Igfbp7 (insulin-like growth factor binding protein 7) - Rat Genome Database

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Gene: Igfbp7 (insulin-like growth factor binding protein 7) Mus musculus
Analyze
Symbol: Igfbp7
Name: insulin-like growth factor binding protein 7
RGD ID: 1314684
MGI Page MGI
Description: Predicted to enable insulin-like growth factor binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within inner ear development. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Orthologous to human IGFBP7 (insulin like growth factor binding protein 7).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AG; AGM; angiomodulin; Fst; Fstl2; IBP-7; IGF-binding protein 7; IGFBP-7; insulin-like growth factor-binding protein 7; mac2; Mac25
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39577,497,092 - 77,555,892 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl577,497,087 - 77,555,888 (-)EnsemblGRCm39 Ensembl
GRCm38577,349,240 - 77,408,045 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl577,349,240 - 77,408,041 (-)EnsemblGRCm38mm10GRCm38
MGSCv37577,778,265 - 77,837,070 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36578,424,020 - 78,482,816 (-)NCBIMGSCv36mm8
Celera574,616,957 - 74,675,885 (-)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map541.71NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
arachidonic acid  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buspirone  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carnosic acid  (EXP)
CHIR 99021  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
cisplatin  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
dibromoacetic acid  (ISO)
dibutyl phthalate  (ISO)
dichromium trioxide  (ISO)
dipentyl phthalate  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (ISO)
folic acid  (EXP,ISO)
furan  (ISO)
graphene oxide  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (ISO)
mercury dibromide  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (EXP)
rotenone  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
topotecan  (ISO)
triacsin C  (ISO)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
XAV939  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis. Cheriyan VT, etal., PLoS One. 2014 Apr 1;9(4):e93711. doi: 10.1371/journal.pone.0093711. eCollection 2014.
2. Comprehensive analysis of endoplasmic reticulum-related and secretome gene expression profiles in the progression of non-alcoholic fatty liver disease. Gao R, etal., Front Endocrinol (Lausanne). 2022 Aug 12;13:967016. doi: 10.3389/fendo.2022.967016. eCollection 2022.
3. Prognostic impact of tumor-specific insulin-like growth factor binding protein 7 (IGFBP7) levels in breast cancer: a prospective cohort study. Godina C, etal., Carcinogenesis. 2021 Nov 12;42(11):1314-1325. doi: 10.1093/carcin/bgab090.
4. The change of circulating insulin like growth factor binding protein 7 levels may correlate with postoperative cognitive dysfunction. Jiang J, etal., Neurosci Lett. 2015 Feb 19;588:125-30. doi: 10.1016/j.neulet.2014.12.046. Epub 2014 Dec 24.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Burn-induced changes in IGF-I and IGF-binding proteins are partially glucocorticoid dependent. Lang CH, etal., Am J Physiol Regul Integr Comp Physiol. 2002 Jan;282(1):R207-15.
7. Target genes associated with lipid and glucose metabolism in non-alcoholic fatty liver disease. Li T, etal., Lipids Health Dis. 2019 Dec 5;18(1):211. doi: 10.1186/s12944-019-1154-9.
8. Insulin resistance is associated with increased serum concentration of IGF-binding protein-related protein 1 (IGFBP-rP1/MAC25). Lopez-Bermejo A, etal., Diabetes. 2006 Aug;55(8):2333-9.
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Protection of rats from thioacetamide-induced hepatic fibrosis by the extracts of a traditional Uighur medicine Cichorium glandulosum. Qin D, etal., Iran J Basic Med Sci. 2014 Nov;17(11):879-85.
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress. Tanaka T, etal., Am J Pathol. 2000 Jun;156(6):2149-57.
17. Insulin-like growth factor binding protein 7 accelerates hepatic steatosis and insulin resistance in non-alcoholic fatty liver disease. Yan H, etal., Clin Exp Pharmacol Physiol. 2019 Dec;46(12):1101-1110. doi: 10.1111/1440-1681.13159. Epub 2019 Aug 29.
18. Transcriptomic profiling of a multiethnic pediatric NAFLD cohort reveals genes and pathways associated with disease. Yao K, etal., Hepatol Commun. 2022 Jul;6(7):1598-1610. doi: 10.1002/hep4.1940. Epub 2022 Mar 21.
Additional References at PubMed
PMID:8649839   PMID:8889548   PMID:10349636   PMID:10623583   PMID:10820148   PMID:10859029   PMID:11042159   PMID:11076861   PMID:11112448   PMID:12477932   PMID:12730667   PMID:12847218  
PMID:14521955   PMID:16047381   PMID:16141072   PMID:16141073   PMID:16452166   PMID:16602821   PMID:16844427   PMID:17213798   PMID:18287559   PMID:19048112   PMID:19334288   PMID:19542015  
PMID:20204282   PMID:20630940   PMID:21795542   PMID:21835307   PMID:21873635   PMID:21873981   PMID:22159717   PMID:23028860   PMID:23250396   PMID:23525041   PMID:23563309   PMID:23584732  
PMID:23851500   PMID:24006456   PMID:24145187   PMID:24194600   PMID:24505323   PMID:24952961   PMID:25053427   PMID:25819415   PMID:26134413   PMID:26238476   PMID:27224923   PMID:27397633  
PMID:27626380   PMID:27989801   PMID:28071719   PMID:28619711   PMID:29323161   PMID:30333037   PMID:30635555   PMID:31152924   PMID:31287495   PMID:31661774   PMID:31797049   PMID:31836710  
PMID:31889368   PMID:33105483   PMID:33326113   PMID:34613814   PMID:35752325   PMID:36166296   PMID:37270777   PMID:38218180   PMID:38355793   PMID:38840498  


Genomics

Comparative Map Data
Igfbp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39577,497,092 - 77,555,892 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl577,497,087 - 77,555,888 (-)EnsemblGRCm39 Ensembl
GRCm38577,349,240 - 77,408,045 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl577,349,240 - 77,408,041 (-)EnsemblGRCm38mm10GRCm38
MGSCv37577,778,265 - 77,837,070 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36578,424,020 - 78,482,816 (-)NCBIMGSCv36mm8
Celera574,616,957 - 74,675,885 (-)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map541.71NCBI
IGFBP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38457,030,773 - 57,110,385 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl457,030,773 - 57,110,385 (-)EnsemblGRCh38hg38GRCh38
GRCh37457,896,939 - 57,976,551 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36457,592,001 - 57,671,296 (-)NCBINCBI36Build 36hg18NCBI36
Build 34457,738,173 - 57,817,467NCBI
Celera455,402,268 - 55,481,287 (-)NCBICelera
Cytogenetic Map4q12NCBI
HuRef453,850,811 - 53,930,091 (-)NCBIHuRef
CHM1_1457,933,093 - 58,012,367 (-)NCBICHM1_1
T2T-CHM13v2.0460,522,210 - 60,601,772 (-)NCBIT2T-CHM13v2.0
Igfbp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,091,681 - 31,151,623 (+)NCBIGRCr8
mRatBN7.21430,737,414 - 30,797,317 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1430,737,164 - 30,797,314 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1431,117,785 - 31,178,240 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,426,112 - 32,486,565 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01430,910,759 - 30,971,221 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01433,010,300 - 33,070,193 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,010,300 - 33,070,190 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01432,803,851 - 32,863,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41433,010,198 - 33,070,055 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11433,010,197 - 33,070,052 (+)NCBI
Celera1430,057,050 - 30,116,691 (+)NCBICelera
Cytogenetic Map14p11NCBI
Igfbp7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544714,047,732 - 14,108,414 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544714,048,834 - 14,110,264 (+)NCBIChiLan1.0ChiLan1.0
IGFBP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2372,662,038 - 72,744,322 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1472,870,306 - 72,949,674 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0466,808,845 - 66,888,301 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1473,382,745 - 73,462,087 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl473,382,745 - 73,462,087 (+)Ensemblpanpan1.1panPan2
IGFBP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11349,138,406 - 49,207,235 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1349,138,402 - 49,207,394 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1349,028,576 - 49,097,306 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01349,752,889 - 49,821,655 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1349,721,911 - 49,821,863 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11349,425,405 - 49,494,729 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01348,954,676 - 49,023,903 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01349,900,155 - 49,969,383 (-)NCBIUU_Cfam_GSD_1.0
Igfbp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528527,102,600 - 27,178,901 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648219,118,321 - 19,186,685 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648219,119,339 - 19,186,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFBP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl856,279,895 - 56,357,822 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1856,283,089 - 56,357,822 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2859,064,683 - 59,139,438 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IGFBP7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1711,617,096 - 11,694,530 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606612,195,308 - 12,273,610 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igfbp7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476112,318,006 - 12,387,582 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476112,318,571 - 12,387,489 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Igfbp7
1813 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:178
Count of miRNA genes:85
Interacting mature miRNAs:87
Transcripts:ENSMUST00000046746, ENSMUST00000163898
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572418876106419011Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576190263110190479Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576445064110445225Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
14746981Manh57_mmandible shape 57 (mouse)54716974281169742Mouse
12910784Pwgrq15_mpost-weaning growth rate QTL 15 (mouse)57717582397658215Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576445064110445225Mouse
1301698Pcfm4_mperiosteal circumference and femur length 4 (mouse)Not determined54458584378585965Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576445064110445225Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
10043962Obq27_mobesity QTL 27 (mouse)Not determined55628565590285655Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55960280193602980Mouse
12910816Ogrq2_moverall growth rate QTL 2 (mouse)57717582397658215Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55960280193602980Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55960280193602980Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576280786110280917Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576280786110280917Mouse
13207584Mwmlpt4_mMorris water maze latency to platform, training, 4 (mouse)54632260680322606Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
13207588Mwmlpa4_mMorris water maze latency to platform, all, 4 (mouse)54632260680322606Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576445064110445225Mouse
13464248Ahl13_mage related hearing loss, early onset 13 (mouse)55564587489645995Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55960280193602980Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
4141124Dshv2_mdorsal hippocampal volume 2 (mouse)Not determined57531534898019803Mouse
10044005Ahl7_mage related hearing loss 7 (mouse)Not determined55833050292330641Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576280786110280917Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse

Markers in Region
Igfbp7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37577,778,424 - 77,778,507UniSTSGRCm37
Celera574,617,116 - 74,617,199UniSTS
Cytogenetic Map5C3.3UniSTS
cM Map5 UniSTS
D5Buc53  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38577,385,685 - 77,385,833UniSTSGRCm38
MGSCv37577,814,710 - 77,814,858UniSTSGRCm37
Celera574,653,525 - 74,653,673UniSTS
Cytogenetic Map5C3.3UniSTS
cM Map5 UniSTS
D0Wsu3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38577,367,509 - 77,367,670UniSTSGRCm38
MGSCv37577,796,534 - 77,796,695UniSTSGRCm37
Celera574,635,342 - 74,635,503UniSTS
Cytogenetic Map5C3.3UniSTS
cM MapUN UniSTS
cM Map5 UniSTS
Igfbp7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5C3.3UniSTS
Igfbp7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38577,349,399 - 77,349,482UniSTSGRCm38
MGSCv37577,778,424 - 77,778,507UniSTSGRCm37
Celera574,617,116 - 74,617,199UniSTS
Cytogenetic Map5C3.3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001159518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA200937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB012886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB042198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC122396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC141469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW318969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB869840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC047202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF471478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK622921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L75822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000046746   ⟹   ENSMUSP00000045057
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl577,497,087 - 77,555,888 (-)Ensembl
GRCm38.p6 Ensembl577,349,240 - 77,408,041 (-)Ensembl
Ensembl Acc Id: ENSMUST00000163898   ⟹   ENSMUSP00000128318
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl577,497,095 - 77,555,887 (-)Ensembl
GRCm38.p6 Ensembl577,349,248 - 77,408,040 (-)Ensembl
RefSeq Acc Id: NM_001159518   ⟹   NP_001152990
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39577,497,092 - 77,555,892 (-)NCBI
GRCm38577,349,240 - 77,408,045 (-)ENTREZGENE
MGSCv37577,778,265 - 77,837,070 (-)RGD
Celera574,616,957 - 74,675,885 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_008048   ⟹   NP_032074
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39577,497,092 - 77,555,892 (-)NCBI
GRCm38577,349,240 - 77,408,045 (-)ENTREZGENE
MGSCv37577,778,265 - 77,837,070 (-)RGD
Celera574,616,957 - 74,675,885 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032074   ⟸   NM_008048
- Peptide Label: isoform 2 precursor
- UniProtKB: Q61581 (UniProtKB/Swiss-Prot),   O88812 (UniProtKB/Swiss-Prot),   Q9EQW0 (UniProtKB/Swiss-Prot),   F8WH23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001152990   ⟸   NM_001159518
- Peptide Label: isoform 1 precursor
- UniProtKB: E9Q5D9 (UniProtKB/TrEMBL),   F8WH23 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000045057   ⟸   ENSMUST00000046746
Ensembl Acc Id: ENSMUSP00000128318   ⟸   ENSMUST00000163898
Protein Domains
Ig-like   Ig-like C2-type   IGFBP N-terminal   Kazal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61581-F1-model_v2 AlphaFold Q61581 1-281 view protein structure

Promoters
RGD ID:6886986
Promoter ID:EPDNEW_M6944
Type:initiation region
Name:Igfbp7_1
Description:Mus musculus insulin-like growth factor binding protein 7 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38577,408,041 - 77,408,101EPDNEW
RGD ID:6837735
Promoter ID:MM_KWN:42687
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   Kidney,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000072884,   NM_001159518,   NM_008048
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36577,836,731 - 77,837,231 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1352480 AgrOrtholog
Ensembl Genes ENSMUSG00000036256 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000046746 ENTREZGENE
  ENSMUST00000046746.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSMUST00000163898 ENTREZGENE
  ENSMUST00000163898.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.60.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_rP_mac25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:29817 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1352480 ENTREZGENE
NCBI Gene 29817 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14186 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Igfbp7 PhenoGen
PIRSF IGFBP_rP_mac25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00121 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5E1_MOUSE UniProtKB/TrEMBL
  E9Q5D9 ENTREZGENE, UniProtKB/TrEMBL
  F8WH23 ENTREZGENE, UniProtKB/TrEMBL
  IBP7_MOUSE UniProtKB/Swiss-Prot
  O88812 ENTREZGENE
  Q3U131_MOUSE UniProtKB/TrEMBL
  Q3UFA6_MOUSE UniProtKB/TrEMBL
  Q61581 ENTREZGENE
  Q811C8_MOUSE UniProtKB/TrEMBL
  Q9EQW0 ENTREZGENE
UniProt Secondary O88812 UniProtKB/Swiss-Prot
  Q9EQW0 UniProtKB/Swiss-Prot