_950085
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,506,084 - 63,515,647 (+)NCBI
Sequence:
RefSeq Acc Id: XR_950086
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,506,084 - 63,515,644 (+)NCBI
Sequence:
RefSeq Acc Id: XR_950087
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,506,084 - 63,515,647 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001136007 (Get FASTA)   NCBI Sequence Viewer  
  NP_001136008 (Get FASTA)   NCBI Sequence Viewer  
  NP_001136009 (Get FASTA)   NCBI Sequence Viewer  
  NP_001136010 (Get FASTA)   NCBI Sequence Viewer  
  NP_149092 (Get FASTA)   NCBI Sequence Viewer  
  XP_016873947 (Get FASTA)   NCBI Sequence Viewer  
  XP_047283735 (Get FASTA)   NCBI Sequence Viewer  
  XP_054226283 (Get FASTA)   NCBI Sequence Viewer  
  XP_054226284 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF34676 (Get FASTA)   NCBI Sequence Viewer  
  AAF34677 (Get FASTA)   NCBI Sequence Viewer  
  AAG40863 (Get FASTA)   NCBI Sequence Viewer  
  AAG40864 (Get FASTA)   NCBI Sequence Viewer  
  AAH28222 (Get FASTA)   NCBI Sequence Viewer  
  AAK77328 (Get FASTA)   NCBI Sequence Viewer  
  AAK77329 (Get FASTA)   NCBI Sequence Viewer  
  AAK77330 (Get FASTA)   NCBI Sequence Viewer  
  AAK77331 (Get FASTA)   NCBI Sequence Viewer  
  AEE61163 (Get FASTA)   NCBI Sequence Viewer  
  BAG36579 (Get FASTA)   NCBI Sequence Viewer  
  EAW74151 (Get FASTA)   NCBI Sequence Viewer  
  EAW74152 (Get FASTA)   NCBI Sequence Viewer  
  EAW74153 (Get FASTA)   NCBI Sequence Viewer  
  EAW74154 (Get FASTA)   NCBI Sequence Viewer  
  EAW74155 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000255684
  ENSP00000339374.6
  ENSP00000378116
  ENSP00000378116.4
  ENSP00000394659
  ENSP00000394659.2
  ENSP00000399093
  ENSP00000399093.2
  ENSP00000501500
  ENSP00000501500.1
GenBank Protein Q96DT0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_149092   ⟸   NM_033101
- Peptide Label: isoform 2
- UniProtKB: Q9NZ02 (UniProtKB/Swiss-Prot),   Q9H259 (UniProtKB/Swiss-Prot),   Q9H258 (UniProtKB/Swiss-Prot),   Q96PR9 (UniProtKB/Swiss-Prot),   Q96DT0 (UniProtKB/Swiss-Prot),   Q96DS9 (UniProtKB/Swiss-Prot),   G5E970 (UniProtKB/Swiss-Prot),   B2R9N2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001136007   ⟸   NM_001142535
- Peptide Label: isoform 1
- UniProtKB: A0A140VK26 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001136008   ⟸   NM_001142536
- Peptide Label: isoform 3
- UniProtKB: Q9NZ02 (UniProtKB/Swiss-Prot),   Q9H259 (UniProtKB/Swiss-Prot),   Q9H258 (UniProtKB/Swiss-Prot),   Q96PR9 (UniProtKB/Swiss-Prot),   Q96DT0 (UniProtKB/Swiss-Prot),   Q96DS9 (UniProtKB/Swiss-Prot),   G5E970 (UniProtKB/Swiss-Prot),   B2R9N2 (UniProtKB/Swiss-Prot),   A0A6Q8JG94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001136009   ⟸   NM_001142537
- Peptide Label: isoform 4
- UniProtKB: Q9NZ03 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001136010   ⟸   NM_001142538
- Peptide Label: isoform 5
- UniProtKB: Q9NZ03 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016873947   ⟸   XM_017018458
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSP00000501500   ⟸   ENST00000674247
Ensembl Acc Id: ENSP00000399093   ⟸   ENST00000425950
Ensembl Acc Id: ENSP00000255684   ⟸   ENST00000255684
Ensembl Acc Id: ENSP00000394659   ⟸   ENST00000415491
Ensembl Acc Id: ENSP00000339374   ⟸   ENST00000340246
Ensembl Acc Id: ENSP00000378116   ⟸   ENST00000394618
RefSeq Acc Id: XP_047283735   ⟸   XM_047427779
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054226283   ⟸   XM_054370308
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054226284   ⟸   XM_054370309
- Peptide Label: isoform X2
Protein Domains
Galectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96DT0-F1-model_v2 AlphaFold Q96DT0 1-336 view protein structure

Promoters
RGD ID:6789055
Promoter ID:HG_KWN:13160
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   NB4
Transcripts:NM_001142535,   NM_001142536,   NM_033101
Position:
Human AssemblyChrPosition (strand)Source
Build 361163,029,981 - 63,030,481 (+)MPROMDB
RGD ID:6788979
Promoter ID:HG_KWN:13161
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:NM_001142537,   NM_001142538,   UC009YOT.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361163,030,951 - 63,031,451 (+)MPROMDB
RGD ID:7220765
Promoter ID:EPDNEW_H16128
Type:initiation region
Name:LGALS12_1
Description:galectin 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16129  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,506,105 - 63,506,165EPDNEW
RGD ID:7220767
Promoter ID:EPDNEW_H16129
Type:initiation region
Name:LGALS12_2
Description:galectin 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16128  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381163,506,345 - 63,506,405EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:15788 AgrOrtholog
COSMIC LGALS12 COSMIC
Ensembl Genes ENSG00000133317 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000255684 ENTREZGENE
  ENST00000340246.10 UniProtKB/Swiss-Prot
  ENST00000394618 ENTREZGENE
  ENST00000394618.9 UniProtKB/Swiss-Prot
  ENST00000415491 ENTREZGENE
  ENST00000415491.6 UniProtKB/Swiss-Prot
  ENST00000425950 ENTREZGENE
  ENST00000425950.2 UniProtKB/Swiss-Prot
  ENST00000674247 ENTREZGENE
  ENST00000674247.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot
GTEx ENSG00000133317 GTEx
HGNC ID HGNC:15788 ENTREZGENE
Human Proteome Map LGALS12 Human Proteome Map
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot
  Galectin-like UniProtKB/Swiss-Prot
  Galectin_CRD UniProtKB/Swiss-Prot
KEGG Report hsa:85329 UniProtKB/Swiss-Prot
NCBI Gene 85329 ENTREZGENE
OMIM 606096 OMIM
PANTHER PTHR11346 UniProtKB/Swiss-Prot
  PTHR11346:SF111 UniProtKB/Swiss-Prot
Pfam Gal-bind_lectin UniProtKB/Swiss-Prot
PharmGKB PA30338 PharmGKB
PROSITE GALECTIN UniProtKB/Swiss-Prot
SMART Gal-bind_lectin UniProtKB/Swiss-Prot
  GLECT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot
UniProt A0A140VK26 ENTREZGENE, UniProtKB/TrEMBL
  A0A6Q8JG94 ENTREZGENE, UniProtKB/TrEMBL
  B2R9N2 ENTREZGENE
  G5E970 ENTREZGENE
  LEG12_HUMAN UniProtKB/Swiss-Prot
  Q96DS9 ENTREZGENE
  Q96DT0 ENTREZGENE
  Q96PR9 ENTREZGENE
  Q9H258 ENTREZGENE
  Q9H259 ENTREZGENE
  Q9NZ02 ENTREZGENE
  Q9NZ03 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B2R9N2 UniProtKB/Swiss-Prot
  G5E970 UniProtKB/Swiss-Prot
  Q96DS9 UniProtKB/Swiss-Prot
  Q96PR9 UniProtKB/Swiss-Prot
  Q9H258 UniProtKB/Swiss-Prot
  Q9H259 UniProtKB/Swiss-Prot
  Q9NZ02 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-17 LGALS12  galectin 12    lectin, galactoside binding soluble 12  Symbol and/or name change 5135510 APPROVED
2016-04-12 LGALS12  lectin, galactoside binding soluble 12    lectin, galactoside-binding, soluble, 12  Symbol and/or name change 5135510 APPROVED