Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | RAD1 | Human | (S)-nicotine | multiple interactions | ISO | Rad1 (Mus musculus) | 6480464 | [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | RAD1 | Human | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | increases expression | ISO | Rad1 (Mus musculus) | 6480464 | 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | RAD1 | Human | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | multiple interactions | ISO | Rad1 (Mus musculus) | 6480464 | [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | RAD1 | Human | 17alpha-ethynylestradiol | increases expression | ISO | Rad1 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of RAD1 mRNA | CTD | PMID:17942748 | RAD1 | Human | 17alpha-ethynylestradiol | multiple interactions | ISO | Rad1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RAD1 mRNA | CTD | PMID:17942748 | RAD1 | Human | 1H-pyrazole | increases expression | ISO | Rad1 (Mus musculus) | 6480464 | pyrazole results in increased expression of RAD1 mRNA | CTD | PMID:17945193 | RAD1 | Human | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Rad1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RAD1 mRNA and [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of RAD1 mRNA | CTD | PMID:17942748 and PMID:25975270 | RAD1 | Human | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Rad1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of RAD1 mRNA | CTD | PMID:33387578 | RAD1 | Human | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Rad1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of RAD1 mRNA | CTD | PMID:21570461 | RAD1 | Human | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Rad1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RAD1 mRNA | CTD | PMID:21215274 | RAD1 | Human | 2,6-dinitrotoluene | affects expression | ISO | Rad1 (Rattus norvegicus) | 6480464 | 2 and 6-dinitrotoluene affects the expression of RAD1 mRNA | CTD | PMID:21346803 | RAD1 | Human | 4,4'-diaminodiphenylmethane | decreases expression | ISO | Rad1 (Rattus norvegicus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of RAD1 mRNA | CTD | PMID:30723492 | RAD1 | Human | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of RAD1 mRNA | CTD | PMID:33167477 | RAD1 | Human | arecoline | decreases expression | EXP | | 6480464 | Arecoline results in decreased expression of RAD1 mRNA | CTD | PMID:17682004 | RAD1 | Human | benzo[a]pyrene | increases expression | ISO | Rad1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of RAD1 mRNA | CTD | PMID:19770486 and PMID:22228805 | RAD1 | Human | bisphenol A | decreases expression | ISO | Rad1 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of RAD1 mRNA | CTD | PMID:21932408 | RAD1 | Human | bisphenol A | increases expression | ISO | Rad1 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of RAD1 mRNA | CTD | PMID:25181051 | RAD1 | Human | butanal | decreases expression | EXP | | 6480464 | butyraldehyde results in decreased expression of RAD1 mRNA | CTD | PMID:26079696 | RAD1 | Human | cadmium atom | decreases expression | EXP | | 6480464 | Cadmium results in decreased expression of RAD1 mRNA | CTD | PMID:21120746 | RAD1 | Human | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of RAD1 mRNA | CTD | PMID:38382870 and PMID:38568856 | RAD1 | Human | caffeine | multiple interactions | ISO | Rad1 (Mus musculus) | 6480464 | [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | RAD1 | Human | CGP 52608 | multiple interactions | EXP | | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to RAD1 gene] | CTD | PMID:28238834 | RAD1 | Human | coumestrol | increases expression | EXP | | 6480464 | Coumestrol results in increased expression of RAD1 mRNA | CTD | PMID:19167446 | RAD1 | Human | cylindrospermopsin | decreases expression | EXP | | 6480464 | cylindrospermopsin results in decreased expression of RAD1 mRNA | CTD | PMID:23726867 | RAD1 | Human | dieldrin | affects expression | ISO | Rad1 (Rattus norvegicus) | 6480464 | Dieldrin affects the expression of RAD1 mRNA | CTD | PMID:22546817 | RAD1 | Human | dorsomorphin | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RAD1 mRNA | CTD | PMID:27188386 | RAD1 | Human | doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of RAD1 mRNA | CTD | PMID:29803840 and PMID:36634904 | RAD1 | Human | doxorubicin | multiple interactions | EXP | | 6480464 | [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of RAD1 mRNA and TP53 protein affects the reaction [Doxorubicin results in decreased expression of RAD1 mRNA] | CTD | PMID:36634904 | RAD1 | Human | folic acid | decreases expression | ISO | Rad1 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of RAD1 mRNA | CTD | PMID:25629700 | RAD1 | Human | hydrogen peroxide | decreases expression | EXP | | 6480464 | Hydrogen Peroxide results in decreased expression of RAD1 mRNA | CTD | PMID:18951874 | RAD1 | Human | indole-3-methanol | affects expression | ISO | Rad1 (Rattus norvegicus) | 6480464 | indole-3-carbinol affects the expression of RAD1 mRNA | CTD | PMID:21396975 | RAD1 | Human | kojic acid | increases expression | EXP | | 6480464 | kojic acid results in increased expression of RAD1 mRNA | CTD | PMID:16595896 | RAD1 | Human | Lasiocarpine | multiple interactions | EXP | | 6480464 | [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in decreased expression of RAD1 mRNA | CTD | PMID:33884520 | RAD1 | Human | monocrotaline | multiple interactions | EXP | | 6480464 | [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RAD1 mRNA | CTD | PMID:33884520 | RAD1 | Human | N-acetyl-L-cysteine | multiple interactions | EXP | | 6480464 | Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of RAD1 mRNA] | CTD | PMID:33971260 | RAD1 | Human | nickel dichloride | affects expression | ISO | Rad1 (Rattus norvegicus) | 6480464 | nickel chloride affects the expression of RAD1 mRNA | CTD | PMID:22546817 | RAD1 | Human | nicotine | multiple interactions | ISO | Rad1 (Mus musculus) | 6480464 | [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | RAD1 | Human | O-methyleugenol | decreases expression | ISO | Rad1 (Rattus norvegicus) | 6480464 | methyleugenol results in decreased expression of RAD1 mRNA | CTD | PMID:21659616 | RAD1 | Human | ochratoxin A | decreases acetylation | EXP | | 6480464 | ochratoxin A results in decreased acetylation of RAD1 promoter | CTD | PMID:29098329 | RAD1 | Human | ochratoxin A | multiple interactions | EXP | | 6480464 | [ochratoxin A results in decreased acetylation of RAD1 promoter] which results in decreased expression of RAD1 mRNA | CTD | PMID:29098329 | RAD1 | Human | ochratoxin A | decreases expression | EXP | | 6480464 | ochratoxin A results in decreased expression of RAD1 mRNA | CTD | PMID:29098329 | RAD1 | Human | oxaliplatin | multiple interactions | ISO | Rad1 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of RAD1 mRNA | CTD | PMID:25729387 | RAD1 | Human | paracetamol | affects expression | ISO | Rad1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of RAD1 mRNA | CTD | PMID:17562736 | RAD1 | Human | paracetamol | increases expression | ISO | Rad1 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of RAD1 mRNA | CTD | PMID:33387578 | RAD1 | Human | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of RAD1 mRNA | CTD | PMID:33971260 | RAD1 | Human | paracetamol | multiple interactions | EXP | | 6480464 | Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of RAD1 mRNA] | CTD | PMID:33971260 | RAD1 | Human | phenobarbital | affects expression | ISO | Rad1 (Mus musculus) | 6480464 | Phenobarbital affects the expression of RAD1 mRNA | CTD | PMID:19136022 | RAD1 | Human | phenylmercury acetate | decreases expression | EXP | | 6480464 | Phenylmercuric Acetate results in decreased expression of RAD1 mRNA | CTD | PMID:26272509 | RAD1 | Human | phenylmercury acetate | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RAD1 mRNA | CTD | PMID:27188386 | RAD1 | Human | pirinixic acid | affects expression | ISO | Rad1 (Mus musculus) | 6480464 | pirinixic acid affects the expression of RAD1 mRNA | CTD | PMID:19136022 | RAD1 | Human | pirinixic acid | increases expression | ISO | Rad1 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of RAD1 mRNA | CTD | PMID:18301758 and PMID:18445702 | RAD1 | Human | piroxicam | decreases expression | EXP | | 6480464 | Piroxicam results in decreased expression of RAD1 mRNA | CTD | PMID:21858171 | RAD1 | Human | pregnenolone 16alpha-carbonitrile | increases expression | ISO | Rad1 (Mus musculus) | 6480464 | Pregnenolone Carbonitrile results in increased expression of RAD1 mRNA | CTD | PMID:28903501 | RAD1 | Human | resveratrol | multiple interactions | EXP | | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of RAD1 mRNA | CTD | PMID:23557933 | RAD1 | Human | riddelliine | multiple interactions | EXP | | 6480464 | [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD1 mRNA | CTD | PMID:33884520 | RAD1 | Human | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of RAD1 mRNA | CTD | PMID:18191903 | RAD1 | Human | SB 431542 | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RAD1 mRNA | CTD | PMID:27188386 | RAD1 | Human | silicon dioxide | decreases expression | ISO | Rad1 (Mus musculus) | 6480464 | Silicon Dioxide results in decreased expression of RAD1 mRNA | CTD | PMID:19073995 | RAD1 | Human | tetrachloromethane | increases expression | ISO | Rad1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of RAD1 mRNA | CTD | PMID:31919559 | RAD1 | Human | titanium dioxide | decreases methylation | ISO | Rad1 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of RAD1 gene | CTD | PMID:35295148 | RAD1 | Human | topotecan | multiple interactions | ISO | Rad1 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of RAD1 mRNA | CTD | PMID:25729387 | RAD1 | Human | triphenyl phosphate | affects expression | EXP | | 6480464 | triphenyl phosphate affects the expression of RAD1 mRNA | CTD | PMID:37042841 | RAD1 | Human | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of RAD1 mRNA | CTD | PMID:23179753 | RAD1 | Human | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of RAD1 mRNA | CTD | PMID:25979313 | |